Regulation of aldosterone secretion by mineralocorticoid receptor-mediated signaling
Cherish Chong, Anis Hamid, Tham Yao, Amanda E Garza, Luminita H Pojoga, Gail K Adler, Jose R Romero, Gordon H Williams, Cherish Chong, Anis Hamid, Tham Yao, Amanda E Garza, Luminita H Pojoga, Gail K Adler, Jose R Romero, Gordon H Williams
Abstract
We posit the existence of a paracrine/autocrine negative feedback loop, mediated by the mineralocorticoid receptor (MR), regulating aldosterone secretion. To assess this hypothesis, we asked whether altering MR activity in zona glomerulosa (ZG) cells affects aldosterone production. To this end, we studied ex vivo ZG cells isolated from male Wistar rats fed chow containing either high (1.6% Na+ (HS)) or low (0.03% Na+ (LS)) amount of sodium. Western blot analyses demonstrated that MR was present in both the ZG and zona fasciculata/zona reticularis (ZF/ZR/ZR). In ZG cells isolated from rats on LS chow, MR activation by fludrocortisone produced a 20% and 60% reduction in aldosterone secretion basally and in response to angiotensin II (ANGII) stimulation, respectively. Corticosterone secretion was increased in these cells suggesting that aldosterone synthase activity was being reduced by fludrocortisone. In contrast, canrenoic acid, an MR antagonist, enhanced aldosterone production by up to 30% both basally and in response to ANGII. Similar responses were observed in ZG cells from rats fed HS. Modulating glucocorticoid receptor (GR) activity did not alter aldosterone production by ZG cells; however, altering GR activity did modify corticosterone production from ZF/ZR/ZR cells both basally and in response to adrenocorticotropic hormone (ACTH). Additionally, activating the MR in ZF/ZR/ZR cells strikingly reduced corticosterone secretion. In summary, these data support the hypothesis that negative ultra-short feedback loops regulate adrenal steroidogenesis. In the ZG, aldosterone secretion is regulated by the MR, but not the GR, an effect that appears to be secondary to a change in aldosterone synthase activity.
Keywords: adrenal cortex; aldosterone; corticosterone; zona fasciculata; zona glomerulosa.
© 2017 Society for Endocrinology.
Figures
![Figure 1](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/5464000/bin/nihms847639f1.jpg)
Figure 2
Western blot analyses showing expression…
Figure 2
Western blot analyses showing expression of MR, GR, CYP11B2 and CYP11B1 in zona…
Figure 3
Effect of activation of MR…
Figure 3
Effect of activation of MR by fludrocortisone (FLUDRO) on basal (left panel) and…
Figure 4
Effect of MR inhibition on…
Figure 4
Effect of MR inhibition on baseline and ANGII stimulated aldosterone secretion by isolated…
Figure 5
Corticosterone (CORT) secretion in isolated…
Figure 5
Corticosterone (CORT) secretion in isolated zona glomerulosa cells from rats on a low…
Figure 6
Modulation of MR function in…
Figure 6
Modulation of MR function in zona glomerulosa cells from rats on a high…
Figure 7
Effect of modifying GR activity…
Figure 7
Effect of modifying GR activity on aldosterone secretion in zona glomerulosa cells from…
Figure 8
Inhibition of stimulated corticosterone secretion…
Figure 8
Inhibition of stimulated corticosterone secretion by DEX in zona fasciculata/reticularis cells from low…
Figure 9
RU486 treatment stimulates corticosterone production…
Figure 9
RU486 treatment stimulates corticosterone production in ACTH-stimulated zona fasciculata/reticularis cells from rats fed…
Figure 10
Effect of MR activation on…
Figure 10
Effect of MR activation on corticosterone from low salt (LS, top panels) and…
Figure 11
MR blockade with canrenoate did…
Figure 11
MR blockade with canrenoate did not alter corticosterone secretion in basal and ACTH-stimulated…
- Renin knockout rat: control of adrenal aldosterone and corticosterone synthesis in vitro and adrenal gene expression.Raff H, Gehrand A, Bruder ED, Hoffman MJ, Engeland WC, Moreno C. Raff H, et al. Am J Physiol Regul Integr Comp Physiol. 2015 Jan 1;308(1):R73-7. doi: 10.1152/ajpregu.00440.2014. Epub 2014 Nov 12. Am J Physiol Regul Integr Comp Physiol. 2015. PMID: 25394830 Free PMC article.
- Studies on endothelin receptors in the zonae fasciculata/reticularis of the rat adrenal cortex: contrast with the zona glomerulosa.Kapas S, Cameron LA, Puddefoot JR, Hinson JP. Kapas S, et al. FEBS Lett. 1996 Nov 18;397(2-3):186-90. doi: 10.1016/s0014-5793(96)01133-7. FEBS Lett. 1996. PMID: 8955344
- Both low sodium and high potassium intake increase the level of adrenal angiotensin-II receptor type 1, but not that of adrenocorticotropin receptor.Lehoux JG, Bird IM, Rainey WE, Tremblay A, Ducharme L. Lehoux JG, et al. Endocrinology. 1994 Feb;134(2):776-82. doi: 10.1210/endo.134.2.7507836. Endocrinology. 1994. PMID: 7507836
- Development of adrenal cortex zonation.Xing Y, Lerario AM, Rainey W, Hammer GD. Xing Y, et al. Endocrinol Metab Clin North Am. 2015 Jun;44(2):243-74. doi: 10.1016/j.ecl.2015.02.001. Endocrinol Metab Clin North Am. 2015. PMID: 26038200 Free PMC article. Review.
- Evolution of hormone selectivity in glucocorticoid and mineralocorticoid receptors.Baker ME, Funder JW, Kattoula SR. Baker ME, et al. J Steroid Biochem Mol Biol. 2013 Sep;137:57-70. doi: 10.1016/j.jsbmb.2013.07.009. Epub 2013 Jul 29. J Steroid Biochem Mol Biol. 2013. PMID: 23907018 Review.
- Lysine-specific demethylase 1 deficiency modifies aldosterone synthesis in a sex-specific manner.Tan YJD, Brooks DL, Wong KYH, Huang Y, Romero JR, Williams JS, Pojoga LH. Tan YJD, et al. J Endocrinol. 2022 Dec 12;256(1):e220141. doi: 10.1530/JOE-22-0141. Print 2023 Jan 1. J Endocrinol. 2022. PMID: 36327153 Free PMC article.
- CIRMI-a new term for a concept worthy of further exploration: a narrative review.Nethathe GD, Lipman J, Anderson R, Feldman C. Nethathe GD, et al. Ann Transl Med. 2022 Jun;10(11):646. doi: 10.21037/atm-21-5572. Ann Transl Med. 2022. PMID: 35813323 Free PMC article. Review.
- Mineralocorticoid Receptor Antagonists Decrease the Rates of Positive Screening for Primary Aldosteronism.Tezuka Y, Turcu AF. Tezuka Y, et al. Endocr Pract. 2020 Dec;26(12):1416-1424. doi: 10.4158/EP-2020-0277. Endocr Pract. 2020. PMID: 33471733 Free PMC article.
