Determinants of left ventricular mass in patients on hemodialysis: Frequent Hemodialysis Network (FHN) Trials
Christopher T Chan, Tom Greene, Glenn M Chertow, Alan S Kliger, John B Stokes, Gerald J Beck, John T Daugirdas, Peter Kotanko, Brett Larive, Nathan W Levin, Ravindra L Mehta, Michael Rocco, Javier Sanz, Brigitte M Schiller, Phillip C Yang, Sanjay Rajagopalan, Frequent Hemodialysis Network (FHN) Trial Group, Christopher T Chan, Tom Greene, Glenn M Chertow, Alan S Kliger, John B Stokes, Gerald J Beck, John T Daugirdas, Peter Kotanko, Brett Larive, Nathan W Levin, Ravindra L Mehta, Michael Rocco, Javier Sanz, Brigitte M Schiller, Phillip C Yang, Sanjay Rajagopalan, Frequent Hemodialysis Network (FHN) Trial Group
Abstract
Background: An increase in left ventricular mass (LVM) is associated with mortality and cardiovascular morbidity in patients with end-stage renal disease.
Methods and results: The Frequent Hemodialysis Network (FHN) Daily Trial randomized 245 patients to 12 months of 6 times per week daily in-center hemodialysis or conventional hemodialysis; the FHN Nocturnal Trial randomized 87 patients to 12 months of 6 times per week nocturnal hemodialysis or conventional hemodialysis. The main cardiac secondary outcome was change in LVM. In each trial, we examined whether several predefined baseline demographic or clinical factors as well as change in volume removal, blood pressure, or solute clearance influenced the effect of frequent hemodialysis on LVM. In the Daily Trial, frequent hemodialysis resulted in a significant reduction in LVM (13.1 g; 95% CI, 5.0-21.3 g; P=0.002), LVM index (6.9 g/m(2); 95% CI, 2.4-11.3 g/m(2); P=0.003), and percent change in geometric mean of LVM (7.0%; 95% CI, 1.0%-12.6; P=0.02). Similar trends were noted in the Nocturnal Trial but did not reach statistical significance. In the Daily Trial, a more pronounced effect of frequent hemodialysis on LVM was evident among patients with left ventricular hypertrophy at baseline. Changes in LVM were associated with changes in blood pressure (conventional hemodialysis: R=0.28, P=0.01, daily hemodialysis: R=0.54, P<0.001) and were not significantly associated with changes in other parameters.
Conclusions: Frequent in-center hemodialysis reduces LVM. The benefit of frequent hemodialysis on LVM may be mediated by salutary effects on blood pressure. Clinical Trial Registration- URL: http://www.clinicaltrials.gov. Unique identifier: NCT00264758.
Figures
Histograms describing the baseline distribution of LV mass index divided by gender in the Daily and Nocturnal Trials. LVH was defined as LVM index (LVM/body surface area) > 84.1 g/m2 (male) or >66.8 g/m2 (female) according to Alfakih et al.
The effect of baseline left ventricular mass on the change in left ventricular mass in the Daily Trial.
The effect of baseline left ventricular mass on the change in left ventricular mass in the Daily Trial.
Figure 3A: Closed circles indicate patients with reductions in LV mass greater than 60 g between baseline and 12 months. Although LV mass may be viewed as the response variable in this relationship, we have plotted LV mass on the horizontal axis in Figures 3A–3C to better display the role of these outliers with large LV mass reductions. Correlations between changes in net volume removal and changes in LVM in the Daily Trial (3 Times/Week hemodialysis: Pearson R=0.15, P=0.16, 6 Times/Week hemodialysis: R=0.06, P=0.54) and Nocturnal Trial (3 Times/Week hemodialysis: R=−0.20, P=0.24, 6 Times/Week hemodialysis: R=−0.11, P=0.54) Figure 3B: Correlations between changes in pre-dialysis systolic blood pressures and changes in LVM in the Daily Trial (3 Times/Week hemodialysis: R=0.28, P=0.01, 6 Times/Week hemodialysis: R=0.54, P Figure 3
Figure 3
Figure 3A: Closed circles indicate…
Figure 3
Figure 3A: Closed circles indicate patients with reductions in LV mass greater than…
Figure 3A: Closed circles indicate patients with reductions in LV mass greater than 60 g between baseline and 12 months. Although LV mass may be viewed as the response variable in this relationship, we have plotted LV mass on the horizontal axis in Figures 3A–3C to better display the role of these outliers with large LV mass reductions. Correlations between changes in net volume removal and changes in LVM in the Daily Trial (3 Times/Week hemodialysis: Pearson R=0.15, P=0.16, 6 Times/Week hemodialysis: R=0.06, P=0.54) and Nocturnal Trial (3 Times/Week hemodialysis: R=−0.20, P=0.24, 6 Times/Week hemodialysis: R=−0.11, P=0.54) Figure 3B: Correlations between changes in pre-dialysis systolic blood pressures and changes in LVM in the Daily Trial (3 Times/Week hemodialysis: R=0.28, P=0.01, 6 Times/Week hemodialysis: R=0.54, P Figure 3
Figure 3
Figure 3A: Closed circles indicate…
Figure 3
Figure 3A: Closed circles indicate patients with reductions in LV mass greater than…
Figure 3A: Closed circles indicate patients with reductions in LV mass greater than 60 g between baseline and 12 months. Although LV mass may be viewed as the response variable in this relationship, we have plotted LV mass on the horizontal axis in Figures 3A–3C to better display the role of these outliers with large LV mass reductions. Correlations between changes in net volume removal and changes in LVM in the Daily Trial (3 Times/Week hemodialysis: Pearson R=0.15, P=0.16, 6 Times/Week hemodialysis: R=0.06, P=0.54) and Nocturnal Trial (3 Times/Week hemodialysis: R=−0.20, P=0.24, 6 Times/Week hemodialysis: R=−0.11, P=0.54) Figure 3B: Correlations between changes in pre-dialysis systolic blood pressures and changes in LVM in the Daily Trial (3 Times/Week hemodialysis: R=0.28, P=0.01, 6 Times/Week hemodialysis: R=0.54, P Figure 3
Figure 3
Figure 3A: Closed circles indicate…
Figure 3
Figure 3A: Closed circles indicate patients with reductions in LV mass greater than…
Figure 3A: Closed circles indicate patients with reductions in LV mass greater than 60 g between baseline and 12 months. Although LV mass may be viewed as the response variable in this relationship, we have plotted LV mass on the horizontal axis in Figures 3A–3C to better display the role of these outliers with large LV mass reductions. Correlations between changes in net volume removal and changes in LVM in the Daily Trial (3 Times/Week hemodialysis: Pearson R=0.15, P=0.16, 6 Times/Week hemodialysis: R=0.06, P=0.54) and Nocturnal Trial (3 Times/Week hemodialysis: R=−0.20, P=0.24, 6 Times/Week hemodialysis: R=−0.11, P=0.54) Figure 3B: Correlations between changes in pre-dialysis systolic blood pressures and changes in LVM in the Daily Trial (3 Times/Week hemodialysis: R=0.28, P=0.01, 6 Times/Week hemodialysis: R=0.54, P Figure 3
