The course of response to focal/grid photocoagulation for diabetic macular edema
Diabetic Retinopathy Clinical Research Network, David J Browning, Kellee M Miller, Lloyd Paul Aiello, Roy W Beck, Neil M Bressler, Matthew D Davis, David A DiLoreto, Frederick L Ferris 3rd, Scott M Friedman, Adam R Glassman, Louis C Glazer, Craig Kollman, Andreas K Lauer, Dennis M Marcus, JoAnn Starr, David Browning, Andrew N Antoszyk, Scott M Friedman, Andreas K Lauer, Christina J Flaxel, Michael J Elman, Charles A Garcia, Dennis M Marcus, Harinderjit Singh, Louis C Glazer, Jeffrey D Zheutlin, Frank W Garber, Thomas W Stone, Rick D Isernhagen, David A DiLoreto, Deborah Hoffert, Trexler M Topping, Jeffrey G Gross, Michel Shami, Michael A Novak, David G Miller, George S Sharuk, Jennifer K Sun, Timothy J Murtha, Howard S Lazarus, Carl W Baker, A Thomas Ghuman, Paul A Raskauskas, Ronald J Glatzer, Justin Gottlieb, G Robert Hampton, Bryan K Rutledge, Jeevan R Mathura Jr, John A Wells, Ramin Sarrafizadeh, Amy S Noffke, Clement K Chan, Asha S D Nuthi, Diabetic Retinopathy Clinical Research Network, David J Browning, Kellee M Miller, Lloyd Paul Aiello, Roy W Beck, Neil M Bressler, Matthew D Davis, David A DiLoreto, Frederick L Ferris 3rd, Scott M Friedman, Adam R Glassman, Louis C Glazer, Craig Kollman, Andreas K Lauer, Dennis M Marcus, JoAnn Starr, David Browning, Andrew N Antoszyk, Scott M Friedman, Andreas K Lauer, Christina J Flaxel, Michael J Elman, Charles A Garcia, Dennis M Marcus, Harinderjit Singh, Louis C Glazer, Jeffrey D Zheutlin, Frank W Garber, Thomas W Stone, Rick D Isernhagen, David A DiLoreto, Deborah Hoffert, Trexler M Topping, Jeffrey G Gross, Michel Shami, Michael A Novak, David G Miller, George S Sharuk, Jennifer K Sun, Timothy J Murtha, Howard S Lazarus, Carl W Baker, A Thomas Ghuman, Paul A Raskauskas, Ronald J Glatzer, Justin Gottlieb, G Robert Hampton, Bryan K Rutledge, Jeevan R Mathura Jr, John A Wells, Ramin Sarrafizadeh, Amy S Noffke, Clement K Chan, Asha S D Nuthi
Abstract
Purpose: The purpose of this study was to determine whether eyes with center-involved diabetic macular edema, treated with focal/grid photocoagulation, in which there is a reduction in central subfield thickness (CST) measured with optical coherence tomography after 16 weeks, will continue to improve if retreatment is deferred.
Methods: This is a prospective, multicenter, observational, single-group focal/grid photocoagulation study of 122 eyes with center-involved diabetic macular edema (optical coherence tomography CST > or =250 microm). At the 16-week visit and continuing every 8 weeks, eyes were assessed for retreatment and additional laser treatment was deferred if the visual acuity letter score improved > or =5 letters or optical coherence tomography CST decreased > or =10% compared with the visit 16 weeks prior.
Results: Of the 115 eyes that completed the 16-week visit, 54 (47%) had a decrease in CST by > or =10% compared with baseline. Of these, 26 (48%) had a CST > or =250 microm at 16 weeks and were evaluable at 32 weeks. Eleven (42%; 95% confidence interval, 23-63%) of the 26 eyes had a further decrease in CST > or =10% from 16 weeks to 32 weeks without further treatment.
Conclusion: Sixteen weeks after focal/grid laser for diabetic macular edema in eyes with a definite reduction, but not resolution, of central edema, 23% to 63% likely will continue to improve without additional treatment.
Conflict of interest statement
Conflicts of interest statement: None
Source: PubMed