Realizing the potential of routine viral load testing in sub-Saharan Africa

Wafaa M El-Sadr, Miriam Rabkin, John Nkengasong, Deborah L Birx, Wafaa M El-Sadr, Miriam Rabkin, John Nkengasong, Deborah L Birx

No abstract available

Keywords: HIV; sub-Saharan Africa; viral load.

Figures

Figure 1
Figure 1
Viral load continuum.

References

    1. UNAIDS . Ending AIDS: Progress Towards the 90‐90‐90 Targets. Geneva: UNAIDS; 2017.
    1. UNAIDS . 90‐90‐90: an ambitious treatment target to help end the AIDS epidemic. Geneva: UNAIDS; 2014.
    1. WHO . What's New in Treatment Monitoring: Viral Load and CD4 Testing. Geneva: WHO; 2017.
    1. Cohen MS, Chen YQ, McCauley M, Gamble T, Hosseinipour MC, Kumarasamy N, et al. Prevention of HIV‐1 infection with early antiretroviral therapy. N Engl J Med. 2011;365(6):493–505.
    1. Paterson DL, Swindells S, Mohr J, Brester M, Vergis EN, Squier C, et al. Adherence to protease ‐inhibitor therapy and outcomes in patients with HIV infection. Ann Intern Med. 2000;133(1):21–30.
    1. Lecher S, Williams J, Fonjungo PN, Kim AA, Ellenberger D, Zhang G, et al. Progress with scale‐up of HIV viral load monitoring ‐ seven Sub‐Saharan African Countries, January 2015‐June 2016. MMWR Morb Mortal Wkly Rep. 2016;65(47):1332–5.
    1. Essajee S, Bhairavabhotla R, Penazzato M, Kiragu K, Jani I, Carmona S, et al. Scale‐up of early infant HIV diagnosis and improving access to pediatric HIV care in global plan countries: past and future perspectives. J Acquir Immune Defic Syndr. 2017;75 Suppl 1:S51–8.
    1. Hsiao NY, Stinson K, Myer L. Linkage of HIV‐infected infants from diagnosis to antiretroviral therapy services across the Western Cape, South Africa. PLoS ONE. 2013;8(2):e55308.
    1. Chatterjee A, Tripathi S, Gass R, Hamunime N, Panha S, Kiyaga C, et al. Implementing services for early infant diagnosis (EID) of HIV: a comparative descriptive analysis of national programs in four countries. BMC Public Health. 2011;11:553.
    1. Nuwagaba‐Biribonwoha H, Werq‐Semo B, Abdallah A, Cunningham A, Gamaliel JG, Mtunga S, et al. Introducing a multi‐site program for early diagnosis of HIV infection among HIV‐exposed infants in Tanzania. BMC Pediatr. 2010;10:44.
    1. Drain PK, Rousseau C. Point‐of‐care diagnostics: extending the laboratory network to reach the last mile. Curr Opin HIV AIDS. 2017;12(2):175–81.
    1. WHO . Consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection: recommendations for a public health approach. Geneva: WHO; 2016.
    1. Cahn P. Candidates for inclusion in a universal antiretroviral regimen: dolutegravir. Curr Opin HIV AIDS. 2017;12(4):318–23.
    1. Abrams EJ, Strasser S. 90‐90‐90‐‐Charting a steady course to end the paediatric HIV epidemic. J Int AIDS Soc. 2015;18 Suppl 6:20296.
    1. Jobanputra K, Parker LA, Azih C, Okello V, Maphalala G, Kershberger B, et al. Factors associated with virological failure and suppression after enhanced adherence counselling, in children, adolescents and adults on antiretroviral therapy for HIV in Swaziland. PLoS ONE. 2015;10(2):e0116144.
    1. Bulage L, Ssewanyana I, Nankabirwa V, Nsubuga F, Kihembo C, Pande G, et al. Factors associated with virological non‐suppression among HIV‐positive patients on antiretroviral therapy in Uganda, August 2014–July 2015. BMC Infect Dis. 2017;17:326.
    1. Rangarajan S, Colby DJ, Giang LT, Bui DD, Hung Nguyen H, Tou PB, et al. Factors associated with HIV viral load suppression on antiretroviral therapy in Vietnam. J Virus Erad. 2016;2(2):94–101.
    1. WHO . HIV Drug Resistance Report 2017. Geneva: 2017. Licence: CC BY‐NC‐SA 3.0 IGO.
    1. New Findings Show Significant Progress against HIV Epidemic in Africa, Bringing the 90‐90‐90 Goals within Reach[press release]. New York City, December 1, 2016.
    1. Swaziland Survey Shows Impressive Progress in Confronting the HIV Epidemic[press release]. Paris, July 24, 2017.
    1. Reaching the Third 90: Implementing High Quality Viral Load Monitoring [press release]. New York, August 1, 2016.
    1. Killingo BC, Taro TB, Mosime WN. Community‐driven demand creation for the use of routine viral load testing: a model to scale up routine viral load testing. J Int AIDS Soc. 2017;20 Suppl 7:e25009.
    1. Peter T, Zeh C, Katz Z, Elbireer A, Alemayu B, Vojnov L, et al. Scaling up HIV viral load – lessons from the large‐scale implementation of HIV early infant diagnosis and CD4 testing. J Int AIDS Soc. 2017;20 Suppl 7:e25008.
    1. Ellman TM, Alemayehu B, Abrams EJ, Arpadi S, Howard AA, El‐Sadr WM. Selecting a viral load threshold for routine monitoring in resource‐limited settings: optimizing individual health and population impact. J Int AIDS Soc. 2017;20 Suppl 7:e25007.
    1. Saito S, Doung YT, Metz M, Lee K, Patel H, Sleeman K, et al. Returning HIV‐1 viral load results to participants’‐selected health facilities in national Population‐based HIV Impact Assessment (PHIA) household surveys in three sub‐Saharan African Countries, 2015‐2016. J Int AIDS Soc. 2017;20 Suppl 7:e25004.
    1. Lesosky M, Glass T, Mukonda E, Hsiao NY, Abrams E, Myer L. Optimal timing of viral load monitoring during pregnancy to predict viremia at delivery in HIV‐infected women initiating ART in South Africa: a simulation study. J Int AIDS Soc. 2017;20 Suppl 7:e25000.
    1. Arpadi SM, Shiau S, Pimentel De Gusmao E, Violari A. Routine viral load monitoring in HIV‐infected infants and children in low and middle‐income countries: challenges and opportunities. J Int AIDS Soc. 2017;20 Suppl 7:e25001.
    1. Marcus R, Ferrand RA, Kranzer K, Bekker LG. The case for viral load testing in adolescents in resource limited settings. J Int AIDS Soc. 2017;20 Suppl 7:e25002.
    1. Schwartz SR, Kravanough MM, Sugarman J, Solomon SS, Njindam IM, Rebe K, et al. HIV viral load monitoring among key populations in low‐ and middle‐income countries: challenges and opportunities. J Int AIDS Soc. 2017;20 Suppl 7:e25003.
    1. Barnabas RV, Revill P, Tan N, Phillips A. Cost‐effectiveness of routine viral load monitoring in low‐ and middle‐income countries: a systematic review. J Int AIDS Soc. 2017;20 Suppl 7:e25006.
    1. McNairy ML, El‐Sadr WM. The HIV care continuum: no partial credit given. AIDS. 2012;26(14):1735–8.

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