- Lysine-Specific Demethylase-1 Deficiency Increases Agonist Signaling Via the Mineralocorticoid Receptor.Treesaranuwattana T, Wong KYH, Brooks DL, Tay CS, Williams GH, Williams JS, Pojoga LH. Treesaranuwattana T, et al. Hypertension. 2020 Apr;75(4):1045-1053. doi: 10.1161/HYPERTENSIONAHA.119.13821. Epub 2020 Mar 11. Hypertension. 2020. PMID: 32160100 Free PMC article.
- Steroidogenic acute regulatory protein/aldosterone synthase mediates angiotensin II-induced cardiac fibrosis and hypertrophy.Zhang WW, Zheng RH, Bai F, Sturdivant K, Wang NP, James EA, Bose HS, Zhao ZQ. Zhang WW, et al. Mol Biol Rep. 2020 Feb;47(2):1207-1222. doi: 10.1007/s11033-019-05222-7. Epub 2019 Dec 9. Mol Biol Rep. 2020. PMID: 31820314
- Aldosterone / metabolism*
- Animals
- Corticosterone / blood
- Male
- Rats
- Rats, Wistar
- Receptors, Glucocorticoid / metabolism
- Receptors, Mineralocorticoid / metabolism*
- Signal Transduction / physiology*
- Sodium, Dietary*
- Zona Glomerulosa / metabolism*
- Zona Reticularis / metabolism*
- Receptors, Glucocorticoid
- Receptors, Mineralocorticoid
- Sodium, Dietary
- Aldosterone
- Corticosterone
- Full Text Sources
- Other Literature Sources
- Medical
NCBI Literature Resources
The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Unauthorized use of these marks is strictly prohibited.
National Library of Medicine
8600 Rockville Pike
Bethesda, MD 20894
![Figure 2](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/5464000/bin/nihms847639f2.jpg)
Figure 3
Effect of activation of MR…
Figure 3
Effect of activation of MR by fludrocortisone (FLUDRO) on basal (left panel) and…
Figure 4
Effect of MR inhibition on…
Figure 4
Effect of MR inhibition on baseline and ANGII stimulated aldosterone secretion by isolated…
Figure 5
Corticosterone (CORT) secretion in isolated…
Figure 5
Corticosterone (CORT) secretion in isolated zona glomerulosa cells from rats on a low…
Figure 6
Modulation of MR function in…
Figure 6
Modulation of MR function in zona glomerulosa cells from rats on a high…
Figure 7
Effect of modifying GR activity…
Figure 7
Effect of modifying GR activity on aldosterone secretion in zona glomerulosa cells from…
Figure 8
Inhibition of stimulated corticosterone secretion…
Figure 8
Inhibition of stimulated corticosterone secretion by DEX in zona fasciculata/reticularis cells from low…
Figure 9
RU486 treatment stimulates corticosterone production…
Figure 9
RU486 treatment stimulates corticosterone production in ACTH-stimulated zona fasciculata/reticularis cells from rats fed…
Figure 10
Effect of MR activation on…
Figure 10
Effect of MR activation on corticosterone from low salt (LS, top panels) and…
Figure 11
MR blockade with canrenoate did…
Figure 11
MR blockade with canrenoate did not alter corticosterone secretion in basal and ACTH-stimulated…
- Renin knockout rat: control of adrenal aldosterone and corticosterone synthesis in vitro and adrenal gene expression.Raff H, Gehrand A, Bruder ED, Hoffman MJ, Engeland WC, Moreno C. Raff H, et al. Am J Physiol Regul Integr Comp Physiol. 2015 Jan 1;308(1):R73-7. doi: 10.1152/ajpregu.00440.2014. Epub 2014 Nov 12. Am J Physiol Regul Integr Comp Physiol. 2015. PMID: 25394830 Free PMC article.
- Studies on endothelin receptors in the zonae fasciculata/reticularis of the rat adrenal cortex: contrast with the zona glomerulosa.Kapas S, Cameron LA, Puddefoot JR, Hinson JP. Kapas S, et al. FEBS Lett. 1996 Nov 18;397(2-3):186-90. doi: 10.1016/s0014-5793(96)01133-7. FEBS Lett. 1996. PMID: 8955344
- Both low sodium and high potassium intake increase the level of adrenal angiotensin-II receptor type 1, but not that of adrenocorticotropin receptor.Lehoux JG, Bird IM, Rainey WE, Tremblay A, Ducharme L. Lehoux JG, et al. Endocrinology. 1994 Feb;134(2):776-82. doi: 10.1210/endo.134.2.7507836. Endocrinology. 1994. PMID: 7507836
- Development of adrenal cortex zonation.Xing Y, Lerario AM, Rainey W, Hammer GD. Xing Y, et al. Endocrinol Metab Clin North Am. 2015 Jun;44(2):243-74. doi: 10.1016/j.ecl.2015.02.001. Endocrinol Metab Clin North Am. 2015. PMID: 26038200 Free PMC article. Review.
- Evolution of hormone selectivity in glucocorticoid and mineralocorticoid receptors.Baker ME, Funder JW, Kattoula SR. Baker ME, et al. J Steroid Biochem Mol Biol. 2013 Sep;137:57-70. doi: 10.1016/j.jsbmb.2013.07.009. Epub 2013 Jul 29. J Steroid Biochem Mol Biol. 2013. PMID: 23907018 Review.
- Lysine-specific demethylase 1 deficiency modifies aldosterone synthesis in a sex-specific manner.Tan YJD, Brooks DL, Wong KYH, Huang Y, Romero JR, Williams JS, Pojoga LH. Tan YJD, et al. J Endocrinol. 2022 Dec 12;256(1):e220141. doi: 10.1530/JOE-22-0141. Print 2023 Jan 1. J Endocrinol. 2022. PMID: 36327153 Free PMC article.
- CIRMI-a new term for a concept worthy of further exploration: a narrative review.Nethathe GD, Lipman J, Anderson R, Feldman C. Nethathe GD, et al. Ann Transl Med. 2022 Jun;10(11):646. doi: 10.21037/atm-21-5572. Ann Transl Med. 2022. PMID: 35813323 Free PMC article. Review.
- Mineralocorticoid Receptor Antagonists Decrease the Rates of Positive Screening for Primary Aldosteronism.Tezuka Y, Turcu AF. Tezuka Y, et al. Endocr Pract. 2020 Dec;26(12):1416-1424. doi: 10.4158/EP-2020-0277. Endocr Pract. 2020. PMID: 33471733 Free PMC article.
- Lysine-Specific Demethylase-1 Deficiency Increases Agonist Signaling Via the Mineralocorticoid Receptor.Treesaranuwattana T, Wong KYH, Brooks DL, Tay CS, Williams GH, Williams JS, Pojoga LH. Treesaranuwattana T, et al. Hypertension. 2020 Apr;75(4):1045-1053. doi: 10.1161/HYPERTENSIONAHA.119.13821. Epub 2020 Mar 11. Hypertension. 2020. PMID: 32160100 Free PMC article.
