Effectiveness of unconditional cash transfers combined with lipid-based nutrient supplement and/or behavior change communication to prevent stunting among children in Pakistan: a cluster randomized controlled trial

Sajid Bashir Soofi, Shabina Ariff, Gul Nawaz Khan, Atif Habib, Sumra Kureishy, Yasir Ihtesham, Masawar Hussain, Arjumand Rizvi, Muhammad Sajid, Naveed Akbar, Cecilia Garzon, Saskia de Pee, Zulfiqar A Bhutta, Sajid Bashir Soofi, Shabina Ariff, Gul Nawaz Khan, Atif Habib, Sumra Kureishy, Yasir Ihtesham, Masawar Hussain, Arjumand Rizvi, Muhammad Sajid, Naveed Akbar, Cecilia Garzon, Saskia de Pee, Zulfiqar A Bhutta

Abstract

Background: In Pakistan, the prevalence of stunting among children younger than 5 y has remained above WHO critical thresholds (≥30%) over the past 2 decades.

Objectives: We hypothesized that an unconditional cash transfer (UCT) combined with lipid-based nutrient supplement (LNS) and/or social and behavior change communication (SBCC) will prevent stunting among children 6-23 mo of age.

Methods: This was a 4-arm, community-based cluster randomized controlled trial conducted in the district of Rahim Yar Khan, Pakistan. A total of 1729 children (UCT, n = 434; UCT + SBCC, n = 433; UCT + LNS, n = 430; and UCT + LNS + SBCC, n = 432) were enrolled at 6 mo of age and measured monthly for 18 mo until the age of 24 mo.

Results: At 24 mo of age, children who received UCT + LNS [rate ratio (RR): 0.85; 95% CI: 0.74, 0.97; P = 0.015) and UCT + LNS + SBCC (RR: 0.86; 95% CI: 0.77, 0.96; P = 0.007) had a significantly lower risk of being stunted compared with the UCT arm. No significant difference was noted among children who received UCT + SBCC (RR: 1.03; 95% CI: 0.91, 1.16; P = 0.675) in the risk of being stunted compared with the UCT arm. The pooled prevalence of stunting among children aged 6-23 mo was 41.7%, 44.8%, 38.5%, and 39.3% in UCT, UCT + SBCC, UCT + LNS, and UCT + LNS + SBCC, respectively. In pairwise comparisons, a significant impact on stunting among children in UCT + LNS (P = 0.029) and UCT + LNS + SBCC (P = <0.001) was noted compared with the UCT arm.

Conclusions: UCT combined with LNS and UCT + LNS + SBCC were effective in reducing the prevalence of stunting among children aged 6-23 mo in marginalized populations. UCT + SBCC was not effective in reducing the child stunting prevalence. This trial was registered at clinicaltrials.gov as NCT03299218.

Keywords: children; lipid-based nutrient supplement; social and behavior change communication; stunting; unconditional cash transfer.

© The Author(s) 2021. Published by Oxford University Press on behalf of the American Society for Nutrition.

Figures

FIGURE 1
FIGURE 1
Trial profile. LNS, lipid-based nutrient supplement; SBCC, social and behavior change communication; UCT, unconditional cash transfer.

