Hypofractionated Radiation Therapy With Concomitant Boost in Treating Women After Breast Conserving Surgery

Inclusion Criteria:

• female, aged between 18-70
• pathological confirmed breast invasive carcinoma
• patients after breast lumpectomy(including quadrantectomy) with axillary lymph nodes dissection or sentinel node biopsy
• stage p T 1-2 N 0
• metastasis omitted by routine examinations in 1 months before enrollment
• complete blood count obtained in 2 weeks prior to study entry should meet the following criteria: absolute neutrophil count > 1.8 *10^9/L, hemoglobin > 8.0g/dl, platelet > 75 * 10^9/L
• hepatic and renal function in 2 weeks prior to study entry should be normal
• study entry within 60 days from whichever comes later: surgery or last chemotherapy
• women of childbearing potential must have a negative urine or serum pregnancy test with 2 weeks of study entry
• signs study specific informed consent prior to study entry

Exclusion Criteria:

• breast cancer with stage III/III (AJCC 7th)
• occult breast cancer
• in-situ breast carcinoma
• bilateral breast cancer
• male breast cancer
• breast lymphoma or breast sarcoma
• combined with Paget's disease
• received preoperative treatment(including neoadjuvant chemotherapy, endocrine therapy and target therapy
• positive surgical margin
• axillary lymph nodes dissection or sentinel lymph node biopsy omitted
• regional lymph nodes radiation needed
• boost volume larger than 1/4 of the whole breast
• tumor bed unable to recognize on CT
• prior invasive malignant tumor history
• prior radiation to thoracic
• connective tissue disease, such as active systemic lupus erythematosus and scleroderma, etc.

• severe, active co-morbidity, defined as follows:

  • unstable angina and/or congestive heart failure requiring hospitalization within the last 6 months
  • severe, acute bacterial or fungal infection within the last 2 weeks
  • chronic obstructive pulmonary disease exacerbation or other respiratory illness within 30 days
• pregnant women