A rat model of chronic kidney disease-mineral bone disorder
Sharon M Moe, Neal X Chen, Mark F Seifert, Rachel M Sinders, Dana Duan, Xianming Chen, Yun Liang, J Scott Radcliff, Kenneth E White, Vincent H Gattone 2nd, Sharon M Moe, Neal X Chen, Mark F Seifert, Rachel M Sinders, Dana Duan, Xianming Chen, Yun Liang, J Scott Radcliff, Kenneth E White, Vincent H Gattone 2nd
Abstract
Chronic Kidney Disease-Mineral Bone Disorder (CKD-MBD) is a newly defined syndrome encompassing patients with chronic kidney disease that have a triad of biochemical alterations in calcium, phosphorus and parathyroid hormone, vascular calcification, and bone abnormalities. Here we describe a novel Cy/+ rat model of slowly progressive kidney disease spontaneously developing the three components of CKD-MBD when fed a normal phosphorus diet. Since the renal disorder progressed 'naturally' we studied the effect of dietary manipulation during the course of the disease. Animals with early, but established, chronic kidney disease were fed a casein-based or a grain-based protein diet both of which had equivalent total phosphorus contents. The two different sources of dietary protein had profound effects on the progression of CKD-MBD, likely due to differences in intestinal bioavailability of phosphorus. Although both dietary treatments resulted in the same serum phosphorous levels, the casein-fed animals had increased urinary phosphorus excretion and elevated serum FGF23 compared to the grain-fed rats. This model should help identify early changes in the course of chronic kidney disease that may lead to CKD-MBD.
Figures
![Figure 1. Biochemical changes over time](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/2716076/bin/nihms73709f1a.jpg)
Figure 1. Biochemical changes over time
Cy/+…
Figure 1. Biochemical changes over time
Cy/+ rats were placed on the study diet at…
Figure 1. Biochemical changes over time
Cy/+…
Figure 1. Biochemical changes over time
Cy/+ rats were placed on the study diet at…
Figure 1. Biochemical changes over time
Cy/+…
Figure 1. Biochemical changes over time
Cy/+ rats were placed on the study diet at…
Figure 2. Thoracic aorta calcification
At the…
Figure 2. Thoracic aorta calcification
At the time of sacrifice, the thoracic aorta was removed…
Figure 3. Histologic evaluation of vascular calcification…
Figure 3. Histologic evaluation of vascular calcification and bone
A: A thoracic aorta from a…
Figure 3. Histologic evaluation of vascular calcification…
Figure 3. Histologic evaluation of vascular calcification and bone
A: A thoracic aorta from a…
- R-568 reduces ectopic calcification in a rat model of chronic kidney disease-mineral bone disorder (CKD-MBD).Moe SM, Seifert MF, Chen NX, Sinders RM, Chen X, Duan D, Henley C, Martin D, Gattone VH 2nd. Moe SM, et al. Nephrol Dial Transplant. 2009 Aug;24(8):2371-7. doi: 10.1093/ndt/gfp078. Epub 2009 Mar 3. Nephrol Dial Transplant. 2009. PMID: 19258382
- The pathophysiology of early-stage chronic kidney disease-mineral bone disorder (CKD-MBD) and response to phosphate binders in the rat.Moe SM, Radcliffe JS, White KE, Gattone VH 2nd, Seifert MF, Chen X, Aldridge B, Chen NX. Moe SM, et al. J Bone Miner Res. 2011 Nov;26(11):2672-81. doi: 10.1002/jbmr.485. J Bone Miner Res. 2011. PMID: 21826734
- Adverse Effects of Autoclaved Diets on the Progression of Chronic Kidney Disease and Chronic Kidney Disease-Mineral Bone Disorder in Rats.Biruete A, Srinivasan S, O'Neill KD, Vorland CJ, Hill Gallant KM, Cai W, Uribarri J, Johnston N, Allen MR, Chen NX, Moe SM. Biruete A, et al. Am J Nephrol. 2020;51(5):381-389. doi: 10.1159/000506729. Epub 2020 Mar 6. Am J Nephrol. 2020. PMID: 32146472 Free PMC article.