References

    1. United Nations Children's Fund (UNICEF), World Health Organization, International Bank for Reconstruction and Development/The World Bank . Levels and trends in child malnutrition: key findings of the 2021 edition of the Joint Child Malnutrition Estimates. Geneva (Switzerland): World Health Organization; 2021.
    1. Ozaltin E, Hill K, Subramanian SV. Association of maternal stature with offspring mortality, underweight, and stunting in low- to middle-income countries. JAMA. 2010;303(15):1507–16.
    1. Martorell R, Horta BL, Adair LS, Stein AD, Richter L, Fall CH, Bhargava SK, Biswas SK, Perez L, Barros FC et al. Weight gain in the first two years of life is an important predictor of schooling outcomes in pooled analyses from five birth cohorts from low- and middle-income countries. J Nutr. 2010;140(2):348–54.
    1. Martorell R, Khan LK, Schroeder DG. Reversibility of stunting: epidemiological findings in children from developing countries. Eur J Clin Nutr. 1994;48(1):S45–57.
    1. Thomas D, Strauss J. Health and wages: evidence on men and women in urban Brazil. J Econometrics. 1997;77:159–85.
    1. Kar BR, Rao SL, Chandramouli BA. Cognitive development in children with chronic protein energy malnutrition. Behav Brain Funct. 2008;4:31.
    1. Victora CG, Adair L, Fall C, Hallal PC, Martorell R, Richter L, Sachdev HS; Maternal and Child Undernutrition Study Group. Maternal and child undernutrition: consequences for adult health and human capital. Lancet North Am Ed. 2008;371(9609):340–57.
    1. Martorell R, Zongrone A. Intergenerational influences on child growth and undernutrition. Paediatr Perinat Epidemiol. 2012;26(1):302–14.
    1. Government of Pakistan, Nutrition Wing, Ministry of National Health Services, Regulations and Coordination; and UNICEF. National Nutrition Survey 2018. Islamabad, Pakistan: Government of Pakistan and UNICEF; 2020.
    1. Barber SL, Gertler PJ. The impact of Mexico's conditional cash transfer programme, Oportunidades, on birthweight. Trop Med Int Health. 2008;13(11):1405–14.
    1. Maluccio J, Flores R. Impact evaluation of a conditional cash transfer program: the Nicaraguan Red de Proteccion Social. Washington (DC): International Food Policy Research Institute; 2005.
    1. Lagarde M, Haines A, Palmer N. The impact of conditional cash transfers on health outcomes and use of health services in low and middle income countries. Cochrane Database Syst Rev. 2009;4(4):CD008137.
    1. Shei A, Costa F, Reis MG, Ko AI. The impact of Brazil's Bolsa Família conditional cash transfer program on children's health care utilization and health outcomes. BMC Int Health Hum Rights. 2014;14(1):1.
    1. Rasella D, Aquino R, Santos CA, Paes-Sousa R, Barreto ML. Effect of a conditional cash transfer programme on childhood mortality: a nationwide analysis of Brazilian municipalities. Lancet North Am Ed. 2013;382(9886):57–64.
    1. Bhutta ZA, Das JK, Rizvi A, Gaffey MF, Walker N, Horton S, Webb P, Lartey A, Black RE, Lancet Nutrition Interventions Review Group , et al. Evidence-based interventions for improvement of maternal and child nutrition: what can be done and at what cost?. Lancet North Am Ed. 2013;382(9890):452–77.
    1. Bastagli F, Hagen-Zanker J, Harman L, Barca V, Sturge G, Barca V, Sturge G, Schmidt T, Pellerano L. Cash transfers: what does the evidence say? A rigorous review of programme impact and the role of design and implementation features. London (UK): Overseas Development Institute; 2016.
    1. Huda TM, Alam A, Tahsina T, Hasan MM, Iqbal A, Khan J, Ara G, Ali NB, Al Amin SU, Kirkwood EK et al. Shonjibon cash and counselling: a community-based cluster randomised controlled trial to measure the effectiveness of unconditional cash transfers and mobile behaviour change communications to reduce child undernutrition in rural Bangladesh. BMC Public Health. 2020;20(1):1776.
