Evaluation of the Methods and Management of Acute Coronary Events (EMMACE)-3: protocol for a longitudinal study

O A Alabas, R M West, R G Gillott, R Khatib, A S Hall, C P Gale, EMMACE-3 Investigators, Basel Hanbali, John Davies, Ranjit More, Steve Lindsay, Piers Clifford, Tim Reynolds, Justin Cooke, Shahid Junejo, Samuel McClure, Mark Scoote, Mohammed Ahmed El-Harari, John McDonald, Matthew Faircloth, Mark Appleby, Mohammed Al-Obaidi, Farqad Almagir, Simon Hetherington, Somnath Kumar, Nicola Brooks, Ted Lo, Philip Batin, Raj Khiani, Alan Bagnall, Roger Moore, Christopher Gibbs, Sudipta Chattopadhyay, Honey Thomas, Jolanta Sobolewska, Jo Porter, Venkatesan Suresh, Paul Kalra, Usman El-Sheikh, Anwar Memon, John Rowley, Nigel Capps, Philip Keeling, Mark De Belder, Thuraia Nageh, Philip Lewis, Mark Dayer, Alan Baonall, Adrian Brodison, Ian Hudson, Francesco Lo Monaco, Telal Mudawi, O A Alabas, R M West, R G Gillott, R Khatib, A S Hall, C P Gale, EMMACE-3 Investigators, Basel Hanbali, John Davies, Ranjit More, Steve Lindsay, Piers Clifford, Tim Reynolds, Justin Cooke, Shahid Junejo, Samuel McClure, Mark Scoote, Mohammed Ahmed El-Harari, John McDonald, Matthew Faircloth, Mark Appleby, Mohammed Al-Obaidi, Farqad Almagir, Simon Hetherington, Somnath Kumar, Nicola Brooks, Ted Lo, Philip Batin, Raj Khiani, Alan Bagnall, Roger Moore, Christopher Gibbs, Sudipta Chattopadhyay, Honey Thomas, Jolanta Sobolewska, Jo Porter, Venkatesan Suresh, Paul Kalra, Usman El-Sheikh, Anwar Memon, John Rowley, Nigel Capps, Philip Keeling, Mark De Belder, Thuraia Nageh, Philip Lewis, Mark Dayer, Alan Baonall, Adrian Brodison, Ian Hudson, Francesco Lo Monaco, Telal Mudawi

Abstract

Introduction: Patients with cardiovascular disease are living longer and are more frequently accessing healthcare resources. The Evaluation of the Methods and Management of Acute Coronary Events (EMMACE)-3 national study is designed to improve understanding of the effect of quality of care on health-related outcomes for patients hospitalised with acute coronary syndrome (ACS).

Methods and analysis: EMMACE-3 is a longitudinal study of 5556 patients hospitalised with an ACS in England. The study collects repeated measures of health-related quality of life, information about medications and patient adherence profiles, a survey of hospital facilities, and morbidity and mortality data from linkages to multiple electronic health records. Together with EMMACE-3X and EMMACE-4, EMMACE-3 will assimilate detailed information for about 13 000 patients across more than 60 hospitals in England.

Ethics and dissemination: EMMACE-3 was given a favourable ethical opinion by Leeds (West) Research Ethics committee (REC reference: 10/H131374). On successful application, study data will be shared with academic collaborators. The findings from EMMACE-3 will be disseminated through peer-reviewed publications, at scientific conferences, the media, and through patient and public involvement.

Study registration number: ClinicalTrials.gov Identifier: NCT01808027. Information about the study is also available at EMMACE.org.

Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

Figures

Figure 1
Figure 1
Regional map of English National Health Service hospitals and patients participating in Evaluation of the Methods and Management of Acute Coronary Events (EMMACE)-3.
Figure 2
Figure 2
Evaluation of the Methods and Management of Acute Coronary Events (EMMACE)-3 cumulative recruitment of participants.
Figure 3
Figure 3
Flow chart of the EMMACE studies. MINAP, Myocardial Ischaemia National Audit Project; NHS, National Service Framework; HES, Hospital Episode Statistics; EQ-5D, EuroQol 5-dimension; EMMACE, Evaluation of the Methods and Management of Acute Coronary Events.
Figure 4
Figure 4
Flow diagram showing number of EMMACE-3 participants at each phase of the study (ACS, acute coronary syndrome; EMMACE, Evaluation of the Methods and Management of Acute Coronary Events).

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