- Steroidogenic acute regulatory protein/aldosterone synthase mediates angiotensin II-induced cardiac fibrosis and hypertrophy.Zhang WW, Zheng RH, Bai F, Sturdivant K, Wang NP, James EA, Bose HS, Zhao ZQ. Zhang WW, et al. Mol Biol Rep. 2020 Feb;47(2):1207-1222. doi: 10.1007/s11033-019-05222-7. Epub 2019 Dec 9. Mol Biol Rep. 2020. PMID: 31820314
- Aldosterone / metabolism*
- Animals
- Corticosterone / blood
- Male
- Rats
- Rats, Wistar
- Receptors, Glucocorticoid / metabolism
- Receptors, Mineralocorticoid / metabolism*
- Signal Transduction / physiology*
- Sodium, Dietary*
- Zona Glomerulosa / metabolism*
- Zona Reticularis / metabolism*
- Receptors, Glucocorticoid
- Receptors, Mineralocorticoid
- Sodium, Dietary
- Aldosterone
- Corticosterone
- Full Text Sources
- Other Literature Sources
- Medical
NCBI Literature Resources
The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Unauthorized use of these marks is strictly prohibited.
National Library of Medicine
8600 Rockville Pike
Bethesda, MD 20894
![Figure 3](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/5464000/bin/nihms847639f3.jpg)
Figure 4
Effect of MR inhibition on…
Figure 4
Effect of MR inhibition on baseline and ANGII stimulated aldosterone secretion by isolated…
Figure 5
Corticosterone (CORT) secretion in isolated…
Figure 5
Corticosterone (CORT) secretion in isolated zona glomerulosa cells from rats on a low…
Figure 6
Modulation of MR function in…
Figure 6
Modulation of MR function in zona glomerulosa cells from rats on a high…
Figure 7
Effect of modifying GR activity…
Figure 7
Effect of modifying GR activity on aldosterone secretion in zona glomerulosa cells from…
Figure 8
Inhibition of stimulated corticosterone secretion…
Figure 8
Inhibition of stimulated corticosterone secretion by DEX in zona fasciculata/reticularis cells from low…
Figure 9
RU486 treatment stimulates corticosterone production…
Figure 9
RU486 treatment stimulates corticosterone production in ACTH-stimulated zona fasciculata/reticularis cells from rats fed…
Figure 10
Effect of MR activation on…
Figure 10
Effect of MR activation on corticosterone from low salt (LS, top panels) and…
Figure 11
MR blockade with canrenoate did…
Figure 11
MR blockade with canrenoate did not alter corticosterone secretion in basal and ACTH-stimulated…
- Renin knockout rat: control of adrenal aldosterone and corticosterone synthesis in vitro and adrenal gene expression.Raff H, Gehrand A, Bruder ED, Hoffman MJ, Engeland WC, Moreno C. Raff H, et al. Am J Physiol Regul Integr Comp Physiol. 2015 Jan 1;308(1):R73-7. doi: 10.1152/ajpregu.00440.2014. Epub 2014 Nov 12. Am J Physiol Regul Integr Comp Physiol. 2015. PMID: 25394830 Free PMC article.
- Studies on endothelin receptors in the zonae fasciculata/reticularis of the rat adrenal cortex: contrast with the zona glomerulosa.Kapas S, Cameron LA, Puddefoot JR, Hinson JP. Kapas S, et al. FEBS Lett. 1996 Nov 18;397(2-3):186-90. doi: 10.1016/s0014-5793(96)01133-7. FEBS Lett. 1996. PMID: 8955344
- Both low sodium and high potassium intake increase the level of adrenal angiotensin-II receptor type 1, but not that of adrenocorticotropin receptor.Lehoux JG, Bird IM, Rainey WE, Tremblay A, Ducharme L. Lehoux JG, et al. Endocrinology. 1994 Feb;134(2):776-82. doi: 10.1210/endo.134.2.7507836. Endocrinology. 1994. PMID: 7507836
- Development of adrenal cortex zonation.Xing Y, Lerario AM, Rainey W, Hammer GD. Xing Y, et al. Endocrinol Metab Clin North Am. 2015 Jun;44(2):243-74. doi: 10.1016/j.ecl.2015.02.001. Endocrinol Metab Clin North Am. 2015. PMID: 26038200 Free PMC article. Review.
- Evolution of hormone selectivity in glucocorticoid and mineralocorticoid receptors.Baker ME, Funder JW, Kattoula SR. Baker ME, et al. J Steroid Biochem Mol Biol. 2013 Sep;137:57-70. doi: 10.1016/j.jsbmb.2013.07.009. Epub 2013 Jul 29. J Steroid Biochem Mol Biol. 2013. PMID: 23907018 Review.
- Lysine-specific demethylase 1 deficiency modifies aldosterone synthesis in a sex-specific manner.Tan YJD, Brooks DL, Wong KYH, Huang Y, Romero JR, Williams JS, Pojoga LH. Tan YJD, et al. J Endocrinol. 2022 Dec 12;256(1):e220141. doi: 10.1530/JOE-22-0141. Print 2023 Jan 1. J Endocrinol. 2022. PMID: 36327153 Free PMC article.
- CIRMI-a new term for a concept worthy of further exploration: a narrative review.Nethathe GD, Lipman J, Anderson R, Feldman C. Nethathe GD, et al. Ann Transl Med. 2022 Jun;10(11):646. doi: 10.21037/atm-21-5572. Ann Transl Med. 2022. PMID: 35813323 Free PMC article. Review.
- Mineralocorticoid Receptor Antagonists Decrease the Rates of Positive Screening for Primary Aldosteronism.Tezuka Y, Turcu AF. Tezuka Y, et al. Endocr Pract. 2020 Dec;26(12):1416-1424. doi: 10.4158/EP-2020-0277. Endocr Pract. 2020. PMID: 33471733 Free PMC article.
- Lysine-Specific Demethylase-1 Deficiency Increases Agonist Signaling Via the Mineralocorticoid Receptor.Treesaranuwattana T, Wong KYH, Brooks DL, Tay CS, Williams GH, Williams JS, Pojoga LH. Treesaranuwattana T, et al. Hypertension. 2020 Apr;75(4):1045-1053. doi: 10.1161/HYPERTENSIONAHA.119.13821. Epub 2020 Mar 11. Hypertension. 2020. PMID: 32160100 Free PMC article.
- Steroidogenic acute regulatory protein/aldosterone synthase mediates angiotensin II-induced cardiac fibrosis and hypertrophy.Zhang WW, Zheng RH, Bai F, Sturdivant K, Wang NP, James EA, Bose HS, Zhao ZQ. Zhang WW, et al. Mol Biol Rep. 2020 Feb;47(2):1207-1222. doi: 10.1007/s11033-019-05222-7. Epub 2019 Dec 9. Mol Biol Rep. 2020. PMID: 31820314
- Aldosterone / metabolism*
- Animals
- Corticosterone / blood
- Male
- Rats
- Rats, Wistar
- Receptors, Glucocorticoid / metabolism
- Receptors, Mineralocorticoid / metabolism*
- Signal Transduction / physiology*
- Sodium, Dietary*
- Zona Glomerulosa / metabolism*
- Zona Reticularis / metabolism*
- Receptors, Glucocorticoid
- Receptors, Mineralocorticoid
- Sodium, Dietary
- Aldosterone
- Corticosterone
- Full Text Sources
- Other Literature Sources
- Medical
NCBI Literature Resources
The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Unauthorized use of these marks is strictly prohibited.