Figure 3
Figure 3A: Closed circles indicate…
Figure 3
Figure 3A: Closed circles indicate patients with reductions in LV mass greater than…
Figure 3A: Closed circles indicate patients with reductions in LV mass greater than 60 g between baseline and 12 months. Although LV mass may be viewed as the response variable in this relationship, we have plotted LV mass on the horizontal axis in Figures 3A–3C to better display the role of these outliers with large LV mass reductions. Correlations between changes in net volume removal and changes in LVM in the Daily Trial (3 Times/Week hemodialysis: Pearson R=0.15, P=0.16, 6 Times/Week hemodialysis: R=0.06, P=0.54) and Nocturnal Trial (3 Times/Week hemodialysis: R=−0.20, P=0.24, 6 Times/Week hemodialysis: R=−0.11, P=0.54) Figure 3B: Correlations between changes in pre-dialysis systolic blood pressures and changes in LVM in the Daily Trial (3 Times/Week hemodialysis: R=0.28, P=0.01, 6 Times/Week hemodialysis: R=0.54, P Figure 3
Figure 3
Figure 3A: Closed circles indicate…
Figure 3
Figure 3A: Closed circles indicate patients with reductions in LV mass greater than…
Figure 3A: Closed circles indicate patients with reductions in LV mass greater than 60 g between baseline and 12 months. Although LV mass may be viewed as the response variable in this relationship, we have plotted LV mass on the horizontal axis in Figures 3A–3C to better display the role of these outliers with large LV mass reductions. Correlations between changes in net volume removal and changes in LVM in the Daily Trial (3 Times/Week hemodialysis: Pearson R=0.15, P=0.16, 6 Times/Week hemodialysis: R=0.06, P=0.54) and Nocturnal Trial (3 Times/Week hemodialysis: R=−0.20, P=0.24, 6 Times/Week hemodialysis: R=−0.11, P=0.54) Figure 3B: Correlations between changes in pre-dialysis systolic blood pressures and changes in LVM in the Daily Trial (3 Times/Week hemodialysis: R=0.28, P=0.01, 6 Times/Week hemodialysis: R=0.54, P
All figures (9)
Similar articles
- The Predialysis Serum Sodium Level Modifies the Effect of Hemodialysis Frequency on Left-Ventricular Mass: The Frequent Hemodialysis Network Trials.Raimann JG, Chan CT, Daugirdas JT, Depner T, Greene T, Kaysen GA, Kliger AS, Kotanko P, Larive B, Beck G, Lindsay RM, Rocco MV, Chertow GM, Levin NW; Frequent Hemodialysis Network (FHN) Trial Group. Raimann JG, et al. Kidney Blood Press Res. 2021;46(6):768-776. doi: 10.1159/000519339. Epub 2021 Oct 13. Kidney Blood Press Res. 2021. PMID: 34644706 Free PMC article. Clinical Trial.
- A randomized trial of hemodiafiltration and change in cardiovascular parameters.Mostovaya IM, Bots ML, van den Dorpel MA, Grooteman MP, Kamp O, Levesque R, Ter Wee PM, Nubé MJ, Blankestijn PJ. Mostovaya IM, et al. Clin J Am Soc Nephrol. 2014 Mar;9(3):520-6. doi: 10.2215/CJN.07140713. Epub 2014 Jan 9. Clin J Am Soc Nephrol. 2014. PMID: 24408114 Free PMC article. Clinical Trial.
- The effect of frequent hemodialysis on matrix metalloproteinases, their tissue inhibitors, and FGF23: Implications for blood pressure and left ventricular mass modification in the Frequent Hemodialysis Network trials.Chan CT, Kaysen GA, Beck GJ, Li M, Lo JC, Rocco MV, Kliger AS; FHN Trials. Chan CT, et al. Hemodial Int. 2020 Apr;24(2):162-174. doi: 10.1111/hdi.12807. Epub 2019 Dec 11. Hemodial Int. 2020. PMID: 31826326 Clinical Trial.
- Effects of frequent hemodialysis on ventricular volumes and left ventricular remodeling.Chan CT, Greene T, Chertow GM, Kliger AS, Stokes JB, Beck GJ, Daugirdas JT, Kotanko P, Larive B, Levin NW, Mehta RL, Rocco M, Sanz J, Yang PC, Rajagopalan S; Frequent Hemodialysis Network Trial Group. Chan CT, et al. Clin J Am Soc Nephrol. 2013 Dec;8(12):2106-16. doi: 10.2215/CJN.03280313. Epub 2013 Aug 22. Clin J Am Soc Nephrol. 2013. PMID: 23970131 Free PMC article. Clinical Trial.
- Effects of daily hemodialysis on heart rate variability: results from the Frequent Hemodialysis Network (FHN) Daily Trial.Chan CT, Chertow GM, Daugirdas JT, Greene TH, Kotanko P, Larive B, Pierratos A, Stokes JB; Frequent Hemodialysis Network Daily Trial Group. Chan CT, et al. Nephrol Dial Transplant. 2014 Jan;29(1):168-78. doi: 10.1093/ndt/gft212. Epub 2013 Sep 26. Nephrol Dial Transplant. 2014. PMID: 24078335 Free PMC article. Clinical Trial.
Cited by
- Initiation of Dialysis Is Associated With Impaired Cardiovascular Functional Capacity.Arroyo E, Umukoro PE, Burney HN, Li Y, Li X, Lane KA, Sher SJ, Lu TS, Moe SM, Moorthi R, Coggan AR, McGregor G, Hiemstra TF, Zehnder D, Lim K. Arroyo E, et al. J Am Heart Assoc. 2022 Jul 19;11(14):e025656. doi: 10.1161/JAHA.122.025656. Epub 2022 Jul 5. J Am Heart Assoc. 2022. PMID: 35861826 Free PMC article. Clinical Trial.
- Physiological Mechanisms of Hypertension and Cardiovascular Disease in End-Stage Kidney Disease.Clemmer JS, Shafi T, Obi Y. Clemmer JS, et al. Curr Hypertens Rep. 2022 Oct;24(10):413-424. doi: 10.1007/s11906-022-01203-7. Epub 2022 Jun 16. Curr Hypertens Rep. 2022. PMID: 35708820 Free PMC article. Review.
- The Predialysis Serum Sodium Level Modifies the Effect of Hemodialysis Frequency on Left-Ventricular Mass: The Frequent Hemodialysis Network Trials.Raimann JG, Chan CT, Daugirdas JT, Depner T, Greene T, Kaysen GA, Kliger AS, Kotanko P, Larive B, Beck G, Lindsay RM, Rocco MV, Chertow GM, Levin NW; Frequent Hemodialysis Network (FHN) Trial Group. Raimann JG, et al. Kidney Blood Press Res. 2021;46(6):768-776. doi: 10.1159/000519339. Epub 2021 Oct 13. Kidney Blood Press Res. 2021. PMID: 34644706 Free PMC article. Clinical Trial.
- The Association of Pre-Kidney Transplant Dialysis Modality with de novo Posttransplant Heart Failure.Lenihan CR, Liu S, Airy M, Walther C, Montez-Rath ME, Winkelmayer WC. Lenihan CR, et al. Cardiorenal Med. 2021;11(5-6):209-217. doi: 10.1159/000518535. Epub 2021 Sep 2. Cardiorenal Med. 2021. PMID: 34515084 Free PMC article.
- Comparison of Dialysis Unit and Home Blood Pressures: An Observational Cohort Study.Miskulin DC, Jiang H, Gul A, Pankratz VS, Paine SS, Gassman JJ, Jhamb M, Kwong RY, Negrea L, Ploth DW, Shaffi SK, Harford AM, Zager PG. Miskulin DC, et al. Am J Kidney Dis. 2021 Nov;78(5):640-648. doi: 10.1053/j.ajkd.2021.04.013. Epub 2021 Jun 16. Am J Kidney Dis. 2021. PMID: 34144104 Free PMC article.
