Subtype Diagnosis of Primary Aldosteronism: Is Adrenal Vein Sampling Always Necessary?

Fabrizio Buffolo, Silvia Monticone, Tracy A Williams, Denis Rossato, Jacopo Burrello, Martina Tetti, Franco Veglio, Paolo Mulatero, Fabrizio Buffolo, Silvia Monticone, Tracy A Williams, Denis Rossato, Jacopo Burrello, Martina Tetti, Franco Veglio, Paolo Mulatero

Abstract

Aldosterone producing adenoma and bilateral adrenal hyperplasia are the two most common subtypes of primary aldosteronism (PA) that require targeted and distinct therapeutic approaches: unilateral adrenalectomy or lifelong medical therapy with mineralocorticoid receptor antagonists. According to the 2016 Endocrine Society Guideline, adrenal venous sampling (AVS) is the gold standard test to distinguish between unilateral and bilateral aldosterone overproduction and therefore, to safely refer patients with PA to surgery. Despite significant advances in the optimization of the AVS procedure and the interpretation of hormonal data, a standardized protocol across centers is still lacking. Alternative methods are sought to either localize an aldosterone producing adenoma or to predict the presence of unilateral disease and thereby substantially reduce the number of patients with PA who proceed to AVS. In this review, we summarize the recent advances in subtyping PA for the diagnosis of unilateral and bilateral disease. We focus on the developments in the AVS procedure, the interpretation criteria, and comparisons of the performance of AVS with the alternative methods that are currently available.

Keywords: adrenal vein sampling; aldosterone; aldosterone producing adenoma; bilateral adrenal hyperplasia; cosyntropin stimulation; primary aldosteronism.

Conflict of interest statement

The authors declare no conflict of interest.

References

    1. Käyser S.C., Dekkers T., Groenewoud H.J., van der Wilt G.J., Carel Bakx J., van der Wel M.C., Hermus A.R., Lenders J.W., Deinum J. Study heterogeneity and estimation of prevalence of primary aldosteronism: A systematic review and meta-regression analysis. J. Clin. Endocrinol. Metab. 2016;101:2826–2835. doi: 10.1210/jc.2016-1472.
    1. Monticone S., Burrello J., Tizzani D., Bertello C., Viola A., Buffolo F., Gabetti L., Mengozzi G., Williams T.A., Rabbia F., Veglio F., Mulatero P. Prevalence and Clinical Manifestations of Primary Aldosteronism Encountered in Primary Care Practice. J. Am. Coll. Cardiol. 2017;69:1811–1820. doi: 10.1016/j.jacc.2017.01.052.
    1. Mulatero P., Tizzani D., Viola A., Bertello C., Monticone S., Mengozzi G., Schiavone D., Williams T.A., Einaudi S., La Grotta A., et al. Prevalence and characteristics of familial hyperaldosteronism: The PATOGEN study (Primary Aldosteronism in TOrino-GENetic forms) Hypertension. 2011;58:797–803. doi: 10.1161/HYPERTENSIONAHA.111.175083.
    1. Milliez P., Girerd X., Plouin P.-F., Blacher J., Safar M.E., Mourad J.-J. Evidence for an increased rate of cardiovascular events in patients with primary aldosteronism. J. Am. Coll. Cardiol. 2005;45:1243–1248. doi: 10.1016/j.jacc.2005.01.015.
    1. Mulatero P., Monticone S., Bertello C., Viola A., Tizzani D., Iannaccone A., Crudo V., Burrello J., Milan A., Rabbia F., et al. Long-term cardio- and cerebrovascular events in patients with primary aldosteronism. J. Clin. Endocrinol. Metab. 2013;98:4826–4833. doi: 10.1210/jc.2013-2805.
