Long-term Follow-up of the Helsinki Businessmen Study (HBS)
14 augusti 2015 uppdaterad av: Timo Strandberg, Helsinki University Central Hospital
Long-term Follow-up of the Helsinki Businessmen Study Cohort of Men Born in 1919-1934
The Helsinki Businessmen Study (HBS) is a clinico-epidemiological longitudinal study started in 1964.
It also included a 5-year randomized, controlled multifactorial primary prevention trial of cardiovascular diseases between 1974-1980.
The cohort is being actively followed-up through national registers since the 1980, and since 2000 with regular questionnaire surveys.
Latest in 2015.
Also clinical and laboratory studies have been performed in random subcohorts.
Follow-up is ongoing with new hypothesis-generating research questions.
Studieöversikt
Status
Aktiv, inte rekryterande
Betingelser
Intervention / Behandling
Detaljerad beskrivning
The Helsinki Businessmen Study (HBS) was originally a convenient cohort of male executives and businessmen (born 1919-1934, n=3490), who participated in health check-ups between 1964-1973, but since the beginning of 1970s it has developed into a clinico-epidemiological longitudinal study.
Primary focus was on the prevention of cardiovascular diseases (CVD), but since 2000 focus has been shifting to geriatrics, and with its long follow-up (up to 50 years) HBS can be seen as a "life-course" study.
Traditional CVD risk factors are available from the 1960s and in 1974 participants (available n=3310) were divided in groups according to their clinical status and CVD risk.
Two high-risk groups (n=1222) and low-risk group (n=593) participated in a 5-year multifactorial primary prevention study in 1974-1980 (in-trial and post-trial results have been published in 1985 and 1991).
The whole original cohort has been followed-up from national registers since 1985 and with regular questionnaire surveys since 2000.
Random subcohorts have been studied clinically with laboratory and genetic examinations in 2003 and 2011.
The latest questionnaire survey was performed in winter 2015 by which two thirds of the original cohort had died.
Follow-up of the cohort is ongoing and new research questions formulated..
Studietyp
Observationell
Inskrivning (Faktisk)
3490
Deltagandekriterier
Forskare letar efter personer som passar en viss beskrivning, så kallade behörighetskriterier. Några exempel på dessa kriterier är en persons allmänna hälsotillstånd eller tidigare behandlingar.
Urvalskriterier
Åldrar som är berättigade till studier
31 år till 46 år (Vuxen)
Tar emot friska volontärer
Nej
Kön som är behöriga för studier
Manlig
Testmetod
Icke-sannolikhetsprov
Studera befolkning
Originally a convenient cohort of male executives and businessmen (born 1919-1934, n=3490), who participated in health check-ups during 1964-1973, but since the beginning of 1970s it has developed into a clinic-epidemiological longitudinal study.
Beskrivning
Inclusion Criteria:
- Participants of director studies at the Institute of Occupational Health in Helsinki, Finland, between 1964-1973
Exclusion Criteria:
- Non-participants
Studieplan
Det här avsnittet ger detaljer om studieplanen, inklusive hur studien är utformad och vad studien mäter.
Hur är studien utformad?
Designdetaljer
- Observationsmodeller: Kohort
- Tidsperspektiv: Blivande
Kohorter och interventioner
Grupp / Kohort |
Intervention / Behandling |
|---|---|
|
Total, observational
Various cardiovascular risk groups described below
|
|
|
High-risk intervention
Healthy but at high risk in 1974
|
Multifactorial intervention with lifestyle changes and drugs as needed
|
|
High-risk control
Healthy but at high risk in 1974
|
|
|
Low-risk conrtol
Healthy and at low risk in 1974
|
|
|
Sick control
Medications or clinical disease in 1974
|
|
|
Refused
Refused or no response in 1974
|
Vad mäter studien?