Publication types
- Comparative Study
- Multicenter Study
- Randomized Controlled Trial
- Research Support, N.I.H., Extramural
- Research Support, Non-U.S. Gov't
- Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
- Adult
- Aged
- Blood Pressure
- Canada
- Female
- Humans
- Hypertrophy, Left Ventricular / diagnosis
- Hypertrophy, Left Ventricular / etiology*
- Hypertrophy, Left Ventricular / mortality
- Hypertrophy, Left Ventricular / physiopathology
- Kidney Failure, Chronic / complications
- Kidney Failure, Chronic / mortality
- Kidney Failure, Chronic / physiopathology
- Kidney Failure, Chronic / therapy*
- Linear Models
- Magnetic Resonance Imaging
- Male
- Middle Aged
- Proportional Hazards Models
- Prospective Studies
- Renal Dialysis / adverse effects
- Renal Dialysis / methods*
- Renal Dialysis / mortality
- Risk Assessment
- Risk Factors
- Time Factors
- Treatment Outcome
- United States
Associated data
- ClinicalTrials.gov/NCT00264758
Related information
Grant support
LinkOut - more resources
- Full Text Sources
- Medical
Full text links [x]
[x]
Cite
Copy Download .nbib
Format: AMA APA MLA NLM
Send To [x]
NCBI Literature Resources
The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Unauthorized use of these marks is strictly prohibited.
Follow NCBI
National Library of Medicine
8600 Rockville Pike
Bethesda, MD 20894
Figure 3A: Closed circles indicate patients with reductions in LV mass greater than 60 g between baseline and 12 months. Although LV mass may be viewed as the response variable in this relationship, we have plotted LV mass on the horizontal axis in Figures 3A–3C to better display the role of these outliers with large LV mass reductions. Correlations between changes in net volume removal and changes in LVM in the Daily Trial (3 Times/Week hemodialysis: Pearson R=0.15, P=0.16, 6 Times/Week hemodialysis: R=0.06, P=0.54) and Nocturnal Trial (3 Times/Week hemodialysis: R=−0.20, P=0.24, 6 Times/Week hemodialysis: R=−0.11, P=0.54) Figure 3B: Correlations between changes in pre-dialysis systolic blood pressures and changes in LVM in the Daily Trial (3 Times/Week hemodialysis: R=0.28, P=0.01, 6 Times/Week hemodialysis: R=0.54, P Figure 3
Figure 3
Figure 3A: Closed circles indicate…
Figure 3
Figure 3A: Closed circles indicate patients with reductions in LV mass greater than…
Figure 3A: Closed circles indicate patients with reductions in LV mass greater than 60 g between baseline and 12 months. Although LV mass may be viewed as the response variable in this relationship, we have plotted LV mass on the horizontal axis in Figures 3A–3C to better display the role of these outliers with large LV mass reductions. Correlations between changes in net volume removal and changes in LVM in the Daily Trial (3 Times/Week hemodialysis: Pearson R=0.15, P=0.16, 6 Times/Week hemodialysis: R=0.06, P=0.54) and Nocturnal Trial (3 Times/Week hemodialysis: R=−0.20, P=0.24, 6 Times/Week hemodialysis: R=−0.11, P=0.54) Figure 3B: Correlations between changes in pre-dialysis systolic blood pressures and changes in LVM in the Daily Trial (3 Times/Week hemodialysis: R=0.28, P=0.01, 6 Times/Week hemodialysis: R=0.54, P Figure 3
Figure 3
Figure 3A: Closed circles indicate…
Figure 3
Figure 3A: Closed circles indicate patients with reductions in LV mass greater than…
Figure 3A: Closed circles indicate patients with reductions in LV mass greater than 60 g between baseline and 12 months. Although LV mass may be viewed as the response variable in this relationship, we have plotted LV mass on the horizontal axis in Figures 3A–3C to better display the role of these outliers with large LV mass reductions. Correlations between changes in net volume removal and changes in LVM in the Daily Trial (3 Times/Week hemodialysis: Pearson R=0.15, P=0.16, 6 Times/Week hemodialysis: R=0.06, P=0.54) and Nocturnal Trial (3 Times/Week hemodialysis: R=−0.20, P=0.24, 6 Times/Week hemodialysis: R=−0.11, P=0.54) Figure 3B: Correlations between changes in pre-dialysis systolic blood pressures and changes in LVM in the Daily Trial (3 Times/Week hemodialysis: R=0.28, P=0.01, 6 Times/Week hemodialysis: R=0.54, P Figure 3
Figure 3
Figure 3A: Closed circles indicate…
Figure 3
Figure 3A: Closed circles indicate patients with reductions in LV mass greater than…
Figure 3A: Closed circles indicate patients with reductions in LV mass greater than 60 g between baseline and 12 months. Although LV mass may be viewed as the response variable in this relationship, we have plotted LV mass on the horizontal axis in Figures 3A–3C to better display the role of these outliers with large LV mass reductions. Correlations between changes in net volume removal and changes in LVM in the Daily Trial (3 Times/Week hemodialysis: Pearson R=0.15, P=0.16, 6 Times/Week hemodialysis: R=0.06, P=0.54) and Nocturnal Trial (3 Times/Week hemodialysis: R=−0.20, P=0.24, 6 Times/Week hemodialysis: R=−0.11, P=0.54) Figure 3B: Correlations between changes in pre-dialysis systolic blood pressures and changes in LVM in the Daily Trial (3 Times/Week hemodialysis: R=0.28, P=0.01, 6 Times/Week hemodialysis: R=0.54, P Figure 3
Figure 3
Figure 3A: Closed circles indicate…
Figure 3
Figure 3A: Closed circles indicate patients with reductions in LV mass greater than…
Figure 3A: Closed circles indicate patients with reductions in LV mass greater than 60 g between baseline and 12 months. Although LV mass may be viewed as the response variable in this relationship, we have plotted LV mass on the horizontal axis in Figures 3A–3C to better display the role of these outliers with large LV mass reductions. Correlations between changes in net volume removal and changes in LVM in the Daily Trial (3 Times/Week hemodialysis: Pearson R=0.15, P=0.16, 6 Times/Week hemodialysis: R=0.06, P=0.54) and Nocturnal Trial (3 Times/Week hemodialysis: R=−0.20, P=0.24, 6 Times/Week hemodialysis: R=−0.11, P=0.54) Figure 3B: Correlations between changes in pre-dialysis systolic blood pressures and changes in LVM in the Daily Trial (3 Times/Week hemodialysis: R=0.28, P=0.01, 6 Times/Week hemodialysis: R=0.54, P
All figures (9)
Similar articles
- The Predialysis Serum Sodium Level Modifies the Effect of Hemodialysis Frequency on Left-Ventricular Mass: The Frequent Hemodialysis Network Trials.Raimann JG, Chan CT, Daugirdas JT, Depner T, Greene T, Kaysen GA, Kliger AS, Kotanko P, Larive B, Beck G, Lindsay RM, Rocco MV, Chertow GM, Levin NW; Frequent Hemodialysis Network (FHN) Trial Group. Raimann JG, et al. Kidney Blood Press Res. 2021;46(6):768-776. doi: 10.1159/000519339. Epub 2021 Oct 13. Kidney Blood Press Res. 2021. PMID: 34644706 Free PMC article. Clinical Trial.
- A randomized trial of hemodiafiltration and change in cardiovascular parameters.Mostovaya IM, Bots ML, van den Dorpel MA, Grooteman MP, Kamp O, Levesque R, Ter Wee PM, Nubé MJ, Blankestijn PJ. Mostovaya IM, et al. Clin J Am Soc Nephrol. 2014 Mar;9(3):520-6. doi: 10.2215/CJN.07140713. Epub 2014 Jan 9. Clin J Am Soc Nephrol. 2014. PMID: 24408114 Free PMC article. Clinical Trial.
