The Clinical Efficacy of Autologous Platelet-Rich Plasma Combined with Ultra-Pulsed Fractional CO2 Laser Therapy for Facial Rejuvenation

Qiang Hui, Peng Chang, Bingyu Guo, Yu Zhang, Kai Tao, Qiang Hui, Peng Chang, Bingyu Guo, Yu Zhang, Kai Tao

Abstract

Ultra-pulsed fractional CO2 laser is an efficient, precise, and safe therapeutic intervention for skin refreshing, although accompanied with prolonged edema and erythema. In recent years, autologous platelet-rich plasma (PRP) has been proven to promote wound and soft tissue healing and collagen regeneration. To investigate whether the combination of PRP and ultra-pulsed fractional CO2 laser had a synergistic effect on therapy for facial rejuvenation. Totally, 13 facial aging females were treated with ultra-pulsed fractional CO2 laser. One side of the face was randomly selected as experimental group and injected with PRP, the other side acted as the control group and was injected with physiological saline at the same dose. Comprehensive assessment of clinical efficacy was performed by satisfaction scores, dermatologists' double-blind evaluation and the VISIA skin analysis system. After treatment for 3 months, subjective scores of facial wrinkles, skin texture, and skin elasticity were higher than that in the control group. Similarly, improvement of skin wrinkles, texture, and tightness in the experimental group was better compared with the control group. Additionally, the total duration of erythema, edema, and crusting was decreased, in the experimental group compared with the control group. PRP combined with ultra-pulsed fractional CO2 laser had a synergistic effect on facial rejuvenation, shortening duration of side effects, and promoting better therapeutic effect.

Keywords: adverse events; combination therapy; recovery time; synergistic effect.

Conflict of interest statement

No competing financial interests exist.

Figures

FIG. 1.
FIG. 1.
Schematic overview of autologous platelet-rich plasma (PRP) combined with ultra-pulsed fractional CO2 laser therapy for facial rejuvenation.
FIG. 2.
FIG. 2.
A 57-year-old woman (A) experimental side before treatment, (B) experimental side after treatment for 3 months, (C) control side before treatment, (D) control side after treatment for 3 months. Skin aging was improved, wrinkles of forehead, periocular area were decreased, experimental side was better than that of control side.
FIG. 3.
FIG. 3.
A 52-year-old woman (A) experimental side before treatment, (B) experimental side after treatment for 3 months, (C) control side before treatment, (D) control side after treatment for 3 months. Skin aging was improved, wrinkles of forehead, periocular area were decreased, experimental side was better than that of control side.
FIG. 4.
FIG. 4.
Subjective satisfaction (A) of therapeutic effect on skin wrinkles, texture, and elasticity in experimental and control groups, self-evaluation scores (B) after treatment between experimental and control groups. Combination treatment of PRP and laser was superior to laser treatment alone. *p < 0.05 compared with control group.
FIG. 5.
FIG. 5.
VISIA auxiliary analysis of therapeutic effect on skin wrinkles, texture, and tightness before and after treatment in experimental and control groups. Combination treatment of PRP and laser was superior to laser treatment alone. Scores reflect area and density of wrinkles, texture, and pores, and the smaller scores correspond to better skin status. *p < 0.05 compared with control group.
FIG. 6.
FIG. 6.
Evaluation of total duration of adverse events in experimental and control groups. *p < 0.05 compared with control group.

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