Emergency Department Visits for Atrial Fibrillation in the United States: Trends in Admission Rates and Economic Burden From 2007 to 2014

Guy Rozen, Seyed Mohammadreza Hosseini, M Ihsan Kaadan, Yitschak Biton, E Kevin Heist, Mark Vangel, Moussa C Mansour, Jeremy N Ruskin, Guy Rozen, Seyed Mohammadreza Hosseini, M Ihsan Kaadan, Yitschak Biton, E Kevin Heist, Mark Vangel, Moussa C Mansour, Jeremy N Ruskin

Abstract

Background: Atrial fibrillation (AF) is an increasingly prevalent public health problem and one of the most common causes of emergency department (ED) visits. We aimed to investigate the trends in ED visits and hospital admissions for AF.

Methods and results: This is a repeated cross-sectional analysis of ED visit-level data from the Nationwide Emergency Department Sample for 2007 to 2014. We identified adults who visited EDs in the United States, with a principal diagnosis of AF. A sample of 864 759 ED visits for AF, representing a weighted total of 3 886 520 ED visits, were analyzed. The annual ED visits for AF increased by 30.7% from 411 406 in 2007 (95% confidence interval, 389 819-432 993) to 537 801 (95% confidence interval, 506 747-568 855) in 2014. Patient demographics remained consistent, with an average age of 69 to 70 years and slight female predominance (51%-53%) throughout the study period. Hospital admission rates were stable at ≈70% between 2007 and 2010, after which they gradually declined to 62% in 2014 (Ptrend=0.017). Despite the decline in hospital admission rates, AF hospitalizations increased from 288 225 in 2007 to 333 570 in 2014 because of the increase in total annual ED visits during the study. The adjusted annual charges for admitted AF patients increased by 37% from $7.39 billion in 2007 to $10.1 billion in 2014.

Conclusions: Annual ED visits and hospital admissions for AF increased significantly between 2007 and 2014, despite a reduction in admission rates. These data emphasize the need for widespread implementation of effective strategies aimed at improving the management of patients with AF to reduce hospital admissions and the economic burden of AF.

Keywords: atrial fibrillation; economic burden; emergency department visits; hospitalization.

© 2018 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.

Figures

Figure 1
Figure 1
Changes in emergency department (ED) visits for atrial fibrillation (AF), admission rates, baseline patient characteristics, and comorbidities between 2007 and 2014. The percentage change in ED visits and hospital admissions as well as patient characteristics and major comorbidities are shown. Over the study period, there was a significant trend toward sicker patients presenting to the ED with AF, with an increasing prevalence of hypertension (HTN), diabetes mellitus (DM), congestive heart failure (CHF), chronic kidney disease (CKD), and chronic obstructive pulmonary disease (COPD).
Figure 2
Figure 2
Trends in adult emergency department (ED) visits and atrial fibrillation (AF) ED visits in the United States (2007–2014). The annual volume of ED visits for AF increased significantly from 2007 to 2014, whereas the admission rates gradually declined during the same period. For comparison, all ED visits and admission trends are displayed.
Figure 3
Figure 3
Total annual charges for atrial fibrillation (AF)–related emergency department (ED) visits, resulting in discharge or hospital admissions in the United States (2007–2014). The total annual charges for AF ED visits resulting in discharge and admissions increased significantly from 2007 to 2014. The significant increase in the economic burden of hospital admissions for AF is driven by a combination of the increasing total number of ED visits and hospital admissions and a 37% increase in the median per‐patient hospitalization charge over the study period.
Figure 4
Figure 4
Median hospital charges (adjusted for inflation) per patient: atrial fibrillation (AF) emergency department visits resulting in discharge or hospital admission. The adjusted median per‐patient hospital charges for admitted patients with AF increased significantly in the United States from 2007 to 2014. This was one of the major contributors to the significant increase in the total AF hospitalization economic burden during the study period.

