Genetic Diversity of Cryptosporidium hominis in a Bangladeshi Community as Revealed by Whole-Genome Sequencing
Carol A Gilchrist, James A Cotton, Cecelia Burkey, Tuhinur Arju, Allissia Gilmartin, Ye Lin, Emtiaz Ahmed, Kevin Steiner, Masud Alam, Shahnawaz Ahmed, Guy Robinson, Sultan Uz Zaman, Mamun Kabir, Mandy Sanders, Rachel M Chalmers, Tahmeed Ahmed, Jennie Z Ma, Rashidul Haque, Abu S G Faruque, Matthew Berriman, William A Petri, Carol A Gilchrist, James A Cotton, Cecelia Burkey, Tuhinur Arju, Allissia Gilmartin, Ye Lin, Emtiaz Ahmed, Kevin Steiner, Masud Alam, Shahnawaz Ahmed, Guy Robinson, Sultan Uz Zaman, Mamun Kabir, Mandy Sanders, Rachel M Chalmers, Tahmeed Ahmed, Jennie Z Ma, Rashidul Haque, Abu S G Faruque, Matthew Berriman, William A Petri
Abstract
We studied the genetic diversity of Cryptosporidium hominis infections in slum-dwelling infants from Dhaka over a 2-year period. Cryptosporidium hominis infections were common during the monsoon, and were genetically diverse as measured by gp60 genotyping and whole-genome resequencing. Recombination in the parasite was evidenced by the decay of linkage disequilibrium in the genome over <300 bp. Regions of the genome with high levels of polymorphism were also identified. Yet to be determined is if genomic diversity is responsible in part for the high rate of reinfection, seasonality, and varied clinical presentations of cryptosporidiosis in this population.
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References
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Source: PubMed