    1. Funder J.W., Carey R.M., Mantero F., Murad M.H., Reincke M., Shibata H., Stowasser M., Young W.F. The Management of Primary Aldosteronism: Case Detection, Diagnosis, and Treatment: An Endocrine Society Clinical Practice Guideline. J. Clin. Endocrinol. Metab. 2016;101:1889–1916. doi: 10.1210/jc.2015-4061.
    1. Rossi G.P., Auchus R.J., Brown M., Lenders J.W.M., Naruse M., Plouin P.F., Satoh F., Young W.F. An expert consensus statement on use of adrenal vein sampling for the subtyping of primary aldosteronism. Hypertension. 2014;63:151–160. doi: 10.1161/HYPERTENSIONAHA.113.02097.
    1. Monticone S., Viola A., Rossato D., Veglio F., Reincke M., Gomez-Sanchez C., Mulatero P. Adrenal vein sampling in primary aldosteronism: Towards a standardised protocol. Lancet Diabetes Endocrinol. 2015;3:296–303. doi: 10.1016/S2213-8587(14)70069-5.
    1. Bookstein J.J. Abrams Angiography. 2nd ed. Little Brown; Boston, MA, USA: 1983. The roles of angiography in adrenal disease; pp. 1395–1424.
    1. Walters N.A., Thomson K.R. Practical Interventional Uroradiology. Edward Arnold; Edinburgh, Scotland: 1993. Urogenital Venography.
    1. Mulatero P., Bertello C., Rossato D., Mengozzi G., Milan A., Garrone C., Giraudo G., Passarino G., Garabello D., Verhovez A., et al. Roles of clinical criteria, computed tomography scan, and adrenal vein sampling in differential diagnosis of primary aldosteronism subtypes. J. Clin. Endocrinol. Metab. 2008;93:1366–1371. doi: 10.1210/jc.2007-2055.
    1. White E.A., Schambelan M., Rost C.R., Biglieri E.G., Moss A.A., Korobkin M. Use of computed tomography in diagnosing the cause of primary aldosteronism. N. Engl. J. Med. 1980;303:1503–1507. doi: 10.1056/NEJM198012253032603.
    1. Young W.F., Stanson A.W., Thompson G.B., Grant C.S., Farley D.R., van Heerden J.A. Role for adrenal venous sampling in primary aldosteronism. Surgery. 2004;136:1227–1235. doi: 10.1016/j.surg.2004.06.051.
    1. Nwariaku F.E., Miller B.S., Auchus R., Holt S., Watumull L., Dolmatch B., Nesbitt S., Vongpatanasin W., Victor R., Wians F., et al. Primary hyperaldosteronism: Effect of adrenal vein sampling on surgical outcome. Arch. Surg. 2006;141:497–502. doi: 10.1001/archsurg.141.5.497.
    1. Kempers M.J., Lenders J.W., van Outheusden L., van der Wilt G.J., Schultze Kool L.J., Hermus A.R., Deinum J. Systematic review: Diagnostic procedures to differentiate unilateral from bilateral adrenal abnormality in primary aldosteronism. Ann. Intern. Med. 2009;151:329–337. doi: 10.7326/0003-4819-151-5-200909010-00007.
    1. Dekkers T., Prejbisz A., Kool L.J.S., Groenewoud H.J.M.M., Velema M., Spiering W., Kołodziejczyk-Kruk S., Arntz M., Kądziela J., Langenhuijsen J.F., et al. SPARTACUS Investigators Adrenal vein sampling versus CT scan to determine treatment in primary aldosteronism: An outcome-based randomised diagnostic trial. Lancet Diabetes Endocrinol. 2016;4:739–746. doi: 10.1016/S2213-8587(16)30100-0.
    1. Puar T.H., Khoo J.J., Ng K.S., Kam J.W., Wang K.W. Adrenal vein sampling versus CT scanning in primary aldosteronism. Lancet Diabetes Endocrinol. 2016;4:885–886. doi: 10.1016/S2213-8587(16)30235-2.
