Long-term effects of pediatric extracorporeal shockwave lithotripsy on renal function

Yigit Akin, Selcuk Yucel, Yigit Akin, Selcuk Yucel

Abstract

Introduction: Extracorporeal shock wave lithotripsy (ESWL) is a well-known and successful treatment modality. In addition, it can be used in premature infants. ESWL is used to treat kidney and ureter stones in children. However, although it is a preferred noninvasive treatment in that setting, there is debate about its long-term effects on growing kidneys in children.

Objectives: To investigate the long-term effects of pediatric ESWL on renal function in light of updated literature.

Methods: PubMed and Medline were searched for studies on ESWL in a pediatric population with keywords including efficacy, child, kidney calculi, ureter calculi, lithotripsy, injury, vascular trauma, and shock waves. The research was limited to the English literature during a period from 1980 to 2014. In total, 3,000 articles were evaluated, but only 151 papers were considered. Only the manuscripts directly related to the reviewed subjects were included in the current study.

Results: However, the acute effects of ESWL in kidney are well-described. Although there are limited studies on the long-term effects of ESWL in children, there is a widespread opinion that ESWL is not affecting renal functions in the long-term.

Conclusion: ESWL is a safe, effective, and noninvasive treatment option in children. Although ESWL can cause some acute effects in the kidney, there is no long-term effect on the growing kidneys of children.

Keywords: child; lithotripsy; nephrolithiasis; renal injury; vascular trauma.

