Autologous platelet rich plasma in chronic venous ulcers: study of 17 cases

Sacchidanand Sarvajnamurthy, Shwetha Suryanarayan, Leelavathy Budamakuntala, Deepak Hurkudli Suresh, Sacchidanand Sarvajnamurthy, Shwetha Suryanarayan, Leelavathy Budamakuntala, Deepak Hurkudli Suresh

Abstract

Background: Venous ulcers are wounds that are thought to occur due to improper functioning of venous valves, usually of the legs. They are the major cause of chronic wounds, occurring in 70% to 90% of chronic wound cases. The treatment of venous ulcers also entails substantial costs. Autologous platelet rich plasma (PRP) is a simple office based procedure which helps in enhancing the wound healing by releasing many growth factors like platelet derived growth factors, fibroblast derived growth factors and epidermal growth factors.

Aim: To study the efficacy of autologous platelet rich plasma in the management of chronic venous ulcer.

Methodology: 12 patients with 17 venous ulcers were treated with PRP and treatment outcome was measured by percentage of improvement in area and volume of the ulcer.

Results: 12 patients with 17 ulcers were treated with PRP. The mean age of the patients was 33.5 years (SD 9.82). 10 were males and 2 were females. The mean duration of the healing of the ulcers was in 5.1 weeks (SD 3.1). The mean percentage improvement in the area and volume of the ulcer was 94.7% (SD 11.12) and 95.6% (SD 10.19) respectively.

Conclusions: PRP is safe, simple and effective procedure in treating chronic venous ulcers.

Keywords: Non healing; platelet rich plasma; venous ulcers.

Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
(a) a patient of venous ulcer of duration 3 months, (b) after one sitting of platelet rich plasma, (c) ulcer at 4th week and (d) ulcer being healed at 6th week
Figure 2
Figure 2
A patient with venous ulcer of 2 months duration healed at 5th week requiring four sittings of platelet rich plasma

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Source: PubMed

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