Effects of Dorsal Column Spinal Cord Stimulation on Neuroinflammation: Revisiting Molecular Mechanisms and Clinical Outcomes on Chronic Lumbar/Leg Pain and Failed Back Surgery Syndrome

Marco Echeverria-Villalobos, Justin Mitchell, Juan Fiorda-Diaz, Tristan Weaver, Marco Echeverria-Villalobos, Justin Mitchell, Juan Fiorda-Diaz, Tristan Weaver

Abstract

Objective: In this narrative review, we reviewed and discussed current literature describing the molecular mechanisms leading to neuroinflammation and its role in the onset and progression of chronic neuropathic lumbar and leg pain in patients with persistent spinal pain syndrome. In addition, we reviewed the proposed mechanisms and impact of spinal cord stimulation (SCS) on neuroinflammation.

Methods: A broad search of current literature in PubMed, Embase, Scopus, Cochrane library, Medline/Ovid, and Web of Science was performed using the following terms and their combinations: "biomarkers", "chronic back and leg pain", "cytokines", "neuroinflammation", "spinal cord stimulation (scs)," and "spinal cord modulation". We selected: 1) articles published in the English language between January 2000 and July 2020 2) preclinical and clinical data 3) case reports 4) meta-analysis and systematic reviews and 5) conference abstracts. Manuscripts not disclosing methodology or without full-text availability were excluded.

Discussion: SCS techniques have gradually evolved since inception to include novel methods such as burst-SCS, high frequency SCS, and differential targeted multiplexed SCS. The incidence of chronic pain after spine surgery is highly variable, with at least one third of patients developing persistent spinal pain syndrome. Novel SCS techniques have been associated with improved clinical and functional outcomes thus increasing patient quality of life.

Conclusion: Currently, health care providers rely on different options and methods for SCS when treating patients with refractory chronic lumbar pain and persistent spinal pain syndrome. Nevertheless, compelling clinical trials remain necessary to elucidate the long-term benefits and mechanisms of neuromodulation of all different types of SCS.

Keywords: biomarkers; chronic back and leg pain; cytokines; neuroinflammation; spinal cord stimulation.

Conflict of interest statement

The Ohio State University have received grants for research activities from Medtronic Inc. and SPR therapeutics, Inc. in which MEV, JFD and TW have served as Investigators. In addition, TW have received funds from Medtronic, Inc. for consulting fees within the last year. The authors report no other conflicts of interest in this work.

© 2021 Echeverria-Villalobos et al.

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