Awareness and knowledge about human papillomavirus vaccination and its acceptance in China: a meta-analysis of 58 observational studies

Yanru Zhang, Ying Wang, Li Liu, Yunzhou Fan, Zhihua Liu, Yueyun Wang, Shaofa Nie, Yanru Zhang, Ying Wang, Li Liu, Yunzhou Fan, Zhihua Liu, Yueyun Wang, Shaofa Nie

Abstract

Background: The human papillomavirus (HPV) vaccines have been widely introduced in immunization programs worldwide, however, it is not accepted in mainland China. We aimed to investigate the awareness and knowledge about HPV vaccines and explore the acceptability of vaccination among the Chinese population.

Methods: A meta-analysis was conducted across two English (PubMed, EMBASE) and three Chinese (China National Knowledge Infrastructure, Wan Fang Database and VIP Database for Chinese Technical Periodicals) electronic databases in order to identify HPV vaccination studies conducted in mainland China. We conducted and reported the analysis in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines.

Results: Fifty-eight unique studies representing 19 provinces and municipalities in mainland China were assessed. The pooled awareness and knowledge rates about HPV vaccination were 15.95 % (95 % CI: 12.87-19.29, I (2) = 98.9 %) and 17.55 % (95 % CI: 12.38-24.88, I (2) = 99.8 %), respectively. The female population (17.39 %; 95 % CI: 13.06-22.20, I (2) = 98.8 %) and mixed population (18.55 %; 95 % CI: 14.14-23.42, I (2) = 98.8 %) exhibited higher HPV vaccine awareness than the male population (1.82 %; 95 % CI: 0.50-11.20, I (2) = 98.5 %). Populations of mixed ethnicity had lower HPV vaccine awareness (9.61 %; 95 % CI: 5.95-14.03, I (2) = 99.0 %) than the Han population (20.17 %; 95 % CI: 16.42-24.20, I (2) = 98.3 %). Among different regions, the HPV vaccine awareness was higher in EDA (17.57 %; 95 % CI: 13.36-22.21, I (2) = 98.0 %) and CLDA (17.78 %; 95 % CI: 12.18-24.19, I (2) = 97.6 %) than in WUDA (1.80 %; 95 % CI: 0.02-6.33, I (2) = 98.9 %). Furthermore, 67.25 % (95 % CI: 58.75-75.21, I (2) = 99.8 %) of participants were willing to be vaccinated, while this number was lower for their daughters (60.32 %; 95 % CI: 51.25-69.04, I (2) = 99.2 %). The general adult population (64.72 %; 95 % CI: 55.57-73.36, I (2) = 99.2 %) was more willing to vaccinate their daughters than the parent population (33.78 %; 95 % CI: 26.26-41.74, I (2) = 88.3 %). Safety (50.46 %; 95 % CI: 40.00-60.89, I (2) = 96.6 %) was the main concern about vaccination among the adult population whereas the safety and efficacy (68.19 %; 95 % CI: 53.13-81.52, I (2) = 98.6 %) were the main concerns for unwillingness to vaccinate their daughters.

Conclusions: Low HPV vaccine awareness and knowledge was observed among the Chinese population. HPV vaccine awareness differed across sexes, ethnicities, and regions. Given the limited quality and number of studies included, further research with improved study designis necessary.

Figures

Fig. 1
Fig. 1
PRISMA Flow Diagram for Identification of Studies for Meta-analysis
Fig. 2
Fig. 2
Forest Plot of meta-analysis for HPV vaccine awareness in mainland China, the pooled rate and 95 % CI in the article are from random effects model due to significant heterogeneity which was measured by I2 statistics
Fig. 3
Fig. 3
Forest Plot of meta-analysis for HPV vaccine knowledge in mainland China, the pooled rate and 95 % CI in the article are from random effects model due to significant heterogeneity which was measured by I2 statistics
Fig. 4
Fig. 4
Forest Plot of meta-analysis for acceptability of HPV vaccination(for themselves) in mainland China, the pooled rate and 95 % CI in the article are from random effects model due to significant heterogeneity which was measured by I2 statistics
Fig. 5
Fig. 5
Forest Plot of meta-analysis for acceptability of HPV vaccination(for daughters) in mainland China, the pooled rate and 95 % CI in the article are from random effects model due to significant heterogeneity which was measured by I2 statistics

References

    1. Herzog TJ. New approaches for the management of cervical cancer. Gynecol Oncol. 2003;90(3 Pt 2):S22–7. doi: 10.1016/S0090-8258(03)00466-9.
