Durability of stavudine, lamivudine and nevirapine among advanced HIV-1 infected patients with/without prior co-administration of rifampicin: a 144-week prospective study

Weerawat Manosuthi, Preecha Tantanathip, Wisit Prasithisirikul, Sirirat Likanonsakul, Somnuek Sungkanuparph, Weerawat Manosuthi, Preecha Tantanathip, Wisit Prasithisirikul, Sirirat Likanonsakul, Somnuek Sungkanuparph

Abstract

Background: To date, data on the durability of a regimen of stavudine, lamivudine and nevirapine are very limited, particularly from the resource-limited settings.

Methods: A prospective cohort study was conducted among 140 antiretroviral-naïve patients who were enrolled to initiate d4T, 3TC and NVP between November 2004 and March 2005. The objectives were to determine immunological and virological responses after 144 weeks of antiretroviral therapy. Seventy patients with tuberculosis also received rifampicin during the early period of antiviral treatment (TB group).

Results: Of all, median (IQR) baseline CD4 cell count was 31 (14-79) cells/mm3; median (IQR) baseline HIV-1 RNA was 433,500 (169,000-750,000) copies/mL. The average body weight was 55 kilograms. By intention-to-treat analysis at 144 weeks, the overall percentage of patients who achieved plasma HIV-1 RNA <50 copies/mL was 59.3% (83/140). In subgroup analysis, 61.4% (43/70) patients in TB group and 57.1% (40/70) patients in control group achieved plasma HIV-1 RNA <50 copies/mL (RR = 1.194, 95%CI = 0.608-2.346, P = 0.731). Eight (5.8%) patients discontinued d4T due to neuropathy and/or symptomatic lactic acidosis.

Conclusion: The overall durability and efficacy of antiviral response of d4T, 3TC and NVP are satisfied and they are not different between HIV-1 infected patients with and without co-administration of rifampicin due to tuberculosis. However, stavudine-related adverse effects are concerns.

Trial registration: ClinicalTrials.gov Identifier NCT00703898.

Figures

Figure 1
Figure 1
Proportion of patients who achieved undetectable plasma HIV-1 RNA

Figure 2

Mean CD 4 cell count…

Figure 2

Mean CD 4 cell count between TB and control groups.

Figure 2
Mean CD4 cell count between TB and control groups.

Figure 3

Drug resistance mutations in patients…

Figure 3

Drug resistance mutations in patients with virological failure.

Figure 3
Drug resistance mutations in patients with virological failure.
Figure 2
Figure 2
Mean CD4 cell count between TB and control groups.
Figure 3
Figure 3
Drug resistance mutations in patients with virological failure.

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