Silver as a disinfectant

Nadia Silvestry-Rodriguez, Enue E Sicairos-Ruelas, Charles P Gerba, Kelly R Bright, Nadia Silvestry-Rodriguez, Enue E Sicairos-Ruelas, Charles P Gerba, Kelly R Bright

Abstract

Silver has been used as an antimicrobial for thousands of years. Over the past several decades, it has been introduced into numerous new venues such as in the treatment of water, in dietary supplements, in medical applications, and to produce antimicrobial coatings and products. Silver is often used as an alternative disinfectant in applications in which the use of traditional disinfectants such as chlorine may result in the formation of toxic by-products or cause corrosion of surfaces. Silver has also been demonstrated to produce a synergistic effect in combination with several other disinfectants. Many mechanisms of the antibacterial effect of silver have been described, but its antiviral and antiprotozoal mechanisms are not well understood. Both microbial tolerance and resistance to silver have been reported; however, the effect of silver has been observed against a wide variety of microorganisms over a period of years. Further research is needed to determine the antimicrobial efficacy of silver in these new applications and the effects of its long-term usage.

References

    1. Albright L.J., Wentworth W., Wilson E.M. Technique for measuring metallic salt effects upon the indigenous heterotrophic microflora of a natural water. Water Res. 1972;6:1589–1596. doi: 10.1016/0043-1354(72)90083-8.
    1. Anonymous (2006) Australian pesticides and veterinary medicines authority. . Retrieved Feb. 1, 2006.
    1. Antelman M.S. Anti-pathogenic multivalent silver molecular semiconductors. Precious Metals. 1992;16:141–149.
    1. Armon R., Laot N., Lev O., Shuval H., Fattal B. Controlling biofilm formation by hydrogen peroxide and silver combined disinfectant. Water Sci Technol. 2000;42:187–192.
    1. Auer J., Berent R., Ng C.K., Punzengruber C., Mayr H., Lassnig E., Schwarz C., Puschmann R., Hartl P., Eber B. Early investigation of silver-coated Silzone heart valves prosthesis in 126 patients. J Heart Valve Dis. 2001;10:717–723.
    1. Beer C.W., Guilmartin L.E., McLoughlin T.F., White T.J. Swimming pool disinfection. J Environ Health. 1999;61:9–13.
    1. Bell F.A. Review of effects of silver impregnated carbon filters on microbial water quality. J Am Water Works Assoc. 1991;83:74–76.
    1. Bellantone M., Williams H.D., Hench L.L. Broad-spectrum bactericidal activity of Ag2O-doped bioactive glass. Antimicrob Agents Chemother. 2002;46:1940–1945. doi: 10.1128/AAC.46.6.1940-1945.2002.
    1. Bentham R.H., Broadbent C.R. A model for autumn outbreaks of Legionnaires’ disease associated with cooling-towers, linked to system operation and size. Epidemiol Infect. 1993;111:287–295.
    1. Blaker J.J., Boccaccini A.R., Nazhat S.N. Thermal characterizations of silver-containing bioactive glass-coated sutures. J Biomater Appl. 2005;20:81–98. doi: 10.1177/0885328205054264.
    1. Blanc D.S., Carrara P., Zanetti G., Francioli P. Water disinfection with ozone, copper and silver ions, and temperature increase to control Legionella: seven years of experience in a university teaching hospital. J Hosp Infect. 2005;60:69–72. doi: 10.1016/j.jhin.2004.10.016.
    1. Borgmann S.R. Comparative assessment of different biocides in swimming pool water. Int Biodeterior Biodegrad. 2003;51:291–297. doi: 10.1016/S0964-8305(03)00040-4.
    1. Brady M.J., Lisay C.M., Yurkovetskiy A.V., Sawan S.P. Persistent silver disinfectant for the environmental control of pathogenic bacteria. Am J Infect Control. 2003;31:208–214. doi: 10.1067/mic.2003.23.
    1. Bragg P.D., Rainnie D.J. The effect of silver ions on the respiratory chain of Echerichia coli. Can J Microbiol. 1973;20:883–889.