    1. Mishra GA, Pimple SA, Shastri SS. An overview of prevention and early detection of cervical cancers. Indian J Med Paediatr Oncol. 2011;32(3):125–32. doi: 10.4103/0971-5851.92808.
    1. Arbyn M, Walker A, Meijer CJ. HPV-based cervical-cancer screening in China. Lancet Oncol. 2010;11(12):1112–3. doi: 10.1016/S1470-2045(10)70262-X.
    1. Levine OS, Bloom DE, Cherian T, de Quadros C, Sow S, Wecker J, Duclos P, Greenwood B. The future of immunisation policy, implementation, and financing. Lancet. 2011;378(9789):439–48.
    1. Choi HC, Leung GM, Woo PP, Jit M, Wu JT. Acceptability and uptake of female adolescent HPV vaccination in Hong Kong: a survey of mothers and adolescents. Vaccine. 2013;32(1):78–84. doi: 10.1016/j.vaccine.2013.10.068.
    1. Jarrett C, Wilson R, O’Leary M, Eckersberger E, Larson HJ, Hesitancy SWGoV Strategies for addressing vaccine hesitancy - A systematic review. Vaccine. 2015;33(34):4180–90. doi: 10.1016/j.vaccine.2015.04.040.
    1. Moher D, Liberati A, Tetzlaff J, Altman DG, Group P. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med. 2009;6(7):e1000097. doi: 10.1371/journal.pmed.1000097.
    1. Combie I. Pocket guide to critical appraisal. London: John Wiley&Sons; 1996.
    1. Meiling L, Hongzhuan T, Quan Z, Shaya W, Chang C, Yawei G, Lin S. Realizing the meta-analysis of single rate in R software. J Evid Based Med. 2013;13(3):181–8.
    1. Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ. 1997;315(7109):629–34. doi: 10.1136/bmj.315.7109.629.
    1. Jing X, Yanqin L. Analysis of HPV and HPV vaccine awareness and attitude among College students. Youjiang National Med J. 2014;36(1):72–3.
    1. Xiaojing M, Xiangju M, Jieyun D, Liuge Z, Jing Z, Qianqian Z, Ningning S. Analysis of human papiollomavirus recognition and its influential factors among adult female. Prog Obstet Gynecol. 2013;22(6):491–3.
    1. Bo C. The analysis of the awareness of human papillomavirus (HPV) and HPV vaccine and the willingness of vaccination among Urban and Rural women. Dalian Medical University: Master; 2010.
    1. Juan L. The Analysis of the awareness of human papillomavirus (HPV) and HPV vaccine among Doctors and government officials. Dalian Medical University: Master; 2011.
    1. Xuemin W, Xiangxian F, Yanli Z, Cailing W, Youlin Q. Cervical cancer screening and acceptance of HPV vaccine in women of Shanxi province. Chin J Pubilic Health. 2012;28(5):650–1.
    1. Hong Y, Zhang C, Li X, Lin D, Liu Y. HPV and cervical cancer related knowledge, awareness and testing behaviors in a community sample of female sex workers in China. BMC Public Health. 2013;13:696. doi: 10.1186/1471-2458-13-696.
    1. Shujuan S, Tianfu Y, Liqin Z. HPV infection in female and the cognition about HPV and HPV vaccine. J Tianjin Med Univ. 2013;19(2):127–30. doi: 10.1007/s12209-013-1803-4.
    1. Wenyu X, Juanwen C, Xiaoyan L, Jiaoying Y. Human papilloma virus infection rate of young female and the survey analysis related of knowledge, attitude and behavior. J Qiqihar Univ Med. 2013;34(13):1880–2.