    1. Rossi G.P., Funder J.W. Adrenal Venous Sampling Versus Computed Tomographic Scan to Determine Treatment in Primary Aldosteronism (The SPARTACUS Trial): A Critique. Hypertension. 2017;69:396–397. doi: 10.1161/HYPERTENSIONAHA.116.08820.
    1. Sukor N., Gordon R.D., Ku Y.K., Jones M., Stowasser M. Role of unilateral adrenalectomy in bilateral primary aldosteronism: A 22-year single center experience. J. Clin. Endocrinol. Metab. 2009;94:2437–2445. doi: 10.1210/jc.2008-2803.
    1. Rossi G.P., Barisa M., Allolio B., Auchus R.J., Amar L., Cohen D., Degenhart C., Deinum J., Fischer E., Gordon R., et al. The Adrenal Vein Sampling International Study (AVIS) for Identifying the Major Subtypes of Primary Aldosteronism. J. Clin. Endocrinol. Metab. 2012;97:1606–1614. doi: 10.1210/jc.2011-2830.
    1. Riester A., Fischer E., Degenhart C., Reiser M.F., Bidlingmaier M., Beuschlein F., Reincke M., Quinkler M. Age below 40 or a recently proposed clinical prediction score cannot bypass adrenal venous sampling in primary aldosteronism. J. Clin. Endocrinol. Metab. 2014;99:E1035–E1039. doi: 10.1210/jc.2013-3789.
    1. Lim V., Guo Q., Grant C.S., Thompson G.B., Richards M.L., Farley D.R., Young W.F. Accuracy of adrenal imaging and adrenal venous sampling in predicting surgical cure of primary aldosteronism. J. Clin. Endocrinol. Metab. 2014;99:2712–2719. doi: 10.1210/jc.2013-4146.
    1. Küpers E.M., Amar L., Raynaud A., Plouin P.-F., Steichen O. A clinical prediction score to diagnose unilateral primary aldosteronism. J. Clin. Endocrinol. Metab. 2012;97:3530–3537. doi: 10.1210/jc.2012-1917.
    1. Sze W.C.C., Soh L.M., Lau J.H., Reznek R., Sahdev A., Matson M., Riddoch F., Carpenter R., Berney D., Grossman A.B., et al. Diagnosing unilateral primary aldosteronism—comparison of a clinical prediction score, computed tomography and adrenal venous sampling. Clin. Endocrinol. 2014;81:25–30. doi: 10.1111/cen.12374.
    1. Kobayashi H., Haketa A., Ueno T., Ikeda Y., Hatanaka Y., Tanaka S., Otsuka H., Abe M., Fukuda N., Soma M. Scoring system for the diagnosis of bilateral primary aldosteronism in the outpatient setting before adrenal venous sampling. Clin. Endocrinol. 2016;86:467–472. doi: 10.1111/cen.13278.
    1. Young W.F., Jr., Klee G.G. Primary aldosteronism. Diagnostic evaluation. Endocrinol. Metab. Clin. North Am. 1988;17:367–395.
    1. Lau J.H.G., Sze W.C.C., Reznek R.H., Matson M., Sahdev A., Carpenter R., Berney D.M., Akker S.A., Chew S.L., Grossman A.B., et al. A prospective evaluation of postural stimulation testing, computed tomography and adrenal vein sampling in the differential diagnosis of primary aldosteronism. Clin. Endocrinol. 2012;76:182–188. doi: 10.1111/j.1365-2265.2011.04202.x.
    1. Mulatero P., Stowasser M., Loh K.-C., Fardella C.E., Gordon R.D., Mosso L., Gomez-Sanchez C.E., Veglio F., Young W.F., Jr. Increased diagnosis of primary aldosteronism, including surgically correctable forms, in centers from five continents. J. Clin. Endocrinol. Metab. 2004;89:1045–1050. doi: 10.1210/jc.2003-031337.
