Validation of residual SYNTAX score with second-generation drug-eluting stents: one-year results from the prospective multicentre SEEDS study
Bo Xu, Yue-Jin Yang, Ya-Ling Han, Shu-Zheng Lu, Bao Li, Qiang Liu, Guo-Ying Zhu, Jun-Yu Cui, Lang Li, Ye-Lin Zhao, Ajay J Kirtane, SEEDS Investigators, Yue-Jin Yang, Ya-Ling Han, Shu-Zheng Lu, Bo Xu, Wei-Min Wang, Zhu-Jun Shen, Hong-Wei Li, Bo Liu, Xiaofeng Guo, Yue-Jin Yang, Chao-Wei Mu, Jue Chen, Ke-Fei Dou, Li-Jian Gao, Chong-Jian Li, Hai-Bo Liu, Jie Qian, Shu-Bin Qiao, Xue-Wen Qin, Hong Qiu, Yong-Jian Wu, Liang Xu, Hong-Bing Yan, Shi-Jie You, Zhong-Wei Sun, Fang Wang, Yan Liu, Bao Li, Jing-Ping Wang, Bin Yang, Jin Dong, Qiang Liu, Jian-Xin Weng, Yi Wei, Xiu-Hua Cai, Li-Li Wang, Ya-Ling Han, Ying-Yan Ma, Quan-Min Jing, Hai-Wei Liu, Geng Wang, Xiao-Zeng Wang, Kai Xu, Bin Wang, Jian Zhang, Fei Li, Guo-Ying Zhu, Xi Su, Hua-Yun Liu, Lei Li, Ying Wang, Jin Zhang, Dan Song, Jian Peng, Hua Yan, Guo-Hong Chen, Jun-Xia Li, Jun-Yu Cui, Yu-Jie Shi, Jian Zhang, Lang Li, Xiang-Hong Wu, Ge Xu, Qiao-Lan Jiang, Guo-Qiong Ma, Zu-Yi Yuan, Ning Guo, Jian-Hua Huo, Ying Xiong, Yin-Hui Liu, Ke Han, Zheng Ji, Li Li, Ya-Li Di, Jing-Yi Zhang, Qing-Xia Zhao, Xue-Bin Geng, Jing-Fang Gao, Huai-Lin Liu, Yi-Bo Yang, Xin-Tao Chen, Hong-Jun Yan, Jie Zhang, Hong-Xing Song, Xiao-Guang Mu, Ying Zhang, Dong-Mei Wang, Jun-Xia Li, Li Zhang, Yu-Ying Zhao, Yu-Hong Peng, Cui Wang, Jia-An Sun, Dong-Mei Wang, Hong Zhang, Yan Zhao, Yun-Mei Zhang, Li-Wen Liang, Qiong-Jie Yang, Yin Liu, Xiu-Jun Zhou, Li Yang, Wei Ma, Lu Cao, Jin-Xia Zhang, Qiu-Tang Zeng, Xiao-Bo Mao, Hui Zhu, Gui-Wen Yi, Hai-Bo Yang, Jun Zhang, Shao-Bin Jia, Lin He, Hong-Rui Shi, Yu-Min Chou, Da-Peng Chen, Ning Wei, Hui Huang, Qing-Bin Xu, Hua Chen, Yong-Jian Yang, Da-Chun Yang, Shuang-Tao Ma, Wei-Hong Wang, Jin-Song Chen, Bing Tang, Gang Li, Jun Zhu, De Li, Xin Zhang, Xiao-Hua Su, Shu-Zheng Lu, Feng Xu, Xin Chen, Fei Yuan, Bao-Yan Wan, Shang-Yu Wen, Sheng-Quan Liu, Yan-Hong Li, Li-Jun Ma, Shao-Wen Liu, Guo-Bing Zhang, Wei-Guo Zhou, Wen-Yi Yang, Hao Xu, Wei-Zhen Li, Heng Cao, Jie Chu, Yang Wang, Chun Wu, Hui Xu, Sai-Yong Chen, Yong Sun, Jian'an Wang, Jian-Jing Lin, Cheng Li, Ping Li, Jian Chen, Zheng-Dong Wang, Shao-Fu Zhang, Jian-Ting Gan, Zhong-Wu Xu, Zhi-Hai Lin, Rong Chen, Hong Jiang, Jing Bai, Bo Yang, Xue-Jun Jiang, Hao Xia, Xiao-Hong Wang, Jia-Hua Pan, Jing-Fa Tian, Yun