References

    1. Chaussy C, Schüller J, Schmiedt E, Brandl H, Jocham D, Liedl B. Extracorporeal shock-wave lithotripsy (ESWL) for treatment of urolithiasis. Urology. 1984;23(5 Spec):59–66.
    1. Newman DM, Coury T, Lingeman JE, et al. Extracorporeal shock wave lithotripsy experience in children. J Urol. 1986;136(1 Pt 2):238–240.
    1. Cohen TD, Ehreth J, King LR, Preminger GM. Pediatric urolithiasis: medical and surgical management. Urology. 1996;47(3):292–303.
    1. Sarica K. Pediatric urolithiasis: etiology, specific pathogenesis and medical treatment. Urol Res. 2006;34(2):96–101.
    1. Skolarikos A, Alivizatos G, de la Rosette J. Extracorporeal shock wave lithotripsy 25 years later: complications and their prevention. Eur Urol. 2006;50(5):981–990.
    1. Sun BY, Lee YH, Jiaan BP, Chen KK, Chang LS, Chen KT. Recurrence rate and risk factors for urinary calculi after extracorporeal shock wave lithotripsy. J Urol. 1996;156(3):903–905.
    1. McAteer JA, Evan AP. The acute and long-term adverse effects of shock wave lithotripsy. Semin Nephrol. 2008;28(2):200–213.
    1. Kaji DM, Xie HW, Hardy BE, Sherrod A, Huffman JL. The effects of extracorporeal shock wave lithotripsy on renal growth, function and arterial blood pressure in an animal model. J Urol. 1991;146(2(Pt 2)):544–547.
    1. Cimentepe E, Eroglu M, Oztürk U, et al. Rapid communication: renal apoptosis after shockwave application in rabbit model. J Endourol. 2006;20(12):1091–1095.
    1. Lottmann HB, Archambaud F, Traxer O, Mercier-Pageyral B, Helal B. The efficacy and parenchymal consequences of extracorporeal shock wave lithotripsy in infants. BJU Int. 2000;85(3):311–315.
    1. Goel MC, Baserge NS, Babu RV, Sinha S, Kapoor R. Pediatric kidney: functional outcome after extracorporeal shock wave lithotripsy. J Urol. 1996;155(6):2044–2046.
    1. Dogan HS, Tekgul S. Management of pediatric stone disease. Curr Urol Rep. 2007;8(2):163–173.
    1. Tekgül S, Riedmiller H, Dogan HS. Guidelines on Paediatric Urology. Arnheim, The Netherlands: European Association of Urology; 2013. [Accessed February 4, 2014]. Available from: .
    1. Gnessin E, Chertin L, Chertin B. Current management of paediatric urolithiasis. Pediatr Surg Int. 2012;28(7):659–665.
    1. Brinkmann OA, Griehl A, Kuwertz-Bröking E, Bulla M, Hertle L. Extracorporeal shock wave lithotripsy in children. Efficacy, complications and long-term follow-up. Eur Urol. 2001;39(5):591–597.
    1. Muslumanoglu AY, Tefekli A, Sarilar O, Binbay M, Altunrende F, Ozkuvanci U. Extracorporeal shock wave lithotripsy as first line treatment alternative for urinary tract stones in children: a large scale retrospective analysis. J Urol. 2003;170(6 Pt 1):2405–2408.
    1. Yucel S, Akin Y, Danisman A, Guntekin E. Complications and associated factors of pediatric extracorporeal shock wave lithotripsy. J Urol. 2012;187(5):1812–1816.
    1. Fayad A, El-Sheikh MG, Abdelmohsen M, Abdelraouf H. Evaluation of renal function in children undergoing extracorporeal shock wave lithotripsy. J Urol. 2010;184(3):1111–1114.
    1. Bilen CY, Gunay M, Ozden E, Inci K, Sarikaya S, Tekgul S. Tubeless mini percutaneous nephrolithotomy in infants and preschool children: a preliminary report. J Urol. 2010;184(6):2498–2502.
    1. Newman R, Hackett R, Senior D, et al. Pathologic effects of ESWL on canine renal tissue. Urology. 1987;29(2):194–200.
    1. Shao Y, Connors BA, Evan AP, Willis LR, Lifshitz DA, Lingeman JE. Morphological changes induced in the pig kidney by extracorporeal shock wave lithotripsy: nephron injury. Anat Rec A Discov Mol Cell Evol Biol. 2003;275(1):979–989.
    1. Kaude JV, Williams CM, Millner MR, Scott KN, Finlayson B. Renal morphology and function immediately after extracorporeal shock-wave lithotripsy. AJR Am J Roentgenol. 1985;145(2):305–313.
    1. Baskin LS, Stoller ML. Severe haemorrhage after extracorporeal shock wave lithotripsy: radiological evaluation. Br J Urol. 1992;69(2):214–215.
    1. Maziak DE, Ralph-Edwards A, Deitel M, Wait J, Watt HJ, Marcuzzi A. Massive perirenal and intra-abdominal bleeding after shock-wave lithotripsy: case report. Can J Surg. 1994;37(4):329–332.
    1. Krishnamurthi V, Streem SB. Long-term radiographic and functional outcome of extracorporeal shock wave lithotripsy induced perirenal hematomas. J Urol. 1995;154(5):1673–1675.
    1. Aksoy Y, Ozbey I, Atmaca AF, Polat O. Extracorporeal shock wave lithotripsy in children: experience using a mpl-9000 lithotriptor. World J Urol. 2004;22(2):115–119.
    1. Castillon I, Frieyro O, Gonzalez-Enguita C, Vela-Navarrete R. Colonic perforation after extracorporeal shock wave lithotripsy. BJU Int. 1999;83(6):720–721.
    1. Beatrice J, Strebel RT, Pfammatter T, Röhweder JH, Sulser T. Life-threatening complication after right renal extracorporeal shock wave lithotripsy: large hepatic haematoma requiring embolisation of the right hepatic artery. Eur Urol. 2007;52(3):909–911.
