Effect of exercise intervention on endothelial function and incidence of cardiovascular disease in patients with type 2 diabetes
Sadanori Okada, Aki Hiuge, Hisashi Makino, Ayako Nagumo, Hiroshi Takaki, Harumi Konishi, Yoichi Goto, Yasunao Yoshimasa, Yoshihiro Miyamoto, Sadanori Okada, Aki Hiuge, Hisashi Makino, Ayako Nagumo, Hiroshi Takaki, Harumi Konishi, Yoichi Goto, Yasunao Yoshimasa, Yoshihiro Miyamoto
Abstract
Aim: The effects of exercise intervention and to assess its long-term efficacy in preventing subsequent cardiovascular events in patients with type 2 diabetes were little known on randomized controlled trial.
Methods: Thirty-eight type 2 diabetic patients (21 men and 17 women) were assigned to either the exercise group (n=21) or the control group without exercise training (n=17) by simple randomization. The exercise training group was scheduled for aerobic and resistance exercise programs for 3 months. After the 3-month, we investigated endothelial function, insulin resistance, adipocytokines and inflammatory markers. The endothelial function was evaluated by examining a flow-mediated endothelium-dependent vasodilatation (FMD). Furthermore, we followed the incidence of cardiovascular events for 24 months.
Results: After 3-month, HbA1C was decreased significantly in both groups. FMD was increased from 7.3+/-4.7% to 10.9+/-6.2% only in the exercise group (p<0.05). Long-term follow-up data showed that the control group developed cardiovascular events more frequently than did the exercise group (p<0.05).
Conclusions: Exercise improves endothelial dysfunction independently of glycemic control and insulin sensitivity in patients with type 2 diabetes. The beneficial effects of 3-month exercise to reduce cardiovascular events persist for 24 months.
Source: PubMed