Lung and Heart Function Across Decades of Life in Health
9 september 2026 uppdaterad av: University of California, San Francisco
Lung and Heart Function Across Decades of Life in Healthy Population
The main objective of this study is to develop baseline "normal" reference values of both lung and heart function for healthy adults within the age range relevant to the United States Veteran population who served in the Southwest Asia theater of military operations.
This study will involve performing key components of the Department of Veterans Affairs the Airborne Hazards and Open Burn Pit Center of Excellence (AHOBPCE) and a VA network of Post-Deployment Cardiopulmonary Evaluation Network (PDCEN) Core Clinical Evaluation in asymptomatic unexposed healthy controls without known lung or heart disease to serve as a "normal" control comparator group for veterans evaluated by PDCEN.
Studieöversikt
Status
Rekrytering
Intervention / Behandling
Detaljerad beskrivning
This is an observational study to recruit and thoroughly characterize 200 age- and gender-matched healthy controls without a history of exposure to airborne hazards.
The childhood health and disease profiles of participants will also be evaluated to provide assessment of their physical fitness as adolescents.
The participants will undergo detailed clinical, physiological, and radiological evaluations that will match the PDCEN Core Clinical Evaluation, which includes administration of health, environmental and occupational exposures, respiratory, and physical fitness questionnaires, pulmonary function testing (PFT), forced oscillometry (FOT), cardiopulmonary exercise testing (CPET) with maximum effort, dynamic hyperinflation, and exercise-induced bronchospasm protocols, methacholine challenge testing, transthoracic echocardiography, and computer tomography (CT) of chest, as well as pulmonary and systemic biomarker analysis including fractional exhalation of nitric oxide (FeNO) and peripheral blood sampling for blood count and metabolic panel including liver and kidney function.
Studietyp
Observationell
Inskrivning (Beräknad)
200
Kontakter och platser
Det här avsnittet innehåller kontaktuppgifter för dem som genomför studien och information om var denna studie genomförs.
Studiekontakt
- Namn: Mehrdad Arjomandi, MD
- Telefonnummer: 24393 415-221-4810
- E-post: mehrdad.arjomandi@ucsf.edu
Studieorter
-
-
California
-
San Francisco, California, Förenta staterna, 94143
- Rekrytering
- University of California San Francisco
-
Kontakt:
- Mehrdad Arjomandi, MD
- Telefonnummer: 24393 415-221-4810
- E-post: mehrdad.arjomandi@ucsf.edu
-
-
Deltagandekriterier
Forskare letar efter personer som passar en viss beskrivning, så kallade behörighetskriterier. Några exempel på dessa kriterier är en persons allmänna hälsotillstånd eller tidigare behandlingar.
Urvalskriterier
Åldrar som är berättigade till studier
- Vuxen
- Äldre vuxen
Tar emot friska volontärer
Ja
Testmetod
Icke-sannolikhetsprov
Studera befolkning
Healthy "normal" adults within the age range relevant to the United States Veteran population who served in the Southwest Asia theater of military operations.
Beskrivning
Inclusion Criteria:
- Age 24-68
- U.S. Veteran deployed between 1990 to 2021
- No respiratory complaints (defined as modified Medical Research Council score = 0)
- No use of respiratory medications
Exclusion Criteria:
- Non-English speaking
- Pregnancy
- BMI>35 Kg/m2
- Tobacco smoking within prior year
- Lifetime tobacco smoking of >5 pack-years
- Current inhaled cannabis use (any modality) >2x weekly
- Prior inhaled cannabis uses exceeding 2x weekly within the prior year
- Illicit drug use (other than cannabis)
No prior or current major organ disease, including but not limited to:
- Neuromuscular weakness
- History of malignancy (other than non-melanoma skin cancer)-- HIV/AIDS
- Autoimmune disease
- Solid-organ or hematopoietic stem cell transplant
Cardiovascular disease (other than mild HTN; < 140/90; controlled on 2 or less medications)
- Poorly-controlled HTN (SBP>140 or DBP>90 or use of more than 2 anti-hypertensive medications)
- Any history of congestive heart failure (CHF, either HFpEF or HFrEF)
- Any history of arrythmia (including atrial fibrillation)
Studieplan
Det här avsnittet ger detaljer om studieplanen, inklusive hur studien är utformad och vad studien mäter.
Hur är studien utformad?
Designdetaljer
Vad mäter studien?
Primära resultatmått
Resultatmått |
Åtgärdsbeskrivning |
Tidsram |
|---|---|---|
|
Normal reference values for heart and lung function within the age range relevant to the United States Veteran population.