    1. Breiman R.F., Cozen W., Fields B.S., Mastro T.D., Carr S.J., Spika J.S., Mascola L. Role of air sampling in investigation of an outbreak of Legionnaires’ disease associated with exposure to aerosols from an evaporative condensor. J Infect Dis. 1990;161:1257–1261.
    1. Bright K.R., Gerba C.P., Rusin P.A. Rapid reduction of Staphylococcus aureus populations on stainless steel surfaces by zeolite ceramic coatings containing silver and zinc ions. J Hosp Infect. 2002;52:307–309. doi: 10.1053/jhin.2002.1317.
    1. Broadbent C.R. Legionella in cooling towers: practical research, design, treatment, and control guidelines. In: Barbaree J.M., Breiman R.F., Dufour A.P., editors. Legionella: Current Status and Emerging Perspectives. Washington, DC: American Society for Microbiology; 1993. pp. 217–222.
    1. Brown C.M., Nuorti P.J., Breiman R.F., Hathcock L., Fields B.S., Lipman H.B., Llewellyn G.C., Hofmann J., Cetron M. A community outbreak of Legionnaires’ disease linked to hospital cooling towers; an epidemiological method to calculate dose of exposure. Int J Epidemiol. 1999;28:353–359. doi: 10.1093/ije/28.2.353.
    1. Butkus M.A., Labare M.P., Starke J.A., Moon K., Talbot M. Use of aqueous silver to enhance inactivation of coliphage MS-2 by UV disinfection. Appl Environ Microbiol. 2004;70:2848–2853. doi: 10.1128/AEM.70.5.2848-2853.2004.
    1. Cassells J.M., Yahya M.T., Gerba C.P., Rose J.B. Efficacy of a combined system of copper and silver and free chlorine for inactivation of Naegleria fowleri amoebas in water. Water Sci Technol. 1995;31:119–122. doi: 10.1016/0273-1223(95)00251-H.
    1. CDC Centers for Disease Control and Prevention) Legionnaires’ disease associated with cooling-towers. MMWR. 1994;43:491–493.
    1. Chopra H (2007) The increasing use of silver-based products as antimicrobial agents: a useful development or a cause for concern? J Antimicrob Chemother Feb 19, 2007 (Epub ahead of print).
    1. Cicalini S., Palmieri F., Petrosillo N. Clinical review: new technologies for prevention of intravascular catheter-related infections. Crit Care. 2004;8:157–162. doi: 10.1186/cc2380.
    1. Cowan M.M., Abshire K.Z., Houk S.L., Evans S.M. Antimicrobial efficacy of a silver-zeolite matrix coating on stainless steel. J Ind Microbiol Biotechnol. 2003;30:102–106.
    1. Craun G.F. Surface water supplies and health. J Am Water Works Assoc. 1988;80:40–52.
    1. Darouiche R.O. Anti-infective efficacy of silver-coated medical prostheses. Clin Infect Dis. 1999;29:1371–1377. doi: 10.1086/313561.
    1. Davis R.I., Etris S.F. Development and functions of silver in water-purification and disease-control. Catalysis Today. 1997;36:107–114. doi: 10.1016/S0920-5861(96)00203-9.
    1. Deshpande L.M., Chopade B.A. Plasmid mediated silver resistance in Acinetobacter baumannii. Biometals. 1994;7:49–56. doi: 10.1007/BF00205194.
    1. Dibrov P., Dzioba J., Gosink K.K., Hase C.C. Chemiosmotic mechanism of antimicrobial activity of Ag+ in Vibrio cholerae. Antimicrob Agents Chemother. 2002;46:2668–2670. doi: 10.1128/AAC.46.8.2668-2670.2002.
    1. Efrima S., Bronk B.V. Silver colloids impregnating or coating bacteria. J Phys Chem B. 1998;102:5947–5950. doi: 10.1021/jp9813903.
