Effects of propofol and sevoflurane on blood glucose, hemodynamics, and inflammatory factors of patients with type 2 diabetes mellitus and gastric cancer

Jinhui Liu, Li Yang, Jinhui Liu, Li Yang

Abstract

Effects of propofol and sevoflurane on blood glucose, hemodynamics, and inflammatory factors of patients with type 2 diabetes mellitus (T2DM) and gastric cancer (GC) were investigated. One hundred and ten patients with T2DM and GC, treated in The First Affiliated Hospital of Baotou Medical College (Baotou, China) from January 2017 to December 2018, were selected. Sixty patients anesthetized by propofol were included in the propofol group, whereas 50 patients anesthetized by sevoflurane were included in the sevoflurane group. The level of blood glucose, hemodynamic indicators, and inflammatory factors of the patients in the two groups were compared at T0 (before anesthesia), T1 (2 min after intubation), T2 (5 min after pneumoperitoneum), and T3 (60 min after surgery). Mini-Mental State Examination (MMSE) cognitive function scores were compared at T0 (before anesthesia), T4 (6 h after surgery), and T5 (72 h after surgery) between the two groups. The anesthetic effect and the incidence of adverse reactions were also compared between the two groups. The heart rate (HR), oxygen saturation (SpO2) and average artery pressure decreased slightly and then increased after the surgery was started; whereas, the levels of the serum inflammatory factors first increased and then decreased, to return to their initial levels. MMSE scores of the patients in two groups at T4 were significantly lower than those at T0 (P<0.05), and the MMSE score at T4 was significantly higher in the propofol group than that in the sevoflurane group (P<0.05). The time of spontaneous breathing, verbal response, eye opening, and extubation in the propofol group was significantly shorter than that in the sevoflurane group (P<0.05). The incidence of adverse reactions in the propofol group was lower than that in the sevoflurane group. The effect of propofol is less than that of sevoflurane, thus propofol is more suitable for the anesthesia of patients with T2DM and GC.

Keywords: anesthesia; patients with type 2 diabetes mellitus and gastric cancer; propofol; sevoflurane.

Copyright: © Liu et al.

Figures

Figure 1.
Figure 1.
Comparison of the blood glucose levels of the patients in the two groups. *PaP<0.05, compared with the propofol group at 0 min; bP<0.05, compared with the sevoflurane group at 0 min.
Figure 2.
Figure 2.
Comparison of the hemodynamic indicators of the patients in the two groups. Comparison of (A) HR, (B) SpO2, (C) SBP and (D) MBP in the propofol and sevoflurane group. aP<0.05, compared with the propofol group at 0 min; bP<0.05, compared with the sevoflurane group at 0 min. HR, heart rate; SpO2, oxygen saturation; SBP, systolic blood pressure; MBP, mean blood pressure.
Figure 3.
Figure 3.
Comparison of the levels of serum inflammatory factors of the patients in two groups. (A) The level of IL-1β in the propofol group was lower than that in the sevoflurane group. (B) The level of IL-6 in the propofol group was significantly lower than that in the sevoflurane group (PaP<0.05, compared with the propofol group at 0 min; bP<0.05, compared with the sevoflurane group at 0 min.
Figure 4.
Figure 4.
Comparison of MMSE cognitive function scores of the patients in the two groups. *PaP<0.05, compared with the propofol group at 0 min; bP<0.05, compared with the sevoflurane group at 0 min. MMSE, Mini-Mental State Examination.
Figure 5.
Figure 5.
Comparison of the anesthetic effect of the patients in the two groups. (A) The time of spontaneous breath in the propofol group was shorter than that in the sevoflurane group (P#P<0.05, compared with the propofol group.

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