    1. Chenglian Y, Gang C, Xiumei H, Yueqiu C, Caipin H, Sujuan N, Tie L. Human papillomavirus infection status and investigation of HPV recognition of migrant women. Zhejiang Prev Med. 2012;24(12):64–6.
    1. Wang SM, Zhang SK, Pan XF, Ren ZF, Yang CX, Wang ZZ, Gao XH, Li M, Zheng QQ, Ma W, et al. Human papillomavirus vaccine awareness, acceptability, and decision-making factors among Chinese college students. Asian Pac J Cancer Prev. 2014;15(7):3239–45. doi: 10.7314/APJCP.2014.15.7.3239.
    1. Xiange Long,Chuyue C,Li Z,Yeping C. Investigation of human papillomavirus related knowledge recognition level among higher vocational medical laboratory students. Sci Technol Inf. 2011;32:244-244.
    1. Lina X, Qianya Z, Tao L, Lirong J, Liqin Z, Xiangxian F, Junfei M, Fanghui Z. Investigation of human papillomavirus vaccine recognition and vaccination willingness in HUABEI region. Shanxi Med J. 2013;18:990–3.
    1. Baojian F. Investigation of the cervical cancer screening, HPV infection and HPV vaccine cognitive level among the women at clinical of gynecology. Liaoning University of Traditional Chinese Medicine: Master; 2009.
    1. Jing C, Rezim D, Abliz G, Mijit P, Hua L. Investigation of the awareness of cervical cancer and HPV in Uyghur men from rural area of Kashgar Payzawat of Xinjiang. J Xinjiang Med Univ. 2013;36(9):1365–8.
    1. Ying W. An investigation of the cognition and reception towards HPV vaccine among women living in Hangzhou. Chin Prev Med. 2011;12(4):321–3.
    1. Ablimit X, Abduxkur G, Abliz G. The investigation of the factors related to the knowledge of cervical cancer and HPV in Uygur women. J Xinjiang Med Univ. 2009;32(5):522–5.
    1. Li L. The Investigation of the Prevenlance of the HPV infection, Cervical Cancer and the Acceptance of HPV Vaccine in Uygur Women in Xinjiang Province. Xinjiang Medical University: Doctor; 2010.
    1. Haishan H, Xueling W, Zefang R, Xiaomin Z, Fanghui Z, Youlin Q. Investigation on acceptance of HPV vaccination and its determinants among the parents of junior high school students in Guangzhou. Chin J Dis Control Prev. 2014;18(7):659–62.
    1. Xin H, Shucai L, Mingchen C, Xiaoli W, Hongtu L, Tianjiang M. Investigation on consciousness about human papillomavirus and cervical cancer in college students. Mod Prev Med. 2010;37(21):4097–8.
    1. Dong M, Hui Q, Haiqiu W, Tianming L, Yan Y, Ou L. Investigation on the cognition and acceptability of medical personnel to human papillomavirus and its vaccine in a hospital of Tangshan city. Matern Child Health Care China. 2012;27(3):397–400.
    1. Haiqiu W, Dong M, Disi B. Investigation on the cognitions and attitudes of gynecologists and obstetricians to HPV and its vaccines in Tangshan city. Matern Child Health Care China. 2011;26(36):5772–4.
    1. Abduxkur G, Ismayil A, Abliz G. Investigation on the cognitive degree of Uighur men to cervical cancer and HPV in Hetian prefectureof Xinjiang Uighur autonomous region. Matern Child Health Care China. 2012;27:1203–5.
    1. He H, Fanghui Z, Yao X, Shaoming W, Xiongfei P, Hui L, Feng C, Chunxia Y, Youlin Q. Knowledge and attitude toward HPV and prophylactic HPV vaccine among college students in Chengdu. Mod Prev Med. 2013;40(16):3071–3.
    1. Li J, Li LK, Ma JF, Wei LH, Niyazi M, Li CQ, Xu AD, Wang JB, Liang H, Belinson J et al. Knowledge and attitudes about human papillomavirus (HPV) and HPV vaccines among women living in metropolitan and rural regions of China. Vaccine. 2009;27(8):1210–5.