- Chronic kidney disease--mineral and bone disorder: a complex scenario.Mejía N, Roman-García P, Miar AB, Tavira B, Cannata-Andía JB. Mejía N, et al. Nefrologia. 2011;31(5):514-9. doi: 10.3265/Nefrologia.pre2011.Jun.10926. Nefrologia. 2011. PMID: 21959717 Review. English, Spanish.
- Implications for nutrition practice in the mineral-bone disorder of chronic kidney disease.Moore LW. Moore LW. Nutr Clin Pract. 2011 Aug;26(4):391-400. doi: 10.1177/0884533611413780. Nutr Clin Pract. 2011. PMID: 21775636 Review.
- Mouse Models of Mineral Bone Disorders Associated with Chronic Kidney Disease.Zaloszyc A, Bernardor J, Bacchetta J, Laverny G, Schmitt CP. Zaloszyc A, et al. Int J Mol Sci. 2023 Mar 10;24(6):5325. doi: 10.3390/ijms24065325. Int J Mol Sci. 2023. PMID: 36982400 Free PMC article. Review.
- Cortical porosity occurs at varying degrees throughout the skeleton in rats with chronic kidney disease.Metzger CE, Newman CL, Tippen SP, Golemme NT, Chen NX, Moe SM, Allen MR. Metzger CE, et al. Bone Rep. 2022 Aug 17;17:101612. doi: 10.1016/j.bonr.2022.101612. eCollection 2022 Dec. Bone Rep. 2022. PMID: 36035656 Free PMC article.
- High phosphate intake induces bone loss in nephrectomized thalassemic mice.Wanna-Udom S, Luesiripong C, Sakunrangsit N, Metheepakornchai P, Intharamonthian S, Svasti S, Greenblatt MB, Leelahavanichkul A, Lotinun S. Wanna-Udom S, et al. PLoS One. 2022 May 27;17(5):e0268732. doi: 10.1371/journal.pone.0268732. eCollection 2022. PLoS One. 2022. PMID: 35622784 Free PMC article.
- Calcimimetics Alter Periosteal and Perilacunar Bone Matrix Composition and Material Properties in Early Chronic Kidney Disease.Damrath JG, Moe SM, Wallace JM. Damrath JG, et al. J Bone Miner Res. 2022 Jul;37(7):1297-1306. doi: 10.1002/jbmr.4574. Epub 2022 Jun 3. J Bone Miner Res. 2022. PMID: 35593150 Free PMC article.
- Effects of ferric citrate and intravenous iron sucrose on markers of mineral, bone, and iron homeostasis in a rat model of CKD-MBD.Biruete A, Metzger CE, Chen NX, Swallow EA, Vrabec C, Clinkenbeard EL, Stacy AJ, Srinivasan S, O'Neill K, Avin KG, Allen MR, Moe SM. Biruete A, et al. Nephrol Dial Transplant. 2022 Sep 22;37(10):1857-1867. doi: 10.1093/ndt/gfac162. Nephrol Dial Transplant. 2022. PMID: 35482713 Free PMC article.
- Research Support, N.I.H., Extramural
- Research Support, Non-U.S. Gov't
- Animals
- Caseins / administration & dosage
- Caseins / pharmacology
- Chronic Kidney Disease-Mineral and Bone Disorder / metabolism*
- Disease Models, Animal*
- Disease Progression
- Edible Grain
- Fibroblast Growth Factors / analysis
- Intestinal Absorption
- Kidney Failure, Chronic / complications*
- Minerals / metabolism*
- Phosphorus / blood
- Phosphorus / pharmacokinetics
- Phosphorus / urine
- Rats
- Caseins
- Fgf23 protein, rat
- Minerals
- Phosphorus
- Fibroblast Growth Factors
- Full Text Sources
- Medical
NCBI Literature Resources
The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Unauthorized use of these marks is strictly prohibited.