Primära resultatmått
Resultatmått |
Tidsram |
|---|---|
|
Total mortality: national registers
Tidsram: change from baseline up to 612 months
|
change from baseline up to 612 months
|
Sekundära resultatmått
Resultatmått |
Tidsram |
|---|---|
|
Health-related quality of life: questionnaire data
Tidsram: change from baseline up to 612 months
|
change from baseline up to 612 months
|
|
Geriatric syndromes and disability: questionnaires, clinical examinations, registers
Tidsram: change from baseline up to 612 months
|
change from baseline up to 612 months
|
|
Morbidity: self-report, national registers, hospital and autopsy records
Tidsram: change from baseline up to 612 months
|
change from baseline up to 612 months
|
|
Medications: self-report, national registers
Tidsram: change from baseline up to 612 months
|
change from baseline up to 612 months
|
|
Cause-specific mortality: national registers, autopsy records
Tidsram: change from baseline up to 612 months
|
change from baseline up to 612 months
|
Samarbetspartners och utredare
Det är här du hittar personer och organisationer som är involverade i denna studie.
Utredare
- Huvudutredare: Timo E Strandberg, MD, Helsinki University Central Hospital
Publikationer och användbara länkar
Den som ansvarar för att lägga in information om studien tillhandahåller frivilligt dessa publikationer. Dessa kan handla om allt som har med studien att göra.
Allmänna publikationer
- Strandberg TE, Salomaa VV, Naukkarinen VA, Vanhanen HT, Sarna SJ, Miettinen TA. Long-term mortality after 5-year multifactorial primary prevention of cardiovascular diseases in middle-aged men. JAMA. 1991 Sep 4;266(9):1225-9.
- Miettinen TA, Huttunen JK, Naukkarinen V, Strandberg T, Mattila S, Kumlin T, Sarna S. Multifactorial primary prevention of cardiovascular diseases in middle-aged men. Risk factor changes, incidence, and mortality. JAMA. 1985 Oct 18;254(15):2097-102.
- Strandberg AY, Strandberg TE, Stenholm S, Salomaa VV, Pitkala KH, Tilvis RS. Low midlife blood pressure, survival, comorbidity, and health-related quality of life in old age: the Helsinki Businessmen Study. J Hypertens. 2014 Sep;32(9):1797-804. doi: 10.1097/HJH.0000000000000265.
- Jyvakorpi SK, Urtamo A, Kivimaki M, Salomaa V, Strandberg TE. Association of midlife body composition with old-age health-related quality of life, mortality, and reaching 90 years of age: a 32-year follow-up of a male cohort. Am J Clin Nutr. 2020 Nov 11;112(5):1287-1294. doi: 10.1093/ajcn/nqaa230.
- Jyvakorpi SK, Urtamo A, Kivimaki M, Strandberg TE. Associations of protein source, distribution and healthy dietary pattern with appendicular lean mass in oldest-old men: the Helsinki Businessmen Study (HBS). Eur Geriatr Med. 2020 Aug;11(4):699-704. doi: 10.1007/s41999-020-00330-1. Epub 2020 May 22.
Studieavstämningsdatum
Dessa datum spårar framstegen för inlämningar av studieposter och sammanfattande resultat till ClinicalTrials.gov. Studieposter och rapporterade resultat granskas av National Library of Medicine (NLM) för att säkerställa att de uppfyller specifika kvalitetskontrollstandarder innan de publiceras på den offentliga webbplatsen.
Studera stora datum
Studiestart
1 januari 1964
Primärt slutförande (Förväntat)
1 december 2040
Avslutad studie (Förväntat)
1 december 2040
Studieregistreringsdatum
Först inskickad
10 juni 2015
Först inskickad som uppfyllde QC-kriterierna
14 augusti 2015
Första postat (Uppskatta)
18 augusti 2015
Uppdateringar av studier
Senaste uppdatering publicerad (Uppskatta)
18 augusti 2015
Senaste inskickade uppdateringen som uppfyllde QC-kriterierna
14 augusti 2015
Senast verifierad
1 augusti 2015
Mer information
Termer relaterade till denna studie
Nyckelord
Ytterligare relevanta MeSH-villkor
Andra studie-ID-nummer
- HBS Group
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