Indirect Effect of Azithromycin Use on the Intestinal Microbiome Diversity of Untreated Children: A Randomized Trial

Catherine E Oldenburg, Ali Sié, Boubacar Coulibaly, Lucienne Ouermi, Clarisse Dah, Charlemagne Tapsoba, Till Bärnighausen, Elodie Lebas, Ahmed M Arzika, Susie Cummings, Lina Zhong, Thomas M Lietman, Jeremy D Keenan, Thuy Doan, Catherine E Oldenburg, Ali Sié, Boubacar Coulibaly, Lucienne Ouermi, Clarisse Dah, Charlemagne Tapsoba, Till Bärnighausen, Elodie Lebas, Ahmed M Arzika, Susie Cummings, Lina Zhong, Thomas M Lietman, Jeremy D Keenan, Thuy Doan

Abstract

Cohabiting children may share components of their intestinal microbiome. We evaluated whether receipt of azithromycin in one sibling confers changes to the intestinal microbiome in an untreated sibling compared with placebo in a randomized controlled trial. We found no evidence of an indirect effect of antibiotic use in cohabiting children. Clinical Trials Registrations: NCT03187834.

Figures

Figure 1.
Figure 1.
Posttreatment Simpson (A) and Shannon (B) diversity of gut bacteria in untreated siblings of children treated with azithromycin (red line) or placebo (black line).

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Source: PubMed

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