    1. Wen Y, Pan XF, Zhao ZM, Chen F, Fu CJ, Li SQ, Zhao Y, Chang H, Xue QP, Yang CX. Knowledge of human papillomavirus (HPV) infection, cervical cancer, and HPV vaccine and its correlates among medical students in Southwest China: a multi-center cross-sectional survey. Asian Pac J Cancer Prev. 2014;15(14):5773–9.
    1. Zhao FH, Tiggelaar SM, Hu SY, Zhao N, Hong Y, Niyazi M, Gao XH, Ju LR, Zhang LQ, Feng XX et al. A multi-center survey of HPV knowledge and attitudes toward HPV vaccination among women, government officials, and medical personnel in China. Asian Pac J Cancer Prev. 2012;13(5):2369–78.
    1. Hui Z, Dongxue Y, Chaoxin L, Shaoming W, Yang X, Yuehua P, Dongming W, Jincong Y, Weiquan W. Parental acceptance of junior high school students for human papillomavirus vaccination: a survey at one school in Wuhan. J Public Health Prev Med. 2014;25(1):49–52.
    1. Zhang SK, Pan XF, Wang SM, Yang CX, Gao XH, Wang ZZ, Li M, Ren ZF, Zhao FH, Qiao YL. Perceptions and acceptability of HPV vaccination among parents of young adolescents: a multicenter national survey in China. Vaccine. 2013;31(32):3244–9.
    1. Yanhua H, Gaoping Z, Yan X, Yanhua J, Deyan L, Xinyin Z. A research about awareness and acceptance of HPV vaccines degrees in Shenzhen Luohu community. Mod Hosp. 2014;14(5):144–6.
    1. Dong M, Yan W, Ou L, Wenchang W. Study on medical students knowledge and attitudes regarding HPV and its vaccine. Matern Child Health Care China. 2013;28(28):4699–702.
    1. Mei H, Fanghui Z, Ying H, Jihong D, Longyu L. Survey on awareness and attitude towards HPV and HPV vaccination for cervical cancer prevention among urban women and medical professionals. China Cancer. 2011;20(7):483–8.
    1. Lixia Z. Survey of knowledge and infectious status of human papilloma virus in community and maternal female outpatients. China Trop Med. 2011;11(4):456–7.
    1. Jun Y, Xiaoli W, Xiaohui W. Survey on cognition of HPV vaccine among women living in high prevalence area of cervical cancer in Gansu Province. Chin J Health Educ. 2013;29(10):913–6.
    1. Jing Y, Hongying Y, Zhiling Y, Xianjie T. The survey on female sexuality and HPV awareness in Linxiang district of Yunnan province. Chongqing Yixue. 2013;29:3532–3.
    1. Wei X, Meilu B. Women’s knowledge, attitude, and international concerning cervical cancer screening and human papillomavirus vaccine. J China Japan Friendship Hosp. 2009;23(2):79–82.
    1. Suwen F. Women’s knowledge of Human papillomavirus(HPV) and their attitude towards HPV vaccine. Zhejiang University: Master; 2010.
    1. Yanqiu Z, Kai Z, Zhihong L, Zhangwei, Ruifang W. Analysis of cognition of women and medical personnel on HPV vaccine in Shenzhen city. Mod Diagn Treat. 2015;26(16):3683–4.
    1. Wenliu X, Bixia Z, Peipei J. Analysis of cognition and attitude of inpatients on HPV vaccine related knowledge in three grade A hospital in Hengyang city. Chin Nurs Res. 2015;29(4):1373–5.
    1. Ling W, Yanqiong O, Xiaohui W. Analysis of knowledge of cervical and HPV vaccine among 125 student nurses. J Nurs. 2015;22(17):47–50.
    1. Ling C, Can G, Shumei L. Study on full-time female medical masters’sexual behaviors and knowledge regarding human papillomavirus infection. Med Recapitulate. 2015;21(13):2481–3.
    1. Lihong C. Survey of infection rate and knowledge of HPV vaccine among women in Dongguan city, Guancheng district. Shenzhen J Integr Tradit Chin West Med. 2015;25(19):188–90.
    1. Zou H, Wang W, Ma Y, Wang Y, Zhao F, Wang S, Zhang S, Ma W. How university students view human papillomavirus (HPV) vaccination: A cross-sectional study in Jinan, China. Hum Vaccin Immunother. 2016;12(1):39-46.