    1. Fugita OE, Trigo-Rocha F, Mitre AI, Arap S. Splenic rupture and abscess after extracorporeal shock wave lithotripsy. Urology. 1998;52(2):322–323.
    1. Karakayali F, Sevmiş S, Ayvaz I, Tekin I, Boyvat F, Moray G. Acute necrotizing pancreatitis as a rare complication of extracorporeal shock wave lithotripsy. Int J Urol. 2006;13(5):613–615.
    1. Hassan I, Zietlow SP. Acute pancreatitis after extracorporeal shock wave lithotripsy for a renal calculus. Urology. 2002;60(6):1111.
    1. Oğuzülgen IK, Oğuzülgen AI, Sinik Z, Köktürk O, Ekim N, Karaoğlan U. An unusual cause of urinothorax. Respiration. 2002;l69(3):273–274.
    1. Neri E, Capannini G, Diciolla F, et al. Localized dissection and delayed rupture of the abdominal aorta after extracorporeal shock wave lithotripsy. J Vasc Surg. 2000;31(5):1052–1055.
    1. Tiede JM, Lumpkin EN, Wass CT, Long TR. Hemoptysis following extracorporeal shock wave lithotripsy: a case of lithotripsy-induced pulmonary contusion in a pediatric patient. J Clin Anesth. 2003;15(7):530–533.
    1. Meyer JJ, Cass AS. Subcapsular hematoma of the liver after renal extracorporeal shock wave lithotripsy. J Urol. 1995;154(2 Pt 1):516–517.
    1. Morris JS, Husmann DA, Wilson WT, Preminger GM. Temporal effects of shock wave lithotripsy. J Urol. 1991;145(4):881–883.
    1. Lifshitz DA, Lingeman JE, Zafar FS, Hollensbe DW, Nyhuis AW, Evan AP. Alterations in predicted growth rates of pediatric kidneys treated with extracorporeal shockwave lithotripsy. J Endourol. 1998;12(5):469–475.
    1. Claro Jde A, Denardi F, Ferreira U, Rodrigues Netto N, Jr, Saldanha LB, Figueiredo JF. Effects of extracorporeal shockwave lithotripsy on renal growth and function: an animal model. J Endourol. 1994;8(3):191–194.
    1. Vlajković M, Slavković A, Radovanović M, Sirić Z, Stefanović V, Perović S. Long-term functional outcome of kidneys in children with urolithiasis after ESWL treatment. Eur J Pediatr Surg. 2002;12(2):118–123.
    1. Griffin SJ, Margaryan M, Archambaud F, Sergent-Alaoui A, Lottmann HB. Safety of shock wave lithotripsy for treatment of pediatric urolithiasis: 20-year experience. J Urol. 2010;183(6):2332–2336.
    1. McCullough DL, Yeaman LD, Bo WJ, et al. Effects of shock waves on the rat ovary. J Urol. 1989;141(3):666–669.
    1. Krambeck AE, Gettman MT, Rohlinger AL, Lohse CM, Patterson DE, Segura JW. Diabetes mellitus and hypertension associated with shock wave lithotripsy of renal and proximal ureteral stones at 19 years of followup. J Urol. 2006;175(5):1742–1747.
    1. El-Nahas AR, Awad BA, El-Assmy AM, et al. Are there long-term effects of extracorporeal shockwave lithotripsy in paediatric patients? BJU Int. 2013;111(4):666–671.
    1. de Cógáin M, Krambeck AE, Rule AD, et al. Shock wave lithotripsy and diabetes mellitus: a population-based cohort study. Urology. 2012;79(2):298–302.
    1. Krambeck AE, Rule AD, Li X, Bergstralh EJ, Gettman MT, Lieske JC. Shock wave lithotripsy is not predictive of hypertension among community stone formers at long-term followup. J Urol. 2011;185(1):164–169.
    1. Frick J, Sarica K, Köhle R, Kunit G. Long-term follow-up after extra-corporeal shock wave lithotripsy in children. Eur Urol. 1991;9(3):225–229.
    1. Willis LR, Evan AP, Connors BA, et al. Shockwave lithotripsy: dose-related effects on renal structure, hemodynamics, and tubular function. J Endourol. 2005;19(1):90–101.
    1. Connors BA, Evan AP, Blomgren PM, et al. Reducing shock number dramatically decreases lesion size in a juvenile kidney model. J Endourol. 2006;20(9):607–611.
    1. Connors BA, Evan AP, Willis LR, Blomgren PM, Lingeman JE, Fineberg NS. The effect of discharge voltage on renal injury and impairment caused by lithotripsy in the pig. J Am Soc Nephrol. 2000;11(2):310–318.
    1. Delius M, Enders G, Xuan ZR, Liebich HG, Brendel W. Biological effects of shock waves: kidney damage by shock waves in dogs – dose dependence. Ultrasound Med Biol. 1981;4(2):117–122.
    1. Newman LH, Saltzman B. Identifying risk factors in development of clinically significant post-shock-wave lithotripsy subcapsular hematomas. Urology. 1991;38(1):35–38.
    1. Ozgür BC, Irkilata L, Ekici M, et al. Pediatric extracorporeal shock wave lithotripsy: Multi-institutional results. Urologia. 2014 Feb 26; Epub.
    1. Pishchalnikov YA, McAteer JA, Williams JC, Jr, et al. Evaluation of the LithoGold LG-380 lithotripter: in vitro acoustic characterization and assessment of renal injury in the pig model. J Endourol. 2013;27(5):631–639.
    1. Connors BA, McAteer JA, Evan AP, et al. Evaluation of shock wave lithotripsy injury in the pig using a narrow focal zone lithotriptor. BJU Int. 2012;110(9):1376–1385.

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