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- Ensaio Clínico NCT00800917
A Study of Temsirolimus and Bevacizumab in Recurrent Glioblastoma Multiforme
A Phase II Study of Temsirolimus and Bevacizumab in Recurrent Glioblastoma Multiforme
This trial is an investigator initiated, open label phase II study, where patient with recurrent primary GBM will be considered for the study. Only patients with recurrence after Temozolomide and VEGF-directed therapy with Bevacizumab will be considered for the study. Patients will receive temsirolimus 25 mg IV over 30-60 minutes on days 1, 8, 15 and 22 and bevacizumab 10 mg/kg IV over 30-90 minutes on day 8 and 22. Treatment repeats every 28 days for a maximum of 12 courses in the absence of disease progression or unacceptable toxicity. A safety analysis will be performed when the first 10 patients have received minimum 4 cycles (8 weeks). The study will then be stopped:
If DLT is observed in > 2/10 patients, Occurrence of any serious adverse events not described in the SPC of each agents, If partial remission is not observed in at least 1/10 patients
Visão geral do estudo
Status
Condições
Intervenção / Tratamento
Tipo de estudo
Inscrição (Real)
Estágio
- Fase 2
Contactos e Locais
Locais de estudo
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Copenhagen, Dinamarca
- Rigshospitalet
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Critérios de participação
Critérios de elegibilidade
Idades elegíveis para estudo
Aceita Voluntários Saudáveis
Gêneros Elegíveis para o Estudo
Descrição
Inclusion Criteria:
- Written informed consent
- Histological verification of primary GBM and failure after radiotherapy and temozolomide (TMZ)
- Previously treated with VEGF-directed therapy with bevacizumab
- Previously received radiotherapy and temozolomide
- More than 4 weeks since any of the following prior treatments: chemotherapy (6 weeks for nitrosoureas or mitomycin C)
- Radiotherapy to nontarget lesions or lesions that are not to be biopsied VEGF-directed therapy (including bevacizumab)
- Investigational agents
- More than 6 months since prior major surgery or open biopsy and recovered (only 6 weeks required if operation is for recurrent GBM)
No concurrent medications or substances known to affect or with the potential to affect the activity or pharmacokinetics of the following:
- Temsirolimus
- Bevacizumab
- CYP450 isoenzymes
- ECOG performance status 0-1
- WBC ≥ 3,000 mm³
- Absolute neutrophil count ≥ 1,500/mm³
- Platelet count ≥ 100,000/mm³
- Bilirubin and phosphate normal
- AST and ALT ≤ 2.5 times upper limit of normal
- Creatinine normal OR creatinine clearance ≥ 60 mL/min
- Urine protein: creatinine ratio < 1.0 OR 24-hour urine protein < 1,000 mg
- Fasting cholesterol < 350 mg/dL (cholesterol medications are allowed)
- Fasting triglycerides < 400 mg/dL
- PT INR ≤ 1.5
- Hematocrit < 41% (for males) or < 38% (for females)
- Fertile females must use an approved contraceptive (p-pills, IUD, depot injection of gestagen, subdermal implantation, hormonal vaginal ring or transdermal depot plaster), throughout the study and 3 months after discontinuation of study drugs. Fertile men must use dobbelt barrier method (preservative with sperm inhibiting creme) or female partner uses the above mentioned contraceptive.
- Fertile males must use preservatives.