    1. Kim SS, Rawat R, Mwangi EM, Tesfaye R, Abebe Y, Baker J, Frongillo EA, Ruel MT, Menon P. Exposure to large-scale social and behavior change communication interventions is associated with improvements in infant and young child feeding practices in Ethiopia. PLoS One. 2016;11(10):e0164800.
    1. Kim SS, Nguyen PH, Tran LM, Sanghvi T, Mahmud Z, Haque MR, Afsana K, Frongillo EA, Ruel MT, Menon P. Large scale social and behavior change communication interventions have sustained impacts on infant and young child feeding knowledge and practices: results of a 2-year follow-up study in Bangladesh. J Nutr. 2018;148(10):1605–14.
    1. Dewey KG, Adu-Afarwuah S. Systematic review of the efficacy and effectiveness of complementary feeding interventions in developing countries. Matern Child Nutr. 2008;4:24–85.
    1. Shi L, Zhang J. Recent evidence of the effectiveness of educational interventions for improving complementary feeding practices in developing countries. J Trop Pediatr. 2011;57:91–8.
    1. Lassi ZS, Das JK, Zahid G, Imdad A, Bhutta ZA. Impact of education and provision of complementary feeding on growth and morbidity in children less than 2 years of age in developing countries: a systematic review. BMC Public Health. 2013;13:S13.
    1. de Pee S, Bloem MW. Current and potential role of specially formulated foods and food supplements for preventing malnutrition among 6- to 23-month-old children and for treating moderate malnutrition among 6- to 59-month-old children. Food Nutr Bull. 2009;30(3, Suppl 3):S434–63.
    1. Ackatia-Armah RS, McDonald CM, Doumbia S, Erhardt JG, Hamer DH, Brown KH. Malian children with moderate acute malnutrition who are treated with lipid-based dietary supplements have greater weight gains and recovery rates than those treated with locally produced cereal-legume products: a community-based, cluster-randomized trial. Am J Clin Nutr. 2015;101(3):632–45.
    1. Adu-Afarwuah S, Lartey A, Brown KH, Zlotkin S, Briend A, Dewey KG. Randomized comparison of 3 types of micronutrient supplements for home fortification of complementary foods in Ghana: effects on growth and motor development. Am J Clin Nutr. 2007;86(2):412–20.
    1. Grellety E, Shepherd S, Roederer T, Manzo ML, Doyon S, Ategbo E, Grais RF. Effect of mass supplementation with ready-to-use supplementary food during an anticipated nutritional emergency. PLoS One. 2012;7(9):e44549.
    1. Huybregts L, Houngbé F, Salpéteur C, Brown R, Roberfroid D, Ait-Aissa M, Kolsteren P. The effect of adding ready-to-use supplementary food to a general food distribution on child nutritional status and morbidity: a cluster-randomized controlled trial. PLoS Med. 2012;9(9):e1001313.
    1. Iannotti LL, Dulience SJL, Green J, Joseph S, François J, Anténor M, Lesorogol C, Mounce J, Nickerson NM. Linear growth increased in young children in an urban slum of Haiti: a randomized controlled trial of a lipid-based nutrient supplement. Am J Clin Nutr. 2014;99(1):198–208.
    1. Lopriore C, Guidoum Y, Briend A, Branca F. Spread fortified with vitamins and minerals induces catch-up growth and eradicates severe anemia in stunted refugee children aged 3–6 y. Am J Clin Nutr. 2004;80(4):973–81.
    1. Mangani C, Maleta K, Phuka J, Cheung YB, Thakwalakwa C, Dewey K, Manary M, Puumalainen T, Ashorn P. Effect of complementary feeding with lipid-based nutrient supplements and corn-soy blend on the incidence of stunting and linear growth among 6- to 18-month-old infants and children in rural Malawi. Matern Child Nutr. 2015;11(4):132–43.
    1. Kuusipalo H, Maleta K, Briend A, Manary M, Ashorn P. Growth and change in blood haemoglobin concentration among underweight Malawian infants receiving fortified spreads for 12 weeks: a preliminary trial. J Pediatr Gastroenterol Nutr. 2006;43(4):525–32.
    1. Isanaka S, Nombela N, Djibo A, Poupard M, Van Beckhoven D, Gaboulaud V, Guerin PJ, Grais RF. Effect of preventive supplementation with ready-to-use therapeutic food on the nutritional status, mortality, and morbidity of children aged 6 to 60 months in Niger: a cluster randomized trial. JAMA. 2009;301(3):277–85.
