Reirradiation for locoregionally recurrent non-small cell lung cancer
Melissa A L Vyfhuis, Stephanie Rice, Jill Remick, Sina Mossahebi, Shahed Badiyan, Pranshu Mohindra, Charles B Simone 2nd, Melissa A L Vyfhuis, Stephanie Rice, Jill Remick, Sina Mossahebi, Shahed Badiyan, Pranshu Mohindra, Charles B Simone 2nd
Abstract
Locoregional failure in non-small cell lung cancer (NSCLC) remains high, and the management for recurrent disease in the setting of prior radiotherapy is difficult. Retreatment options such as surgery or systemic therapy are typically limited or frequently result in suboptimal outcomes. Reirradiation (reRT) of thoracic malignancies may be an optimal strategy for providing definitive local control and offering a new chance of cure. Yet, retreatment with radiation therapy can be challenging for fear of excessive toxicities and the inability to safely deliver definitive (≥60 Gy) doses of reRT. However, with recent improvements in radiation delivery techniques and image-guidance, dose-escalation with reRT is possible and outcomes are encouraging. Here, we present a review of various radiation techniques, clinical outcomes and associated toxicities in patients with locoregionally recurrent NSCLC treated primarily with reRT.
Keywords: Reirradiation (reRT); intensity modulated radiation therapy (IMRT); non-small cell lung cancer (NSCLC); proton beam therapy (PBT); stereotactic body radiation therapy (SBRT).
Conflict of interest statement
Conflicts of Interest: The authors have no conflicts of interest to declare.
Source: PubMed