The Integrative Human Microbiome Project
Integrative HMP (iHMP) Research Network Consortium, Lita M Proctor, Heather H Creasy, Jennifer M Fettweis, Jason Lloyd-Price, Anup Mahurkar, Wenyu Zhou, Gregory A Buck, Michael P Snyder, Jerome F Strauss 3rd, George M Weinstock, Owen White, Curtis Huttenhower, Integrative HMP (iHMP) Research Network Consortium, Lita M Proctor, Heather H Creasy, Jennifer M Fettweis, Jason Lloyd-Price, Anup Mahurkar, Wenyu Zhou, Gregory A Buck, Michael P Snyder, Jerome F Strauss 3rd, George M Weinstock, Owen White, Curtis Huttenhower
Abstract
The NIH Human Microbiome Project (HMP) has been carried out over ten years and two phases to provide resources, methods, and discoveries that link interactions between humans and their microbiomes to health-related outcomes. The recently completed second phase, the Integrative Human Microbiome Project, comprised studies of dynamic changes in the microbiome and host under three conditions: pregnancy and preterm birth; inflammatory bowel diseases; and stressors that affect individuals with prediabetes. The associated research begins to elucidate mechanisms of host-microbiome interactions under these conditions, provides unique data resources (at the HMP Data Coordination Center), and represents a paradigm for future multi-omic studies of the human microbiome.
Conflict of interest statement
M.S. is a cofounder of Personalis, Qbio, Sensomics, January, Filtricine and Akna and advisor for Genapsys. The other authors declare no competing interests.
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References
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Source: PubMed