National Library of Medicine
8600 Rockville Pike
Bethesda, MD 20894
![Figure 4](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/5464000/bin/nihms847639f4.jpg)
Figure 5
Corticosterone (CORT) secretion in isolated…
Figure 5
Corticosterone (CORT) secretion in isolated zona glomerulosa cells from rats on a low…
Figure 6
Modulation of MR function in…
Figure 6
Modulation of MR function in zona glomerulosa cells from rats on a high…
Figure 7
Effect of modifying GR activity…
Figure 7
Effect of modifying GR activity on aldosterone secretion in zona glomerulosa cells from…
Figure 8
Inhibition of stimulated corticosterone secretion…
Figure 8
Inhibition of stimulated corticosterone secretion by DEX in zona fasciculata/reticularis cells from low…
Figure 9
RU486 treatment stimulates corticosterone production…
Figure 9
RU486 treatment stimulates corticosterone production in ACTH-stimulated zona fasciculata/reticularis cells from rats fed…
Figure 10
Effect of MR activation on…
Figure 10
Effect of MR activation on corticosterone from low salt (LS, top panels) and…
Figure 11
MR blockade with canrenoate did…
Figure 11
MR blockade with canrenoate did not alter corticosterone secretion in basal and ACTH-stimulated…
- Renin knockout rat: control of adrenal aldosterone and corticosterone synthesis in vitro and adrenal gene expression.Raff H, Gehrand A, Bruder ED, Hoffman MJ, Engeland WC, Moreno C. Raff H, et al. Am J Physiol Regul Integr Comp Physiol. 2015 Jan 1;308(1):R73-7. doi: 10.1152/ajpregu.00440.2014. Epub 2014 Nov 12. Am J Physiol Regul Integr Comp Physiol. 2015. PMID: 25394830 Free PMC article.
- Studies on endothelin receptors in the zonae fasciculata/reticularis of the rat adrenal cortex: contrast with the zona glomerulosa.Kapas S, Cameron LA, Puddefoot JR, Hinson JP. Kapas S, et al. FEBS Lett. 1996 Nov 18;397(2-3):186-90. doi: 10.1016/s0014-5793(96)01133-7. FEBS Lett. 1996. PMID: 8955344
- Both low sodium and high potassium intake increase the level of adrenal angiotensin-II receptor type 1, but not that of adrenocorticotropin receptor.Lehoux JG, Bird IM, Rainey WE, Tremblay A, Ducharme L. Lehoux JG, et al. Endocrinology. 1994 Feb;134(2):776-82. doi: 10.1210/endo.134.2.7507836. Endocrinology. 1994. PMID: 7507836
- Development of adrenal cortex zonation.Xing Y, Lerario AM, Rainey W, Hammer GD. Xing Y, et al. Endocrinol Metab Clin North Am. 2015 Jun;44(2):243-74. doi: 10.1016/j.ecl.2015.02.001. Endocrinol Metab Clin North Am. 2015. PMID: 26038200 Free PMC article. Review.
- Evolution of hormone selectivity in glucocorticoid and mineralocorticoid receptors.Baker ME, Funder JW, Kattoula SR. Baker ME, et al. J Steroid Biochem Mol Biol. 2013 Sep;137:57-70. doi: 10.1016/j.jsbmb.2013.07.009. Epub 2013 Jul 29. J Steroid Biochem Mol Biol. 2013. PMID: 23907018 Review.
- Lysine-specific demethylase 1 deficiency modifies aldosterone synthesis in a sex-specific manner.Tan YJD, Brooks DL, Wong KYH, Huang Y, Romero JR, Williams JS, Pojoga LH. Tan YJD, et al. J Endocrinol. 2022 Dec 12;256(1):e220141. doi: 10.1530/JOE-22-0141. Print 2023 Jan 1. J Endocrinol. 2022. PMID: 36327153 Free PMC article.
- CIRMI-a new term for a concept worthy of further exploration: a narrative review.Nethathe GD, Lipman J, Anderson R, Feldman C. Nethathe GD, et al. Ann Transl Med. 2022 Jun;10(11):646. doi: 10.21037/atm-21-5572. Ann Transl Med. 2022. PMID: 35813323 Free PMC article. Review.
- Mineralocorticoid Receptor Antagonists Decrease the Rates of Positive Screening for Primary Aldosteronism.Tezuka Y, Turcu AF. Tezuka Y, et al. Endocr Pract. 2020 Dec;26(12):1416-1424. doi: 10.4158/EP-2020-0277. Endocr Pract. 2020. PMID: 33471733 Free PMC article.
- Lysine-Specific Demethylase-1 Deficiency Increases Agonist Signaling Via the Mineralocorticoid Receptor.Treesaranuwattana T, Wong KYH, Brooks DL, Tay CS, Williams GH, Williams JS, Pojoga LH. Treesaranuwattana T, et al. Hypertension. 2020 Apr;75(4):1045-1053. doi: 10.1161/HYPERTENSIONAHA.119.13821. Epub 2020 Mar 11. Hypertension. 2020. PMID: 32160100 Free PMC article.
- Steroidogenic acute regulatory protein/aldosterone synthase mediates angiotensin II-induced cardiac fibrosis and hypertrophy.Zhang WW, Zheng RH, Bai F, Sturdivant K, Wang NP, James EA, Bose HS, Zhao ZQ. Zhang WW, et al. Mol Biol Rep. 2020 Feb;47(2):1207-1222. doi: 10.1007/s11033-019-05222-7. Epub 2019 Dec 9. Mol Biol Rep. 2020. PMID: 31820314
- Aldosterone / metabolism*
- Animals
- Corticosterone / blood
- Male
- Rats
- Rats, Wistar
- Receptors, Glucocorticoid / metabolism
- Receptors, Mineralocorticoid / metabolism*
- Signal Transduction / physiology*
- Sodium, Dietary*
- Zona Glomerulosa / metabolism*
- Zona Reticularis / metabolism*
- Receptors, Glucocorticoid
- Receptors, Mineralocorticoid
- Sodium, Dietary
- Aldosterone
- Corticosterone
- Full Text Sources
- Other Literature Sources
- Medical
NCBI Literature Resources
The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Unauthorized use of these marks is strictly prohibited.
