Persistent swallowing disorders after extubation in mechanically ventilated patients in ICU: a two-center prospective study

G Beduneau, V Souday, J C Richard, J F Hamel, D Carpentier, J M Chretien, P Bouchetemble, L Laccoureye, A Astier, V Tanguy, A Mercat, F Beloncle, F Tamion, G Beduneau, V Souday, J C Richard, J F Hamel, D Carpentier, J M Chretien, P Bouchetemble, L Laccoureye, A Astier, V Tanguy, A Mercat, F Beloncle, F Tamion

Abstract

Background: Persistent swallowing disorders (SD) are non-pulmonary complications of mechanical ventilation (MV). However, there are few clinical studies on persistent SD in critically ill patients undergoing tracheal intubation for MV. The aim of the present study was to assess the incidence and characteristics of clinical manifestations associated with persistent SD.

Methods: We prospectively evaluated in patients requiring more than 7 days of invasive MV the incidence and characteristics of clinical manifestations related to persistent SD. For this purpose, quality of swallowing was assessed within 24 h after extubation by an experienced physical therapist not directly involved in patient management. Swallowing assessment consisted in a specific standardized test combining a swallowing test and a full clinical evaluation of the cranial nerves involved in swallowing. In patients with SD on the first test, a second test was done within 48 h in order to discriminate between transient and persistent SD.

Results: Among the 482 patients mechanically ventilated more than 7 days, 138 were enrolled in this study. The first test performed 24 h after extubation revealed SD in 35 patients (25%). According to the second test performed 48 h later, SD were considered transient in 21 (15%) and persistent in 14 (10%) cases. Patients with persistent SD were older (66 ± 16 vs 58 ± 15 years), had lower bodyweight at admission (76 ± 15 vs 87 ± 23 kg) and received less often neuromuscular blocking agents (36% vs 66%) compared to patients without or with only transient SD. Patients with persistent SD had longer duration of Intensive Care Unit (ICU) stay after first extubation and longer delay to oral feeding than patients without or with only transient SD, respectively, 11 ± 9 vs 7 ± 6 days and 23 ± 33 vs 5 ± 7 days.

Conclusions: Based on a specific standardized clinical test, 25% of patients mechanically ventilated more than 7 days exhibited clinical manifestations of SD. However, SD were considered as persistent after extubation in only 10% of them. Persistent SD were associated with longer duration of ICU stay after extubation and longer time of enteral feeding.

Trial registration: The study is registered with Clinical Trials (NCT01360580).

Keywords: Mechanical ventilation; Mechanical ventilation weaning; Prolonged intubation; Swallowing disorder.

Conflict of interest statement

We declare that we have no competing interests.

Figures

Fig. 1
Fig. 1
Study flowchart
Fig. 2
Fig. 2
Results of swallowing test

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