Diagnosing and treating active myocarditis

Abstract

The treatment of dilated cardiomyopathy is palliative and, hence, has little effect on the natural history. Therapy directed toward the cause rather than the effect will be necessary before mortality can be affected. Active myocarditis is postulated to be the cause of dilated cardiomyopathy in a subset of patients. A model of murine coxsackievirus B3 myocarditis has immunopathogenic parallels to the disease in humans and suggests that persistent autoimmune reactivity following viral clearance leads to progressive myocyte damage and dilated cardiomyopathy. In preliminary uncontrolled studies, patients with myocarditis have shown clinical and histologic improvement with the addition of immunosuppressive therapy, but there may also be a significant rate of spontaneous improvement. A multicenter study currently acquiring patients is designed to determine the efficacy of immunosuppression and the natural history of active myocarditis.