National Library of Medicine
8600 Rockville Pike
Bethesda, MD 20894
![Figure 5](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/5464000/bin/nihms847639f5.jpg)
Figure 6
Modulation of MR function in…
Figure 6
Modulation of MR function in zona glomerulosa cells from rats on a high…
Figure 7
Effect of modifying GR activity…
Figure 7
Effect of modifying GR activity on aldosterone secretion in zona glomerulosa cells from…
Figure 8
Inhibition of stimulated corticosterone secretion…
Figure 8
Inhibition of stimulated corticosterone secretion by DEX in zona fasciculata/reticularis cells from low…
Figure 9
RU486 treatment stimulates corticosterone production…
Figure 9
RU486 treatment stimulates corticosterone production in ACTH-stimulated zona fasciculata/reticularis cells from rats fed…
Figure 10
Effect of MR activation on…
Figure 10
Effect of MR activation on corticosterone from low salt (LS, top panels) and…
Figure 11
MR blockade with canrenoate did…
Figure 11
MR blockade with canrenoate did not alter corticosterone secretion in basal and ACTH-stimulated…
- Renin knockout rat: control of adrenal aldosterone and corticosterone synthesis in vitro and adrenal gene expression.Raff H, Gehrand A, Bruder ED, Hoffman MJ, Engeland WC, Moreno C. Raff H, et al. Am J Physiol Regul Integr Comp Physiol. 2015 Jan 1;308(1):R73-7. doi: 10.1152/ajpregu.00440.2014. Epub 2014 Nov 12. Am J Physiol Regul Integr Comp Physiol. 2015. PMID: 25394830 Free PMC article.
- Studies on endothelin receptors in the zonae fasciculata/reticularis of the rat adrenal cortex: contrast with the zona glomerulosa.Kapas S, Cameron LA, Puddefoot JR, Hinson JP. Kapas S, et al. FEBS Lett. 1996 Nov 18;397(2-3):186-90. doi: 10.1016/s0014-5793(96)01133-7. FEBS Lett. 1996. PMID: 8955344
- Both low sodium and high potassium intake increase the level of adrenal angiotensin-II receptor type 1, but not that of adrenocorticotropin receptor.Lehoux JG, Bird IM, Rainey WE, Tremblay A, Ducharme L. Lehoux JG, et al. Endocrinology. 1994 Feb;134(2):776-82. doi: 10.1210/endo.134.2.7507836. Endocrinology. 1994. PMID: 7507836
- Development of adrenal cortex zonation.Xing Y, Lerario AM, Rainey W, Hammer GD. Xing Y, et al. Endocrinol Metab Clin North Am. 2015 Jun;44(2):243-74. doi: 10.1016/j.ecl.2015.02.001. Endocrinol Metab Clin North Am. 2015. PMID: 26038200 Free PMC article. Review.
- Evolution of hormone selectivity in glucocorticoid and mineralocorticoid receptors.Baker ME, Funder JW, Kattoula SR. Baker ME, et al. J Steroid Biochem Mol Biol. 2013 Sep;137:57-70. doi: 10.1016/j.jsbmb.2013.07.009. Epub 2013 Jul 29. J Steroid Biochem Mol Biol. 2013. PMID: 23907018 Review.
- Lysine-specific demethylase 1 deficiency modifies aldosterone synthesis in a sex-specific manner.Tan YJD, Brooks DL, Wong KYH, Huang Y, Romero JR, Williams JS, Pojoga LH. Tan YJD, et al. J Endocrinol. 2022 Dec 12;256(1):e220141. doi: 10.1530/JOE-22-0141. Print 2023 Jan 1. J Endocrinol. 2022. PMID: 36327153 Free PMC article.
- CIRMI-a new term for a concept worthy of further exploration: a narrative review.Nethathe GD, Lipman J, Anderson R, Feldman C. Nethathe GD, et al. Ann Transl Med. 2022 Jun;10(11):646. doi: 10.21037/atm-21-5572. Ann Transl Med. 2022. PMID: 35813323 Free PMC article. Review.
- Mineralocorticoid Receptor Antagonists Decrease the Rates of Positive Screening for Primary Aldosteronism.Tezuka Y, Turcu AF. Tezuka Y, et al. Endocr Pract. 2020 Dec;26(12):1416-1424. doi: 10.4158/EP-2020-0277. Endocr Pract. 2020. PMID: 33471733 Free PMC article.
- Lysine-Specific Demethylase-1 Deficiency Increases Agonist Signaling Via the Mineralocorticoid Receptor.Treesaranuwattana T, Wong KYH, Brooks DL, Tay CS, Williams GH, Williams JS, Pojoga LH. Treesaranuwattana T, et al. Hypertension. 2020 Apr;75(4):1045-1053. doi: 10.1161/HYPERTENSIONAHA.119.13821. Epub 2020 Mar 11. Hypertension. 2020. PMID: 32160100 Free PMC article.
- Steroidogenic acute regulatory protein/aldosterone synthase mediates angiotensin II-induced cardiac fibrosis and hypertrophy.Zhang WW, Zheng RH, Bai F, Sturdivant K, Wang NP, James EA, Bose HS, Zhao ZQ. Zhang WW, et al. Mol Biol Rep. 2020 Feb;47(2):1207-1222. doi: 10.1007/s11033-019-05222-7. Epub 2019 Dec 9. Mol Biol Rep. 2020. PMID: 31820314
- Aldosterone / metabolism*
- Animals
- Corticosterone / blood
- Male
- Rats
- Rats, Wistar
- Receptors, Glucocorticoid / metabolism
- Receptors, Mineralocorticoid / metabolism*
- Signal Transduction / physiology*
- Sodium, Dietary*
- Zona Glomerulosa / metabolism*
- Zona Reticularis / metabolism*
- Receptors, Glucocorticoid
- Receptors, Mineralocorticoid
- Sodium, Dietary
- Aldosterone
- Corticosterone
- Full Text Sources
- Other Literature Sources
- Medical
NCBI Literature Resources
The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Unauthorized use of these marks is strictly prohibited.
National Library of Medicine
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![Figure 6](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/5464000/bin/nihms847639f6.jpg)
Figure 7
Effect of modifying GR activity…
Figure 7
Effect of modifying GR activity on aldosterone secretion in zona glomerulosa cells from…
Figure 8
Inhibition of stimulated corticosterone secretion…
Figure 8
Inhibition of stimulated corticosterone secretion by DEX in zona fasciculata/reticularis cells from low…
Figure 9
RU486 treatment stimulates corticosterone production…
Figure 9
RU486 treatment stimulates corticosterone production in ACTH-stimulated zona fasciculata/reticularis cells from rats fed…
Figure 10
Effect of MR activation on…
Figure 10
Effect of MR activation on corticosterone from low salt (LS, top panels) and…
Figure 11
MR blockade with canrenoate did…
Figure 11
MR blockade with canrenoate did not alter corticosterone secretion in basal and ACTH-stimulated…
- Renin knockout rat: control of adrenal aldosterone and corticosterone synthesis in vitro and adrenal gene expression.Raff H, Gehrand A, Bruder ED, Hoffman MJ, Engeland WC, Moreno C. Raff H, et al. Am J Physiol Regul Integr Comp Physiol. 2015 Jan 1;308(1):R73-7. doi: 10.1152/ajpregu.00440.2014. Epub 2014 Nov 12. Am J Physiol Regul Integr Comp Physiol. 2015. PMID: 25394830 Free PMC article.