Wen, Jia Liu, Zhan-Quan Li, Li Liu, Yun-Qi Shi, Cheng-Yang Li, Na Zhang, Yan-Zhen Zhang, Hai-Bin Song, Yong-Guang Li, Zheng Zhang, Dong Wang, Ming Bai, Bo Zhang, Ming Pan, Su-Yu You, Zheng Wan, Bo Bian, Meng-Meng Li, Wen-Nan Liu, Yi Wang, Bin Liu, Zhi-Hui Wang, Xiao-Hao Zhang, Jin-Fa Jiang, Wen-Jun Xu, Hao-Ming Song, Ru-Hui Liu, Jia-Hong Xu, Yang Liu, Chao-Hui Hu, Xiao-Yi Qu, Chang-Qian Wang, Yu-Qi Fan, Kan Chen, Jing-Chao Hu, Zhao-Yan Xu, Jian-Min Li, Xi-Li Yang, Yu-An Li, Zhao-Lun Zhou, Hui-Liang Liu, Wei Han, Lei Wang, Ji-Hua Sheng, Yu-Jie Wei, Ying Liu, Jiao Zhang, Wei-Min Li, Ling Jing, Guo Dong, Yong-Tai Gong, Shu-Sen Yang, Li-Yun Song, Yue Li, Li-Jun Zhou, Dang-Hui Sun, Lin Yuan, Xue-Bo Liu, Dai-Fu Zhang, Yu-Lu Liang, Wei Gang Qi, Yan Lai, Yi-An Yao, Ye Gu, Yi-Qiang Yuan, Jian-Li Wang, Yu-Jie Zhao, Li Yu, Xiao-Ting Yin, Hong-Jie Ning, Si-Quan Niu, Jun-Xing Lai, Qiang Ren, An-Jian Song, Liang-Long Chen, Xing-Chun Zheng, Yu-Chen, Jian Qiu, Chang-Jiang Hong, Guang-Cheng Xiang, Zhi-Hua Gong, Yun-Jun Ruan, Shao-Ying Pan, Xiao-Long Gu, Rui Li, Hua Xiao, Jia-Yong Liang, Dan-Dan Peng, Le-Feng Wang, Li Xu, Hao Sun, Sheng-Li Du, Ying-Zhong Lin, Shao-Ming Qin, Ling Liu, Guang-Ma Xu, Guang-Wei Wu, Hong Lin, Xu-Ping Li, Chun-Hua Mo, Zi-Shan Hou, Yan-Jin Wei, Qiu-Lin Zhang, Kai Liu, Ze-Sheng Xu, Shi-Peng Dai, Li-Fu Miao, Yan-Ping Yin, Xi-Wei Deng, Guan-Xu Tan, Wen- Jian Liang, Hong Liu, Zheng-Han Lee, Yi-Heng Li, Shih-Huang Chan, Ping-Yen Liu, Chih-Chan Lin, Ju-Yi Chen, Wen-Hui Tseng, Rong-Tian Wang, Chi-Hung Huang, Po-Ching Chou, Bo Xu, Yue-Jin Yang, Ya-Ling Han, Shu-Zheng Lu, Bao Li, Qiang Liu, Guo-Ying Zhu, Jun-Yu Cui, Lang Li, Ye-Lin Zhao, Ajay J Kirtane, SEEDS Investigators, Yue-Jin Yang, Ya-Ling Han, Shu-Zheng Lu, Bo Xu, Wei-Min Wang, Zhu-Jun Shen, Hong-Wei Li, Bo Liu, Xiaofeng Guo, Yue-Jin Yang, Chao-Wei Mu, Jue Chen, Ke-Fei Dou, Li-Jian Gao, Chong-Jian Li, Hai-Bo Liu, Jie Qian, Shu-Bin Qiao, Xue-Wen Qin, Hong Qiu, Yong-Jian Wu, Liang Xu, Hong-Bing Yan, Shi-Jie You, Zhong-Wei Sun, Fang Wang, Yan Liu, Bao Li, Jing-Ping Wang, Bin Yang, Jin Dong, Qiang Liu, Jian-Xin Weng, Yi Wei, Xiu-Hua Cai, Li-Li Wang, Ya-Ling Han, Ying-Yan Ma, Quan-Min Jing, Hai-Wei Liu, Geng Wang, Xiao-Zeng Wang, Kai Xu, Bin Wang, Jian Zhang, Fei Li, Guo-Ying Zhu, Xi Su, Hua-Yun Liu, Lei Li, Ying Wang, Jin Zhang, Dan Song, Jian Peng, Hua Yan, Guo-Hong Chen, Jun-Xia