References

    1. Chugh SS, Havmoeller R, Narayanan K, Singh D, Rienstra M, Benjamin EJ, Gillum RF, Kim YH, McAnulty JH Jr, Zheng ZJ, Forouzanfar MH, Naghavi M, Mensah GA, Ezzati M, Murray CJ. Worldwide epidemiology of atrial fibrillation: a global burden of disease 2010 study. Circulation. 2014;129:837–847.
    1. Colilla S, Crow A, Petkun W, Singer DE, Simon T, Liu X. Estimates of current and future incidence and prevalence of atrial fibrillation in the U.S. adult population. Am J Cardiol. 2013;112:1142–1147.
    1. Kalantarian S, Ay H, Gollub RL, Lee H, Retzepi K, Mansour M, Ruskin JN. Association between atrial fibrillation and silent cerebral infarctions: a systematic review and meta‐analysis. Ann Intern Med. 2014;161:650–658.
    1. Kwok CS, Loke YK, Hale R, Potter JF, Myint PK. Atrial fibrillation and incidence of dementia: a systematic review and meta‐analysis. Neurology. 2011;76:914–922.
    1. Stewart S, Hart CL, Hole DJ, McMurray JJ. A population‐based study of the long‐term risks associated with atrial fibrillation: 20‐year follow‐up of the Renfrew/Paisley study. Am J Med. 2002;113:359–364.
    1. Benjamin EJ, Wolf PA, D'Agostino RB, Silbershatz H, Kannel WB, Levy D. Impact of atrial fibrillation on the risk of death: the Framingham Heart Study. Circulation. 1998;98:946–952.
    1. Coyne KS, Paramore C, Grandy S, Mercader M, Reynolds M, Zimetbaum P. Assessing the direct costs of treating nonvalvular atrial fibrillation in the United States. Value Health. 2006;9:348–356.
    1. Wattigney WA, Mensah GA, Croft JB. Increasing trends in hospitalization for atrial fibrillation in the United States, 1985 through 1999: implications for primary prevention. Circulation. 2003;108:711–716.
    1. Patel NJ, Deshmukh A, Pant S, Singh V, Patel N, Arora S, Shah N, Chothani A, Savani GT, Mehta K, Parikh V, Rathod A, Badheka AO, Lafferty J, Kowalski M, Mehta JL, Mitrani RD, Viles‐Gonzalez JF, Paydak H. Contemporary trends of hospitalization for atrial fibrillation in the United States, 2000 through 2010: implications for healthcare planning. Circulation. 2014;129:2371–2379.
    1. Lee WC, Lamas GA, Balu S, Spalding J, Wang Q, Pashos CL. Direct treatment cost of atrial fibrillation in the elderly American population: a Medicare perspective. J Med Econ. 2008;11:281–298.
    1. Stiell IG, Macle L; CCS Atrial Fibrillation Guidelines Committee . Canadian cardiovascular society atrial fibrillation guidelines 2010: management of recent‐onset atrial fibrillation and flutter in the emergency department. Can J Cardiol. 2011;27:38–46.
    1. von Besser K, Mills AM. Is discharge to home after emergency department cardioversion safe for the treatment of recent‐onset atrial fibrillation? Ann Emerg Med. 2011;58:517–520.
    1. Sacchetti A, Williams J, Levi S, Akula D. Impact of emergency department management of atrial fibrillation on hospital charges. West J Emerg Med. 2013;14:55–57.
    1. Bellew SD, Bremer ML, Kopecky SL, Lohse CM, Munger TM, Robelia PM, Smars PA. Impact of an emergency department observation unit management algorithm for atrial fibrillation. J Am Heart Assoc. 2016;5:e002984 DOI: 10.1161/JAHA.115.002984.
    1. Ptaszek LM, White B, Lubitz SA, Carnicelli AP, Heist EK, Ellinor PT, Machado M, Wasfy JH, Ruskin JN, Armstrong K, Brown DF, Biddinger PD, Mansour M. Effect of a multidisciplinary approach for the management of patients with atrial fibrillation in the emergency department on hospital admission rate and length of stay. Am J Cardiol. 2016;118:64–71.