- Studies on endothelin receptors in the zonae fasciculata/reticularis of the rat adrenal cortex: contrast with the zona glomerulosa.Kapas S, Cameron LA, Puddefoot JR, Hinson JP. Kapas S, et al. FEBS Lett. 1996 Nov 18;397(2-3):186-90. doi: 10.1016/s0014-5793(96)01133-7. FEBS Lett. 1996. PMID: 8955344
- Both low sodium and high potassium intake increase the level of adrenal angiotensin-II receptor type 1, but not that of adrenocorticotropin receptor.Lehoux JG, Bird IM, Rainey WE, Tremblay A, Ducharme L. Lehoux JG, et al. Endocrinology. 1994 Feb;134(2):776-82. doi: 10.1210/endo.134.2.7507836. Endocrinology. 1994. PMID: 7507836
- Development of adrenal cortex zonation.Xing Y, Lerario AM, Rainey W, Hammer GD. Xing Y, et al. Endocrinol Metab Clin North Am. 2015 Jun;44(2):243-74. doi: 10.1016/j.ecl.2015.02.001. Endocrinol Metab Clin North Am. 2015. PMID: 26038200 Free PMC article. Review.
- Evolution of hormone selectivity in glucocorticoid and mineralocorticoid receptors.Baker ME, Funder JW, Kattoula SR. Baker ME, et al. J Steroid Biochem Mol Biol. 2013 Sep;137:57-70. doi: 10.1016/j.jsbmb.2013.07.009. Epub 2013 Jul 29. J Steroid Biochem Mol Biol. 2013. PMID: 23907018 Review.
- Lysine-specific demethylase 1 deficiency modifies aldosterone synthesis in a sex-specific manner.Tan YJD, Brooks DL, Wong KYH, Huang Y, Romero JR, Williams JS, Pojoga LH. Tan YJD, et al. J Endocrinol. 2022 Dec 12;256(1):e220141. doi: 10.1530/JOE-22-0141. Print 2023 Jan 1. J Endocrinol. 2022. PMID: 36327153 Free PMC article.
- CIRMI-a new term for a concept worthy of further exploration: a narrative review.Nethathe GD, Lipman J, Anderson R, Feldman C. Nethathe GD, et al. Ann Transl Med. 2022 Jun;10(11):646. doi: 10.21037/atm-21-5572. Ann Transl Med. 2022. PMID: 35813323 Free PMC article. Review.
- Mineralocorticoid Receptor Antagonists Decrease the Rates of Positive Screening for Primary Aldosteronism.Tezuka Y, Turcu AF. Tezuka Y, et al. Endocr Pract. 2020 Dec;26(12):1416-1424. doi: 10.4158/EP-2020-0277. Endocr Pract. 2020. PMID: 33471733 Free PMC article.
- Lysine-Specific Demethylase-1 Deficiency Increases Agonist Signaling Via the Mineralocorticoid Receptor.Treesaranuwattana T, Wong KYH, Brooks DL, Tay CS, Williams GH, Williams JS, Pojoga LH. Treesaranuwattana T, et al. Hypertension. 2020 Apr;75(4):1045-1053. doi: 10.1161/HYPERTENSIONAHA.119.13821. Epub 2020 Mar 11. Hypertension. 2020. PMID: 32160100 Free PMC article.
- Steroidogenic acute regulatory protein/aldosterone synthase mediates angiotensin II-induced cardiac fibrosis and hypertrophy.Zhang WW, Zheng RH, Bai F, Sturdivant K, Wang NP, James EA, Bose HS, Zhao ZQ. Zhang WW, et al. Mol Biol Rep. 2020 Feb;47(2):1207-1222. doi: 10.1007/s11033-019-05222-7. Epub 2019 Dec 9. Mol Biol Rep. 2020. PMID: 31820314
- Aldosterone / metabolism*
- Animals
- Corticosterone / blood
- Male
- Rats
- Rats, Wistar
- Receptors, Glucocorticoid / metabolism
- Receptors, Mineralocorticoid / metabolism*
- Signal Transduction / physiology*
- Sodium, Dietary*
- Zona Glomerulosa / metabolism*
- Zona Reticularis / metabolism*
- Receptors, Glucocorticoid
- Receptors, Mineralocorticoid
- Sodium, Dietary
- Aldosterone
- Corticosterone
- Full Text Sources
- Other Literature Sources
- Medical
NCBI Literature Resources
The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Unauthorized use of these marks is strictly prohibited.
National Library of Medicine
8600 Rockville Pike
Bethesda, MD 20894
![Figure 7](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/5464000/bin/nihms847639f7.jpg)
Figure 8
Inhibition of stimulated corticosterone secretion…
Figure 8
Inhibition of stimulated corticosterone secretion by DEX in zona fasciculata/reticularis cells from low…
Figure 9
RU486 treatment stimulates corticosterone production…
Figure 9
RU486 treatment stimulates corticosterone production in ACTH-stimulated zona fasciculata/reticularis cells from rats fed…
Figure 10
Effect of MR activation on…
Figure 10
Effect of MR activation on corticosterone from low salt (LS, top panels) and…
Figure 11
MR blockade with canrenoate did…
Figure 11
MR blockade with canrenoate did not alter corticosterone secretion in basal and ACTH-stimulated…
- Renin knockout rat: control of adrenal aldosterone and corticosterone synthesis in vitro and adrenal gene expression.Raff H, Gehrand A, Bruder ED, Hoffman MJ, Engeland WC, Moreno C. Raff H, et al. Am J Physiol Regul Integr Comp Physiol. 2015 Jan 1;308(1):R73-7. doi: 10.1152/ajpregu.00440.2014. Epub 2014 Nov 12. Am J Physiol Regul Integr Comp Physiol. 2015. PMID: 25394830 Free PMC article.
- Studies on endothelin receptors in the zonae fasciculata/reticularis of the rat adrenal cortex: contrast with the zona glomerulosa.Kapas S, Cameron LA, Puddefoot JR, Hinson JP. Kapas S, et al. FEBS Lett. 1996 Nov 18;397(2-3):186-90. doi: 10.1016/s0014-5793(96)01133-7. FEBS Lett. 1996. PMID: 8955344
- Both low sodium and high potassium intake increase the level of adrenal angiotensin-II receptor type 1, but not that of adrenocorticotropin receptor.Lehoux JG, Bird IM, Rainey WE, Tremblay A, Ducharme L. Lehoux JG, et al. Endocrinology. 1994 Feb;134(2):776-82. doi: 10.1210/endo.134.2.7507836. Endocrinology. 1994. PMID: 7507836
- Development of adrenal cortex zonation.Xing Y, Lerario AM, Rainey W, Hammer GD. Xing Y, et al. Endocrinol Metab Clin North Am. 2015 Jun;44(2):243-74. doi: 10.1016/j.ecl.2015.02.001. Endocrinol Metab Clin North Am. 2015. PMID: 26038200 Free PMC article. Review.
- Evolution of hormone selectivity in glucocorticoid and mineralocorticoid receptors.Baker ME, Funder JW, Kattoula SR. Baker ME, et al. J Steroid Biochem Mol Biol. 2013 Sep;137:57-70. doi: 10.1016/j.jsbmb.2013.07.009. Epub 2013 Jul 29. J Steroid Biochem Mol Biol. 2013. PMID: 23907018 Review.