    1. Environmental Protection Agency (2002) National Secondary Drinking Water Regulations. . Retrieved July 7, 2006.
    1. Feng Q.L., Wu J., Chen G.Q., Cui F.Z., Kim T.N., Kim J.O. A mechanistic study of the antibacterial effect of silver ions on Escherichia coli and Staphylococcus aureus. J Biomed Mater Res. 2000;52:662–668. doi: 10.1002/1097-4636(20001215)52:4<662::AID-JBM10>;2-3.
    1. Fliermans C.B., Cherry W.B., Orrison L.H., Smith S.J., Tison D.L., Pope D.H. Ecological distribution of Legionella pneumophila. Appl Environ Microbiol. 1981;41:9–16.
    1. Foegeding P.M., Busta F.F. Chemical food preservatives. In: Block S.S., editor. Disinfection, Sterilization, and Preservation. 4th Ed. Philadelphia: Lea & Febiger; 1991. p. 842.
    1. Fox C.L., Modak S.M. Mechanisms of silver sulfadiazine action on burn wound infections. Antimicrob Agents Chemother. 1974;5:582–588.
    1. Furr J.R., Russell A.D., Turner T.D., Andrews A. Antibacterial activity of Actisorb Plus, Actisorb and silver nitrate. J Hosp Infect. 1994;27:201–208. doi: 10.1016/0195-6701(94)90128-7.
    1. Galeano B., Korff E., Nicholson W.L. Inactivation of vegetative cells, but not spores, of Bacillus anthracis, B. cereus, and B. subtilis on stainless steel surfaces coated with an antimicrobial silver-and zinc-containing zeolite formulation. Appl Environ Microbiol. 2003;69:4329–4331. doi: 10.1128/AEM.69.7.4329-4331.2003.
    1. Gentry H., Cope S. Using silver to reduce catheter-associated urinary tract infections. Nurs Stand. 2005;19:51–54.
    1. George N., Faoagali J., Muller M. Silvazine (silver sulfadiazine and chlorhexidine) activity against 200 clinical isolates. Burns. 1997;23:493–495. doi: 10.1016/S0305-4179(97)00047-8.
    1. Ghandour W., Hubbard J.A., Diestrung J., Hughes M.N., Poole P.K. The uptake of silver ions by Escherichia coli K12: toxic effects and interaction with copper ions. Appl Microbiol Biotechnol. 1988;28:559–565. doi: 10.1007/BF00250412.
    1. Goddard P.A., Bull T.A. Accumulation of silver by growing and non-growing populations of Citrobacter intermedius B6. Appl Microbiol Biotechnol. 1989;31:314–319.
    1. Grier N. Silver and its compounds. In: Block S.S., editor. Disinfection, Sterilization, and Preservation. 3rd Ed. Philadelphia: Lea & Febiger; 1983. pp. 375–389.
    1. Gupta A., Maynes M., Silver S. Effects of halides on plasmid-mediated silver resistance in Escherichia coli. Appl Environ Microbiol. 1998;64:5042–5045.
    1. Han J., Duan S., Yang Q., Gao C., Zhang B., He H., Dong X. Efficient and quick inactivation of SARS coronavirus and others microbes exposed to the surfaces of some metals catalysts. Biomed Environ Sci. 2005;18:176–180.
    1. Heggers J., Goodheart R.E., Washington J., McCoy L., Carino E., Dang T., Edgar P., Maness C., Chinkes D. Therapeutic efficacy of three silver dressings in an infected animal model. J Burn Care Rehabil. 2005;26:53–56. doi: 10.1097/01.BCR.0000150298.57472.26.
    1. Heining C.F., Jr Catalyst-assisted oxidative sanitation. Ozone Sci Eng. 1993;12:533.
    1. Hotta M., Nakamima H., Yamamoto K., Aono M. Antibacterial temporary filling materials: the effect of adding various ratios of Ag-Zn-zeolite. J Oral Rehabil. 1998;25:485–489. doi: 10.1046/j.1365-2842.1998.00265.x.
    1. Ibarluzea J., Moreno B., Zigorraga C., Castilla T., Martinez M., Santamaria J. Determinants of the microbiological water quality of indoor swimming-pools in relation to disinfection. Water Res. 1998;32:865–871. doi: 10.1016/S0043-1354(97)00290-X.
