Denne side blev automatisk oversat, og nøjagtigheden af ​​oversættelsen er ikke garanteret. Der henvises til engelsk version for en kildetekst.

Lung and Heart Function Across Decades of Life in Health

8. juni 2026 opdateret af: University of California, San Francisco

Lung and Heart Function Across Decades of Life in Healthy Population

The main objective of this study is to develop baseline "normal" reference values of both lung and heart function for healthy adults within the age range relevant to the United States Veteran population who served in the Southwest Asia theater of military operations.

This study will involve performing key components of the Department of Veterans Affairs the Airborne Hazards and Open Burn Pit Center of Excellence (AHOBPCE) and a VA network of Post-Deployment Cardiopulmonary Evaluation Network (PDCEN) Core Clinical Evaluation in asymptomatic unexposed healthy controls without known lung or heart disease to serve as a "normal" control comparator group for veterans evaluated by PDCEN.

Studieoversigt

Status

Rekruttering

Betingelser

Intervention / Behandling

Detaljeret beskrivelse

This is an observational study to recruit and thoroughly characterize 200 age- and gender-matched healthy controls without a history of exposure to airborne hazards. The childhood health and disease profiles of participants will also be evaluated to provide assessment of their physical fitness as adolescents. The participants will undergo detailed clinical, physiological, and radiological evaluations that will match the PDCEN Core Clinical Evaluation, which includes administration of health, environmental and occupational exposures, respiratory, and physical fitness questionnaires, pulmonary function testing (PFT), forced oscillometry (FOT), cardiopulmonary exercise testing (CPET) with maximum effort, dynamic hyperinflation, and exercise-induced bronchospasm protocols, methacholine challenge testing, transthoracic echocardiography, and computer tomography (CT) of chest, as well as pulmonary and systemic biomarker analysis including fractional exhalation of nitric oxide (FeNO) and peripheral blood sampling for blood count and metabolic panel including liver and kidney function.

Undersøgelsestype

Observationel

Tilmelding (Anslået)

200

Kontakter og lokationer

Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.

Studiekontakt

Studiesteder

  • Forenede Stater
    • California
      • San Francisco, California, Forenede Stater, 94143
        • Rekruttering
        • University of California San Francisco
        • Kontakt:

Deltagelseskriterier

Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.

Berettigelseskriterier

Aldre berettiget til at studere

  • Voksen
  • Ældre voksen

Tager imod sunde frivillige

Ja

Prøveudtagningsmetode

Ikke-sandsynlighedsprøve

Studiebefolkning

Healthy "normal" adults within the age range relevant to the United States Veteran population who served in the Southwest Asia theater of military operations.

Beskrivelse

Inclusion Criteria:

  • Age 24-68
  • No respiratory complaints (defined as modified Medical Research Council score = 0)
  • No use of respiratory medications

Exclusion Criteria:

  • Non-English speaking
  • Pregnancy
  • BMI>35 Kg/m2
  • Tobacco smoking within prior year
  • Lifetime tobacco smoking of >5 pack-years
  • Current inhaled cannabis use (any modality) >2x weekly
  • Prior inhaled cannabis uses exceeding 2x weekly within the prior year
  • Illicit drug use (other than cannabis)

  • No prior or current major organ disease, including but not limited to:

    • Neuromuscular weakness
    • History of malignancy (other than non-melanoma skin cancer)-- HIV/AIDS
    • Autoimmune disease
    • Solid-organ or hematopoietic stem cell transplant

    • Cardiovascular disease (other than mild HTN; < 140/90; controlled on 2 or less medications)

      • Poorly-controlled HTN (SBP>140 or DBP>90 or use of more than 2 anti-hypertensive medications)
      • Any history of congestive heart failure (CHF, either HFpEF or HFrEF)
      • Any history of arrythmia (including atrial fibrillation)

Studieplan

Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
Normal reference values for heart and lung function within the age range relevant to the United States Veteran population.
Tidsramme: 2 years
Pulmonary Function Testing: The purpose of this test is to determine the participant's lungs' capacity.
2 years
Normal reference values for heart and lung function within the age range relevant to the United States Veteran population.
Tidsramme: 2 years
Cardiopulmonary Exercise Testing: The purpose of this test is to determine the participant's lung and heart capacity during maximum exercise.
2 years
Normal reference values for heart and lung function within the age range relevant to the United States Veteran population.
Tidsramme: 2 years
Echocardiogram: The purpose of this test is to determine how well the subject's heart is functioning and identify causes of cardiac-related symptoms.
2 years

Sekundære resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
Normal reference values for heart and lung function within the age range relevant to the United States Veteran population.
Tidsramme: 2 years
FeNO: The purpose of this test is to measure a marker of inflammation in the lungs.
2 years
Normal reference values for heart and lung function within the age range relevant to the United States Veteran population.
Tidsramme: 2 years
Forced Oscillation Technique: The purpose of this test is to determine the resistance of the airways in the subject's lungs.
2 years
Normal reference values for heart and lung function within the age range relevant to the United States Veteran population.
Tidsramme: 2 years
Methacholine Challenge Test: The purpose of this test is to determine how irritable the participant's airways are by administering gradually increasing doses of methacholine.
2 years
Normal reference values for heart and lung function within the age range relevant to the United States Veteran population.
Tidsramme: 2 years
Chest CT: The purpose of this test is to examine for abnormalities and to help diagnose the cause of signs or symptoms of chest disease.
2 years
Normal reference values for heart and lung function within the age range relevant to the United States Veteran population.
Tidsramme: 2 years
Peripheral Blood Draw: The purpose of this blood draw is to determine metabolic and blood inflammatory markers.
2 years

Samarbejdspartnere og efterforskere

Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.

Sponsor

University of California, San Francisco

Samarbejdspartnere

US Department of Veterans Affairs

Efterforskere

  • Ledende efterforsker: Mehrdad Arjomandi, MD, University of California, San Francisco

Publikationer og nyttige links

Den person, der er ansvarlig for at indtaste oplysninger om undersøgelsen, leverer frivilligt disse publikationer. Disse kan handle om alt relateret til undersøgelsen.

Generelle publikationer

Datoer for undersøgelser

Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.

Studer store datoer

Studiestart (Faktiske)

1. august 2024

Primær færdiggørelse (Anslået)

31. december 2030

Studieafslutning (Anslået)

31. december 2030

Datoer for studieregistrering

Først indsendt

1. juni 2026

Først indsendt, der opfyldte QC-kriterier

8. juni 2026

Først opslået (Faktiske)

11. juni 2026

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Faktiske)

11. juni 2026

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

8. juni 2026

Sidst verificeret

1. juni 2026

Mere information

Begreber relateret til denne undersøgelse

Nøgleord

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

  • UCSF IRB#24-41051

Plan for individuelle deltagerdata (IPD)

Planlægger du at dele individuelle deltagerdata (IPD)?

INGEN

Lægemiddel- og udstyrsoplysninger, undersøgelsesdokumenter

Studerer et amerikansk FDA-reguleret lægemiddelprodukt

Ingen

Studerer et amerikansk FDA-reguleret enhedsprodukt

Ingen

Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .

Kliniske forsøg med Healthy control

Søg i lignende forsøg

Sponsorer og samarbejdspartnere

Medicinske tilstande

Narkotikainterventioner

CROs by country

CROs in Papua New Guinea

Betingelser

Sjældne sygdomme

Narkotikainterventioner

Kosttilskud

Sponsor / samarbejdspartnere

Placeringer

Abonner