    1. Phillips J.L., Walther M.M., Pezzullo J.C., Rayford W., Choyke P.L., Berman A.A., Linehan W.M., Doppman J.L., Gill J.R., Jr. Predictive value of preoperative tests in discriminating bilateral adrenal hyperplasia from an aldosterone-producing adrenal adenoma. J. Clin. Endocrinol. Metab. 2000;85:4526–4533. doi: 10.1210/jcem.85.12.7086.
    1. Sonoyama T., Sone M., Miyashita K., Tamura N., Yamahara K., Park K., Oyamada N., Taura D., Inuzuka M., Kojima K., et al. Significance of adrenocorticotropin stimulation test in the diagnosis of an aldosterone-producing adenoma. J. Clin. Endocrinol. Metab. 2011;96:2771–2778. doi: 10.1210/jc.2011-0573.
    1. Moriya A., Yamamoto M., Kobayashi S., Nagamine T., Takeichi-Hattori N., Nagao M., Harada T., Tanimura-Inagaki K., Onozawa S., Murata S., et al. ACTH stimulation test and computed tomography are useful for differentiating the subtype of primary aldosteronism. Endocr. J. 2017;64:65–73. doi: 10.1507/endocrj.EJ16-0297.
    1. Eisenhofer G., Dekkers T., Peitzsch M., Dietz A.S., Bidlingmaier M., Treitl M., Williams T.A., Bornstein S.R., Haase M., Rump L.C., Willenberg H.S., Beuschlein F., Deinum J., Lenders J.W.M., Reincke M. Mass Spectrometry-Based Adrenal and Peripheral Venous Steroid Profiling for Subtyping Primary Aldosteronism. Clin. Chem. 2016;62:514–524. doi: 10.1373/clinchem.2015.251199.
    1. Mulatero P., di Cella S.M., Monticone S., Schiavone D., Manzo M., Mengozzi G., Rabbia F., Terzolo M., Gomez-Sanchez E.P., Gomez-Sanchez C.E., et al. 18-Hydroxycorticosterone, 18-hydroxycortisol, and 18-oxocortisol in the diagnosis of primary aldosteronism and its subtypes. J. Clin. Endocrinol. Metab. 2012;97:881–889. doi: 10.1210/jc.2011-2384.
    1. Satoh F., Morimoto R., Ono Y., Iwakura Y., Omata K., Kudo M., Takase K., Seiji K., Sasamoto H., Honma S., et al. Measurement of peripheral plasma 18-oxocortisol can discriminate unilateral adenoma from bilateral diseases in patients with primary aldosteronism. Hypertension. 2015;65:1096–1102. doi: 10.1161/HYPERTENSIONAHA.114.04453.
    1. Rossi G.P., Ragazzo F., Seccia T.M., Maniero C., Barisa M., Calò L.A., Frigo A.C., Fassina A., Pessina A.C. Hyperparathyroidism can be useful in the identification of primary aldosteronism due to aldosterone-producing adenoma. Hypertension. 2012;60:431–436. doi: 10.1161/HYPERTENSIONAHA.112.195891.
    1. Burton T.J., Mackenzie I.S., Balan K., Koo B., Bird N., Soloviev D.V., Azizan E.A.B., Aigbirhio F., Gurnell M., Brown M.J. Evaluation of the sensitivity and specificity of (11)C-metomidate positron emission tomography (PET)-CT for lateralizing aldosterone secretion by Conn’s adenomas. J. Clin. Endocrinol. Metab. 2012;97:100–109. doi: 10.1210/jc.2011-1537.
    1. Gomez-Sanchez C.E., Montgomery M., Ganguly A., Holland O.B., Gomez-Sanchez E.P., Grim C.E., Weinberger M.H. Elevated urinary excretion of 18-oxocortisol in glucocorticoid-suppressible aldosteronism. J. Clin. Endocrinol. Metab. 1984;59:1022–1024. doi: 10.1210/jcem-59-5-1022.