- The effect of frequent hemodialysis on matrix metalloproteinases, their tissue inhibitors, and FGF23: Implications for blood pressure and left ventricular mass modification in the Frequent Hemodialysis Network trials.Chan CT, Kaysen GA, Beck GJ, Li M, Lo JC, Rocco MV, Kliger AS; FHN Trials. Chan CT, et al. Hemodial Int. 2020 Apr;24(2):162-174. doi: 10.1111/hdi.12807. Epub 2019 Dec 11. Hemodial Int. 2020. PMID: 31826326 Clinical Trial.
- Effects of frequent hemodialysis on ventricular volumes and left ventricular remodeling.Chan CT, Greene T, Chertow GM, Kliger AS, Stokes JB, Beck GJ, Daugirdas JT, Kotanko P, Larive B, Levin NW, Mehta RL, Rocco M, Sanz J, Yang PC, Rajagopalan S; Frequent Hemodialysis Network Trial Group. Chan CT, et al. Clin J Am Soc Nephrol. 2013 Dec;8(12):2106-16. doi: 10.2215/CJN.03280313. Epub 2013 Aug 22. Clin J Am Soc Nephrol. 2013. PMID: 23970131 Free PMC article. Clinical Trial.
- Effects of daily hemodialysis on heart rate variability: results from the Frequent Hemodialysis Network (FHN) Daily Trial.Chan CT, Chertow GM, Daugirdas JT, Greene TH, Kotanko P, Larive B, Pierratos A, Stokes JB; Frequent Hemodialysis Network Daily Trial Group. Chan CT, et al. Nephrol Dial Transplant. 2014 Jan;29(1):168-78. doi: 10.1093/ndt/gft212. Epub 2013 Sep 26. Nephrol Dial Transplant. 2014. PMID: 24078335 Free PMC article. Clinical Trial.
Cited by
- Initiation of Dialysis Is Associated With Impaired Cardiovascular Functional Capacity.Arroyo E, Umukoro PE, Burney HN, Li Y, Li X, Lane KA, Sher SJ, Lu TS, Moe SM, Moorthi R, Coggan AR, McGregor G, Hiemstra TF, Zehnder D, Lim K. Arroyo E, et al. J Am Heart Assoc. 2022 Jul 19;11(14):e025656. doi: 10.1161/JAHA.122.025656. Epub 2022 Jul 5. J Am Heart Assoc. 2022. PMID: 35861826 Free PMC article. Clinical Trial.
- Physiological Mechanisms of Hypertension and Cardiovascular Disease in End-Stage Kidney Disease.Clemmer JS, Shafi T, Obi Y. Clemmer JS, et al. Curr Hypertens Rep. 2022 Oct;24(10):413-424. doi: 10.1007/s11906-022-01203-7. Epub 2022 Jun 16. Curr Hypertens Rep. 2022. PMID: 35708820 Free PMC article. Review.
- The Predialysis Serum Sodium Level Modifies the Effect of Hemodialysis Frequency on Left-Ventricular Mass: The Frequent Hemodialysis Network Trials.Raimann JG, Chan CT, Daugirdas JT, Depner T, Greene T, Kaysen GA, Kliger AS, Kotanko P, Larive B, Beck G, Lindsay RM, Rocco MV, Chertow GM, Levin NW; Frequent Hemodialysis Network (FHN) Trial Group. Raimann JG, et al. Kidney Blood Press Res. 2021;46(6):768-776. doi: 10.1159/000519339. Epub 2021 Oct 13. Kidney Blood Press Res. 2021. PMID: 34644706 Free PMC article. Clinical Trial.
- The Association of Pre-Kidney Transplant Dialysis Modality with de novo Posttransplant Heart Failure.Lenihan CR, Liu S, Airy M, Walther C, Montez-Rath ME, Winkelmayer WC. Lenihan CR, et al. Cardiorenal Med. 2021;11(5-6):209-217. doi: 10.1159/000518535. Epub 2021 Sep 2. Cardiorenal Med. 2021. PMID: 34515084 Free PMC article.
- Comparison of Dialysis Unit and Home Blood Pressures: An Observational Cohort Study.Miskulin DC, Jiang H, Gul A, Pankratz VS, Paine SS, Gassman JJ, Jhamb M, Kwong RY, Negrea L, Ploth DW, Shaffi SK, Harford AM, Zager PG. Miskulin DC, et al. Am J Kidney Dis. 2021 Nov;78(5):640-648. doi: 10.1053/j.ajkd.2021.04.013. Epub 2021 Jun 16. Am J Kidney Dis. 2021. PMID: 34144104 Free PMC article.
Publication types
- Comparative Study
- Multicenter Study
- Randomized Controlled Trial
- Research Support, N.I.H., Extramural
- Research Support, Non-U.S. Gov't
- Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
- Adult
- Aged
- Blood Pressure
- Canada
- Female
- Humans
- Hypertrophy, Left Ventricular / diagnosis
- Hypertrophy, Left Ventricular / etiology*
- Hypertrophy, Left Ventricular / mortality
- Hypertrophy, Left Ventricular / physiopathology
- Kidney Failure, Chronic / complications
- Kidney Failure, Chronic / mortality
- Kidney Failure, Chronic / physiopathology
- Kidney Failure, Chronic / therapy*
- Linear Models
- Magnetic Resonance Imaging
- Male
- Middle Aged
- Proportional Hazards Models
- Prospective Studies
- Renal Dialysis / adverse effects
- Renal Dialysis / methods*
- Renal Dialysis / mortality
- Risk Assessment
- Risk Factors
- Time Factors
- Treatment Outcome
- United States
Associated data
- ClinicalTrials.gov/NCT00264758
Related information
Grant support
LinkOut - more resources
- Full Text Sources
- Medical
Full text links [x]
[x]
Cite
Copy Download .nbib
Format: AMA APA MLA NLM
Send To [x]
NCBI Literature Resources
The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Unauthorized use of these marks is strictly prohibited.
