Results of treatment with telmisartan-amlodipine in hypertensive patients
Thomas W Littlejohn 3rd, Claudio R Majul, Rafael Olvera, Mary Seeber, Maureen Kobe, Robert Guthrie, Wille Oigman, Study Investigators, H Baglivo, M Bendersky, E Kuschnir, P Rodriguez, A Villamil, J Felicio, P Jardim, O Kohlman, D Mion Jr, M Alpizar, R Alvarado, J Illescas, A Meaney, J Parra, R Peralta, I Rodriguez, H Sanchez, S Trevethan, D Bernhardi, A Briel, S Chetty, E Janari, J Jurgens, C Kahanowitz, D Lakha, H Makan, I Mitha, P Nel, P Patel, Z Vawda, N Wellington, J Agaiby, J Anderson, G Balaji, H Bays, N Bertini, W Bestermann Jr, K Blaze, A Borge, J Boscia 3rd, T Brobyn, J Brodnan, V Brown, T Cavalieri, C Chappel, A Chen, D Cheung, S Christensen, S Chrysant, C Cooper, T Copeland, C DeBusk, D DeSantis, B Douglas, J Ervin, P Fiacco, T Fiel, J George, L Gilderman, R Gilman, R Glover 3rd, A Goetsch, R Graf, A Graff, M Graves, J Gutmann, C Hall, W Harper, D Henry, H Hidalgo Jr, J Holland, D Honeycutt, C Johnson, A Khan, B Khan, P Klaassen, M Kozinn, S Kreis, K Layne, J Lee, A Lewin, C-S Liang, L Ligon, T Linder, R Lipetz, M Lucas, R Marple, J Meli, C Mello, R Middleton, S Mion-Bet, K Mootoo, A Murray, J Naidu, P Narayan, J Navarro, J Neutel, A Niederman, R Noble, A Patron, F Phillips, W Pleskow, H Punzi, G Raad, T Raoof, P Raskin, A Razzetti, L Reed, H Resnick, J Schmidt, R Schreiman, D Schumacher, M Seidner, K Self, G Serfer, W Shapiro, J Silverfield, S Slabic, R Sockolov, J Sparks, R Struble, C Thompson, P Toth, T Treimer, P Vrooman, D Webster, G Willis, S Willsie, D Wright, S Yates, Thomas W Littlejohn 3rd, Claudio R Majul, Rafael Olvera, Mary Seeber, Maureen Kobe, Robert Guthrie, Wille Oigman, Study Investigators, H Baglivo, M Bendersky, E Kuschnir, P Rodriguez, A Villamil, J Felicio, P Jardim, O Kohlman, D Mion Jr, M Alpizar, R Alvarado, J Illescas, A Meaney, J Parra, R Peralta, I Rodriguez, H Sanchez, S Trevethan, D Bernhardi, A Briel, S Chetty, E Janari, J Jurgens, C Kahanowitz, D Lakha, H Makan, I Mitha, P Nel, P Patel, Z Vawda, N Wellington, J Agaiby, J Anderson, G Balaji, H Bays, N Bertini, W Bestermann Jr, K Blaze, A Borge, J Boscia 3rd, T Brobyn, J Brodnan, V Brown, T Cavalieri, C Chappel, A Chen, D Cheung, S Christensen, S Chrysant, C Cooper, T Copeland, C DeBusk, D DeSantis, B Douglas, J Ervin, P Fiacco, T Fiel, J George, L Gilderman, R Gilman, R Glover 3rd, A Goetsch, R Graf, A Graff, M Graves, J Gutmann, C Hall, W Harper, D Henry, H Hidalgo Jr, J Holland, D Honeycutt, C Johnson, A Khan, B Khan, P Klaassen, M Kozinn, S Kreis, K Layne, J Lee, A Lewin, C-S Liang, L Ligon, T Linder, R Lipetz, M Lucas, R Marple, J Meli, C Mello, R Middleton, S Mion-Bet, K Mootoo, A Murray, J Naidu, P Narayan, J Navarro, J Neutel, A Niederman, R Noble, A Patron, F Phillips, W Pleskow, H Punzi, G Raad, T Raoof, P Raskin, A Razzetti, L Reed, H Resnick, J Schmidt, R Schreiman, D Schumacher, M Seidner, K Self, G Serfer, W Shapiro, J Silverfield, S Slabic, R Sockolov, J Sparks, R Struble, C Thompson, P Toth, T Treimer, P Vrooman, D Webster, G Willis, S Willsie, D Wright, S Yates
Abstract
This randomized 4 x 4 factorial study determined the efficacy and safety of telmisartan (T) plus amlodipine (A) in hypertensive patients. Adults (N=1461) with stage 1 or 2 hypertension (baseline blood pressure [BP]: 153.2[12.1]/101.7[4.3] mm Hg) were randomized to 1 of 16 treatment groups with T 0, 20, 40, 80 mg and A 0, 2.5, 5, 10 mg for 8 weeks. In-clinic BP reductions were greater with combination therapy than respective monotherapies. The greatest least-square mean systolic/diastolic BP reductions were observed with T80 mg plus A10 mg (-26.4/-20.1 mm Hg; P<.05 compared with both monotherapies). BP control was also greatest in the T80-mg plus A10-mg group (76.5% [overall control] and 85.3% [diastolic BP control]), and BP response rates >90% with this combination. Peripheral edema was most common in the A10-mg group (17.8%); however, this rate was notably lower when A was used in combination with T: 11.4% (T20/A10), 6.2% (T40/A10), and 11.3% (T80/A10).
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Source: PubMed