    1. Zou H, Meng X, Jia T, Zhu C, Chen X, Li X, Xu J, Ma W, Zhang X. Awareness and acceptance of human papillomavirus (HPV) vaccination among males attending a major sexual health clinic in Wuxi, China: A cross-sectional study. Hum Vaccin immunother. 2015 (Epub ahead of print).
    1. Zhang SK, Pan XF, Wang SM, Yang CX, Gao XH, Wang ZZ, Li M, Ren ZF, Zheng QQ, Ma W et al. Knowledge of human papillomavirus vaccination and related factors among parents of young adolescents: a nationwide survey in China. Ann Epidemiol. 2015;25(4):231–5.
    1. Xiaomin Z, Zefang R, Xueling W, Wei L, Youlin Q. Knowledge and attitude of the students in Sun Yat-sen University regarding human papillomavirus and its vaccine. Mod Prev Med. 2015;42(10):1822–5.
    1. Wang W, Ma Y, Wang X, Zou H, Zhao F, Wang S, Zhang S, Zhao Y, Marley G, Ma W. Acceptability of human papillomavirus vaccine among parents of junior middle school students in Jinan. China Vaccine. 2015;33(22):2570–6.
    1. Qiong L, Dongling Q, Wenliu X, Yanping W. Survey of knowledge of HPV infection among 590 vocational school students. Today Nurs. 2015;5:158–9.
    1. Qiaoyang Z, Chuncha W, Yaping X, Yanyue C. Cervical cancer incidence and knowledge of cervical cancer and HPV among women. Chin J Pub Health Manage. 2015;31(5):768–9.
    1. Qian S, Hong L, HUa L, Liping Y. Survey of infection situation and knowledge of high risk HPV among women working in entertainment places in Gaoqiao area International. J Lab Med. 2015;36(8):1018–25.
    1. Liping M, Jianmei L, Yanhong J, Yuanwen L, Xuan H, Li Y. Analysis of women’s cognition to HPV and HPV vaccine in Bao’ann District. Shenzhen City J Pub Health Prev Med. 2015;26(5):54–7.
    1. Juhong L, Kai Z. Survey of HPV vaccine knowledgement and demand situation. Chin Gen Pract Nurs. 2015;13(16):1562–3.
    1. Gu C, Niccolai LM, Yang S, Wang X, Tao L. Human papillomavirus vaccine acceptability among female undergraduate students in China: the role of knowledge and psychosocial factors. J Clin Nurs. 2015;24(19–20):2765–78. doi: 10.1111/jocn.12871.
    1. Bixia Z, Wenliu X, Peipei J, Wangrong, Yanping W. Survey of HPV and HPV vaccine among women in Hengyang city. Chin Nurs Res. 2015;29(2):755–7.
    1. Ayizuoremu · mutailipu, Sayipujiamali · mijiti. Lin GG. Investigation and analysis on cognition of cervical cancer,HPV and HPV vaccine among Uygur and Han women in Xinjiang. Mater Child Health Care China. 2015;30(3):434–7.
    1. Abudukadeer A, Azam S, Mutailipu AZ, Qun L, Guilin G, Mijiti S. Knowledge and attitude of Uyghur women in Xinjiang province of China related to the prevention and early detection of cervical cancer. World J Surg Oncol. 2015;13:110. doi: 10.1186/s12957-015-0531-8.
    1. Pan XF, Zhao ZM, Sun J, Chen F, Wen QL, Liu K, Song GQ, Zhang JJ, Wen Y, Fu CJ et al. Acceptability and correlates of primary and secondary prevention of cervical cancer among medical students in southwest China: implications for cancer education. PLoS One. 2014;9(10):e110353.
    1. Fu CJ, Pan XF, Zhao ZM, Saheb-Kashaf M, Chen F, Wen Y, Yang CX, Zhong XN. Knowledge, perceptions and acceptability of HPV vaccination among medical students in Chongqing, China. Asian Pac J Cancer Prev. 2014;15(15):6187–93.
