How Anesthetic, Analgesic and Other Non-Surgical Techniques During Cancer Surgery Might Affect Postoperative Oncologic Outcomes: A Summary of Current State of Evidence

Patrice Forget, Jose A Aguirre, Ivanka Bencic, Alain Borgeat, Allessandro Cama, Claire Condron, Christina Eintrei, Pilar Eroles, Anil Gupta, Tim G Hales, Daniela Ionescu, Mark Johnson, Pawel Kabata, Iva Kirac, Daqing Ma, Zhirajr Mokini, Jose Luis Guerrero Orriach, Michael Retsky, Sergio Sandrucci, Wiebke Siekmann, Ljilja Štefančić, Gina Votta-Vellis, Cara Connolly, Donal Buggy, Patrice Forget, Jose A Aguirre, Ivanka Bencic, Alain Borgeat, Allessandro Cama, Claire Condron, Christina Eintrei, Pilar Eroles, Anil Gupta, Tim G Hales, Daniela Ionescu, Mark Johnson, Pawel Kabata, Iva Kirac, Daqing Ma, Zhirajr Mokini, Jose Luis Guerrero Orriach, Michael Retsky, Sergio Sandrucci, Wiebke Siekmann, Ljilja Štefančić, Gina Votta-Vellis, Cara Connolly, Donal Buggy

Abstract

The question of whether anesthetic, analgesic or other perioperative intervention during cancer resection surgery might influence long-term oncologic outcomes has generated much attention over the past 13 years. A wealth of experimental and observational clinical data have been published, but the results of prospective, randomized clinical trials are awaited. The European Union supports a pan-European network of researchers, clinicians and industry partners engaged in this question (COST Action 15204: Euro-Periscope). In this narrative review, members of the Euro-Periscope network briefly summarize the current state of evidence pertaining to the potential effects of the most commonly deployed anesthetic and analgesic techniques and other non-surgical interventions during cancer resection surgery on tumor recurrence or metastasis.

Keywords: analgesia; anesthesia; cancer.

Conflict of interest statement

The authors declare no conflict of interest.

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Source: PubMed

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