Long-term Follow-up of the Helsinki Businessmen Study (HBS)
14 de agosto de 2015 actualizado por: Timo Strandberg, Helsinki University Central Hospital
Long-term Follow-up of the Helsinki Businessmen Study Cohort of Men Born in 1919-1934
The Helsinki Businessmen Study (HBS) is a clinico-epidemiological longitudinal study started in 1964.
It also included a 5-year randomized, controlled multifactorial primary prevention trial of cardiovascular diseases between 1974-1980.
The cohort is being actively followed-up through national registers since the 1980, and since 2000 with regular questionnaire surveys.
Latest in 2015.
Also clinical and laboratory studies have been performed in random subcohorts.
Follow-up is ongoing with new hypothesis-generating research questions.
Descripción general del estudio
Estado
Activo, no reclutando
Intervención / Tratamiento
Descripción detallada
The Helsinki Businessmen Study (HBS) was originally a convenient cohort of male executives and businessmen (born 1919-1934, n=3490), who participated in health check-ups between 1964-1973, but since the beginning of 1970s it has developed into a clinico-epidemiological longitudinal study.
Primary focus was on the prevention of cardiovascular diseases (CVD), but since 2000 focus has been shifting to geriatrics, and with its long follow-up (up to 50 years) HBS can be seen as a "life-course" study.
Traditional CVD risk factors are available from the 1960s and in 1974 participants (available n=3310) were divided in groups according to their clinical status and CVD risk.
Two high-risk groups (n=1222) and low-risk group (n=593) participated in a 5-year multifactorial primary prevention study in 1974-1980 (in-trial and post-trial results have been published in 1985 and 1991).
The whole original cohort has been followed-up from national registers since 1985 and with regular questionnaire surveys since 2000.
Random subcohorts have been studied clinically with laboratory and genetic examinations in 2003 and 2011.
The latest questionnaire survey was performed in winter 2015 by which two thirds of the original cohort had died.
Follow-up of the cohort is ongoing and new research questions formulated..
Tipo de estudio
De observación
Inscripción (Actual)
3490
Criterios de participación
Los investigadores buscan personas que se ajusten a una determinada descripción, denominada criterio de elegibilidad. Algunos ejemplos de estos criterios son el estado de salud general de una persona o tratamientos previos.
Criterio de elegibilidad
Edades elegibles para estudiar
31 años a 46 años (Adulto)
Acepta Voluntarios Saludables
No
Géneros elegibles para el estudio
Masculino
Método de muestreo
Muestra no probabilística
Población de estudio
Originally a convenient cohort of male executives and businessmen (born 1919-1934, n=3490), who participated in health check-ups during 1964-1973, but since the beginning of 1970s it has developed into a clinic-epidemiological longitudinal study.
Descripción
Inclusion Criteria:
- Participants of director studies at the Institute of Occupational Health in Helsinki, Finland, between 1964-1973
Exclusion Criteria:
- Non-participants
Plan de estudios
Esta sección proporciona detalles del plan de estudio, incluido cómo está diseñado el estudio y qué mide el estudio.
¿Cómo está diseñado el estudio?
Detalles de diseño
- Modelos observacionales: Grupo
- Perspectivas temporales: Futuro
Cohortes e Intervenciones
Grupo / Cohorte |
Intervención / Tratamiento |
|---|---|
|
Total, observational
Various cardiovascular risk groups described below
|
|
|
High-risk intervention
Healthy but at high risk in 1974
|
Multifactorial intervention with lifestyle changes and drugs as needed
|
|
High-risk control
Healthy but at high risk in 1974
|
|
|
Low-risk conrtol
Healthy and at low risk in 1974
|
|
|
Sick control
Medications or clinical disease in 1974
|
|
|
Refused
Refused or no response in 1974
|
¿Qué mide el estudio?
