Randomized controlled trial of superovulation and insemination for infertility associated with minimal or mild endometriosis
I S Tummon, L J Asher, J S Martin, T Tulandi, I S Tummon, L J Asher, J S Martin, T Tulandi
Abstract
Objective: To evaluate the efficacy of superovulation and IUI versus no treatment for infertility associated with minimal or mild endometriosis.
Design: Randomized trial.
Setting(s): London Health Sciences Centre, University Campus, The University of Western Ontario, London, Ontario; and Royal Victoria Hospital, McGill University, Montreal, Quebec, Canada.
Patient(s): Three hundred eleven cycles in 103 couples in whom minimal or mild endometriosis was the sole identified subfertility factor.
Intervention(s): Superovulation with FSH and IUI.
Main outcome measure(s): Live birth.
Result(s): Live birth followed 14 of 127 (11%) superovulation and IUI cycles and 4 of 184 (2%) no-treatment cycles. The odds ratio was 5.6 (95% confidence interval 1.8 to 17.4) in favor of superovulation and IUI.
Conclusion(s): Treatment with superovulation and IUI was associated with superior outcome both by crude live-birth rates and proportional hazard analysis.
Source: PubMed