Efficacy of multiparametric telemonitoring on respiratory outcomes in elderly people with COPD: a randomized controlled trial

Claudio Pedone, Domenica Chiurco, Simone Scarlata, Raffaele Antonelli Incalzi, Claudio Pedone, Domenica Chiurco, Simone Scarlata, Raffaele Antonelli Incalzi

Abstract

Background: Chronic obstructive pulmonary disease (COPD) is a highly prevalent condition associated with a high health care resource consumption and health care expenditures, driven mainly by exacerbations-related hospitalizations. Telemedicine has been proposed as a mean for timely detection of exacerbation, but the available evidence is inadequate to provide conclusive information on its efficacy. The aim of this study is to evaluate the efficacy of a telemonitoring system in reducing COPD-related hospitalizations in an elderly population with COPD.

Methods: This is a parallel arms, randomized trial including patients aged 65 or older with COPD in GOLD stages II and III enrolled in a Pulmonary Medicine outpatient facility. Patients were randomly assigned to receive a non-invasive system able to telemonitor vital signs (oxygen saturation, heart rate, near-body temperature, overall physical activity) or standard care, and were followed up for 9 months. The outcome measures were the number of exacerbations and exacerbation-related hospitalization.

Results: Fifty patients were included in the telemonitoring group and 49 in the control group. The incidence rate of respiratory events was 28/100 person/years in the telemonitoring group vs. 42/100 person/years in the control group (incidence rate ratio: 0.67, 95% CI: 0.32 - 1.36). The corresponding figures for hospital admissions where 13/100 person/years and 20/100 person/years, respectively (IRR: 0.66, 95% CI: 0.21 - 1.86).

Conclusions: In our study, COPD patients followed up with the aid of a multiparametric remote monitoring system experienced a lower rate of exacerbations and COPD-related hospitalizations compared to patients followed up using the standard model of care. These results need to be replicated in larger studies before they can be applied to the general COPD population.

Trial registration number: NCT01481506 (clinicaltrials.gov).

Funding: co-financed by Lazio Region and Intersistemi Inc.

Figures

Figure 1
Figure 1
Flow diagram of the study.
Figure 2
Figure 2
Cumulative incidence of events.
Figure 3
Figure 3
Arterial oxygen saturation in the three days preceding the respiratory event. Trend of the arterial oxygen saturation in the three days before a respiratory event. Each line represents data from a single patient.

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