National Library of Medicine
8600 Rockville Pike
Bethesda, MD 20894
![Figure 1. Biochemical changes over time](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/2716076/bin/nihms73709f1b.jpg)
Figure 1. Biochemical changes over time
Cy/+…
Figure 1. Biochemical changes over time
Cy/+ rats were placed on the study diet at…
Figure 1. Biochemical changes over time
Cy/+…
Figure 1. Biochemical changes over time
Cy/+ rats were placed on the study diet at…
Figure 2. Thoracic aorta calcification
At the…
Figure 2. Thoracic aorta calcification
At the time of sacrifice, the thoracic aorta was removed…
Figure 3. Histologic evaluation of vascular calcification…
Figure 3. Histologic evaluation of vascular calcification and bone
A: A thoracic aorta from a…
Figure 3. Histologic evaluation of vascular calcification…
Figure 3. Histologic evaluation of vascular calcification and bone
A: A thoracic aorta from a…
- R-568 reduces ectopic calcification in a rat model of chronic kidney disease-mineral bone disorder (CKD-MBD).Moe SM, Seifert MF, Chen NX, Sinders RM, Chen X, Duan D, Henley C, Martin D, Gattone VH 2nd. Moe SM, et al. Nephrol Dial Transplant. 2009 Aug;24(8):2371-7. doi: 10.1093/ndt/gfp078. Epub 2009 Mar 3. Nephrol Dial Transplant. 2009. PMID: 19258382
- The pathophysiology of early-stage chronic kidney disease-mineral bone disorder (CKD-MBD) and response to phosphate binders in the rat.Moe SM, Radcliffe JS, White KE, Gattone VH 2nd, Seifert MF, Chen X, Aldridge B, Chen NX. Moe SM, et al. J Bone Miner Res. 2011 Nov;26(11):2672-81. doi: 10.1002/jbmr.485. J Bone Miner Res. 2011. PMID: 21826734
- Adverse Effects of Autoclaved Diets on the Progression of Chronic Kidney Disease and Chronic Kidney Disease-Mineral Bone Disorder in Rats.Biruete A, Srinivasan S, O'Neill KD, Vorland CJ, Hill Gallant KM, Cai W, Uribarri J, Johnston N, Allen MR, Chen NX, Moe SM. Biruete A, et al. Am J Nephrol. 2020;51(5):381-389. doi: 10.1159/000506729. Epub 2020 Mar 6. Am J Nephrol. 2020. PMID: 32146472 Free PMC article.
- Chronic kidney disease--mineral and bone disorder: a complex scenario.Mejía N, Roman-García P, Miar AB, Tavira B, Cannata-Andía JB. Mejía N, et al. Nefrologia. 2011;31(5):514-9. doi: 10.3265/Nefrologia.pre2011.Jun.10926. Nefrologia. 2011. PMID: 21959717 Review. English, Spanish.
- Implications for nutrition practice in the mineral-bone disorder of chronic kidney disease.Moore LW. Moore LW. Nutr Clin Pract. 2011 Aug;26(4):391-400. doi: 10.1177/0884533611413780. Nutr Clin Pract. 2011. PMID: 21775636 Review.
- Mouse Models of Mineral Bone Disorders Associated with Chronic Kidney Disease.Zaloszyc A, Bernardor J, Bacchetta J, Laverny G, Schmitt CP. Zaloszyc A, et al. Int J Mol Sci. 2023 Mar 10;24(6):5325. doi: 10.3390/ijms24065325. Int J Mol Sci. 2023. PMID: 36982400 Free PMC article. Review.
