Point-of-care end-tidal carbon monoxide reflects severity of hemolysis in sickle cell anemia
Ashutosh Lal, Lasandra Patterson, Alisa Goldrich, Anne Marsh, Ashutosh Lal, Lasandra Patterson, Alisa Goldrich, Anne Marsh
Abstract
Carbon monoxide (CO) production from heme catabolism is increased with hemolysis. A portable end-tidal CO (ETCO) monitor was used to analyze breath samples in 16 children with sickle cell anemia (SCA, 5-14 years). Median (range) ETCO for SCA was 4.35 ppm (1.8-9.7) versus 0.80 ppm (0.2-2.3) for controls (P < 0.001). ETCOc >2.1 ppm provided sensitivity and specificity of 93.8% (69.8-99.8%) for detecting SCA. ETCO correlated with reticulocytosis (P = 0.015) and bilirubin (P = 0.009), and was 32% lower in children receiving hydroxyurea (P = 0.09). Point-of-care ETCO analysis may prove useful for non-invasive monitoring of hemolysis and as a screening test for SCA.
Keywords: hemoglobinopathies; red blood cell disorders; sickle cell anemia.
Conflict of interest statement
Conflict of Interest: None
© 2015 Wiley Periodicals, Inc.
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Source: PubMed