Li, Jun-Yu Cui, Yu-Jie Shi, Jian Zhang, Lang Li, Xiang-Hong Wu, Ge Xu, Qiao-Lan Jiang, Guo-Qiong Ma, Zu-Yi Yuan, Ning Guo, Jian-Hua Huo, Ying Xiong, Yin-Hui Liu, Ke Han, Zheng Ji, Li Li, Ya-Li Di, Jing-Yi Zhang, Qing-Xia Zhao, Xue-Bin Geng, Jing-Fang Gao, Huai-Lin Liu, Yi-Bo Yang, Xin-Tao Chen, Hong-Jun Yan, Jie Zhang, Hong-Xing Song, Xiao-Guang Mu, Ying Zhang, Dong-Mei Wang, Jun-Xia Li, Li Zhang, Yu-Ying Zhao, Yu-Hong Peng, Cui Wang, Jia-An Sun, Dong-Mei Wang, Hong Zhang, Yan Zhao, Yun-Mei Zhang, Li-Wen Liang, Qiong-Jie Yang, Yin Liu, Xiu-Jun Zhou, Li Yang, Wei Ma, Lu Cao, Jin-Xia Zhang, Qiu-Tang Zeng, Xiao-Bo Mao, Hui Zhu, Gui-Wen Yi, Hai-Bo Yang, Jun Zhang, Shao-Bin Jia, Lin He, Hong-Rui Shi, Yu-Min Chou, Da-Peng Chen, Ning Wei, Hui Huang, Qing-Bin Xu, Hua Chen, Yong-Jian Yang, Da-Chun Yang, Shuang-Tao Ma, Wei-Hong Wang, Jin-Song Chen, Bing Tang, Gang Li, Jun Zhu, De Li, Xin Zhang, Xiao-Hua Su, Shu-Zheng Lu, Feng Xu, Xin Chen, Fei Yuan, Bao-Yan Wan, Shang-Yu Wen, Sheng-Quan Liu, Yan-Hong Li, Li-Jun Ma, Shao-Wen Liu, Guo-Bing Zhang, Wei-Guo Zhou, Wen-Yi Yang, Hao Xu, Wei-Zhen Li, Heng Cao, Jie Chu, Yang Wang, Chun Wu, Hui Xu, Sai-Yong Chen, Yong Sun, Jian'an Wang, Jian-Jing Lin, Cheng Li, Ping Li, Jian Chen, Zheng-Dong Wang, Shao-Fu Zhang, Jian-Ting Gan, Zhong-Wu Xu, Zhi-Hai Lin, Rong Chen, Hong Jiang, Jing Bai, Bo Yang, Xue-Jun Jiang, Hao Xia, Xiao-Hong Wang, Jia-Hua Pan, Jing-Fa Tian, Yun Wen, Jia Liu, Zhan-Quan Li, Li Liu, Yun-Qi Shi, Cheng-Yang Li, Na Zhang, Yan-Zhen Zhang, Hai-Bin Song, Yong-Guang Li, Zheng Zhang, Dong Wang, Ming Bai, Bo Zhang, Ming Pan, Su-Yu You, Zheng Wan, Bo Bian, Meng-Meng Li, Wen-Nan Liu, Yi Wang, Bin Liu, Zhi-Hui Wang, Xiao-Hao Zhang, Jin-Fa Jiang, Wen-Jun Xu, Hao-Ming Song, Ru-Hui Liu, Jia-Hong Xu, Yang Liu, Chao-Hui Hu, Xiao-Yi Qu, Chang-Qian Wang, Yu-Qi Fan, Kan Chen, Jing-Chao Hu, Zhao-Yan Xu, Jian-Min Li, Xi-Li Yang, Yu-An Li, Zhao-Lun Zhou, Hui-Liang Liu, Wei Han, Lei Wang, Ji-Hua Sheng, Yu-Jie Wei, Ying Liu, Jiao Zhang, Wei-Min Li, Ling Jing, Guo Dong, Yong-Tai Gong, Shu-Sen Yang, Li-Yun Song, Yue Li, Li-Jun Zhou, Dang-Hui Sun, Lin Yuan, Xue-Bo Liu, Dai-Fu Zhang, Yu-Lu Liang, Wei Gang Qi, Yan Lai, Yi-An Yao, Ye Gu, Yi-Qiang Yuan, Jian-Li Wang, Yu-Jie Zhao, Li Yu, Xiao-Ting Yin, Hong-Jie Ning, Si-Quan Niu, Jun-Xing Lai, Qiang Ren, An-Jian Song, Liang-Long Chen, Xing-Chun Zheng, Yu-Chen, Jian