    1. Geller D.S., Zhang J., Wisgerhof M.V., Shackleton C., Kashgarian M., Lifton R.P. A novel form of human mendelian hypertension featuring nonglucocorticoid-remediable aldosteronism. J. Clin. Endocrinol. Metab. 2008;93:3117–3123. doi: 10.1210/jc.2008-0594.
    1. Williams T.A., Peitzsch M., Dietz A.S., Dekkers T., Bidlingmaier M., Riester A., Treitl M., Rhayem Y., Beuschlein F., Lenders J.W.M., et al. Genotype-Specific Steroid Profiles Associated With Aldosterone-Producing Adenomas. Hypertension. 2016;67:139–145. doi: 10.1161/HYPERTENSIONAHA.115.06186.
    1. Azizan E.A.B., Lam B.Y.H., Newhouse S.J., Zhou J., Kuc R.E., Clarke J., Happerfield L., Marker A., Hoffman G.J., Brown M.J. Microarray, qPCR, and KCNJ5 sequencing of aldosterone-producing adenomas reveal differences in genotype and phenotype between zona glomerulosa- and zona fasciculata-like tumors. J. Clin. Endocrinol. Metab. 2012;97:E819–E829. doi: 10.1210/jc.2011-2965.
    1. Monticone S., Castellano I., Versace K., Lucatello B., Veglio F., Gomez-Sanchez C.E., Williams T.A., Mulatero P. Immunohistochemical, genetic and clinical characterization of sporadic aldosterone-producing adenomas. Mol. Cell. Endocrinol. 2015;411:146–154. doi: 10.1016/j.mce.2015.04.022.
    1. Choi M., Scholl U.I., Yue P., Björklund P., Zhao B., Nelson-Williams C., Ji W., Cho Y., Patel A., Men C.J., et al. K+ channel mutations in adrenal aldosterone-producing adenomas and hereditary hypertension. Science. 2011;331:768–772. doi: 10.1126/science.1198785.
    1. Mulatero P., Monticone S., Rainey W.E., Veglio F., Williams T.A. Role of KCNJ5 in familial and sporadic primary aldosteronism. Nat. Rev. Endocrinol. 2013;9:104–112. doi: 10.1038/nrendo.2012.230.
    1. Williams T.A., Lenders J.W.M., Burrello J., Beuschlein F., Reincke M. KCNJ5 Mutations: Sex, Salt and Selection. Horm. Metab. Res. 2015;47:953–958. doi: 10.1055/s-0035-1565090.
    1. Hennings J., Sundin A., Hägg A., Hellman P. 11C-metomidate positron emission tomography after dexamethasone suppression for detection of small adrenocortical adenomas in primary aldosteronism. Langenbecks Arch. Surg. 2010;395:963–967. doi: 10.1007/s00423-010-0681-7.
    1. Mendichovszky I.A., Powlson A.S., Manavaki R., Aigbirhio F.I., Cheow H., Buscombe J.R., Gurnell M., Gilbert F.J. Targeted Molecular Imaging in Adrenal Disease-An Emerging Role for Metomidate PET-CT. Diagnostics. 2016;6:42. doi: 10.3390/diagnostics6040042.
    1. Abe T., Naruse M., Young W.F., Kobashi N., Doi Y., Izawa A., Akama K., Okumura Y., Ikenaga M., Kimura H. A Novel CYP11B2-Specific Imaging Agent for Detection of Unilateral Subtypes of Primary Aldosteronism. J. Clin. Endocrinol. Metab. 2016;101:1008–1015. doi: 10.1210/jc.2015-3431.
    1. Daniil G., Fernandes-Rosa F.L., Chemin J., Blesneac I., Beltrand J., Polak M., Jeunemaitre X., Boulkroun S., Amar L., Strom T.M., et al. CACNA1H Mutations Are Associated With Different Forms of Primary Aldosteronism. EBioMedicine. 2016;13:225–236. doi: 10.1016/j.ebiom.2016.10.002.
