Fluid accumulation threshold measured by acute body weight change after admission in general surgical intensive care units: how much should be concerning?

Abstract

Background: The objective of this study (ClinicalTrials.gov: NCT01351506) was to identify the threshold level of fluid accumulation measured by acute body weight (BW) change during the first week in a general surgical intensive care unit (ICU), which is associated with ICU mortality and other adverse outcomes.

Methods: Four hundred sixty-five patients were prospectively followed for a 28-day period. The maximum BW change threshold during the first week was evaluated by the maximum percentage change in BW from the ICU admission weight (Max%ΔBW). Daily screening of adverse events in the ICU were recorded. The cutoff point of Max%ΔBW on ICU mortality was defined by considering the area under the receiver operating characteristic (ROC) curve, intersection of the sensitivity and specificity, and the Youden Index. Univariable and multivariable regression analyses were used to demonstrate the associations. Statistical significance was defined as P<0.05.

Results: The appropriate cutoff value of Max%ΔBW threshold was 5%. Regarding the multivariable regression model, in overall patients, the occurrence of the following adverse events (expressed as adjusted odds ratio [95% confidence interval]) were significantly associated with a Max%ΔBW of >5%: ICU mortality (2.38 [1.25-4.54]) (P=0.008), ICU mortality in patients without renal replacement therapy (RRT) (2.47 [1.21-5.06]) (P=0.013), reintubation within 72 hours (2.51 [1.04-6.00]) (P=0.039), RRT requirement (2.67 [1.13-6.33]) (P=0.026), and delirium (1.97 [1.08-3.57]) (P=0.025). Regarding the postoperative subgroup, a Max%ΔBW value of more than 5% was significantly associated with: ICU mortality (3.87 [1.38-10.85]) (P=0.010), ICU mortality in patients without RRT (6.32 [1.85-21.64]) (P=0.003), reintubation within 72 hours (4.44 [1.30-15.16]) (P=0.017), and vasopressor requirement (2.04 [1.04-4.01]) (P=0.037).

Conclusion: Fluid accumulation, measured as acute BW change of more than the threshold of 5% during the first week of ICU admission, is associated with adverse outcomes of higher ICU mortality, especially in the patients without RRT, with reintubation within 72 hours, with RRT requirement, with vasopressor requirement, and with delirium. Some of these effects were higher in postoperative patients. This threshold value might be an indicator for caution during fluid management in surgical ICU.

Keywords: adverse events; body weight change; fluid accumulation; surgical intensive care unit.

Figures

Figure 1

The study flow and number of weighed patients within the first 7 days of ICU admission. Abbreviation: ICU, intensive care unit.

Figure 2

The box plot of the daily percentage weight change, categorized by ICU survival status. Note: The P-value was the value for comparison between, each day of surviving and nonsurviving patients, body weight change percentages. Abbreviation: ICU, intensive care unit.

Figure 3

The ROC curve (A) and the intersection of sensitivity and specificity to define the optimal cutoff point (B) of Max%ΔBW for ICU mortality. Abbreviations: CI, confidence interval; ICU, intensive care unit; Max%ΔBW, maximum percentage change in body weight; ROC, receiver-operating characteristics.

Figure 4

The OR and 95% CI of ICU mortality, categorized by six groups, of Max%ΔBW within the first week of ICU admission. Abbreviations: CI, confidence interval; ICU, intensive care unit; Max%ΔBW, maximum percentage change in body weight; OR, odds ratio.