Emerging use of combination therapies for the management of type 2 diabetes - focus on saxagliptin and dapagliflozin

Huan Yu, Vincent C Woo, Huan Yu, Vincent C Woo

Abstract

Aims: The aim of this article is to review the safety and efficacy data of dapagliflozin, saxagliptin, and their combination in the management of patients with type 2 diabetes. Evidence for the use of the single-tablet combination formulation is also presented.

Methods: A nonsystematic literature review was performed using the Ovid, PubMed, and Google Scholar databases.

Results: The addition of dapagliflozin/saxagliptin to metformin can lower mean hemoglobin A1c by as much as 1.47% and lead to weight loss of 0.5-2.0 kg. The risk of genital infections with combination therapy is lower than observed with dapagliflozin alone, suggestive of a protective effect. Adverse event risk at 52-week follow-up was not increased beyond that seen with either monotherapy.

Conclusion: Dapagliflozin/saxagliptin combination is generally well tolerated and is an effective tool in helping patients with diabetes improve glycemic control.

Keywords: DPP4 inhibitor; SGLT2 inhibitor; diabetes mellitus; single-tablet combination.

Conflict of interest statement

Disclosure Dr. Huan Yu has no potential conflicts of interest. Dr. Vincent C Woo has received funds from the following organizations for speaking, advisory boards, and/or clinical research: Astra Zeneca, Bristol Myers Squibb, Merck, Lilly, Novo Nordisk, Sanofi, Roche, Abbott, Boehringer Ingelheim, Pfizer, Janssen, and Novartis.

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