- Lysine-specific demethylase 1 deficiency modifies aldosterone synthesis in a sex-specific manner.Tan YJD, Brooks DL, Wong KYH, Huang Y, Romero JR, Williams JS, Pojoga LH. Tan YJD, et al. J Endocrinol. 2022 Dec 12;256(1):e220141. doi: 10.1530/JOE-22-0141. Print 2023 Jan 1. J Endocrinol. 2022. PMID: 36327153 Free PMC article.
- CIRMI-a new term for a concept worthy of further exploration: a narrative review.Nethathe GD, Lipman J, Anderson R, Feldman C. Nethathe GD, et al. Ann Transl Med. 2022 Jun;10(11):646. doi: 10.21037/atm-21-5572. Ann Transl Med. 2022. PMID: 35813323 Free PMC article. Review.
- Mineralocorticoid Receptor Antagonists Decrease the Rates of Positive Screening for Primary Aldosteronism.Tezuka Y, Turcu AF. Tezuka Y, et al. Endocr Pract. 2020 Dec;26(12):1416-1424. doi: 10.4158/EP-2020-0277. Endocr Pract. 2020. PMID: 33471733 Free PMC article.
- Lysine-Specific Demethylase-1 Deficiency Increases Agonist Signaling Via the Mineralocorticoid Receptor.Treesaranuwattana T, Wong KYH, Brooks DL, Tay CS, Williams GH, Williams JS, Pojoga LH. Treesaranuwattana T, et al. Hypertension. 2020 Apr;75(4):1045-1053. doi: 10.1161/HYPERTENSIONAHA.119.13821. Epub 2020 Mar 11. Hypertension. 2020. PMID: 32160100 Free PMC article.
- Steroidogenic acute regulatory protein/aldosterone synthase mediates angiotensin II-induced cardiac fibrosis and hypertrophy.Zhang WW, Zheng RH, Bai F, Sturdivant K, Wang NP, James EA, Bose HS, Zhao ZQ. Zhang WW, et al. Mol Biol Rep. 2020 Feb;47(2):1207-1222. doi: 10.1007/s11033-019-05222-7. Epub 2019 Dec 9. Mol Biol Rep. 2020. PMID: 31820314
- Aldosterone / metabolism*
- Animals
- Corticosterone / blood
- Male
- Rats
- Rats, Wistar
- Receptors, Glucocorticoid / metabolism
- Receptors, Mineralocorticoid / metabolism*
- Signal Transduction / physiology*
- Sodium, Dietary*
- Zona Glomerulosa / metabolism*
- Zona Reticularis / metabolism*
- Receptors, Glucocorticoid
- Receptors, Mineralocorticoid
- Sodium, Dietary
- Aldosterone
- Corticosterone
- Full Text Sources
- Other Literature Sources
- Medical
NCBI Literature Resources
The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Unauthorized use of these marks is strictly prohibited.
National Library of Medicine
8600 Rockville Pike
Bethesda, MD 20894
![Figure 8](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/5464000/bin/nihms847639f8.jpg)
Figure 9
RU486 treatment stimulates corticosterone production…
Figure 9
RU486 treatment stimulates corticosterone production in ACTH-stimulated zona fasciculata/reticularis cells from rats fed…
Figure 10
Effect of MR activation on…
Figure 10
Effect of MR activation on corticosterone from low salt (LS, top panels) and…
Figure 11
MR blockade with canrenoate did…
Figure 11
MR blockade with canrenoate did not alter corticosterone secretion in basal and ACTH-stimulated…
- Renin knockout rat: control of adrenal aldosterone and corticosterone synthesis in vitro and adrenal gene expression.Raff H, Gehrand A, Bruder ED, Hoffman MJ, Engeland WC, Moreno C. Raff H, et al. Am J Physiol Regul Integr Comp Physiol. 2015 Jan 1;308(1):R73-7. doi: 10.1152/ajpregu.00440.2014. Epub 2014 Nov 12. Am J Physiol Regul Integr Comp Physiol. 2015. PMID: 25394830 Free PMC article.
- Studies on endothelin receptors in the zonae fasciculata/reticularis of the rat adrenal cortex: contrast with the zona glomerulosa.Kapas S, Cameron LA, Puddefoot JR, Hinson JP. Kapas S, et al. FEBS Lett. 1996 Nov 18;397(2-3):186-90. doi: 10.1016/s0014-5793(96)01133-7. FEBS Lett. 1996. PMID: 8955344
- Both low sodium and high potassium intake increase the level of adrenal angiotensin-II receptor type 1, but not that of adrenocorticotropin receptor.Lehoux JG, Bird IM, Rainey WE, Tremblay A, Ducharme L. Lehoux JG, et al. Endocrinology. 1994 Feb;134(2):776-82. doi: 10.1210/endo.134.2.7507836. Endocrinology. 1994. PMID: 7507836
- Development of adrenal cortex zonation.Xing Y, Lerario AM, Rainey W, Hammer GD. Xing Y, et al. Endocrinol Metab Clin North Am. 2015 Jun;44(2):243-74. doi: 10.1016/j.ecl.2015.02.001. Endocrinol Metab Clin North Am. 2015. PMID: 26038200 Free PMC article. Review.
- Evolution of hormone selectivity in glucocorticoid and mineralocorticoid receptors.Baker ME, Funder JW, Kattoula SR. Baker ME, et al. J Steroid Biochem Mol Biol. 2013 Sep;137:57-70. doi: 10.1016/j.jsbmb.2013.07.009. Epub 2013 Jul 29. J Steroid Biochem Mol Biol. 2013. PMID: 23907018 Review.
- Lysine-specific demethylase 1 deficiency modifies aldosterone synthesis in a sex-specific manner.Tan YJD, Brooks DL, Wong KYH, Huang Y, Romero JR, Williams JS, Pojoga LH. Tan YJD, et al. J Endocrinol. 2022 Dec 12;256(1):e220141. doi: 10.1530/JOE-22-0141. Print 2023 Jan 1. J Endocrinol. 2022. PMID: 36327153 Free PMC article.
- CIRMI-a new term for a concept worthy of further exploration: a narrative review.Nethathe GD, Lipman J, Anderson R, Feldman C. Nethathe GD, et al. Ann Transl Med. 2022 Jun;10(11):646. doi: 10.21037/atm-21-5572. Ann Transl Med. 2022. PMID: 35813323 Free PMC article. Review.
- Mineralocorticoid Receptor Antagonists Decrease the Rates of Positive Screening for Primary Aldosteronism.Tezuka Y, Turcu AF. Tezuka Y, et al. Endocr Pract. 2020 Dec;26(12):1416-1424. doi: 10.4158/EP-2020-0277. Endocr Pract. 2020. PMID: 33471733 Free PMC article.
