Routine ketorolac at oocyte retrieval decreases postoperative narcotic use by more than 50

Emily A Seidler, Denis A Vaughan, Angela Q Leung, Denny Sakkas, David A Ryley, Alan S Penzias, Emily A Seidler, Denis A Vaughan, Angela Q Leung, Denny Sakkas, David A Ryley, Alan S Penzias

Abstract

Objective: To study the impact of routine ketorolac administration during oocyte retrieval on the proportion of patients who require postoperative narcotics for analgesia.

Design: Retrospective cohort study.

Setting: Single, university-affiliated infertility clinic.

Patients: All women undergoing oocyte retrieval between July and November 2016 (non-ketorolac group [NKG]; n = 826) and April-August 2017 (ketorolac group, KG; n = 1780).

Interventions: A single 30 mg intravenous dose of ketorolac was administered after the oocyte retrieval procedure.

Main outcome measures: The number of patients who required postoperative narcotic analgesia, postoperative complication rate, and fresh embryo transfer pregnancy outcomes were examined.

Results: In the KG, we found a significant decrease in the patients who required narcotics after oocyte retrieval compared with the NKG (12% KG vs. 25.5% NKG). We found no significant change in the clinical pregnancy rate (CPR) resulting from fresh embryo transfer after our intervention (NKG CPR 32.6%, KG CPR 32.4%). Furthermore, there was no increase in postoperative bleeding complications in the KG.

Conclusions: Routine use of ketorolac at the time of oocyte retrieval may decrease the rate of postoperative opioid use without adversely impacting pregnancy and complication rates.

Keywords: IVF; NSAID; ketorolac; non-narcotic analgesia; oocyte retrieval; postoperative pain control.

© 2021 The Authors.

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Source: PubMed

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