    1. Barrett TW, Vermeulen MJ, Self WH, Jenkins CA, Ferreira AJ, Atzema CL. Emergency department management of atrial fibrillation in the United States versus Ontario, Canada. J Am Coll Cardiol. 2015;65:2258–2260.
    1. von Elm E, Altman DG, Egger M, Pocock SJ, Gotzsche PC, Vandenbroucke JP; STROBE Initiative . The strengthening the reporting of observational studies in epidemiology (STROBE) statement: guidelines for reporting observational studies. PLoS Med. 2007;4:e296.
    1. Cuzick J. A Wilcoxon‐type test for trend. Stat Med. 1985;4:87–90.
    1. Barrett TW, Self WH, Jenkins CA, Storrow AB, Heavrin BS, McNaughton CD, Collins SP, Goldberger JJ. Predictors of regional variations in hospitalizations following emergency department visits for atrial fibrillation. Am J Cardiol. 2013;112:1410–1416.
    1. McDonald AJ, Pelletier AJ, Ellinor PT, Camargo CA Jr. Increasing US emergency department visit rates and subsequent hospital admissions for atrial fibrillation from 1993 to 2004. Ann Emerg Med. 2008;51:58–65.
    1. Lin MP, Ma J, Weissman JS, Bernard KR, Schuur JD. Hospital‐level variation and predictors of admission after ED visits for atrial fibrillation: 2006 to 2011. Am J Emerg Med. 2016;34:2094–2100.
    1. Atzema CL, Austin PC, Miller E, Chong AS, Yun L, Dorian P. A population‐based description of atrial fibrillation in the emergency department, 2002 to 2010. Ann Emerg Med. 2013;62:570–577.e577.
    1. Rosychuk RJ, Graham MM, Holroyd BR, Rowe BH. Emergency department presentations for atrial fibrillation and flutter in Alberta: a large population‐based study. BMC Emerg Med. 2017;17:2.
    1. Redfearn DP, Furqan MA, Enriquez A, Barber D, Shaw C, Simpson C, Baranchuk A, Michael K, Abdollah H, Brison RJ. Emergency department re‐presentation for atrial fibrillation and atrial flutter. Can J Cardiol. 2016;32:344–348.
    1. Zuckerman RB, Sheingold SH, Orav EJ, Ruhter J, Epstein AM. Readmissions, observation, and the hospital readmissions reduction program. N Engl J Med. 2016;374:1543–1551.
    1. Kirchhof P, Benussi S, Kotecha D, Ahlsson A, Atar D, Casadei B, Castella M, Diener HC, Heidbuchel H, Hendriks J, Hindricks G, Manolis AS, Oldgren J, Popescu BA, Schotten U, Van Putte B, Vardas P, Agewall S, Camm J, Baron Esquivias G, Budts W, Carerj S, Casselman F, Coca A, De Caterina R, Deftereos S, Dobrev D, Ferro JM, Filippatos G, Fitzsimons D, Gorenek B, Guenoun M, Hohnloser SH, Kolh P, Lip GY, Manolis A, McMurray J, Ponikowski P, Rosenhek R, Ruschitzka F, Savelieva I, Sharma S, Suwalski P, Tamargo JL, Taylor CJ, Van Gelder IC, Voors AA, Windecker S, Zamorano JL, Zeppenfeld K. 2016 ESC guidelines for the management of atrial fibrillation developed in collaboration with EACTS. Eur Heart J. 2016;37:2893–2962.
    1. January CT, Wann LS, Alpert JS, Calkins H, Cigarroa JE, Jr Cleveland JC, Conti JB, Ellinor PT, Ezekowitz MD, Field ME, Murray KT, Sacco RL, Stevenson WG, Tchou PJ, Tracy CM, Yancy CW; American College of Cardiology/American Heart Association Task Force on Practice Guidelines . 2014 AHA/ACC/HRS guideline for the management of patients with atrial fibrillation: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the Heart Rhythm Society. J Am Coll Cardiol. 2014;64:e1–e76.
    1. Krijthe BP, Kunst A, Benjamin EJ, Lip GY, Franco OH, Hofman A, Witteman JC, Stricker BH, Heeringa J. Projections on the number of individuals with atrial fibrillation in the European Union, from 2000 to 2060. Eur Heart J. 2013;34:2746–2751.
    1. Zoni‐Berisso M, Lercari F, Carazza T, Domenicucci S. Epidemiology of atrial fibrillation: European perspective. Clin Epidemiol. 2014;6:213–220.

Source: PubMed

3
Prenumerera