Follow NCBI
National Library of Medicine
8600 Rockville Pike
Bethesda, MD 20894
Figure 3A: Closed circles indicate patients with reductions in LV mass greater than 60 g between baseline and 12 months. Although LV mass may be viewed as the response variable in this relationship, we have plotted LV mass on the horizontal axis in Figures 3A–3C to better display the role of these outliers with large LV mass reductions. Correlations between changes in net volume removal and changes in LVM in the Daily Trial (3 Times/Week hemodialysis: Pearson R=0.15, P=0.16, 6 Times/Week hemodialysis: R=0.06, P=0.54) and Nocturnal Trial (3 Times/Week hemodialysis: R=−0.20, P=0.24, 6 Times/Week hemodialysis: R=−0.11, P=0.54) Figure 3B: Correlations between changes in pre-dialysis systolic blood pressures and changes in LVM in the Daily Trial (3 Times/Week hemodialysis: R=0.28, P=0.01, 6 Times/Week hemodialysis: R=0.54, P Figure 3
Figure 3
Figure 3A: Closed circles indicate…
Figure 3
Figure 3A: Closed circles indicate patients with reductions in LV mass greater than…
Figure 3A: Closed circles indicate patients with reductions in LV mass greater than 60 g between baseline and 12 months. Although LV mass may be viewed as the response variable in this relationship, we have plotted LV mass on the horizontal axis in Figures 3A–3C to better display the role of these outliers with large LV mass reductions. Correlations between changes in net volume removal and changes in LVM in the Daily Trial (3 Times/Week hemodialysis: Pearson R=0.15, P=0.16, 6 Times/Week hemodialysis: R=0.06, P=0.54) and Nocturnal Trial (3 Times/Week hemodialysis: R=−0.20, P=0.24, 6 Times/Week hemodialysis: R=−0.11, P=0.54) Figure 3B: Correlations between changes in pre-dialysis systolic blood pressures and changes in LVM in the Daily Trial (3 Times/Week hemodialysis: R=0.28, P=0.01, 6 Times/Week hemodialysis: R=0.54, P Figure 3
Figure 3
Figure 3A: Closed circles indicate…
Figure 3
Figure 3A: Closed circles indicate patients with reductions in LV mass greater than…
Figure 3A: Closed circles indicate patients with reductions in LV mass greater than 60 g between baseline and 12 months. Although LV mass may be viewed as the response variable in this relationship, we have plotted LV mass on the horizontal axis in Figures 3A–3C to better display the role of these outliers with large LV mass reductions. Correlations between changes in net volume removal and changes in LVM in the Daily Trial (3 Times/Week hemodialysis: Pearson R=0.15, P=0.16, 6 Times/Week hemodialysis: R=0.06, P=0.54) and Nocturnal Trial (3 Times/Week hemodialysis: R=−0.20, P=0.24, 6 Times/Week hemodialysis: R=−0.11, P=0.54) Figure 3B: Correlations between changes in pre-dialysis systolic blood pressures and changes in LVM in the Daily Trial (3 Times/Week hemodialysis: R=0.28, P=0.01, 6 Times/Week hemodialysis: R=0.54, P Figure 3
Figure 3
Figure 3A: Closed circles indicate…
Figure 3
Figure 3A: Closed circles indicate patients with reductions in LV mass greater than…
Figure 3A: Closed circles indicate patients with reductions in LV mass greater than 60 g between baseline and 12 months. Although LV mass may be viewed as the response variable in this relationship, we have plotted LV mass on the horizontal axis in Figures 3A–3C to better display the role of these outliers with large LV mass reductions. Correlations between changes in net volume removal and changes in LVM in the Daily Trial (3 Times/Week hemodialysis: Pearson R=0.15, P=0.16, 6 Times/Week hemodialysis: R=0.06, P=0.54) and Nocturnal Trial (3 Times/Week hemodialysis: R=−0.20, P=0.24, 6 Times/Week hemodialysis: R=−0.11, P=0.54) Figure 3B: Correlations between changes in pre-dialysis systolic blood pressures and changes in LVM in the Daily Trial (3 Times/Week hemodialysis: R=0.28, P=0.01, 6 Times/Week hemodialysis: R=0.54, P
All figures (9)
Similar articles
- The Predialysis Serum Sodium Level Modifies the Effect of Hemodialysis Frequency on Left-Ventricular Mass: The Frequent Hemodialysis Network Trials.Raimann JG, Chan CT, Daugirdas JT, Depner T, Greene T, Kaysen GA, Kliger AS, Kotanko P, Larive B, Beck G, Lindsay RM, Rocco MV, Chertow GM, Levin NW; Frequent Hemodialysis Network (FHN) Trial Group. Raimann JG, et al. Kidney Blood Press Res. 2021;46(6):768-776. doi: 10.1159/000519339. Epub 2021 Oct 13. Kidney Blood Press Res. 2021. PMID: 34644706 Free PMC article. Clinical Trial.
- A randomized trial of hemodiafiltration and change in cardiovascular parameters.Mostovaya IM, Bots ML, van den Dorpel MA, Grooteman MP, Kamp O, Levesque R, Ter Wee PM, Nubé MJ, Blankestijn PJ. Mostovaya IM, et al. Clin J Am Soc Nephrol. 2014 Mar;9(3):520-6. doi: 10.2215/CJN.07140713. Epub 2014 Jan 9. Clin J Am Soc Nephrol. 2014. PMID: 24408114 Free PMC article. Clinical Trial.
- The effect of frequent hemodialysis on matrix metalloproteinases, their tissue inhibitors, and FGF23: Implications for blood pressure and left ventricular mass modification in the Frequent Hemodialysis Network trials.Chan CT, Kaysen GA, Beck GJ, Li M, Lo JC, Rocco MV, Kliger AS; FHN Trials. Chan CT, et al. Hemodial Int. 2020 Apr;24(2):162-174. doi: 10.1111/hdi.12807. Epub 2019 Dec 11. Hemodial Int. 2020. PMID: 31826326 Clinical Trial.
- Effects of frequent hemodialysis on ventricular volumes and left ventricular remodeling.Chan CT, Greene T, Chertow GM, Kliger AS, Stokes JB, Beck GJ, Daugirdas JT, Kotanko P, Larive B, Levin NW, Mehta RL, Rocco M, Sanz J, Yang PC, Rajagopalan S; Frequent Hemodialysis Network Trial Group. Chan CT, et al. Clin J Am Soc Nephrol. 2013 Dec;8(12):2106-16. doi: 10.2215/CJN.03280313. Epub 2013 Aug 22. Clin J Am Soc Nephrol. 2013. PMID: 23970131 Free PMC article. Clinical Trial.
- Effects of daily hemodialysis on heart rate variability: results from the Frequent Hemodialysis Network (FHN) Daily Trial.Chan CT, Chertow GM, Daugirdas JT, Greene TH, Kotanko P, Larive B, Pierratos A, Stokes JB; Frequent Hemodialysis Network Daily Trial Group. Chan CT, et al. Nephrol Dial Transplant. 2014 Jan;29(1):168-78. doi: 10.1093/ndt/gft212. Epub 2013 Sep 26. Nephrol Dial Transplant. 2014. PMID: 24078335 Free PMC article. Clinical Trial.
Cited by
- Initiation of Dialysis Is Associated With Impaired Cardiovascular Functional Capacity.Arroyo E, Umukoro PE, Burney HN, Li Y, Li X, Lane KA, Sher SJ, Lu TS, Moe SM, Moorthi R, Coggan AR, McGregor G, Hiemstra TF, Zehnder D, Lim K. Arroyo E, et al. J Am Heart Assoc. 2022 Jul 19;11(14):e025656. doi: 10.1161/JAHA.122.025656. Epub 2022 Jul 5. J Am Heart Assoc. 2022. PMID: 35861826 Free PMC article. Clinical Trial.
- Physiological Mechanisms of Hypertension and Cardiovascular Disease in End-Stage Kidney Disease.Clemmer JS, Shafi T, Obi Y. Clemmer JS, et al. Curr Hypertens Rep. 2022 Oct;24(10):413-424. doi: 10.1007/s11906-022-01203-7. Epub 2022 Jun 16. Curr Hypertens Rep. 2022. PMID: 35708820 Free PMC article. Review.
- The Predialysis Serum Sodium Level Modifies the Effect of Hemodialysis Frequency on Left-Ventricular Mass: The Frequent Hemodialysis Network Trials.Raimann JG, Chan CT, Daugirdas JT, Depner T, Greene T, Kaysen GA, Kliger AS, Kotanko P, Larive B, Beck G, Lindsay RM, Rocco MV, Chertow GM, Levin NW; Frequent Hemodialysis Network (FHN) Trial Group. Raimann JG, et al. Kidney Blood Press Res. 2021;46(6):768-776. doi: 10.1159/000519339. Epub 2021 Oct 13. Kidney Blood Press Res. 2021. PMID: 34644706 Free PMC article. Clinical Trial.