    1. Bureau of Statistics Punjab, Planning & Development Board, Government of the Punjab . Multiple Indicator Cluster Survey Punjab, 2017–18, Survey Findings Report. Lahore, Pakistan: Bureau of Statistics Punjab, Planning & Development Board, Government of the Punjab; 2018.
    1. Khan GN, Kureishy S, Akbar N, Nasir M, Hussain M, Ahmed I, Bux R, Rizvi A, Ullah A, Hussain A et al. A stunting prevention cluster randomized controlled trial: leveraging the social protection system to prevent stunting in district Rahim Yar Khan, Punjab, Pakistan. [Internet]. Islamabad/Bangkok: World Food Programme; 2019 [cited 2020 Sep 16]. Available from: .
    1. Khan GN, Kureishy S, Ariff S, Habib MA, Usmani AA, Mubarik A, Hussain M, Akbar N, Rodriguez de Castro P, Garzon AC et al. Specialized nutritious food combined with cash transfers and social and behavior change communication to prevent stunting among children aged 6 to 23 months in Pakistan: protocol for a cluster randomized controlled trial. JMIR Res Protoc. 2020;9(8):e19001.
    1. Bureau of Statistics Punjab, Planning & Development Department, Government of the Punjab, UNICEF Punjab . Multiple Indicator Cluster Survey Punjab, 2014. [Internet]. Lahore, Pakistan: Bureau of Statistics Punjab, Planning & Development Department, Government of the Punjab and UNICEF Punjab; 2016; [cited 2020 Mar 12]. Available from: .
    1. Donner A, Klar N. Design and analysis of cluster randomization trials in health research. Hoboken (NJ): Wiley; 2010.
    1. Pagel C, Prost A, Lewycka S, Das S, Colbourn T, Mahapatra R, Azad K, Costello A, Osrin D. Intracluster correlation coefficients and coefficients of variation for perinatal outcomes from five cluster-randomised controlled trials in low and middle-income countries: results and methodological implications. Trials. 2011;12(1):151.
    1. Das JK, Salam RA, Prinzo ZW, Sheikh SS, Bhutta ZA. Provision of preventive lipid-based nutrient supplements given with complementary foods to infants and young children 6 to 23 months of age for health, nutrition, and developmental outcomes. Cochrane Database Syst Rev. 2019;5:CD012611.
    1. Galasso E, Weber AM, Stewart CP, Ratsifandrihamanana L, Fernald LCH. Effects of nutritional supplementation and home visiting on growth and development in young children in Madagascar: a cluster-randomised controlled trial. Lancet Glob Health. 2019;7(9):e1257–68.
    1. Leroy JL, Olney D, Ruel M. Tubaramure, a food-assisted integrated health and nutrition program, reduces child stunting in Burundi: a cluster-randomized controlled intervention trial. J Nutr. 2018;148:445–52.
    1. Adubra L, Le Port A, Kameli Y, Fortin S, Mahamadou T, Ruel MT, Martin-Prevel Y, Savy M. Conditional cash transfer and/or lipid-based nutrient supplement targeting the first 1000 d of life increased attendance at preventive care services but did not improve linear growth in young children in rural Mali: results of a cluster-randomized controlled trial. Am J Clin Nutr. 2019;110(6):1476–90.
    1. Olney DK, Pedehombga A, Ruel MT, Dillon A. A 2-year integrated agriculture and nutrition and health behavior change communication program targeted to women in Burkina Faso reduces anemia, wasting, and diarrhea in children 3–12.9 months of age at baseline: a cluster-randomized controlled trial. J Nutr. 2015;145(6):1317–24.
    1. Briaux J, Martin-Prevel Y, Carles S, Fortin S, Kameli Y, Adubra L, Renk A, Agboka Y, Romedenne M, Mukantambara F et al. Evaluation of an unconditional cash transfer program targeting children's first-1,000-days linear growth in rural Togo: a cluster-randomized controlled trial. PLoS Med. 2020;17(11):e1003388.
    1. Kumar D, Goel NK, Kalia M, Swami HM, Singh R. Gap between awareness and practices regarding maternal and child health among women in an urban slum community. Indian J Pediatr. 2008;75(5):455–8.

Source: PubMed

3
Subskrybuj