Qiu, Chang-Jiang Hong, Guang-Cheng Xiang, Zhi-Hua Gong, Yun-Jun Ruan, Shao-Ying Pan, Xiao-Long Gu, Rui Li, Hua Xiao, Jia-Yong Liang, Dan-Dan Peng, Le-Feng Wang, Li Xu, Hao Sun, Sheng-Li Du, Ying-Zhong Lin, Shao-Ming Qin, Ling Liu, Guang-Ma Xu, Guang-Wei Wu, Hong Lin, Xu-Ping Li, Chun-Hua Mo, Zi-Shan Hou, Yan-Jin Wei, Qiu-Lin Zhang, Kai Liu, Ze-Sheng Xu, Shi-Peng Dai, Li-Fu Miao, Yan-Ping Yin, Xi-Wei Deng, Guan-Xu Tan, Wen- Jian Liang, Hong Liu, Zheng-Han Lee, Yi-Heng Li, Shih-Huang Chan, Ping-Yen Liu, Chih-Chan Lin, Ju-Yi Chen, Wen-Hui Tseng, Rong-Tian Wang, Chi-Hung Huang, Po-Ching Chou
Abstract
Aims: The SYNTAX score has been proposed as a valuable tool to characterise coronary anatomy prospectively based on its complexity. This study evaluated the prognostic value on adverse outcomes of the residual SYNTAX score (rSS) in patients with complex lesions treated with an everolimus-eluting stent (EES).
Methods and results: One thousand eight hundred and fifty-one patients with small vessel (reference diameter <2.75 mm), long lesion (length >25 mm), or multivessel (>2 target vessels) disease who underwent percutaneous coronary intervention (PCI) with EES in the prospective SEEDS (A Registry To Evaluate Safety And Effectiveness Of Everolimus Drug Eluting Stent For Coronary Revascularization) trial were categorised into low (<6), mid (>6-<12) and high (>12) baseline SYNTAX score (bSS) groups, and into low (=0), mid (>0-<5) and high (>5) rSS groups. Mean bSS and rSS were 10.87±7.26 and 2.18±3.97, respectively; 64% of patients had complete revascularisation (rSS=0). At 12 months the primary outcome of ischaemia-driven target vessel failure (TVF, composite of cardiac death, target vessel myocardial infarction and ischaemia-driven target vessel revascularisation) was significantly higher in the high bSS and rSS groups than in the respective lower groups (p<0.01 for both). In multivariable analysis, rSS was an independent predictor of TVF (hazard ratio: 1.403, 95% confidence interval: 1.081 to 1.820, p=0.01).
Conclusions: Twelve-month TVF was significantly higher in the highest rSS group; rSS with a cut-off of 5 might therefore allow the risk stratification of patients with complex lesions treated with a second-generation drug-eluting stent (Clinical-Trials.gov identifier: NCT 01157455).
Trial registration: ClinicalTrials.gov NCT01157455.
Source: PubMed