    1. Hu SY, Hong Y, Zhao FH, Lewkowitz AK, Chen F, Zhang WH, Pan QJ, Zhang X, Fei C, Li H et al. Prevalence of HPV infection and cervical intraepithelial neoplasia and attitudes towards HPV vaccination among Chinese women Aged 18–25 in Jiangsu Province. Chin J Cancer Res. 2011;23(1):25–32.
    1. Rathfisch G, Gungor I, Uzun E, Keskin O, Tencere Z. Human papillomavirus vaccines and cervical cancer: awareness, knowledge, and risk perception among Turkish undergraduate students. J Cancer Educ. 2015;30(1):116–23. doi: 10.1007/s13187-014-0703-1.
    1. Ozyer S, Uzunlar O, Ozler S, Kaymak O, Baser E, Gungor T, Mollamahmutoglu L. Awareness of Turkish female adolescents and young women about HPV and their attitudes towards HPV vaccination. Asian Pac J Cancer Prev. 2013;14(8):4877–81.
    1. Marlow LA, Zimet GD, McCaffery KJ, Ostini R, Waller J. Knowledge of human papillomavirus (HPV) and HPV vaccination: an international comparison. Vaccine. 2013;31(5):763–9. doi: 10.1016/j.vaccine.2012.11.083.
    1. Pitts MK, Dyson SJ, Rosenthal DA, Garland SM. Knowledge and awareness of human papillomavirus (HPV): attitudes towards HPV vaccination among a representative sample of women in Victoria, Australia. Sex Health. 2007;4(3):177–80. doi: 10.1071/SH07023.
    1. Reiter PL, Stubbs B, Panozzo CA, Whitesell D, Brewer NT. HPV and HPV vaccine education intervention: effects on parents, healthcare staff, and school staff. Cancer Epidemiol Biomarkers Prev. 2011;20(11):2354–61. doi: 10.1158/1055-9965.EPI-11-0562.
    1. Hopfer S. Effects of a narrative HPV vaccination intervention aimed at reaching college women: a randomized controlled trial. Prev Sci. 2012;13(2):173–82. doi: 10.1007/s11121-011-0254-1.
    1. Marlow LA, Wardle J, Forster AS, Waller J. Ethnic differences in human papillomavirus awareness and vaccine acceptability. J Epidemiol Community Health. 2009;63(12):1010–5. doi: 10.1136/jech.2008.085886.
    1. Marlow LA. HPV vaccination among ethnic minorities in the UK: knowledge, acceptability and attitudes. Br J Cancer. 2011;105(4):486–92. doi: 10.1038/bjc.2011.272.
    1. Cunningham MS, Davison C, Aronson KJ. HPV vaccine acceptability in Africa: a systematic review. Prev Med. 2014;69:274–9. doi: 10.1016/j.ypmed.2014.08.035.
    1. Molokwu J, Fernandez NP, Martin C. HPV awareness and vaccine acceptability in hispanic women living along the US-Mexico border. J Immigr Minor Health. 2014;16(3):540–5. doi: 10.1007/s10903-013-9855-z.
    1. Constantine NA, Jerman P. Acceptance of human papillomavirus vaccination among Californian parents of daughters: a representative statewide analysis. J Adolesc Health. 2007;40(2):108–15. doi: 10.1016/j.jadohealth.2006.10.007.
    1. Dahlstrom LA, Tran TN, Lundholm C, Young C, Sundstrom K, Sparen P. Attitudes to HPV vaccination among parents of children aged 12–15 years-a population-based survey in Sweden. Int J Cancer. 2010;126(2):500–7. doi: 10.1002/ijc.24712.
    1. Ezeanochie MC, Olagbuji BN. Human papilloma virus vaccine: determinants of acceptability by mothers for adolescents in Nigeria. Afr J Reprod Health. 2014;18(3):154–8.
    1. Lu B, Kumar A, Castellsague X, Giuliano AR. Efficacy and safety of prophylactic vaccines against cervical HPV infection and diseases among women: a systematic review & meta-analysis. BMC Infect Dis. 2011;11:13. doi: 10.1186/1471-2334-11-13.
    1. Prygiel M, Janaszek-Seydlitz W. [Efficacy and safety of vaccines against human papillomavirus (HPV)] Przegl Epidemiol. 2012;66(4):657–65.