    1. Innes M.E., Umraw N., Fish J.S., Gomez M., Cartotto R.C. The use of silver coated dressings on donor site wounds: a prospective, controlled matched pair study. Burns. 2001;27:621–627. doi: 10.1016/S0305-4179(01)00015-8.
    1. Inoue Y., Hoshino M., Takahashi H., Noguchi T., Murata T., Kanzaki Y., Hamashima H., Sasatsu M. Bactericidal activity of Ag-zeolite mediated by reactive oxygen species under aerated conditions. J Inorg Biochem. 2002;92:37–42. doi: 10.1016/S0162-0134(02)00489-0.
    1. Ionescu A., Payne N., Fraser A.G., Giddings J., Grunkemeier G.L., Butchart E.G. Incidence of embolism and paravalvar leak after St Jude Silzone valve implantation: experience from the Cardiff Embolic Risk Factor Study. Heart. 2003;89:1055–1061. doi: 10.1136/heart.89.9.1055.
    1. Isenberg S.J. The dilemma of neonatal ophthalmic prophylaxis. West J Med. 1990;153:190–191.
    1. Kadar M., Janossy L., Nagy G., Takatsy Z.S., Koller M., Simon M., Pohl Antiviral effect of a new disinfectant containing a silver complex and hydrogen peroxide as active agents. Wien Mitteil Wasser-Abwasser-Gewaesser. 1993;112:62–64.
    1. Kawahara K., Tsuruda K., Morishita M., Uchida M. Antibacterial effect of silver-zeolite on oral bacteria under anaerobic conditions. Dent Mater. 2000;16:452–455. doi: 10.1016/S0109-5641(00)00050-6.
    1. Kebabjian R.S. Disinfection of public pools and management of fecal accidents. J Environ Health. 1995;58:8–12.
    1. Kim H., Shim J., Lee S. Formation of disinfection by-products in chlorinated swimming pool water. Chemosphere. 2002;46:123–130. doi: 10.1016/S0045-6535(00)00581-6.
    1. Kim J., Cho M., Oh B., Choi S., Yoon J. Control of bacterial growth in water using synthesized inorganic disinfectant. Chemosphere. 2004;55:775–780. doi: 10.1016/j.chemosphere.2003.11.014.
    1. Kim T.N., Feng Q.L., Kim J.O., Wu J., Wang H., Chen G.C., Cui F.Z. Antimicrobial effects of metal ions (Ag+,Cu2+, Zn2+) in hydroxyapatite. J Mater Sci Mater Med. 1998;9:129–134. doi: 10.1023/A:1008811501734.
    1. Klueh U., Wagner V., Kelly S., Johnson A., Bryers J.D. Efficacy of silver-coated fabric to prevent bacterial colonization and subsequent device-based biofilm formation. J Biomed Mater Res. 2000;53:621–631. doi: 10.1002/1097-4636(2000)53:6<621::AID-JBM2>;2-Q.
    1. Krause G.A. Neue Wege zur Wasserterilisierung. München: Bermann; 1928.
    1. Landeen L.K., Yahya M.T., Gerba C.P. Efficacy of copper and silver ions and reduced levels of free chlorine in inactivation of Legionella pneumophila. Appl Environ Microbiol. 1989;55:3045–3050.
    1. Li X.Z., Nikaido H., Williams K.E. Silver-resistant mutants of Escherichia coli display active efflux of Ag+ and are deficient in porins. J Bacteriol. 1997;179:6127–6132.
    1. Liau S.Y., Read D.C., Pugh W.J., Furr J.R., Russell A.D. Interaction of silver-nitrate with readily identifiable groups: relationship to the antibacterial action of silver ions. Lett Appl Microbiol. 1997;25:279–283. doi: 10.1046/j.1472-765X.1997.00219.x.
    1. Liedberg H., Lundeberg T., Ekman P. Refinements in the coating of urethral catheters reduces the incidence of catheter-associated bacteriuria. An experimental and clinical study. Eur Urol. 1990;17:236–240.