Tidsram: 2 years
|
Pulmonary Function Testing: The purpose of this test is to determine the participant's lungs' capacity.
|
2 years
|
|
Normal reference values for heart and lung function within the age range relevant to the United States Veteran population.
Tidsram: 2 years
|
Cardiopulmonary Exercise Testing: The purpose of this test is to determine the participant's lung and heart capacity during maximum exercise.
|
2 years
|
|
Normal reference values for heart and lung function within the age range relevant to the United States Veteran population.
Tidsram: 2 years
|
Echocardiogram: The purpose of this test is to determine how well the subject's heart is functioning and identify causes of cardiac-related symptoms.
|
2 years
|
Sekundära resultatmått
Resultatmått |
Åtgärdsbeskrivning |
Tidsram |
|---|---|---|
|
Normal reference values for heart and lung function within the age range relevant to the United States Veteran population.
Tidsram: 2 years
|
FeNO: The purpose of this test is to measure a marker of inflammation in the lungs.
|
2 years
|
|
Normal reference values for heart and lung function within the age range relevant to the United States Veteran population.
Tidsram: 2 years
|
Forced Oscillation Technique: The purpose of this test is to determine the resistance of the airways in the subject's lungs.
|
2 years
|
|
Normal reference values for heart and lung function within the age range relevant to the United States Veteran population.
Tidsram: 2 years
|
Methacholine Challenge Test: The purpose of this test is to determine how irritable the participant's airways are by administering gradually increasing doses of methacholine.
|
2 years
|
|
Normal reference values for heart and lung function within the age range relevant to the United States Veteran population.
Tidsram: 2 years
|
Chest CT: The purpose of this test is to examine for abnormalities and to help diagnose the cause of signs or symptoms of chest disease.
|
2 years
|
|
Normal reference values for heart and lung function within the age range relevant to the United States Veteran population.
Tidsram: 2 years
|
Peripheral Blood Draw: The purpose of this blood draw is to determine metabolic and blood inflammatory markers.
|
2 years
|
Samarbetspartners och utredare
Det är här du hittar personer och organisationer som är involverade i denna studie.
Samarbetspartners
Utredare
- Huvudutredare: Mehrdad Arjomandi, MD, University of California, San Francisco
Publikationer och användbara länkar
Den som ansvarar för att lägga in information om studien tillhandahåller frivilligt dessa publikationer. Dessa kan handla om allt som har med studien att göra.
Allmänna publikationer
- Zeng S, Nishihama M, Weldemichael L, Lozier H, Gold WM, Arjomandi M. Effect of twice daily inhaled albuterol on cardiopulmonary exercise outcomes, dynamic hyperinflation, and symptoms in secondhand tobacco-exposed persons with preserved spirometry and air trapping: a randomized controlled trial. BMC Pulm Med. 2024 Jan 20;24(1):44. doi: 10.1186/s12890-023-02808-7.
- Zeng S, Dunn M, Gold WM, Kizer JR, Arjomandi M. Remote exposure to secondhand tobacco smoke is associated with lower exercise capacity through effects on oxygen pulse, a proxy of cardiac stroke volume. BMJ Open Respir Res. 2022 May;9(1):e001217. doi: 10.1136/bmjresp-2022-001217.
Studieavstämningsdatum
Dessa datum spårar framstegen för inlämningar av studieposter och sammanfattande resultat till ClinicalTrials.gov. Studieposter och rapporterade resultat granskas av National Library of Medicine (NLM) för att säkerställa att de uppfyller specifika kvalitetskontrollstandarder innan de publiceras på den offentliga webbplatsen.
Studera stora datum
Studiestart (Faktisk)
1 augusti 2024
Primärt slutförande (Beräknad)
31 december 2030
Avslutad studie (Beräknad)
31 december 2030
Studieregistreringsdatum
Först inskickad
1 juni 2026
Först inskickad som uppfyllde QC-kriterierna
8 juni 2026
Första postat (Faktisk)
11 juni 2026
Uppdateringar av studier
Senaste uppdatering publicerad (Faktisk)
14 september 2026
Senaste inskickade uppdateringen som uppfyllde QC-kriterierna
9 september 2026
Senast verifierad
1 september 2026
Mer information
Termer relaterade till denna studie
Nyckelord
Ytterligare relevanta MeSH-villkor
Andra studie-ID-nummer
- UCSF IRB#24-41051
Plan för individuella deltagardata (IPD)
Planerar du att dela individuella deltagardata (IPD)?
NEJ
Läkemedels- och apparatinformation, studiedokument
Studerar en amerikansk FDA-reglerad läkemedelsprodukt
Nej
Studerar en amerikansk FDA-reglerad produktprodukt
Nej
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