A multicenter, cross-sectional, observational study of budesonide/formoterol maintenance and reliever therapy in real-world settings
Jiangtao Lin, Jing Li, Wencheng Yu, Yuejian Liu, Chuntao Liu, Ping Chen, Huijie He, Bei He, Shuang Liu, Xiangdong Zhou, Jiangtao Lin, Jing Li, Wencheng Yu, Yuejian Liu, Chuntao Liu, Ping Chen, Huijie He, Bei He, Shuang Liu, Xiangdong Zhou
Abstract
Background: To assess the level of asthma control achieved with budesonide/formoterol in Chinese patients with asthma, based on the Global Initiative for Asthma (GINA) definition and Asthma Control Test (ACT) score.
Methods: This multicenter, cross-sectional study (NCT01785901) evaluated asthma control levels in Chinese patients receiving physician-prescribed budesonide/formoterol treatment. Adults with a diagnosis of asthma ≥6 months and receiving budesonide/formoterol treatment ≥3 months before screening were consecutively enrolled. Data including medical and medication history were collected using face-to-face questionnaires and physical examinations during a single visit.
Results: A total of 1483 asthma out-patients from 27 medical centers were enrolled; 217 (14.6%) were treated with budesonide/formoterol using a fixed-dose strategy and 1266 (85.4%) with the SMART (Symbicort® Maintenance And Reliever Therapy) strategy. According to GINA criteria, asthma was controlled in 58.6% (95% CI: 56.1%-61.1%) of patients and was either controlled or partly controlled in 94.1% (95% CI: 92.8%-95.3%) of patients. According to ACT score, asthma was completely controlled in 22.4% (95% CI: 20.3%-24.6%) of patients and was either completely or well controlled in 83.3% (95% CI: 81.4%-85.2%) of patients. Multivariate logistic regression analysis revealed that a >5-year history of asthma and an age of >50 years were factors associated with lower levels of asthma control.
Conclusions: This study demonstrated high levels of asthma control (GINA: controlled and partly controlled and ACT: completely and well controlled) in Chinese patients with asthma treated with budesonide/formoterol. Greater age and a longer disease history were associated with lower levels of asthma control.
Trial registration: ClinicalTrials.govNCT01785901. Registered February 5, 2013.
Keywords: Asthma Control Test; GINA; ICS/LABA; SMART; Symbicort Maintenance And Reliever Therapy.
Copyright © 2017 Elsevier Ltd. All rights reserved.
Source: PubMed