The outcomes of kidney transplantation in hepatitis B surface antigen (HBsAg)-negative recipients receiving graft from HBsAg-positive donors: a retrospective, propensity score-matched study
W Chancharoenthana, N Townamchai, K Pongpirul, P Kittiskulnam, A Leelahavanichkul, Y Avihingsanon, C Suankratay, S Wattanatorn, W Kittikowit, K Praditpornsilpa, K Tungsanga, S Eiam-Ong, W Chancharoenthana, N Townamchai, K Pongpirul, P Kittiskulnam, A Leelahavanichkul, Y Avihingsanon, C Suankratay, S Wattanatorn, W Kittikowit, K Praditpornsilpa, K Tungsanga, S Eiam-Ong
Abstract
The outcomes of kidney transplantation (KT) from hepatitis B surface antigen-positive [HBsAg(+)] donors to HBsAg(-) recipients remain inconclusive, possibly due to substantial differences in methodological and statistical models, number of patients, follow-up duration, hepatitis B virus (HBV) prophylactic regimens and hepatitis B surface antibody (anti-HBs) levels. The present retrospective, longitudinal study (clinicaltrial.gov NCT02044588) using propensity score matching technique was conducted to compare outcomes of KT between HBsAg(-) recipients with anti-HBs titer above 100 mIU/mL undergoing KT from HBsAg(+) donors (n = 43) and HBsAg(-) donors (n = 86). During the median follow-up duration of 58.2 months (range 16.7-158.3 months), there were no significant differences in graft and patient survivals. No HBV-infective markers, including HBsAg, hepatitis B core antibody, hepatitis B extracellular antigen and HBV DNA quantitative test were detected in HBsAg(+) donor group. Renal pathology outcomes revealed comparable incidences of kidney allograft rejection while there were no incidences of HBV-associated glomerulonephritis and viral antigen staining. Recipients undergoing KT from HBsAg(+) donors with no HBV prophylaxis (n = 20) provided comparable outcomes with those treated with lamivudine alone (n = 21) or lamivudine in combination with HBV immunoglobulin (n = 2). In conclusion, KT without HBV prophylaxis from HBsAg(+) donors without hepatitis B viremia to HBsAg(-) recipients with anti-HBs titer above 100 mIU/mL provides excellent graft and patient survivals without evidence of HBV transmission.
Keywords: Clinical research/practice; donors and donation: donor-derived infections; graft survival; infection and infectious agents; infectious disease; kidney disease: infectious; kidney transplantation/nephrology; organ allocation; viral: hepatitis B.
© Copyright 2014 The American Society of Transplantation and the American Society of Transplant Surgeons.
Source: PubMed