- Cortical porosity occurs at varying degrees throughout the skeleton in rats with chronic kidney disease.Metzger CE, Newman CL, Tippen SP, Golemme NT, Chen NX, Moe SM, Allen MR. Metzger CE, et al. Bone Rep. 2022 Aug 17;17:101612. doi: 10.1016/j.bonr.2022.101612. eCollection 2022 Dec. Bone Rep. 2022. PMID: 36035656 Free PMC article.
- High phosphate intake induces bone loss in nephrectomized thalassemic mice.Wanna-Udom S, Luesiripong C, Sakunrangsit N, Metheepakornchai P, Intharamonthian S, Svasti S, Greenblatt MB, Leelahavanichkul A, Lotinun S. Wanna-Udom S, et al. PLoS One. 2022 May 27;17(5):e0268732. doi: 10.1371/journal.pone.0268732. eCollection 2022. PLoS One. 2022. PMID: 35622784 Free PMC article.
- Calcimimetics Alter Periosteal and Perilacunar Bone Matrix Composition and Material Properties in Early Chronic Kidney Disease.Damrath JG, Moe SM, Wallace JM. Damrath JG, et al. J Bone Miner Res. 2022 Jul;37(7):1297-1306. doi: 10.1002/jbmr.4574. Epub 2022 Jun 3. J Bone Miner Res. 2022. PMID: 35593150 Free PMC article.
- Effects of ferric citrate and intravenous iron sucrose on markers of mineral, bone, and iron homeostasis in a rat model of CKD-MBD.Biruete A, Metzger CE, Chen NX, Swallow EA, Vrabec C, Clinkenbeard EL, Stacy AJ, Srinivasan S, O'Neill K, Avin KG, Allen MR, Moe SM. Biruete A, et al. Nephrol Dial Transplant. 2022 Sep 22;37(10):1857-1867. doi: 10.1093/ndt/gfac162. Nephrol Dial Transplant. 2022. PMID: 35482713 Free PMC article.
- Research Support, N.I.H., Extramural
- Research Support, Non-U.S. Gov't
- Animals
- Caseins / administration & dosage
- Caseins / pharmacology
- Chronic Kidney Disease-Mineral and Bone Disorder / metabolism*
- Disease Models, Animal*
- Disease Progression
- Edible Grain
- Fibroblast Growth Factors / analysis
- Intestinal Absorption
- Kidney Failure, Chronic / complications*
- Minerals / metabolism*
- Phosphorus / blood
- Phosphorus / pharmacokinetics
- Phosphorus / urine
- Rats
- Caseins
- Fgf23 protein, rat
- Minerals
- Phosphorus
- Fibroblast Growth Factors
- Full Text Sources
- Medical
NCBI Literature Resources
The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Unauthorized use of these marks is strictly prohibited.
National Library of Medicine
8600 Rockville Pike
Bethesda, MD 20894
![Figure 1. Biochemical changes over time](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/2716076/bin/nihms73709f1c.jpg)
Figure 1. Biochemical changes over time
Cy/+…
Figure 1. Biochemical changes over time
Cy/+ rats were placed on the study diet at…
Figure 2. Thoracic aorta calcification
At the…
Figure 2. Thoracic aorta calcification
At the time of sacrifice, the thoracic aorta was removed…
Figure 3. Histologic evaluation of vascular calcification…
Figure 3. Histologic evaluation of vascular calcification and bone
A: A thoracic aorta from a…
Figure 3. Histologic evaluation of vascular calcification…
Figure 3. Histologic evaluation of vascular calcification and bone
A: A thoracic aorta from a…
- R-568 reduces ectopic calcification in a rat model of chronic kidney disease-mineral bone disorder (CKD-MBD).Moe SM, Seifert MF, Chen NX, Sinders RM, Chen X, Duan D, Henley C, Martin D, Gattone VH 2nd. Moe SM, et al. Nephrol Dial Transplant. 2009 Aug;24(8):2371-7. doi: 10.1093/ndt/gfp078. Epub 2009 Mar 3. Nephrol Dial Transplant. 2009. PMID: 19258382
- The pathophysiology of early-stage chronic kidney disease-mineral bone disorder (CKD-MBD) and response to phosphate binders in the rat.Moe SM, Radcliffe JS, White KE, Gattone VH 2nd, Seifert MF, Chen X, Aldridge B, Chen NX. Moe SM, et al. J Bone Miner Res. 2011 Nov;26(11):2672-81. doi: 10.1002/jbmr.485. J Bone Miner Res. 2011. PMID: 21826734
- Adverse Effects of Autoclaved Diets on the Progression of Chronic Kidney Disease and Chronic Kidney Disease-Mineral Bone Disorder in Rats.Biruete A, Srinivasan S, O'Neill KD, Vorland CJ, Hill Gallant KM, Cai W, Uribarri J, Johnston N, Allen MR, Chen NX, Moe SM. Biruete A, et al. Am J Nephrol. 2020;51(5):381-389. doi: 10.1159/000506729. Epub 2020 Mar 6. Am J Nephrol. 2020. PMID: 32146472 Free PMC article.