- The Association of Pre-Kidney Transplant Dialysis Modality with de novo Posttransplant Heart Failure.Lenihan CR, Liu S, Airy M, Walther C, Montez-Rath ME, Winkelmayer WC. Lenihan CR, et al. Cardiorenal Med. 2021;11(5-6):209-217. doi: 10.1159/000518535. Epub 2021 Sep 2. Cardiorenal Med. 2021. PMID: 34515084 Free PMC article.
- Comparison of Dialysis Unit and Home Blood Pressures: An Observational Cohort Study.Miskulin DC, Jiang H, Gul A, Pankratz VS, Paine SS, Gassman JJ, Jhamb M, Kwong RY, Negrea L, Ploth DW, Shaffi SK, Harford AM, Zager PG. Miskulin DC, et al. Am J Kidney Dis. 2021 Nov;78(5):640-648. doi: 10.1053/j.ajkd.2021.04.013. Epub 2021 Jun 16. Am J Kidney Dis. 2021. PMID: 34144104 Free PMC article.
Publication types
- Comparative Study
- Multicenter Study
- Randomized Controlled Trial
- Research Support, N.I.H., Extramural
- Research Support, Non-U.S. Gov't
- Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
- Adult
- Aged
- Blood Pressure
- Canada
- Female
- Humans
- Hypertrophy, Left Ventricular / diagnosis
- Hypertrophy, Left Ventricular / etiology*
- Hypertrophy, Left Ventricular / mortality
- Hypertrophy, Left Ventricular / physiopathology
- Kidney Failure, Chronic / complications
- Kidney Failure, Chronic / mortality
- Kidney Failure, Chronic / physiopathology
- Kidney Failure, Chronic / therapy*
- Linear Models
- Magnetic Resonance Imaging
- Male
- Middle Aged
- Proportional Hazards Models
- Prospective Studies
- Renal Dialysis / adverse effects
- Renal Dialysis / methods*
- Renal Dialysis / mortality
- Risk Assessment
- Risk Factors
- Time Factors
- Treatment Outcome
- United States
Associated data
- ClinicalTrials.gov/NCT00264758
Related information
Grant support
LinkOut - more resources
- Full Text Sources
- Medical
Full text links [x]
[x]
Cite
Copy Download .nbib
Format: AMA APA MLA NLM
Send To [x]
NCBI Literature Resources
The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Unauthorized use of these marks is strictly prohibited.
Follow NCBI
National Library of Medicine
8600 Rockville Pike
Bethesda, MD 20894
Figure 3A: Closed circles indicate patients with reductions in LV mass greater than 60 g between baseline and 12 months. Although LV mass may be viewed as the response variable in this relationship, we have plotted LV mass on the horizontal axis in Figures 3A–3C to better display the role of these outliers with large LV mass reductions. Correlations between changes in net volume removal and changes in LVM in the Daily Trial (3 Times/Week hemodialysis: Pearson R=0.15, P=0.16, 6 Times/Week hemodialysis: R=0.06, P=0.54) and Nocturnal Trial (3 Times/Week hemodialysis: R=−0.20, P=0.24, 6 Times/Week hemodialysis: R=−0.11, P=0.54) Figure 3B: Correlations between changes in pre-dialysis systolic blood pressures and changes in LVM in the Daily Trial (3 Times/Week hemodialysis: R=0.28, P=0.01, 6 Times/Week hemodialysis: R=0.54, P Figure 3
Figure 3
Figure 3A: Closed circles indicate…
Figure 3
Figure 3A: Closed circles indicate patients with reductions in LV mass greater than…
Figure 3A: Closed circles indicate patients with reductions in LV mass greater than 60 g between baseline and 12 months. Although LV mass may be viewed as the response variable in this relationship, we have plotted LV mass on the horizontal axis in Figures 3A–3C to better display the role of these outliers with large LV mass reductions. Correlations between changes in net volume removal and changes in LVM in the Daily Trial (3 Times/Week hemodialysis: Pearson R=0.15, P=0.16, 6 Times/Week hemodialysis: R=0.06, P=0.54) and Nocturnal Trial (3 Times/Week hemodialysis: R=−0.20, P=0.24, 6 Times/Week hemodialysis: R=−0.11, P=0.54) Figure 3B: Correlations between changes in pre-dialysis systolic blood pressures and changes in LVM in the Daily Trial (3 Times/Week hemodialysis: R=0.28, P=0.01, 6 Times/Week hemodialysis: R=0.54, P Figure 3
Figure 3
Figure 3A: Closed circles indicate…
Figure 3
Figure 3A: Closed circles indicate patients with reductions in LV mass greater than…
Figure 3A: Closed circles indicate patients with reductions in LV mass greater than 60 g between baseline and 12 months. Although LV mass may be viewed as the response variable in this relationship, we have plotted LV mass on the horizontal axis in Figures 3A–3C to better display the role of these outliers with large LV mass reductions. Correlations between changes in net volume removal and changes in LVM in the Daily Trial (3 Times/Week hemodialysis: Pearson R=0.15, P=0.16, 6 Times/Week hemodialysis: R=0.06, P=0.54) and Nocturnal Trial (3 Times/Week hemodialysis: R=−0.20, P=0.24, 6 Times/Week hemodialysis: R=−0.11, P=0.54) Figure 3B: Correlations between changes in pre-dialysis systolic blood pressures and changes in LVM in the Daily Trial (3 Times/Week hemodialysis: R=0.28, P=0.01, 6 Times/Week hemodialysis: R=0.54, P
All figures (9)
Similar articles
- The Predialysis Serum Sodium Level Modifies the Effect of Hemodialysis Frequency on Left-Ventricular Mass: The Frequent Hemodialysis Network Trials.Raimann JG, Chan CT, Daugirdas JT, Depner T, Greene T, Kaysen GA, Kliger AS, Kotanko P, Larive B, Beck G, Lindsay RM, Rocco MV, Chertow GM, Levin NW; Frequent Hemodialysis Network (FHN) Trial Group. Raimann JG, et al. Kidney Blood Press Res. 2021;46(6):768-776. doi: 10.1159/000519339. Epub 2021 Oct 13. Kidney Blood Press Res. 2021. PMID: 34644706 Free PMC article. Clinical Trial.
- A randomized trial of hemodiafiltration and change in cardiovascular parameters.Mostovaya IM, Bots ML, van den Dorpel MA, Grooteman MP, Kamp O, Levesque R, Ter Wee PM, Nubé MJ, Blankestijn PJ. Mostovaya IM, et al. Clin J Am Soc Nephrol. 2014 Mar;9(3):520-6. doi: 10.2215/CJN.07140713. Epub 2014 Jan 9. Clin J Am Soc Nephrol. 2014. PMID: 24408114 Free PMC article. Clinical Trial.
- The effect of frequent hemodialysis on matrix metalloproteinases, their tissue inhibitors, and FGF23: Implications for blood pressure and left ventricular mass modification in the Frequent Hemodialysis Network trials.Chan CT, Kaysen GA, Beck GJ, Li M, Lo JC, Rocco MV, Kliger AS; FHN Trials. Chan CT, et al. Hemodial Int. 2020 Apr;24(2):162-174. doi: 10.1111/hdi.12807. Epub 2019 Dec 11. Hemodial Int. 2020. PMID: 31826326 Clinical Trial.
