- ICH GCP
- Registro de ensaios clínicos dos EUA
- Ensaio Clínico NCT01400399
Cosmetic Evaluation of Lumpectomy Versus Oncolytic Mammoplasty With Bilateral Breast Reduction for Early Stage Breast Cancer
8 de dezembro de 2015 atualizado por: Coastal Carolina Radiation Oncology
Phase II Evaluation of Hypofractionated Breast Irradiation in Patients Undergoing Standard Lumpectomy or Oncolytic Mammoplasty With Bilateral Breast Reduction
This study will evaluate the cosmetic outcome and examine factors contributing to cosmetic outcome in women treated with lumpectomy or bilateral breast reduction mammoplasty/mastopexy (BRM) followed by hypofractionated whole breast irradiation.
Breast conservation is now an established method of treatment for early breast cancer.
Because breast conservation is essentially a cosmetic alternative to mastectomy, quality of life, cosmetic outcome and tumor control are all important considerations during comprehensive treatment planning.
Irradiation schemes have been demonstrated to be efficacious and with excellent short term cosmetic outcomes.
However, their interaction with currently evolving surgical techniques needs to be examined in order to maintain optimal local control while preserving cosmetic outcome.
Visão geral do estudo
Status
Desconhecido
Condições
Descrição detalhada
Breast cancer outcomes and cosmesis may differ by race.
Limited but controversial data suggests that African-American women have worse cosmetic outcomes with hypofractionated irradiation than with conventional breast conservation.
A growing body of data also suggests that African-American women have diminished oncologic outcomes when compared to Caucasian women in the United States.
Further evaluation is needed to better understand the reason for these discrepancies.
Tipo de estudo
Observacional
Inscrição (Antecipado)
84
Contactos e Locais
Esta seção fornece os detalhes de contato para aqueles que conduzem o estudo e informações sobre onde este estudo está sendo realizado.
Contato de estudo
- Nome: Belinda Lissor, AAS, CCRP
- Número de telefone: 910-251-1839
- E-mail: blissor@ccradonc.com
Estude backup de contato
- Nome: Amy Elder, MSN, BSc, CCRP, OCN
- Número de telefone: 910-251-1839
- E-mail: aelder@ccradonc.com
Locais de estudo
-
-
North Carolina
-
Supply, North Carolina, Estados Unidos, 28462
- Ativo, não recrutando
- South Atlantic Radiation Oncology
-
Wilmington, North Carolina, Estados Unidos, 28401
- Recrutamento
- Coastal Carolina Radiation Oncology
-
Wilmington, North Carolina, Estados Unidos, 28401
- Recrutamento
- Zimmer Cancer Center
-
-
Critérios de participação
Os pesquisadores procuram pessoas que se encaixem em uma determinada descrição, chamada de critérios de elegibilidade. Alguns exemplos desses critérios são a condição geral de saúde de uma pessoa ou tratamentos anteriores.
Critérios de elegibilidade
Idades elegíveis para estudo
50 anos e mais velhos (Adulto, Adulto mais velho)
Aceita Voluntários Saudáveis
Não
Gêneros Elegíveis para o Estudo
Fêmea
Método de amostragem
Amostra Não Probabilística
População do estudo
Breast cancer patients who have had a lumpectomy or bilateral reduction mammoplasty followed by hypofractionated irradiation.
Descrição
Inclusion Criteria:
- Ductal carcinoma in situ (DCIS) or invasive ductal, medullary, papillary, colloid (mucinous) lobular or tubular histologies.
- American Joint Committee on Cancer (AJCC) DCIS or Stage T1- T2, N0 histologically confirmed invasive carcinoma of the breast treated with partial mastectomy with axillary evaluation as appropriate, axillary node dissection or sentinel node biopsy (SLN). Patients with DCIS with or without SLN or axillary node dissection are eligible. Patients greater than 70 years old, with stage 1 disease who are estrogen/progesterone receptor positive (ER/PR+), with or without SLN or axillary node dissection are also eligible.
- Partial mastectomy with or without reconstruction consisting of local tissue rearrangement and/or reduction mammoplasty (ipsilateral and bilateral). Patients who have undergone surgery and/or chemotherapy prior to treatment with radiation therapy are still eligible for enrollment and all evaluations and photographs will begin prior to radiation. Retrospective Placement of at least 3 surgical clips in the lumpectomy cavity is strongly encouraged. Retrospective data may be collected on women who have completed their entire course of treatment as long as they are formally consented.
- Unifocal breast cancer which may be encompassed by excision of a single portion of breast tissue.
- Negative inked histologic margins of partial mastectomy or re-excision specimen to be confirmed prior to radiation. Positive margins are unacceptable. Every effort should be made by the surgeon to obtain negative margins with the initial excision.