- Chronic kidney disease--mineral and bone disorder: a complex scenario.Mejía N, Roman-García P, Miar AB, Tavira B, Cannata-Andía JB. Mejía N, et al. Nefrologia. 2011;31(5):514-9. doi: 10.3265/Nefrologia.pre2011.Jun.10926. Nefrologia. 2011. PMID: 21959717 Review. English, Spanish.
- Implications for nutrition practice in the mineral-bone disorder of chronic kidney disease.Moore LW. Moore LW. Nutr Clin Pract. 2011 Aug;26(4):391-400. doi: 10.1177/0884533611413780. Nutr Clin Pract. 2011. PMID: 21775636 Review.
- Mouse Models of Mineral Bone Disorders Associated with Chronic Kidney Disease.Zaloszyc A, Bernardor J, Bacchetta J, Laverny G, Schmitt CP. Zaloszyc A, et al. Int J Mol Sci. 2023 Mar 10;24(6):5325. doi: 10.3390/ijms24065325. Int J Mol Sci. 2023. PMID: 36982400 Free PMC article. Review.
- Cortical porosity occurs at varying degrees throughout the skeleton in rats with chronic kidney disease.Metzger CE, Newman CL, Tippen SP, Golemme NT, Chen NX, Moe SM, Allen MR. Metzger CE, et al. Bone Rep. 2022 Aug 17;17:101612. doi: 10.1016/j.bonr.2022.101612. eCollection 2022 Dec. Bone Rep. 2022. PMID: 36035656 Free PMC article.
- High phosphate intake induces bone loss in nephrectomized thalassemic mice.Wanna-Udom S, Luesiripong C, Sakunrangsit N, Metheepakornchai P, Intharamonthian S, Svasti S, Greenblatt MB, Leelahavanichkul A, Lotinun S. Wanna-Udom S, et al. PLoS One. 2022 May 27;17(5):e0268732. doi: 10.1371/journal.pone.0268732. eCollection 2022. PLoS One. 2022. PMID: 35622784 Free PMC article.
- Calcimimetics Alter Periosteal and Perilacunar Bone Matrix Composition and Material Properties in Early Chronic Kidney Disease.Damrath JG, Moe SM, Wallace JM. Damrath JG, et al. J Bone Miner Res. 2022 Jul;37(7):1297-1306. doi: 10.1002/jbmr.4574. Epub 2022 Jun 3. J Bone Miner Res. 2022. PMID: 35593150 Free PMC article.
