Screening and risk factors of exocrine pancreatic insufficiency in critically ill adult patients receiving enteral nutrition

Sheng Wang, Lijie Ma, Yugang Zhuang, Bojie Jiang, Xiangyu Zhang, Sheng Wang, Lijie Ma, Yugang Zhuang, Bojie Jiang, Xiangyu Zhang

Abstract

Introduction: Malnutrition is a frequent problem associated with detrimental clinical outcomes in critically ill patients. To avoid malnutrition, most studies focus on the prevention of inadequate nutrition delivery, whereas little attention is paid to the potential role of exocrine pancreatic insufficiency (EPI). In this trial, we aim to evaluate the prevalence of EPI and identify its potential risk factors in critically ill adult patients without preexisting pancreatic diseases.

Methods: In this prospective cross-sectional study, we recruited 563 adult patients with critical illnesses. All details of the patients were documented, stool samples were collected three to five days following the initiation of enteral nutrition, and faecal elastase 1 (FE-1) concentrations were assayed using an enzyme-linked immunosorbent assay kit. Blood samples were also taken to determine serum amylase and lipase activity.

Results: The percentages of recruited patients with EPI (FE-1 concentration <200 μg/g) and severe EPI (FE-1 concentration <100 μg/g) were 52.2% and 18.3%, respectively. The incidences of steatorrhea were significantly different (P < 0.05) among the patients without EPI, with moderate EPI (FE-1 concentration = 100 to 200 μg/g) and severe EPI (FE-1 concentration < 100 μg/g). Both multivariate logistic regression analysis and z-tests indicated that the occurrence of EPI was closely associated with shock, sepsis, diabetes, cardiac arrest, hyperlactacidemia, invasive mechanical ventilation and haemodialysis.

Conclusions: More than 50% of critically ill adult patients without primary pancreatic diseases had EPI, and nearly one-fifth of them had severe EPI. The risk factors for EPI included shock, sepsis, diabetes, cardiac arrest, hyperlactacidemia, invasive mechanical ventilation and haemodialysis.

Trial registration: NCT01753024.

Figures

Figure 1
Figure 1
The CONSORT flow diagram for the study participants. EN, enteral nutrition.
Figure 2
Figure 2
Occurrence of exocrine pancreatic insufficiency, severe exocrine pancreatic insufficiency, hyperamylasemia and hyperlipasemia in critically ill adult patients. EPI, exocrine pancreatic insufficiency; H-amylase, hyperamylasemia; H-lipase, hyperlipasemia.

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