Effect of diclofenac with B vitamins on the treatment of acute pain originated by lower-limb fracture and surgery

Héctor A Ponce-Monter, Mario I Ortiz, Alexis F Garza-Hernández, Raúl Monroy-Maya, Marisela Soto-Ríos, Lourdes Carrillo-Alarcón, Gerardo Reyes-García, Eduardo Fernández-Martínez, Héctor A Ponce-Monter, Mario I Ortiz, Alexis F Garza-Hernández, Raúl Monroy-Maya, Marisela Soto-Ríos, Lourdes Carrillo-Alarcón, Gerardo Reyes-García, Eduardo Fernández-Martínez

Abstract

The aim of this study was to compare the efficacy of diclofenac, for the treatment of acute pain originated by lower-limb fracture and surgery, with that of diclofenac plus B vitamins. This was a single-center, prospective, randomized, and double-blinded clinical trial. Patients with lower-limb closed fractures rated their pain on a 10 cm visual analog scale (VAS). Patients were then randomized to receive diclofenac or diclofenac plus B vitamins (thiamine, pyridoxine, and cyanocobalamin) intramuscularly twice daily. Patient evaluations of pain intensity were recorded throughout two periods: twenty-four hours presurgery and twenty-four hours postsurgical. One hundred twenty-two patients completed the study. The subjects' assessments of limb pain on the VAS showed a significant reduction from baseline values regardless of the treatment group. Diclofenac plus B vitamins combination was more effective to reduce the pain than diclofenac alone. The results showed that the addition of B vitamins to diclofenac increased its analgesic effect. The novelty of this paper consists in that diclofenac and diclofenac plus B vitamins were useful for treatment of acute pain originated by lower-limb fracture and surgery.

Figures

Figure 1
Figure 1
Time course of the effect of diclofenac alone or diclofenac plus B vitamins for the treatment of pain produced by lower-limb fracture and surgery. The points represent the average ± standard error of the media values of the visual analogous scale (VAS) evaluated at different hours. *Significantly different from diclofenac group (P < 0.05). #Significantly different from diclofenac + B vitamins group (P < 0.05).

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