- Negative post-partial mastectomy mammography (if malignancy associated micro-calcifications were initially present.)
- Tamoxifen or Arimidex therapy is allowed. If chemotherapy is administered prior to radiation (but following surgery), then a minimum of two weeks must elapse prior to the start of radiation therapy.
- The patient must be 50 years of age or older.
- Signed study-specific informed consent form prior to study entry.
Exclusion Criteria:
- Patients enrolled on another clinical trial involving any treatment which may affect the cosmesis of the bilateral breasts. This would include the taking of medications, vitamin supplements, variation in radiation or surgery or topical application to the breast.
- Patients who are node positive.
- Patients with distant metastases.
- Palpable or radiographically suspicious contralateral axillary, supraclavicular, infraclavicular or internal mammary nodes, unless there is histologic confirmation that these nodes are negative for tumor.
- Any previously treated contralateral breast carcinoma or synchronous ipsilateral breast carcinoma.
- Prior non-hormonal therapy or radiation therapy for the current breast cancer; prior chemotherapy if administered less than two weeks from the start of therapy.
- Patients with Paget's disease of the nipple.
- Patients with prior breast reconstructive surgery including breast mastopexy or breast augmentation.
- Patients with skin involvement, regardless of tumor size.
- Patients with collagenous diseases, specifically systemic lupus erythematosis, scleroderma or dermatomyositis.
- Patients with severe peripheral vascular disease or coronary artery disease (ex. Previous acute myocardial infarction requiring stents or coronary artery bypass graft within past two years; prior bypass graft of any type etc.)
- Patients with co-existing medical conditions with life expectancy less than 5 years.
- Patients with psychiatric disorders that would preclude obtaining informed consent.
- Other malignancy except non-melanomatous skin cancer less than 5 years prior to participation in this study; the disease free interval from any prior carcinoma must be continuous.
- Patients who are pregnant or lactating.
Plano de estudo
Esta seção fornece detalhes do plano de estudo, incluindo como o estudo é projetado e o que o estudo está medindo.
Como o estudo é projetado?
Detalhes do projeto
O que o estudo está medindo?
Medidas de resultados primários
Medida de resultado |
Prazo |
---|---|
Evaluation of cosmetic results as judged by the patient, surgeon and radiation oncologist at stated follow-up intervals that will judge cosmesis by serial photography and quality of life (QOL) forms.
Prazo: 10 years
|
10 years
|
Medidas de resultados secundários
Medida de resultado |
Prazo |
---|---|
Ipsilateral breast recurrence rate. Disease status will be evaluated at routine patient follow-up appointments including routine mammography.
Prazo: 10 years
|
10 years
|
Contralateral breast cancer rate. This will be monitored according to routine protocol including yearly mammograms and clinical breast exams.
Prazo: 10 years
|
10 years
|
Colaboradores e Investigadores
É aqui que você encontrará pessoas e organizações envolvidas com este estudo.
Patrocinador
Investigadores
- Investigador principal: Michael Nichols, MD, PhD, Coastal Carolina Radiation Oncology
Datas de registro do estudo
Essas datas acompanham o progresso do registro do estudo e os envios de resumo dos resultados para ClinicalTrials.gov. Os registros do estudo e os resultados relatados são revisados pela National Library of Medicine (NLM) para garantir que atendam aos padrões específicos de controle de qualidade antes de serem publicados no site público.
Datas Principais do Estudo
Início do estudo
1 de agosto de 2010
Conclusão Primária (Antecipado)
1 de agosto de 2016
Conclusão do estudo (Antecipado)
1 de agosto de 2020
Datas de inscrição no estudo
Enviado pela primeira vez
20 de julho de 2011
Enviado pela primeira vez que atendeu aos critérios de CQ
20 de julho de 2011
Primeira postagem (Estimativa)
22 de julho de 2011
Atualizações de registro de estudo
Última Atualização Postada (Estimativa)
9 de dezembro de 2015
Última atualização enviada que atendeu aos critérios de controle de qualidade
8 de dezembro de 2015
Última verificação
1 de dezembro de 2015
Mais Informações
Termos relacionados a este estudo
Palavras-chave
Termos MeSH relevantes adicionais
Outros números de identificação do estudo
- ZCC-2010
- U54CA142152-02 (Concessão/Contrato do NIH dos EUA)
Essas informações foram obtidas diretamente do site clinicaltrials.gov sem nenhuma alteração. Se você tiver alguma solicitação para alterar, remover ou atualizar os detalhes do seu estudo, entre em contato com register@clinicaltrials.gov. Assim que uma alteração for implementada em clinicaltrials.gov, ela também será atualizada automaticamente em nosso site .