    1. Lin Y.S., Stout J.E., Yu V.L., Vidic R.D. Disinfection of water distribution systems for Legionella. Semin Respir Infect. 1998;13:147–159.
    1. Lin Y.S., Vidic R.D., Stout J.E., Yu V.L. Negative effect of high pH on biocidal efficacy of copper and silver ions in controlling Legionella pneumophila. Appl Environ Microbiol. 2002;68:2711–2715. doi: 10.1128/AEM.68.6.2711-2715.2002.
    1. Liu Z., Stout J.E., Tedesco L., Boldin M., Hwang C., Diven W.F., Yu V.L. Controlled evaluation of copper-silver ionization in eradicating Legionella pneumophila from a hospital water distribution system. J Infect Dis. 1994;169:919–922.
    1. Lundeberg T. Prevention of catheter-associated urinary-tract infections by use of silver-impregnated catheters. Lancet. 1986;2:1031. doi: 10.1016/S0140-6736(86)92629-2.
    1. Manal M.G., Mayo M.S., May L.L., Simmons R.B., Ahearn D.G. In vitro evaluation of the efficacy of a silver-coated catheter. Curr Microbiol. 1996;33:1–5. doi: 10.1007/s002849900064.
    1. Martinez S.S., Alvarez A.G., Esteban M. Electrolytically generated silver and copper ions to treat cooling water: an environmentally friendly novel alternative. Int J Hydrogen Energy. 2004;29:921–932. doi: 10.1016/j.ijhydene.2003.06.002.
    1. Matsumura Y., Yoshikata K., Kunisaki S., Tsuchido T. Mode of bactericidal action of silver zeolite and its comparison with that of silver nitrate. Appl Environ Microbiol. 2003;69:4278–4281. doi: 10.1128/AEM.69.7.4278-4281.2003.
    1. Mietzner S., Schwille R.C., Farley A., Wald E.R., Ge J.H., States S.J., Libert T., Wadowsky R.M., Miuetzner S. Efficacy of thermal treatment and copper-silver ionization for controlling Legionella pneumophila in high-volume hot water plumbing systems in hospitals. Am J Infect Control. 1997;25:452–457. doi: 10.1016/S0196-6553(97)90066-3.
    1. Modak S.M., Fox C.L., Jr Binding of silver sulfadiazine to the cellular components of Pseudomonas aeruginosa. Biochem Pharmacol. 1973;22:2391–2404. doi: 10.1016/0006-2952(73)90341-9.
    1. Modak S.M., Sampath L., Fox C.L., Jr Combined topical use of silver sulfadiazine and antibiotics as a possible solution to bacterial resistance in burn wounds. J Burn Care Rehabil. 1988;9:359–363. doi: 10.1097/00004630-198807000-00009.
    1. Moudgal C.J., Lipscomb J.C., Bruce R.M. Potential health effects of drinking water disinfection by-products using quantitative structure toxicity relationship. Toxicology. 2000;147:109–131. doi: 10.1016/S0300-483X(00)00188-8.
    1. Nover L., Scharf K.D., Neuman D. Formation of cytoplasmic heat shock protein granules in tomato cell cultures and leaves. Mol Cell Biol. 1983;3:1648–1655.
    1. Pedahzur R., Katzenelson D., Barnea N., Lev O., Shuval H., Ulitzur S. The efficacy of long-lasting residual drinking water disinfectants based on hydrogen peroxide and silver. Water Sci Technol. 2000;42:293–298.
    1. Poon V.K., Burd A. In vitro cytotoxity of silver: implication for clinical wound care. Burns. 2004;30:140–147. doi: 10.1016/j.burns.2003.09.030.
    1. Quintavalla S., Vicini L. Antimicrobial food packaging in meat industry. Meat Sci. 2002;62:373–380. doi: 10.1016/S0309-1740(02)00121-3.
    1. Rafter J, Grenier J, Denkewicz R (1999) US Patent #5,858,246. January 12, 1999; US Patent #5,935,609. August 10, 1999.