    1. Daunt N. Adrenal vein sampling: How to make it quick, easy, and successful. Radiographics. 2005;25(Suppl. S1):S143–S158. doi: 10.1148/rg.25si055514.
    1. Monticone S., Satoh F., Dietz A.S., Goupil R., Lang K., Pizzolo F., Gordon R.D., Morimoto R., Reincke M., Stowasser M., Mulatero P. Clinical Management and Outcomes of Adrenal Hemorrhage Following Adrenal Vein Sampling in Primary Aldosteronism. Hypertension. 2016;67:146–152. doi: 10.1161/HYPERTENSIONAHA.115.06305.
    1. Seccia T.M., Miotto D., Battistel M., Motta R., Barisa M., Maniero C., Pessina A.C., Rossi G.P. A stress reaction affects assessment of selectivity of adrenal venous sampling and of lateralization of aldosterone excess in primary aldosteronism. Eur. J. Endocrinol. 2012;166:869–875. doi: 10.1530/EJE-11-0972.
    1. Almarzooqi M.-K., Chagnon M., Soulez G., Giroux M.-F., Gilbert P., Oliva V.L., Perreault P., Bouchard L., Bourdeau I., Lacroix A., et al. Adrenal vein sampling in primary aldosteronism: Concordance of simultaneous vs sequential sampling. Eur. J. Endocrinol. 2017;176:159–167. doi: 10.1530/EJE-16-0701.
    1. Satoh F., Morimoto R., Seiji K., Satani N., Ota H., Iwakura Y., Ono Y., Kudo M., Nezu M., Omata K., et al. Is there a role for segmental adrenal venous sampling and adrenal sparing surgery in patients with primary aldosteronism? Eur. J. Endocrinol. 2015;173:465–477. doi: 10.1530/EJE-14-1161.
    1. Satani N., Ota H., Seiji K., Morimoto R., Kudo M., Iwakura Y., Ono Y., Nezu M., Omata K., Ito S., et al. Intra-adrenal Aldosterone Secretion: Segmental Adrenal Venous Sampling for Localization. Radiology. 2016;278:265–274. doi: 10.1148/radiol.2015142159.
    1. Melby J.C., Spark R.F., Dale S.L., Egdahl R.H., Kahn P.C. Diagnosis and localization of aldosterone-producing adenomas by adrenal-vein cateterization. N. Engl. J. Med. 1967;277:1050–1056. doi: 10.1056/NEJM196711162772002.
    1. El Ghorayeb N., Mazzuco T.L., Bourdeau I., Mailhot J.-P., Zhu P.S., Thérasse E., Lacroix A. Basal and Post-ACTH Aldosterone and Its Ratios Are Useful During Adrenal Vein Sampling in Primary Aldosteronism. J. Clin. Endocrinol. Metab. 2016;101:1826–1835. doi: 10.1210/jc.2015-3915.
    1. Wolley M.J., Ahmed A.H., Gordon R.D., Stowasser M. Does ACTH improve the diagnostic performance of adrenal vein sampling for subtyping primary aldosteronism? Clin. Endocrinol. 2016;85:703–709. doi: 10.1111/cen.13110.
    1. Monticone S., Satoh F., Giacchetti G., Viola A., Morimoto R., Kudo M., Iwakura Y., Ono Y., Turchi F., Paci E., et al. Effect of adrenocorticotropic hormone stimulation during adrenal vein sampling in primary aldosteronism. Hypertension. 2012;59:840–846. doi: 10.1161/HYPERTENSIONAHA.111.189548.
    1. Seccia T.M., Miotto D., de Toni R., Pitter G., Mantero F., Pessina A.C., Rossi G.P. Adrenocorticotropic hormone stimulation during adrenal vein sampling for identifying surgically curable subtypes of primary aldosteronism: Comparison of 3 different protocols. Hypertension. 2009;53:761–766. doi: 10.1161/HYPERTENSIONAHA.108.128553.
