Murine typhus and febrile illness, Nepal
Mark D Zimmerman, David R Murdoch, Patrick J Rozmajzl, Buddha Basnyat, Christopher W Woods, Allen L Richards, Ram Hari Belbase, David A Hammer, Trevor P Anderson, L Barth Reller, Mark D Zimmerman, David R Murdoch, Patrick J Rozmajzl, Buddha Basnyat, Christopher W Woods, Allen L Richards, Ram Hari Belbase, David A Hammer, Trevor P Anderson, L Barth Reller
Abstract
Murine typhus was diagnosed by PCR in 50 (7%) of 756 adults with febrile illness seeking treatment at Patan Hospital in Kathmandu, Nepal. Of patients with murine typhus, 64% were women, 86% were residents of Kathmandu, and 90% were unwell during the winter. No characteristics clearly distinguished typhus patients from those with blood culture-positive enteric fever.
References
- Murdoch DR, Woods CW, Zimmerman MD, Dull PM, Belbase RH, Keenan AJ, et al. The etiology of febrile illness in adults presenting to Patan Hospital in Kathmandu, Nepal. Am J Trop Med Hyg. 2004;70:670–5.
- Singhsilarak T, Leowattana W, Looareesuwan S, Wongchotigul V, Jiang J, Richards AL, et al. Detection of Orientia tsutsugamushi in clinical samples by a quantitative real-time polymerase chain reaction. Am J Trop Med Hyg. 2005;72:640–1.
- Saisongkorh W, Chenchittikul M, Silpapojakul K. Evaluation of nested PCR for the diagnosis of scrub typhus among patients with acute pyrexia of unknown origin. Trans R Soc Trop Med Hyg. 2004;98:360–6. 10.1016/j.trstmh.2003.10.012
- Kim D-M, Yun NR, Yang TY, Lee JH, Yang JT, Shim S-K, et al. Usefulness of nested PCR for the diagnosis of scrub typhus in clinical practice: a prospective study. Am J Trop Med Hyg. 2006;75:542–5.
- Henry KM, Jiang J, Rozmajzl PJ, Azad AF, Macaluso KR, Richards AL. Development of quantitative real-time PCR assays to detect Rickettsia typhi and Rickettsia felis, the causative agents of murine typhus and flea-borne spotted fever. Mol Cell Probes. 2007;21:17–23. 10.1016/j.mcp.2006.06.002
- Zhang L-J, Li X-M, Zhang D-R, Zhang J-S, Di Y, Luan M-C, et al. Molecular epidemic survey on co-prevalence of scrub typhus and marine (sic) typhus in Yuxi city, Yunnan province of China. Chin Med J (Engl). 2007;120:1314–8.
- Schriefer ME, Sacci JB, Dumler JS, Bullen MG, Azad AF. Identification of a novel rickettsial infection in a patient diagnosed with murine typhus. J Clin Microbiol. 1994;32:949–54.
- Williams SG, Sacci JB, Schriefer ME, Andersen EM, Fujioka KK, Sorvillo FJ, et al. Typhus and typhuslike rickettsiae associated with opossums and their fleas in Los Angeles County, California. J Clin Microbiol. 1992;30:1758–62.
- Kim D-M, Kim HL, Park CY, Tyang TY, Lee JH, Yang JT, et al. Clinical usefulness of eschar polymerase chain reaction for the diagnosis of scrub typhus: a prospective study. Clin Infect Dis. 2006;43:1296–300. 10.1086/508464
- Stenos J, Graves SR, Unsworth NB. A highly sensitive and specific real-time PCR assay for the detection of spotted fever and typhus group rickettsiae. Am J Trop Med Hyg. 2005;73:1083–5.
- Blacksell SD, Sharma NP, Phumratanaprapin W, Jenjaroen K, Peacock SJ, White NJ, et al. Serological and blood culture investigations of Nepalese fever patients. Trans R Soc Trop Med Hyg. 2007;101:686–90. 10.1016/j.trstmh.2007.02.015
- Brown GW, Shirai A, Gan E, Bernthal P. Antibodies to typhus in Eastern Nepal. Trans R Soc Trop Med Hyg. 1981;75:586–7. 10.1016/0035-9203(81)90210-8
- Bernabeu-Wittel M, Pachón J, Alarcón A, López-Cortés LF, Viciana P, Jiménez-Mejías ME, et al. Murine typhus as a common cause of fever of intermediate duration. A 17-year study in the south of Spain. Arch Intern Med. 1999;159:872–6. 10.1001/archinte.159.8.872
- Whiteford SF, Taylor JP, Dumler JS. Clinical, laboratory, and epidemiologic features of murine typhus in 97 Texas children. Arch Pediatr Adolesc Med. 2001;155:396–400.
- Maskey AP, Day JN, Tuan PQ, Thwaites GE, Campbell JI, Zimmerman M, et al. Salmonella enterica serovar Paratyphi A and S. enterica serovar Typhi cause indistinguishable clinical syndromes in Kathmandu, Nepal. Clin Infect Dis. 2006;42:1247–53. 10.1086/503033
Source: PubMed