- Effects of frequent hemodialysis on ventricular volumes and left ventricular remodeling.Chan CT, Greene T, Chertow GM, Kliger AS, Stokes JB, Beck GJ, Daugirdas JT, Kotanko P, Larive B, Levin NW, Mehta RL, Rocco M, Sanz J, Yang PC, Rajagopalan S; Frequent Hemodialysis Network Trial Group. Chan CT, et al. Clin J Am Soc Nephrol. 2013 Dec;8(12):2106-16. doi: 10.2215/CJN.03280313. Epub 2013 Aug 22. Clin J Am Soc Nephrol. 2013. PMID: 23970131 Free PMC article. Clinical Trial.
- Effects of daily hemodialysis on heart rate variability: results from the Frequent Hemodialysis Network (FHN) Daily Trial.Chan CT, Chertow GM, Daugirdas JT, Greene TH, Kotanko P, Larive B, Pierratos A, Stokes JB; Frequent Hemodialysis Network Daily Trial Group. Chan CT, et al. Nephrol Dial Transplant. 2014 Jan;29(1):168-78. doi: 10.1093/ndt/gft212. Epub 2013 Sep 26. Nephrol Dial Transplant. 2014. PMID: 24078335 Free PMC article. Clinical Trial.
Cited by
- Initiation of Dialysis Is Associated With Impaired Cardiovascular Functional Capacity.Arroyo E, Umukoro PE, Burney HN, Li Y, Li X, Lane KA, Sher SJ, Lu TS, Moe SM, Moorthi R, Coggan AR, McGregor G, Hiemstra TF, Zehnder D, Lim K. Arroyo E, et al. J Am Heart Assoc. 2022 Jul 19;11(14):e025656. doi: 10.1161/JAHA.122.025656. Epub 2022 Jul 5. J Am Heart Assoc. 2022. PMID: 35861826 Free PMC article. Clinical Trial.
- Physiological Mechanisms of Hypertension and Cardiovascular Disease in End-Stage Kidney Disease.Clemmer JS, Shafi T, Obi Y. Clemmer JS, et al. Curr Hypertens Rep. 2022 Oct;24(10):413-424. doi: 10.1007/s11906-022-01203-7. Epub 2022 Jun 16. Curr Hypertens Rep. 2022. PMID: 35708820 Free PMC article. Review.
- The Predialysis Serum Sodium Level Modifies the Effect of Hemodialysis Frequency on Left-Ventricular Mass: The Frequent Hemodialysis Network Trials.Raimann JG, Chan CT, Daugirdas JT, Depner T, Greene T, Kaysen GA, Kliger AS, Kotanko P, Larive B, Beck G, Lindsay RM, Rocco MV, Chertow GM, Levin NW; Frequent Hemodialysis Network (FHN) Trial Group. Raimann JG, et al. Kidney Blood Press Res. 2021;46(6):768-776. doi: 10.1159/000519339. Epub 2021 Oct 13. Kidney Blood Press Res. 2021. PMID: 34644706 Free PMC article. Clinical Trial.
- The Association of Pre-Kidney Transplant Dialysis Modality with de novo Posttransplant Heart Failure.Lenihan CR, Liu S, Airy M, Walther C, Montez-Rath ME, Winkelmayer WC. Lenihan CR, et al. Cardiorenal Med. 2021;11(5-6):209-217. doi: 10.1159/000518535. Epub 2021 Sep 2. Cardiorenal Med. 2021. PMID: 34515084 Free PMC article.
- Comparison of Dialysis Unit and Home Blood Pressures: An Observational Cohort Study.Miskulin DC, Jiang H, Gul A, Pankratz VS, Paine SS, Gassman JJ, Jhamb M, Kwong RY, Negrea L, Ploth DW, Shaffi SK, Harford AM, Zager PG. Miskulin DC, et al. Am J Kidney Dis. 2021 Nov;78(5):640-648. doi: 10.1053/j.ajkd.2021.04.013. Epub 2021 Jun 16. Am J Kidney Dis. 2021. PMID: 34144104 Free PMC article.
Publication types
- Comparative Study
- Multicenter Study
- Randomized Controlled Trial
- Research Support, N.I.H., Extramural
- Research Support, Non-U.S. Gov't
- Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
- Adult
- Aged
- Blood Pressure
- Canada
- Female
- Humans
- Hypertrophy, Left Ventricular / diagnosis
- Hypertrophy, Left Ventricular / etiology*
- Hypertrophy, Left Ventricular / mortality
- Hypertrophy, Left Ventricular / physiopathology
- Kidney Failure, Chronic / complications
- Kidney Failure, Chronic / mortality
- Kidney Failure, Chronic / physiopathology
- Kidney Failure, Chronic / therapy*
- Linear Models
- Magnetic Resonance Imaging
- Male
- Middle Aged
- Proportional Hazards Models
- Prospective Studies
- Renal Dialysis / adverse effects
- Renal Dialysis / methods*
- Renal Dialysis / mortality
- Risk Assessment
- Risk Factors
- Time Factors
- Treatment Outcome
- United States
Associated data
- ClinicalTrials.gov/NCT00264758
Related information
Grant support
LinkOut - more resources
- Full Text Sources
- Medical
Full text links [x]
[x]
Cite
Copy Download .nbib
Format: AMA APA MLA NLM
Send To [x]
NCBI Literature Resources
The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Unauthorized use of these marks is strictly prohibited.
Follow NCBI
National Library of Medicine
8600 Rockville Pike
Bethesda, MD 20894
Figure 3A: Closed circles indicate patients with reductions in LV mass greater than 60 g between baseline and 12 months. Although LV mass may be viewed as the response variable in this relationship, we have plotted LV mass on the horizontal axis in Figures 3A–3C to better display the role of these outliers with large LV mass reductions. Correlations between changes in net volume removal and changes in LVM in the Daily Trial (3 Times/Week hemodialysis: Pearson R=0.15, P=0.16, 6 Times/Week hemodialysis: R=0.06, P=0.54) and Nocturnal Trial (3 Times/Week hemodialysis: R=−0.20, P=0.24, 6 Times/Week hemodialysis: R=−0.11, P=0.54) Figure 3B: Correlations between changes in pre-dialysis systolic blood pressures and changes in LVM in the Daily Trial (3 Times/Week hemodialysis: R=0.28, P=0.01, 6 Times/Week hemodialysis: R=0.54, P Figure 3
Figure 3
Figure 3A: Closed circles indicate…
Figure 3
Figure 3A: Closed circles indicate patients with reductions in LV mass greater than…
Figure 3A: Closed circles indicate patients with reductions in LV mass greater than 60 g between baseline and 12 months. Although LV mass may be viewed as the response variable in this relationship, we have plotted LV mass on the horizontal axis in Figures 3A–3C to better display the role of these outliers with large LV mass reductions. Correlations between changes in net volume removal and changes in LVM in the Daily Trial (3 Times/Week hemodialysis: Pearson R=0.15, P=0.16, 6 Times/Week hemodialysis: R=0.06, P=0.54) and Nocturnal Trial (3 Times/Week hemodialysis: R=−0.20, P=0.24, 6 Times/Week hemodialysis: R=−0.11, P=0.54) Figure 3B: Correlations between changes in pre-dialysis systolic blood pressures and changes in LVM in the Daily Trial (3 Times/Week hemodialysis: R=0.28, P=0.01, 6 Times/Week hemodialysis: R=0.54, P
All figures (9)
Similar articles
- The Predialysis Serum Sodium Level Modifies the Effect of Hemodialysis Frequency on Left-Ventricular Mass: The Frequent Hemodialysis Network Trials.Raimann JG, Chan CT, Daugirdas JT, Depner T, Greene T, Kaysen GA, Kliger AS, Kotanko P, Larive B, Beck G, Lindsay RM, Rocco MV, Chertow GM, Levin NW; Frequent Hemodialysis Network (FHN) Trial Group. Raimann JG, et al. Kidney Blood Press Res. 2021;46(6):768-776. doi: 10.1159/000519339. Epub 2021 Oct 13. Kidney Blood Press Res. 2021. PMID: 34644706 Free PMC article. Clinical Trial.