    1. Young W.F., Stanson A.W. What are the keys to successful adrenal venous sampling (AVS) in patients with primary aldosteronism? Clin. Endocrinol. 2009;70:14–17. doi: 10.1111/j.1365-2265.2008.03450.x.
    1. Stowasser M., Gordon R.D., Gunasekera T.G., Cowley D.C., Ward G., Archibald C., Smithers B.M. High rate of detection of primary aldosteronism, including surgically treatable forms, after “non-selective” screening of hypertensive patients. J. Hypertens. 2003;21:2149–2157. doi: 10.1097/00004872-200311000-00025.
    1. Vonend O., Ockenfels N., Gao X., Allolio B., Lang K., Mai K., Quack I., Saleh A., Degenhart C., Seufert J., et al. Adrenal venous sampling: Evaluation of the German Conn’s registry. Hypertension. 2011;57:990–995. doi: 10.1161/HYPERTENSIONAHA.110.168484.
    1. Betz M.J., Degenhart C., Fischer E., Pallauf A., Brand V., Linsenmaier U., Beuschlein F., Bidlingmaier M., Reincke M. Adrenal vein sampling using rapid cortisol assays in primary aldosteronism is useful in centers with low success rates. Eur. J. Endocrinol. 2011;165:301–306. doi: 10.1530/EJE-11-0287.
    1. Auchus R.J., Michaelis C., Wians F.H., Jr., Dolmatch B.L., Josephs S.C., Trimmer C.K., Anderson M.E., Nwariaku F.E. Rapid cortisol assays improve the success rate of adrenal vein sampling for primary aldosteronism. Ann. Surg. 2009;249:318–321. doi: 10.1097/SLA.0b013e3181961d77.
    1. Mengozzi G., Rossato D., Bertello C., Garrone C., Milan A., Pagni R., Veglio F., Mulatero P. Rapid cortisol assay during adrenal vein sampling in patients with primary aldosteronism. Clin. Chem. 2007;53:1968–1971. doi: 10.1373/clinchem.2007.092080.
    1. Yoneda T., Karashima S., Kometani M., Usukura M., Demura M., Sanada J., Minami T., Koda W., Gabata T., Matsui O., et al. Impact of New Quick Gold Nanoparticle-Based Cortisol Assay During Adrenal Vein Sampling for Primary Aldosteronism. J. Clin. Endocrinol. Metab. 2016;101:2554–2561. doi: 10.1210/jc.2016-1011.
    1. Chang C.-C., Lee B.-C., Liu K.-L., Chang Y.-C., Wu V.-C., Huang K.-H. Non-stimulated adrenal venous sampling using Dyna computed tomography in patients with primary aldosteronism. Sci. Rep. 2016;6:37143. doi: 10.1038/srep37143.
    1. Mulatero P., Bertello C., Sukor N., Gordon R., Rossato D., Daunt N., Leggett D., Mengozzi G., Veglio F., Stowasser M. Impact of different diagnostic criteria during adrenal vein sampling on reproducibility of subtype diagnosis in patients with primary aldosteronism. Hypertension. 2010;55:667–673. doi: 10.1161/HYPERTENSIONAHA.109.146613.
    1. Mailhot J.-P., Traistaru M., Soulez G., Ladouceur M., Giroux M.-F., Gilbert P., Zhu P.S., Bourdeau I., Oliva V.L., Lacroix A., et al. Adrenal Vein Sampling in Primary Aldosteronism: Sensitivity and Specificity of Basal Adrenal Vein to Peripheral Vein Cortisol and Aldosterone Ratios to Confirm Catheterization of the Adrenal Vein. Radiology. 2015;277:887–894. doi: 10.1148/radiol.2015142413.
