Multiple functions of the vesicular proton pump in nerve terminals
Lucia Tabares, Bill Betz, Lucia Tabares, Bill Betz
Abstract
Synaptic vesicles are acidified by a proton pump (vATPase), which allows vesicular uptake of neurotransmitters. After vesicle exocytosis, continued operation of the vATPase would seem to serve no useful function. In this issue of Neuron, however, Zhang and colleagues show that continued pumping alkalinizes the cytoplasm, accelerating endocytosis.
Copyright © 2010 Elsevier Inc. All rights reserved.
Source: PubMed