- A randomized trial of hemodiafiltration and change in cardiovascular parameters.Mostovaya IM, Bots ML, van den Dorpel MA, Grooteman MP, Kamp O, Levesque R, Ter Wee PM, Nubé MJ, Blankestijn PJ. Mostovaya IM, et al. Clin J Am Soc Nephrol. 2014 Mar;9(3):520-6. doi: 10.2215/CJN.07140713. Epub 2014 Jan 9. Clin J Am Soc Nephrol. 2014. PMID: 24408114 Free PMC article. Clinical Trial.
- The effect of frequent hemodialysis on matrix metalloproteinases, their tissue inhibitors, and FGF23: Implications for blood pressure and left ventricular mass modification in the Frequent Hemodialysis Network trials.Chan CT, Kaysen GA, Beck GJ, Li M, Lo JC, Rocco MV, Kliger AS; FHN Trials. Chan CT, et al. Hemodial Int. 2020 Apr;24(2):162-174. doi: 10.1111/hdi.12807. Epub 2019 Dec 11. Hemodial Int. 2020. PMID: 31826326 Clinical Trial.
- Effects of frequent hemodialysis on ventricular volumes and left ventricular remodeling.Chan CT, Greene T, Chertow GM, Kliger AS, Stokes JB, Beck GJ, Daugirdas JT, Kotanko P, Larive B, Levin NW, Mehta RL, Rocco M, Sanz J, Yang PC, Rajagopalan S; Frequent Hemodialysis Network Trial Group. Chan CT, et al. Clin J Am Soc Nephrol. 2013 Dec;8(12):2106-16. doi: 10.2215/CJN.03280313. Epub 2013 Aug 22. Clin J Am Soc Nephrol. 2013. PMID: 23970131 Free PMC article. Clinical Trial.
- Effects of daily hemodialysis on heart rate variability: results from the Frequent Hemodialysis Network (FHN) Daily Trial.Chan CT, Chertow GM, Daugirdas JT, Greene TH, Kotanko P, Larive B, Pierratos A, Stokes JB; Frequent Hemodialysis Network Daily Trial Group. Chan CT, et al. Nephrol Dial Transplant. 2014 Jan;29(1):168-78. doi: 10.1093/ndt/gft212. Epub 2013 Sep 26. Nephrol Dial Transplant. 2014. PMID: 24078335 Free PMC article. Clinical Trial.
Cited by
- Initiation of Dialysis Is Associated With Impaired Cardiovascular Functional Capacity.Arroyo E, Umukoro PE, Burney HN, Li Y, Li X, Lane KA, Sher SJ, Lu TS, Moe SM, Moorthi R, Coggan AR, McGregor G, Hiemstra TF, Zehnder D, Lim K. Arroyo E, et al. J Am Heart Assoc. 2022 Jul 19;11(14):e025656. doi: 10.1161/JAHA.122.025656. Epub 2022 Jul 5. J Am Heart Assoc. 2022. PMID: 35861826 Free PMC article. Clinical Trial.
- Physiological Mechanisms of Hypertension and Cardiovascular Disease in End-Stage Kidney Disease.Clemmer JS, Shafi T, Obi Y. Clemmer JS, et al. Curr Hypertens Rep. 2022 Oct;24(10):413-424. doi: 10.1007/s11906-022-01203-7. Epub 2022 Jun 16. Curr Hypertens Rep. 2022. PMID: 35708820 Free PMC article. Review.
- The Predialysis Serum Sodium Level Modifies the Effect of Hemodialysis Frequency on Left-Ventricular Mass: The Frequent Hemodialysis Network Trials.Raimann JG, Chan CT, Daugirdas JT, Depner T, Greene T, Kaysen GA, Kliger AS, Kotanko P, Larive B, Beck G, Lindsay RM, Rocco MV, Chertow GM, Levin NW; Frequent Hemodialysis Network (FHN) Trial Group. Raimann JG, et al. Kidney Blood Press Res. 2021;46(6):768-776. doi: 10.1159/000519339. Epub 2021 Oct 13. Kidney Blood Press Res. 2021. PMID: 34644706 Free PMC article. Clinical Trial.
- The Association of Pre-Kidney Transplant Dialysis Modality with de novo Posttransplant Heart Failure.Lenihan CR, Liu S, Airy M, Walther C, Montez-Rath ME, Winkelmayer WC. Lenihan CR, et al. Cardiorenal Med. 2021;11(5-6):209-217. doi: 10.1159/000518535. Epub 2021 Sep 2. Cardiorenal Med. 2021. PMID: 34515084 Free PMC article.
- Comparison of Dialysis Unit and Home Blood Pressures: An Observational Cohort Study.Miskulin DC, Jiang H, Gul A, Pankratz VS, Paine SS, Gassman JJ, Jhamb M, Kwong RY, Negrea L, Ploth DW, Shaffi SK, Harford AM, Zager PG. Miskulin DC, et al. Am J Kidney Dis. 2021 Nov;78(5):640-648. doi: 10.1053/j.ajkd.2021.04.013. Epub 2021 Jun 16. Am J Kidney Dis. 2021. PMID: 34144104 Free PMC article.
Publication types
- Comparative Study
- Multicenter Study
- Randomized Controlled Trial
- Research Support, N.I.H., Extramural
- Research Support, Non-U.S. Gov't
- Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
- Adult
- Aged
- Blood Pressure
- Canada
- Female
- Humans
- Hypertrophy, Left Ventricular / diagnosis
- Hypertrophy, Left Ventricular / etiology*
- Hypertrophy, Left Ventricular / mortality
- Hypertrophy, Left Ventricular / physiopathology
- Kidney Failure, Chronic / complications
- Kidney Failure, Chronic / mortality
- Kidney Failure, Chronic / physiopathology
- Kidney Failure, Chronic / therapy*
- Linear Models
- Magnetic Resonance Imaging
- Male
- Middle Aged
- Proportional Hazards Models
- Prospective Studies
- Renal Dialysis / adverse effects
- Renal Dialysis / methods*
- Renal Dialysis / mortality
- Risk Assessment
- Risk Factors
- Time Factors
- Treatment Outcome
- United States
Associated data
- ClinicalTrials.gov/NCT00264758
Related information
Grant support
LinkOut - more resources
- Full Text Sources
- Medical
Full text links [x]
[x]
Cite
Copy Download .nbib
Format: AMA APA MLA NLM
Send To [x]
Figure 3A: Closed circles indicate patients with reductions in LV mass greater than 60 g between baseline and 12 months. Although LV mass may be viewed as the response variable in this relationship, we have plotted LV mass on the horizontal axis in Figures 3A–3C to better display the role of these outliers with large LV mass reductions. Correlations between changes in net volume removal and changes in LVM in the Daily Trial (3 Times/Week hemodialysis: Pearson R=0.15, P=0.16, 6 Times/Week hemodialysis: R=0.06, P=0.54) and Nocturnal Trial (3 Times/Week hemodialysis: R=−0.20, P=0.24, 6 Times/Week hemodialysis: R=−0.11, P=0.54) Figure 3B: Correlations between changes in pre-dialysis systolic blood pressures and changes in LVM in the Daily Trial (3 Times/Week hemodialysis: R=0.28, P=0.01, 6 Times/Week hemodialysis: R=0.54, P
All figures (9)
Source: PubMed