    1. Umakoshi H., Naruse M., Wada N., Ichijo T., Kamemura K., Matsuda Y., Fujii Y., Kai T., Fukuoka T., Sakamoto R., et al. WAVES-J Study Group Adrenal Venous Sampling in Patients With Positive Screening but Negative Confirmatory Testing for Primary Aldosteronism. Hypertension. 2016;67:1014–1019. doi: 10.1161/HYPERTENSIONAHA.115.06607.
    1. Stowasser M. Adrenal venous sampling for differentiating unilateral from bilateral primary aldosteronism: Still the best, but could be better. Hypertension. 2015;65:704–706. doi: 10.1161/HYPERTENSIONAHA.115.04930.
    1. Monticone S., Satoh F., Viola A., Fischer E., Vonend O., Bernini G., Lucatello B., Quinkler M., Ronconi V., Morimoto R., et al. Aldosterone suppression on contralateral adrenal during adrenal vein sampling does not predict blood pressure response after adrenalectomy. J. Clin. Endocrinol. Metab. 2014;99:4158–4166. doi: 10.1210/jc.2014-2345.
    1. Umakoshi H., Tanase-Nakao K., Wada N., Ichijo T., Sone M., Inagaki N., Katabami T., Kamemura K., Matsuda Y., Fujii Y., et al. Importance of contralateral aldosterone suppression during adrenal vein sampling in the subtype evaluation of primary aldosteronism. Clin. Endocrinol. 2015;83:462–467. doi: 10.1111/cen.12761.
    1. Wolley M.J., Gordon R.D., Ahmed A.H., Stowasser M. Does contralateral suppression at adrenal venous sampling predict outcome following unilateral adrenalectomy for primary aldosteronism? A retrospective study. J. Clin. Endocrinol. Metab. 2015;100:1477–1484. doi: 10.1210/jc.2014-3676.
    1. Auchus R.J., Wians F.H., Anderson M.E., Dolmatch B.L., Trimmer C.K., Josephs S.C., Chan D., Toomay S., Nwariaku F.E. What we still do not know about adrenal vein sampling for primary aldosteronism. Horm. Metab. Res. 2010;42:411–415. doi: 10.1055/s-0030-1252060.
    1. Espiner E.A., Ross D.G., Yandle T.G., Richards A.M., Hunt P.J. Predicting surgically remedial primary aldosteronism: Role of adrenal scanning, posture testing, and adrenal vein sampling. J. Clin. Endocrinol. Metab. 2003;88:3637–3644. doi: 10.1210/jc.2002-022051.
    1. Dekkers T., Deinum J., Schultzekool L.J., Blondin D., Vonend O., Hermus A.R.R.M., Peitzsch M., Rump L.C., Antoch G., Sweep F.C.G.J., et al. Plasma metanephrine for assessing the selectivity of adrenal venous sampling. Hypertension. 2013;62:1152–1157. doi: 10.1161/HYPERTENSIONAHA.113.01601.
    1. Eisenhofer G., Keiser H., Friberg P., Mezey E., Huynh T.T., Hiremagalur B., Ellingson T., Duddempudi S., Eijsbouts A., Lenders J.W. Plasma metanephrines are markers of pheochromocytoma produced by catechol-O-methyltransferase within tumors. J. Clin. Endocrinol. Metab. 1998;83:2175–2185. doi: 10.1210/jcem.83.6.4870.
    1. Goupil R., Wolley M., Ungerer J., McWhinney B., Mukai K., Naruse M., Gordon R.D., Stowasser M. Use of plasma metanephrine to aid adrenal venous sampling in combined aldosterone and cortisol over-secretion. Endocrinol. Diabet. Metab. Case Rep. 2015;2015:150075. doi: 10.1530/EDM-15-0075.
    1. Nishikawa T., Omura M., Satoh F., Shibata H., Takahashi K., Tamura N., Tanabe A. Guidelines for the diagnosis and treatment of primary aldosteronism—The Japan Endocrine Society 2009. Endocr. J. 2011;58:711–721. doi: 10.1507/endocrj.EJ11-0133.

Source: PubMed

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