Medidas de resultado primarias
Medida de resultado |
Periodo de tiempo |
|---|---|
|
Total mortality: national registers
Periodo de tiempo: change from baseline up to 612 months
|
change from baseline up to 612 months
|
Medidas de resultado secundarias
Medida de resultado |
Periodo de tiempo |
|---|---|
|
Health-related quality of life: questionnaire data
Periodo de tiempo: change from baseline up to 612 months
|
change from baseline up to 612 months
|
|
Geriatric syndromes and disability: questionnaires, clinical examinations, registers
Periodo de tiempo: change from baseline up to 612 months
|
change from baseline up to 612 months
|
|
Morbidity: self-report, national registers, hospital and autopsy records
Periodo de tiempo: change from baseline up to 612 months
|
change from baseline up to 612 months
|
|
Medications: self-report, national registers
Periodo de tiempo: change from baseline up to 612 months
|
change from baseline up to 612 months
|
|
Cause-specific mortality: national registers, autopsy records
Periodo de tiempo: change from baseline up to 612 months
|
change from baseline up to 612 months
|
Colaboradores e Investigadores
Aquí es donde encontrará personas y organizaciones involucradas en este estudio.
Patrocinador
Investigadores
- Investigador principal: Timo E Strandberg, MD, Helsinki University Central Hospital
Publicaciones y enlaces útiles
La persona responsable de ingresar información sobre el estudio proporciona voluntariamente estas publicaciones. Estos pueden ser sobre cualquier cosa relacionada con el estudio.
Publicaciones Generales
- Strandberg TE, Salomaa VV, Naukkarinen VA, Vanhanen HT, Sarna SJ, Miettinen TA. Long-term mortality after 5-year multifactorial primary prevention of cardiovascular diseases in middle-aged men. JAMA. 1991 Sep 4;266(9):1225-9.
- Miettinen TA, Huttunen JK, Naukkarinen V, Strandberg T, Mattila S, Kumlin T, Sarna S. Multifactorial primary prevention of cardiovascular diseases in middle-aged men. Risk factor changes, incidence, and mortality. JAMA. 1985 Oct 18;254(15):2097-102.
- Strandberg AY, Strandberg TE, Stenholm S, Salomaa VV, Pitkala KH, Tilvis RS. Low midlife blood pressure, survival, comorbidity, and health-related quality of life in old age: the Helsinki Businessmen Study. J Hypertens. 2014 Sep;32(9):1797-804. doi: 10.1097/HJH.0000000000000265.
- Jyvakorpi SK, Urtamo A, Kivimaki M, Salomaa V, Strandberg TE. Association of midlife body composition with old-age health-related quality of life, mortality, and reaching 90 years of age: a 32-year follow-up of a male cohort. Am J Clin Nutr. 2020 Nov 11;112(5):1287-1294. doi: 10.1093/ajcn/nqaa230.
- Jyvakorpi SK, Urtamo A, Kivimaki M, Strandberg TE. Associations of protein source, distribution and healthy dietary pattern with appendicular lean mass in oldest-old men: the Helsinki Businessmen Study (HBS). Eur Geriatr Med. 2020 Aug;11(4):699-704. doi: 10.1007/s41999-020-00330-1. Epub 2020 May 22.
Fechas de registro del estudio
Estas fechas rastrean el progreso del registro del estudio y los envíos de resultados resumidos a ClinicalTrials.gov. Los registros del estudio y los resultados informados son revisados por la Biblioteca Nacional de Medicina (NLM) para asegurarse de que cumplan con los estándares de control de calidad específicos antes de publicarlos en el sitio web público.
Fechas importantes del estudio
Inicio del estudio
1 de enero de 1964
Finalización primaria (Anticipado)
1 de diciembre de 2040
Finalización del estudio (Anticipado)
1 de diciembre de 2040
Fechas de registro del estudio
Enviado por primera vez
10 de junio de 2015
Primero enviado que cumplió con los criterios de control de calidad
14 de agosto de 2015
Publicado por primera vez (Estimar)
18 de agosto de 2015
Actualizaciones de registros de estudio
Última actualización publicada (Estimar)
18 de agosto de 2015
Última actualización enviada que cumplió con los criterios de control de calidad
14 de agosto de 2015
Última verificación
1 de agosto de 2015
Más información
Términos relacionados con este estudio
Palabras clave
Términos MeSH relevantes adicionales
Otros números de identificación del estudio
- HBS Group
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