Extravascular lung water in patients with severe sepsis: a prospective cohort study

Greg S Martin, Stephanie Eaton, Meredith Mealer, Marc Moss, Greg S Martin, Stephanie Eaton, Meredith Mealer, Marc Moss

Abstract

Introduction: Few investigations have prospectively examined extravascular lung water (EVLW) in patients with severe sepsis. We sought to determine whether EVLW may contribute to lung injury in these patients by quantifying the relationship of EVLW to parameters of lung injury, to determine the effects of chronic alcohol abuse on EVLW, and to determine whether EVLW may be a useful tool in the diagnosis of acute respiratory distress syndrome (ARDS).

Methods: The present prospective cohort study was conducted in consecutive patients with severe sepsis from a medical intensive care unit in an urban university teaching hospital. In each patient, transpulmonary thermodilution was used to measure cardiovascular hemodynamics and EVLW for 7 days via an arterial catheter placed within 72 hours of meeting criteria for severe sepsis.

Results: A total of 29 patients were studied. Twenty-five of the 29 patients (86%) were mechanically ventilated, 15 of the 29 patients (52%) developed ARDS, and overall 28-day mortality was 41%. Eight out of 14 patients (57%) with non-ARDS severe sepsis had high EVLW with significantly greater hypoxemia than did those patient with low EVLW (mean arterial oxygen tension/fractional inspired oxygen ratio 230.7 +/- 36.1 mmHg versus 341.2 +/- 92.8 mmHg; P < 0.001). Four out of 15 patients with severe sepsis with ARDS maintained a low EVLW and had better 28-day survival than did ARDS patients with high EVLW (100% versus 36%; P = 0.03). ARDS patients with a history of chronic alcohol abuse had greater EVLW than did nonalcoholic patients (19.9 ml/kg versus 8.7 ml/kg; P < 0.0001). The arterial oxygen tension/fractional inspired oxygen ratio, lung injury score, and chest radiograph scores correlated with EVLW (r2 = 0.27, r2 = 0.18, and r2 = 0.28, respectively; all P < 0.0001).

Conclusions: More than half of the patients with severe sepsis but without ARDS had increased EVLW, possibly representing subclinical lung injury. Chronic alcohol abuse was associated with increased EVLW, whereas lower EVLW was associated with survival. EVLW correlated moderately with the severity of lung injury but did not account for all respiratory derangements. EVLW may improve both risk stratification and management of patients with severe sepsis.

Figures

Figure 1
Figure 1
Longitudinal measures of (a) extravascular lung water (EVLW) and (b) oxygenation (arterial oxygen tension [PaO2]/inspired fractional oxygen [FiO2] ratio) in patients with severe sepsis, stratified by survival. Vertical bars indicate standard errors. *Significant between-group differences at the marked time points; P < 0.001 for EVLW differences over time, by analysis of variance.
Figure 2
Figure 2
Scatter plot showing the relationship between (a) oxygenation (arterial oxygen tension [PaO2]/inspired fractional oxygen [FiO2] ratio) and extravascular lung water (EVLW) in all patients (R2 by linear regression = 0.27; P < 0.001), and (b) between minimum PaO2/FiO2 ratio and maximum EVLW in nonsurvivors (R2 = 0.60; P = 0.005).

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