Exclusion Criteria:
- Clinically significant cardiovascular disease, including the following:
- Cerebrovascular accident within the past 6 months
- Transient ischemic attack within the past 6 months
- Myocardial ischemia within the past 6 months
- Myocardial infarction within the past 6 months
- Other thromboembolic event within the past 6 months
- Unstable angina within the past 6 months
- Uncontrolled hypertension (i.e., hypertension despite maximal therapy)
- New York Heart Association class II-IV heart disease
- Congestive heart failure
- Serious cardiac arrhythmia requiring medication
- Clinically significant peripheral vascular disease
- Uncontrolled intercurrent illness
- Ongoing or active infection
- One of the following within the past 6 months
- Abdominal fistula
- Gastrointestinal perforation
- Intra-abdominal abscess
- Serious or nonhealing wound, ulcer, or bone fracture
- Psychiatric illness or social situations that would preclude study compliance
- Uncontrolled diabetes
- Hemoglobin A1c > 7%
- Concurrent non-study related surgical procedures
- Concurrent treatment with CYP3A4 inducers or inhibitors
- Other concurrent anticancer agents or therapies
- Significant traumatic injury within the past 28 days
- History of allergic reactions to compounds of similar chemical or biological composition to temsirolimus or bevacizumab
- Hypersensitivity to Chinese hamster ovary cell products or other recombinant human antibodies (e.g., infliximab)
- Pregnancy or nursing
- Patients previously intolerant to bevacizumab
- Anticoagulant therapy
Plano de estudo
Como o estudo é projetado?
Detalhes do projeto
- Finalidade Principal: Tratamento
- Alocação: Não randomizado
- Modelo Intervencional: Atribuição de grupo único
- Mascaramento: Nenhum (rótulo aberto)
O que o estudo está medindo?
Medidas de resultados primários
Medida de resultado |
Prazo |
---|---|
Progression-free survival in months
Prazo: From start of treatment to death or progression
|
From start of treatment to death or progression
|
Medidas de resultados secundários
Medida de resultado |
Prazo |
---|---|
Adverse events
Prazo: every 2 weeks
|
every 2 weeks
|
Objective tumor response rate
Prazo: every 8 weeks
|
every 8 weeks
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Pre- vs post-treatment measurements of biomarkers and vascular system/immune system parameters
Prazo: weekly for the first 4 weeks, then every 8 weeks
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weekly for the first 4 weeks, then every 8 weeks
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Correlation with biomarkers
Prazo: at the end of the study
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at the end of the study
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Colaboradores e Investigadores
Patrocinador
Datas de registro do estudo
Datas Principais do Estudo
Início do estudo
Conclusão Primária (Real)
Conclusão do estudo (Real)
Datas de inscrição no estudo
Enviado pela primeira vez
Enviado pela primeira vez que atendeu aos critérios de CQ
Primeira postagem (Estimativa)
Atualizações de registro de estudo
Última Atualização Postada (Estimativa)
Última atualização enviada que atendeu aos critérios de controle de qualidade
Última verificação
Mais Informações
Termos relacionados a este estudo
Termos MeSH relevantes adicionais
- Neoplasias por Tipo Histológico
- Neoplasias
- Neoplasias Glandulares e Epiteliais
- Astrocitoma
- Glioma
- Neoplasias Neuroepiteliais
- Tumores Neuroectodérmicos
- Neoplasias, Células Germinativas e Embrionárias
- Neoplasias, Tecido Nervoso
- Glioblastoma
- Efeitos Fisiológicos das Drogas
- Agentes Anti-Infecciosos
- Agentes Antineoplásicos
- Agentes imunossupressores
- Fatores imunológicos
- Agentes Antineoplásicos Imunológicos
- Inibidores de angiogênese
- Agentes Moduladores da Angiogênese
- Substâncias de crescimento
- Inibidores de crescimento
- Agentes antibacterianos
- Antibióticos, Antineoplásicos
- Antifúngicos
- Bevacizumabe
- Sirolimo
Outros números de identificação do estudo
- BEV-CCI-779-GBM-02
- Eudract no.: 2008-003679-40
Essas informações foram obtidas diretamente do site clinicaltrials.gov sem nenhuma alteração. Se você tiver alguma solicitação para alterar, remover ou atualizar os detalhes do seu estudo, entre em contato com register@clinicaltrials.gov. Assim que uma alteração for implementada em clinicaltrials.gov, ela também será atualizada automaticamente em nosso site .
Ensaios clínicos em Glioblastoma multiforme
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