    1. Human papillomavirus vaccines: WHO position paper, October 2014-Recommendations. Vaccine. 2015;33:4383.
    1. Goncalves AK, Cobucci RN, Rodrigues HM, de Melo AG, Giraldo PC. Safety, tolerability and side effects of human papillomavirus vaccines: a systematic quantitative review. Braz J Infect Dis. 2014;18(6):651–9. doi: 10.1016/j.bjid.2014.02.005.
    1. Macartney KK, Chiu C, Georgousakis M, Brotherton JM. Safety of human papillomavirus vaccines: a review. Drug Saf. 2013;36(6):393–412. doi: 10.1007/s40264-013-0039-5.
    1. Kang S, Kim KH, Kim YT, Kim YT, Kim JH, Song YS, Shin SH, Ryu HS, Han JW, Kang JH et al. Safety and immunogenicity of a vaccine targeting human papillomavirus types 6, 11, 16 and 18: a randomized, placebo-controlled trial in 176 Korean subjects. Int J Gynecol Cancer. 2008;18(5):1013–9.
    1. Bhatla N, Suri V, Basu P, Shastri S, Datta SK, Bi D, Descamps DJ, Bock HL, Indian HPVVSG. Immunogenicity and safety of human papillomavirus-16/18 AS04-adjuvanted cervical cancer vaccine in healthy Indian women. J Obstet Gynaecol Res. 2010;36(1):123–32.
    1. Khatun S, Akram Hussain SM, Chowdhury S, Ferdous J, Hossain F, Begum SR, Jahan M, Tabassum S, Khatun S, Karim AB. Safety and immunogenicity profile of human papillomavirus-16/18 AS04 adjuvant cervical cancer vaccine: a randomized controlled trial in healthy adolescent girls of Bangladesh. Jpn J Clin Oncol. 2012;42(1):36–41.
    1. Harper DM, Franco EL, Wheeler C, Ferris DG, Jenkins D, Schuind A, Zahaf T, Innis B, Naud P, De Carvalho NS et al. Efficacy of a bivalent L1 virus-like particle vaccine in prevention of infection with human papillomavirus types 16 and 18 in young women: a randomised controlled trial. Lancet. 2004;364(9447):1757–65.
    1. Reisinger KS, Block SL, Lazcano-Ponce E, Samakoses R, Esser MT, Erick J, Puchalski D, Giacoletti KE, Sings HL, Lukac S et al. Safety and persistent immunogenicity of a quadrivalent human papillomavirus types 6, 11, 16, 18 L1 virus-like particle vaccine in preadolescents and adolescents: a randomized controlled trial. Pediatr Infect Dis J. 2007;26(3):201–9.
    1. Lazcano-Ponce E, Perez G, Cruz-Valdez A, Zamilpa L, Aranda-Flores C, Hernandez-Nevarez P, Viramontes JL, Salgado-Hernandez J, James M, Lu S et al. Impact of a quadrivalent HPV6/11/16/18 vaccine in Mexican women: public health implications for the region. Arch Med Res. 2009;40(6):514–24.
    1. Munoz N, Manalastas Jr R, Pitisuttithum P, Tresukosol D, Monsonego J, Ault K, Clavel C, Luna J, Myers E, Hood S et al. Safety, immunogenicity, and efficacy of quadrivalent human papillomavirus (types 6, 11, 16, 18) recombinant vaccine in women aged 24–45 years: a randomised, double-blind trial. Lancet. 2009;373(9679):1949–57.
    1. Kim YJ, Kim KT, Kim JH, Cha SD, Kim JW, Bae DS, Nam JH, Ahn WS, Choi HS, Ng T et al. Vaccination with a human papillomavirus (HPV)-16/18 AS04-adjuvanted cervical cancer vaccine in Korean girls aged 10–14 years. J Korean Med Sci. 2010;25(8):1197–204.
    1. Medina DM, Valencia A, de Velasquez A, Huang LM, Prymula R, Garcia-Sicilia J, Rombo L, David MP, Descamps D, Hardt K et al. Safety and immunogenicity of the HPV-16/18 AS04-adjuvanted vaccine: a randomized, controlled trial in adolescent girls. J Adolesc Health. 2010;46(5):414–21.
