Soluble Flt1 levels are associated with cardiac dysfunction in Black women with and without severe preeclampsia

Lisa Levine, Zolt Arany, Adina Kern-Goldberger, Nathanael Koelper, Jennifer Lewey, Mary D Sammel, Michal A Elovitz, Bonnie Ky, Lisa Levine, Zolt Arany, Adina Kern-Goldberger, Nathanael Koelper, Jennifer Lewey, Mary D Sammel, Michal A Elovitz, Bonnie Ky

Abstract

Background: We evaluate soluble fms-like tyrosine kinase-1 (sFlt-1) levels and cardiac function during pregnancy and postpartum among Black women with and without preeclampsia. Study design: Prospective longitudinal cohort study from 2015 to 2017 of Black women with preterm severe preeclampsia and normotensive pregnant controls.We obtained echocardiograms and sFlt-1 levels during pregnancy and postpartum. Results: 93 Black women were included (43 cases, 50 controls). Higher sFlt1 levels were correlated with worse longitudinal strain, diastolic dysfunction, decreased ventricular-arterial coupling, and increased chamber and arterial elastance at the time of preeclampsia diagnosis and postpartum. Conclusions: Higher sFlt1 levels are associated with cardiovascular dysfunction during pregnancy and postpartum.

Keywords: Black women; cardiac function; echocardiogram; longitudinal strain; preeclampsia; soluble Flt.

Figures

Figure 1:. Correlation between baseline sFlt1 levels…
Figure 1:. Correlation between baseline sFlt1 levels and echocardiogram measurements at baseline visit (visit 1) and postpartum (visit 2).
Description: Pairwise spearman rank correlation between baseline sFlt1 levels and echocardiogram measurements at baseline visit (visit 1) and postpartum (visit 2). Blue hue indicates positive correlation; red hue indicates negative correlation. Darker shading indicates stronger correlation. † denotes p-value

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