- Effects of ferric citrate and intravenous iron sucrose on markers of mineral, bone, and iron homeostasis in a rat model of CKD-MBD.Biruete A, Metzger CE, Chen NX, Swallow EA, Vrabec C, Clinkenbeard EL, Stacy AJ, Srinivasan S, O'Neill K, Avin KG, Allen MR, Moe SM. Biruete A, et al. Nephrol Dial Transplant. 2022 Sep 22;37(10):1857-1867. doi: 10.1093/ndt/gfac162. Nephrol Dial Transplant. 2022. PMID: 35482713 Free PMC article.
- Research Support, N.I.H., Extramural
- Research Support, Non-U.S. Gov't
- Animals
- Caseins / administration & dosage
- Caseins / pharmacology
- Chronic Kidney Disease-Mineral and Bone Disorder / metabolism*
- Disease Models, Animal*
- Disease Progression
- Edible Grain
- Fibroblast Growth Factors / analysis
- Intestinal Absorption
- Kidney Failure, Chronic / complications*
- Minerals / metabolism*
- Phosphorus / blood
- Phosphorus / pharmacokinetics
- Phosphorus / urine
- Rats
- Caseins
- Fgf23 protein, rat
- Minerals
- Phosphorus
- Fibroblast Growth Factors
- Full Text Sources
- Medical
NCBI Literature Resources
The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Unauthorized use of these marks is strictly prohibited.
National Library of Medicine
8600 Rockville Pike
Bethesda, MD 20894
![Figure 1. Biochemical changes over time](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/2716076/bin/nihms73709f1d.jpg)
Figure 2. Thoracic aorta calcification
At the…
Figure 2. Thoracic aorta calcification
At the time of sacrifice, the thoracic aorta was removed…
Figure 3. Histologic evaluation of vascular calcification…
Figure 3. Histologic evaluation of vascular calcification and bone
A: A thoracic aorta from a…
Figure 3. Histologic evaluation of vascular calcification…
Figure 3. Histologic evaluation of vascular calcification and bone
A: A thoracic aorta from a…
- R-568 reduces ectopic calcification in a rat model of chronic kidney disease-mineral bone disorder (CKD-MBD).Moe SM, Seifert MF, Chen NX, Sinders RM, Chen X, Duan D, Henley C, Martin D, Gattone VH 2nd. Moe SM, et al. Nephrol Dial Transplant. 2009 Aug;24(8):2371-7. doi: 10.1093/ndt/gfp078. Epub 2009 Mar 3. Nephrol Dial Transplant. 2009. PMID: 19258382
- The pathophysiology of early-stage chronic kidney disease-mineral bone disorder (CKD-MBD) and response to phosphate binders in the rat.Moe SM, Radcliffe JS, White KE, Gattone VH 2nd, Seifert MF, Chen X, Aldridge B, Chen NX. Moe SM, et al. J Bone Miner Res. 2011 Nov;26(11):2672-81. doi: 10.1002/jbmr.485. J Bone Miner Res. 2011. PMID: 21826734
- Adverse Effects of Autoclaved Diets on the Progression of Chronic Kidney Disease and Chronic Kidney Disease-Mineral Bone Disorder in Rats.Biruete A, Srinivasan S, O'Neill KD, Vorland CJ, Hill Gallant KM, Cai W, Uribarri J, Johnston N, Allen MR, Chen NX, Moe SM. Biruete A, et al. Am J Nephrol. 2020;51(5):381-389. doi: 10.1159/000506729. Epub 2020 Mar 6. Am J Nephrol. 2020. PMID: 32146472 Free PMC article.
- Chronic kidney disease--mineral and bone disorder: a complex scenario.Mejía N, Roman-García P, Miar AB, Tavira B, Cannata-Andía JB. Mejía N, et al. Nefrologia. 2011;31(5):514-9. doi: 10.3265/Nefrologia.pre2011.Jun.10926. Nefrologia. 2011. PMID: 21959717 Review. English, Spanish.
- Implications for nutrition practice in the mineral-bone disorder of chronic kidney disease.Moore LW. Moore LW. Nutr Clin Pract. 2011 Aug;26(4):391-400. doi: 10.1177/0884533611413780. Nutr Clin Pract. 2011. PMID: 21775636 Review.