    1. Reasoner D.J., Blannon J.C., Geldreich E.E. Microbial characteristics of third faucet point-of-use devices. J Am Water Works Assoc. 1987;79:60–66.
    1. Richards R.M. Antimicrobial action of silver nitrate. Microbios. 1981;31:83–91.
    1. Rohr U., Senger M., Selenka F., Turley R., Wilhelm M. Four years of experience with silver-copper ionization for control of Legionella in a German university hospital hot water plumbing system. Clin Infect Dis. 1999;29:1507–1511. doi: 10.1086/313512.
    1. Rohr U., Weber S., Selenka F., Wilhelm M. Impact of silver and copper on the survival of amoebae and ciliated protozoa in vitro. Int J Hyg Environ Health. 2000;203:87–89. doi: 10.1078/S1438-4639(04)70013-9.
    1. Rosenkranz H.S., Carr H.S. Silver sulfadiazine: effect on the growth and metabolism of bacteria. Antimicrob Agents Chemother. 1972;2:367–372.
    1. Rusin P., Gerba C. Association of chlorination and UV irradiation to increasing antibiotic resistance in bacteria. Rev Environ Contam Toxicol. 2001;171:1–52.
    1. Rusin P., Bright K., Gerba C. Rapid reduction of Legionella pneumophila on stainless steel with zeolite coatings containing silver and zinc ions. Lett Appl Microbiol. 2003;36:69–72. doi: 10.1046/j.1472-765X.2003.01265.x.
    1. Russell A.D., Hugo W.B. Antimicrobial activity and action of silver. Prog Med Chem. 1994;31:351–370. doi: 10.1016/S0079-6468(08)70024-9.
    1. Samuni A., Aronovitch J., Chevio M., Czapski G. In: Life Chemistry Reports. 2nd Ed. Rottilio G., Bannister J.V., editors. New York: Harwood Academic; 1984. pp. 39–47.
    1. Schreurs W.J., Rosenberg H. Effect of silver ions on transport and retention of phosphate by Escherichia coli. J Bacteriol. 1982;152:7–13.
    1. Shakibaie M.R., Kapadnis B.P., Dhakephalker P., Chopade B.A. Removal of silver from photographic wastewater effluent using Acinetobacter baumannii BL54. Can J Microbiol. 1999;45:995–1000. doi: 10.1139/cjm-45-12-995.
    1. Silver S. Bacterial silver resistance: molecular biology and uses and misuses of silver compounds. FEMS Microbiol Rev. 2003;27:341–353. doi: 10.1016/S0168-6445(03)00047-0.
    1. Singer M. The role of antimicrobial agents in swimming pools. Int Biodeterior. 1990;26:159–168. doi: 10.1016/0265-3036(90)90056-D.
    1. Slawson R.M., Lee H., Trevors J.T. Bacterial interactions with silver. Biol Metals. 1990;3:151–154. doi: 10.1007/BF01140573.
    1. Slawson R.M., Van Dyke M.I., Lee H., Trevors J.T. Germanium and silver resistance, accumulation, and toxicity in microorganisms. Plasmid. 1992;27:72–79. doi: 10.1016/0147-619X(92)90008-X.
    1. Solioz M., Odermatt A. Copper and silver transport by CopB-ATPase in membrane vesicles of Enterococcus hirae. J Biol Chem. 1995;270:9217–9221. doi: 10.1074/jbc.270.9.4349.
    1. Spacciapoli P., Buxton D., Rothstein D., Friden P. Antimicrobial activity of silver nitrate against periodontal pathogens. J Periodontal Res. 2001;36:108–113. doi: 10.1034/j.1600-0765.2001.360207.x.
    1. Starodub M.E., Trevors J.T. Silver accumulation and resistance in Escherichia coli R1. J Inorg Biochem. 1990;39:317–325. doi: 10.1016/0162-0134(90)80030-2.
    1. Stout J.E., Yu V.L. Legionellosis. N Engl J Med. 1997;337:682–687. doi: 10.1056/NEJM199709043371006.
    1. Stout J.E., Yu V.L. Experiences of the first 16 hospitals using copper-silver ionization for Legionella control: implications for the evaluation of other disinfection modalities. Infect Control Hosp Epidemiol. 2003;24:563–568. doi: 10.1086/502251.