    1. Ngan HY, Cheung AN, Tam KF, Chan KK, Tang HW, Bi D, Descamps D, Bock HL. Human papillomavirus-16/18 AS04-adjuvanted cervical cancer vaccine: immunogenicity and safety in healthy Chinese women from Hong Kong. Hong Kong Med J. 2010;16(3):171–9.
    1. Kim SC, Song YS, Kim YT, Kim YT, Ryu KS, Gunapalaiah B, Bi D, Bock HL, Park JS. Human papillomavirus 16/18 AS04-adjuvanted cervical cancer vaccine: immunogenicity and safety in 15–25 years old healthy Korean women. J Gynecol Oncol. 2011;22(2):67–75.
    1. Szarewski A, Poppe WA, Skinner SR, Wheeler CM, Paavonen J, Naud P, Salmeron J, Chow SN, Apter D, Kitchener H et al. Efficacy of the human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine in women aged 15–25 years with and without serological evidence of previous exposure to HPV-16/18. Int J Cancer. 2012;131(1):106–16.
    1. Rambout L, Tashkandi M, Hopkins L, Tricco AC. Self-reported barriers and facilitators to preventive human papillomavirus vaccination among adolescent girls and young women: a systematic review. Prev Med. 2014;58:22–32. doi: 10.1016/j.ypmed.2013.10.009.
    1. Pomfret TC, Gagnon JM, Jr, Gilchrist AT. Quadrivalent human papillomavirus (HPV) vaccine: a review of safety, efficacy, and pharmacoeconomics. J Clin Pharm Ther. 2011;36(1):1–9. doi: 10.1111/j.1365-2710.2009.01150.x.
    1. Chatterjee A, O’Keefe C. Current controversies in the USA regarding vaccine safety. Expert Rev Vaccines. 2010;9(5):497–502. doi: 10.1586/erv.10.36.
    1. Black S, Rappuoli R. A crisis of public confidence in vaccines. Sci Transl Med. 2010;2(61):61mr61. doi: 10.1126/scitranslmed.3001738.
    1. Larson HJ, Cooper LZ, Eskola J, Katz SL, Ratzan S. Addressing the vaccine confidence gap. Lancet. 2011;378(9790):526–35. doi: 10.1016/S0140-6736(11)60678-8.
    1. Larson HJ, Smith DM, Paterson P, Cumming M, Eckersberger E, Freifeld CC, Ghinai I, Jarrett C, Paushter L, Brownstein JS et al. Measuring vaccine confidence: analysis of data obtained by a media surveillance system used to analyse public concerns about vaccines. Lancet Infect Dis. 2013;13(7):606–13.
    1. Poljak M. Prophylactic human papillomavirus vaccination and primary prevention of cervical cancer: issues and challenges. Clin Microbiol Infect. 2012;18(Suppl 5):64–9. doi: 10.1111/j.1469-0691.2012.03946.x.
    1. Perkins RB, Zisblatt L, Legler A, Trucks E, Hanchate A, Gorin SS. Effectiveness of a provider-focused intervention to improve HPV vaccination rates in boys and girls. Vaccine. 2015;33(9):1223–9. doi: 10.1016/j.vaccine.2014.11.021.
    1. Cohen EL, Head KJ. Identifying knowledge-attitude-practice gaps to enhance HPV vaccine diffusion. J Health Commun. 2013;18(10):1221–34. doi: 10.1080/10810730.2013.778357.
    1. Gough E, Kempf MC, Graham L, Manzanero M, Hook EW, Bartolucci A, Chamot E. HIV and hepatitis B and C incidence rates in US correctional populations and high risk groups: a systematic review and meta-analysis. BMC Public Health. 2010;10:777.
    1. Allen JD, Coronado GD, Williams RS, Glenn B, Escoffery C, Fernandez M, Tuff RA, Wilson KM, Mullen PD. A systematic review of measures used in studies of human papillomavirus (HPV) vaccine acceptability. Vaccine. 2010;28(24):4027–37.

Source: PubMed

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