- Lysine-Specific Demethylase-1 Deficiency Increases Agonist Signaling Via the Mineralocorticoid Receptor.Treesaranuwattana T, Wong KYH, Brooks DL, Tay CS, Williams GH, Williams JS, Pojoga LH. Treesaranuwattana T, et al. Hypertension. 2020 Apr;75(4):1045-1053. doi: 10.1161/HYPERTENSIONAHA.119.13821. Epub 2020 Mar 11. Hypertension. 2020. PMID: 32160100 Free PMC article.
- Steroidogenic acute regulatory protein/aldosterone synthase mediates angiotensin II-induced cardiac fibrosis and hypertrophy.Zhang WW, Zheng RH, Bai F, Sturdivant K, Wang NP, James EA, Bose HS, Zhao ZQ. Zhang WW, et al. Mol Biol Rep. 2020 Feb;47(2):1207-1222. doi: 10.1007/s11033-019-05222-7. Epub 2019 Dec 9. Mol Biol Rep. 2020. PMID: 31820314
- Aldosterone / metabolism*
- Animals
- Corticosterone / blood
- Male
- Rats
- Rats, Wistar
- Receptors, Glucocorticoid / metabolism
- Receptors, Mineralocorticoid / metabolism*
- Signal Transduction / physiology*
- Sodium, Dietary*
- Zona Glomerulosa / metabolism*
- Zona Reticularis / metabolism*
- Receptors, Glucocorticoid
- Receptors, Mineralocorticoid
- Sodium, Dietary
- Aldosterone
- Corticosterone
- Full Text Sources
- Other Literature Sources
- Medical
NCBI Literature Resources
The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Unauthorized use of these marks is strictly prohibited.
National Library of Medicine
8600 Rockville Pike
Bethesda, MD 20894
![Figure 9](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/5464000/bin/nihms847639f9.jpg)
Figure 10
Effect of MR activation on…
Figure 10
Effect of MR activation on corticosterone from low salt (LS, top panels) and…
Figure 11
MR blockade with canrenoate did…
Figure 11
MR blockade with canrenoate did not alter corticosterone secretion in basal and ACTH-stimulated…
- Renin knockout rat: control of adrenal aldosterone and corticosterone synthesis in vitro and adrenal gene expression.Raff H, Gehrand A, Bruder ED, Hoffman MJ, Engeland WC, Moreno C. Raff H, et al. Am J Physiol Regul Integr Comp Physiol. 2015 Jan 1;308(1):R73-7. doi: 10.1152/ajpregu.00440.2014. Epub 2014 Nov 12. Am J Physiol Regul Integr Comp Physiol. 2015. PMID: 25394830 Free PMC article.
- Studies on endothelin receptors in the zonae fasciculata/reticularis of the rat adrenal cortex: contrast with the zona glomerulosa.Kapas S, Cameron LA, Puddefoot JR, Hinson JP. Kapas S, et al. FEBS Lett. 1996 Nov 18;397(2-3):186-90. doi: 10.1016/s0014-5793(96)01133-7. FEBS Lett. 1996. PMID: 8955344
- Both low sodium and high potassium intake increase the level of adrenal angiotensin-II receptor type 1, but not that of adrenocorticotropin receptor.Lehoux JG, Bird IM, Rainey WE, Tremblay A, Ducharme L. Lehoux JG, et al. Endocrinology. 1994 Feb;134(2):776-82. doi: 10.1210/endo.134.2.7507836. Endocrinology. 1994. PMID: 7507836
- Development of adrenal cortex zonation.Xing Y, Lerario AM, Rainey W, Hammer GD. Xing Y, et al. Endocrinol Metab Clin North Am. 2015 Jun;44(2):243-74. doi: 10.1016/j.ecl.2015.02.001. Endocrinol Metab Clin North Am. 2015. PMID: 26038200 Free PMC article. Review.
- Evolution of hormone selectivity in glucocorticoid and mineralocorticoid receptors.Baker ME, Funder JW, Kattoula SR. Baker ME, et al. J Steroid Biochem Mol Biol. 2013 Sep;137:57-70. doi: 10.1016/j.jsbmb.2013.07.009. Epub 2013 Jul 29. J Steroid Biochem Mol Biol. 2013. PMID: 23907018 Review.
- Lysine-specific demethylase 1 deficiency modifies aldosterone synthesis in a sex-specific manner.Tan YJD, Brooks DL, Wong KYH, Huang Y, Romero JR, Williams JS, Pojoga LH. Tan YJD, et al. J Endocrinol. 2022 Dec 12;256(1):e220141. doi: 10.1530/JOE-22-0141. Print 2023 Jan 1. J Endocrinol. 2022. PMID: 36327153 Free PMC article.
- CIRMI-a new term for a concept worthy of further exploration: a narrative review.Nethathe GD, Lipman J, Anderson R, Feldman C. Nethathe GD, et al. Ann Transl Med. 2022 Jun;10(11):646. doi: 10.21037/atm-21-5572. Ann Transl Med. 2022. PMID: 35813323 Free PMC article. Review.
- Mineralocorticoid Receptor Antagonists Decrease the Rates of Positive Screening for Primary Aldosteronism.Tezuka Y, Turcu AF. Tezuka Y, et al. Endocr Pract. 2020 Dec;26(12):1416-1424. doi: 10.4158/EP-2020-0277. Endocr Pract. 2020. PMID: 33471733 Free PMC article.
- Lysine-Specific Demethylase-1 Deficiency Increases Agonist Signaling Via the Mineralocorticoid Receptor.Treesaranuwattana T, Wong KYH, Brooks DL, Tay CS, Williams GH, Williams JS, Pojoga LH. Treesaranuwattana T, et al. Hypertension. 2020 Apr;75(4):1045-1053. doi: 10.1161/HYPERTENSIONAHA.119.13821. Epub 2020 Mar 11. Hypertension. 2020. PMID: 32160100 Free PMC article.
- Steroidogenic acute regulatory protein/aldosterone synthase mediates angiotensin II-induced cardiac fibrosis and hypertrophy.Zhang WW, Zheng RH, Bai F, Sturdivant K, Wang NP, James EA, Bose HS, Zhao ZQ. Zhang WW, et al. Mol Biol Rep. 2020 Feb;47(2):1207-1222. doi: 10.1007/s11033-019-05222-7. Epub 2019 Dec 9. Mol Biol Rep. 2020. PMID: 31820314
- Aldosterone / metabolism*
- Animals
- Corticosterone / blood
- Male
- Rats
- Rats, Wistar
- Receptors, Glucocorticoid / metabolism
- Receptors, Mineralocorticoid / metabolism*
- Signal Transduction / physiology*
- Sodium, Dietary*
- Zona Glomerulosa / metabolism*
- Zona Reticularis / metabolism*
- Receptors, Glucocorticoid
- Receptors, Mineralocorticoid
- Sodium, Dietary
- Aldosterone
- Corticosterone
- Full Text Sources
- Other Literature Sources
- Medical
![Figure 10](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/5464000/bin/nihms847639f10.jpg)
Figure 11
MR blockade with canrenoate did…
Figure 11
MR blockade with canrenoate did not alter corticosterone secretion in basal and ACTH-stimulated…
![Figure 11](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/5464000/bin/nihms847639f11.jpg)
Source: PubMed