    1. Stout J.E., Lin Y.S., Goetz A.M., Muder R.R. Controlling Legionella in hospital water systems: experience with the superheat-and-flush method and coppersilver ionization. Infect Control Hosp Epidemiol. 1998;19:911–914.
    1. Straub T.M., Gerba C.P., Zhou X., Price R., Yahya M.T. Synergistic inactivaction of Escherichia coli and MS-2 coliphage by chloramine and cupric chloride. Water Res. 1995;29:811–818. doi: 10.1016/0043-1354(94)00213-Q.
    1. Takai K.T., Ohtsuka T., Senda Y., Nakao M., Yamamoto K., Matsuoka-Junji J., Hirai Y. Antibacterial properties of antimicrobial-finished textile products. Microbiol Immunol. 2002;46:75–81.
    1. Thurman R.B., Gerba C.P. The molecular mechanisms of copper and silver ion disinfection of bacteria and viruses. CRC Crit Rev Environ Control. 1989;18:295–315. doi: 10.1080/10643388909388351.
    1. Tzagoloff H., Pratt D. The initial steps in infection with coliphage M13. Virology. 1964;24:372–380. doi: 10.1016/0042-6822(64)90174-6.
    1. Uchida M. Antimicrobial zeolite and its application. Chem Ind. 1995;46:48–54.
    1. Ulkur E., Oncul O., Karagoz H., Celikoz B., Cavuslu S. Comparison of silvercoated dressing (Acticoat), chlorhexidine acetate 0.5% (Bactigrass), and silver sulfadiazine 1% (Silverdin) for topical antibacterial effect in Pseudomonas aeruginosa-contaminated, full-skin thickness burn wounds in rats. J Burn Care Rehabil. 2005;26:430–433. doi: 10.1097/01.bcr.0000176879.27535.09.
    1. Von Gunten U., Driedger A., Gallard H., Salhi E. By-products formation during drinking water disinfection: a tool to assess disinfection efficiency? Water Res. 2001;35:2095–2099. doi: 10.1016/S0043-1354(01)00051-3.
    1. Wahlberg V. Reconsideration of Credé prophylaxis. A study of maternity and neonatal care. Acta Paediatr Scand. 1982;295:1–73.
    1. Water Quality Association . Use/Purchase of Home Water Treatment Systems. Naperville, IL: National Consumer Water Quality Survey; 2001.
    1. Williams R.L., Grashoff G.J., Williams D.F. The biocompatibility of silver. Crit Rev Biocompat. 1989;5:221–243.
    1. Wood J.M. Microbiological strategies in resistance to metal ion toxicity. In: Sigel H., editor. Metal Ions in Biological Systems. New York: Marcel Dekker; 1984. pp. 333–351.
    1. World Health Organization . Guidelines for Drinking-Water Quality. 2nd Ed. Geneva, Switzerland: WHO; 1996.
    1. Yahya M.T., Landeen L.K., Messina M.C., Kutz S.M., Schulze R., Gerba C.P. Disinfection of bacteria in water systems by using electrolytically generated copper: silver and reduced levels of free chlorine. Can J Microbiol. 1990;36:109–116.
    1. Yahya M.T., Straub T.M., Gerba C.P. Inactivation of coliphage MS-2 and poliovirus by copper, silver and chlorine. Can J Microbiol. 1992;38:430–435. doi: 10.1139/m92-072.
    1. Yoshida K., Tanagawa M., Matsumoto S., Yamada T., Atsuta M. Antibacterial activity of resin composites with silver-containing materials. Eur J Oral Sci. 1999;107:290–296. doi: 10.1046/j.0909-8836.1999.eos107409.x.
    1. Zacheus O.M., Martikainen P.J. Occurrence of Legionellae in hot water distribution systems of Finnish apartment buildings. Can J Microbiol. 1994;40:993–999. doi: 10.1139/m94-159.

Source: PubMed

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