SGLT-2 Inhibitors in Heart Failure: Current Management, Unmet Needs, and Therapeutic Prospects

Carolyn S P Lam, Chanchal Chandramouli, Vineeta Ahooja, Subodh Verma, Carolyn S P Lam, Chanchal Chandramouli, Vineeta Ahooja, Subodh Verma

No abstract available

Keywords: SGLT‐2 inhibitors; heart failure; type 2 diabetes mellitus; unmet needs.

Figures

Figure 1
Figure 1
Key unmet needs in the management of HF.5, 6, 32, 33 ACE indicates angiotensin‐converting enzyme; HF, heart failure; HFpEF, heart failure with preserved ejection fraction; HFrEF, heart failure with reduced ejection fraction; RAAS, renin‐angiotensin‐aldosterone system.
Figure 2
Figure 2
Mechanistic rationale for investigating SGLT‐2 inhibitors in HF beyond T2D. CV indicates cardiovascular; HF, heart failure; SGLT‐2, sodium‐glucose cotransporter‐2; T2D, type 2 diabetes mellitus.
Figure 3
Figure 3
Ongoing trials of SGLT‐2 inhibitors in HF.104, 105, 106, 107, 108, 109, 110, 111, 112, 113, 114 *Dual SGLT‐1/SGLT‐2 receptor antagonist. EF indicates ejection fraction; LPLV, last patient last visit; SGLT‐2, sodium‐glucose co‐transporter‐2; T2D, type 2 diabetes mellitus.

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    1. NCT02998970. Effects of Empagliflozin on Cardiac Structure in Patients With Type 2 Diabetes (EMPA‐HEART). 2019. Available at: . Accessed July 22, 2019.
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    1. NCT03448406. This Study Tests Empagliflozin in Patients With Chronic Heart Failure With Preserved Ejection Fraction (HFpEF). The Study Looks at How Far Patients Can Walk in 6 Minutes and at Their Heart Failure Symptoms. 2019. Available at: . Accessed July 22, 2019.
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