- Mouse Models of Mineral Bone Disorders Associated with Chronic Kidney Disease.Zaloszyc A, Bernardor J, Bacchetta J, Laverny G, Schmitt CP. Zaloszyc A, et al. Int J Mol Sci. 2023 Mar 10;24(6):5325. doi: 10.3390/ijms24065325. Int J Mol Sci. 2023. PMID: 36982400 Free PMC article. Review.
- Cortical porosity occurs at varying degrees throughout the skeleton in rats with chronic kidney disease.Metzger CE, Newman CL, Tippen SP, Golemme NT, Chen NX, Moe SM, Allen MR. Metzger CE, et al. Bone Rep. 2022 Aug 17;17:101612. doi: 10.1016/j.bonr.2022.101612. eCollection 2022 Dec. Bone Rep. 2022. PMID: 36035656 Free PMC article.
- High phosphate intake induces bone loss in nephrectomized thalassemic mice.Wanna-Udom S, Luesiripong C, Sakunrangsit N, Metheepakornchai P, Intharamonthian S, Svasti S, Greenblatt MB, Leelahavanichkul A, Lotinun S. Wanna-Udom S, et al. PLoS One. 2022 May 27;17(5):e0268732. doi: 10.1371/journal.pone.0268732. eCollection 2022. PLoS One. 2022. PMID: 35622784 Free PMC article.
- Calcimimetics Alter Periosteal and Perilacunar Bone Matrix Composition and Material Properties in Early Chronic Kidney Disease.Damrath JG, Moe SM, Wallace JM. Damrath JG, et al. J Bone Miner Res. 2022 Jul;37(7):1297-1306. doi: 10.1002/jbmr.4574. Epub 2022 Jun 3. J Bone Miner Res. 2022. PMID: 35593150 Free PMC article.
- Effects of ferric citrate and intravenous iron sucrose on markers of mineral, bone, and iron homeostasis in a rat model of CKD-MBD.Biruete A, Metzger CE, Chen NX, Swallow EA, Vrabec C, Clinkenbeard EL, Stacy AJ, Srinivasan S, O'Neill K, Avin KG, Allen MR, Moe SM. Biruete A, et al. Nephrol Dial Transplant. 2022 Sep 22;37(10):1857-1867. doi: 10.1093/ndt/gfac162. Nephrol Dial Transplant. 2022. PMID: 35482713 Free PMC article.
- Research Support, N.I.H., Extramural
- Research Support, Non-U.S. Gov't
- Animals
- Caseins / administration & dosage
- Caseins / pharmacology
- Chronic Kidney Disease-Mineral and Bone Disorder / metabolism*
- Disease Models, Animal*
- Disease Progression
- Edible Grain
- Fibroblast Growth Factors / analysis
- Intestinal Absorption
- Kidney Failure, Chronic / complications*
- Minerals / metabolism*
- Phosphorus / blood
- Phosphorus / pharmacokinetics
- Phosphorus / urine
- Rats
- Caseins
- Fgf23 protein, rat
- Minerals
- Phosphorus
- Fibroblast Growth Factors
- Full Text Sources
- Medical
![Figure 2. Thoracic aorta calcification](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/2716076/bin/nihms73709f2.jpg)
Figure 3. Histologic evaluation of vascular calcification…
Figure 3. Histologic evaluation of vascular calcification and bone
A: A thoracic aorta from a…
Figure 3. Histologic evaluation of vascular calcification…
Figure 3. Histologic evaluation of vascular calcification and bone
A: A thoracic aorta from a…
![Figure 3. Histologic evaluation of vascular calcification…](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/2716076/bin/nihms73709f3a.jpg)
![Figure 3. Histologic evaluation of vascular calcification…](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/2716076/bin/nihms73709f3b.jpg)
Source: PubMed