Systematic review and meta-analysis on management of hemodialysis catheter-related bacteremia

Abstract

Hemodialysis catheter-related bacteremia is a common clinical problem with several management options. We performed a systematic review and meta-analysis to determine cure proportions with systemic antibiotics, antibiotic lock solution, and guidewire exchange. We searched databases and registries; conference proceedings from relevant medical societies; and article reference lists. Data regarding management approach, cure, follow-up, recurrence, complications, and microbiology were abstracted and pooled from 28 selected publications. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated from a mixed effects logistic regression model. In total, 1596 patients with tunneled hemodialysis catheter-related bacteremia were divided into groups on the basis of treatment with systemic antibiotics (n=697), antibiotic lock solution (n=546), or guidewire exchange (n=353). Antibiotic lock solution and guidewire exchange had similar cure proportions that were superior to systemic antibiotics alone (OR, 2.08; 95% CI, 1.25 to 3.45; P<0.01 for antibiotic lock solution; OR, 2.88; 95% CI, 1.82 to 4.55; P<0.001 for guidewire exchange versus systemic antibiotics). Cure proportions were highest for coagulase-negative staphylococci followed by gram-negative rods and Staphylococcus aureus. Among S. aureus infections, guidewire exchange led to a higher cure proportion than systemic antibiotics or antibiotic lock solution (OR, 3.33; 95% CI, 1.17 to 9.46; P=0.02; OR, 4.72; 95% CI, 1.79 to 12.46; P=0.002, respectively). Thus, results of this study suggest that tunneled hemodialysis catheter-related bacteremia should be treated with either guidewire exchange or antibiotic lock solution. Future studies should address prospectively whether one strategy is better than the other overall and for specific pathogens.

Keywords: antibiotic lock solution; bacteremia; guidewire exchange; hemodialysis.

Copyright © 2014 by the American Society of Nephrology.

Figures

Figure 1.

Flowchart showing the study selection process. Number of studies screened, assessed for eligibility, and included in the meta-analysis and reasons for exclusion of full-text articles.

Figure 2.

Funnel plot for the three groups combined in one plot. The funnel is on the side, with the spout (larger sample sizes) toward the right side of the plot.

Figure 3.

Success rates and 95% CIs for individual studies in the three treatment groups. The vertical lines give the mean success rates (and 95% confidence bands; shaded areas) for each group, taking into account within-group variation. We also provide the numbers cured and total infected for each study and the duration of follow-up in days. There were significant differences in cure proportions between ABL and SABX (OR, 2.08; 95% CI, 1.25 to 3.45; P<0.01) and between GWX and SABX (OR, 2.88; 95% CI, 1.82 to 4.55; P<0.001). The difference between GWX and ABL was not significant (OR, 1.39; 95% CI, 0.78 to 2.46; P=0.27).

Figure 4.

Box plots of success rates stratified by the type of infecting pathogen, overall (upper left panel), and by type of treatment. Circles denote outliers. The highest cure proportion was for CNS followed by GNR and S. aureus. The ORs of a cure were CNS versus GNR, 1.71 (95% CI, 0.99 to 2.97; P=0.06); CNS versus S. aureus, 3.13 (95% CI, 1.73 to 5.67; P<0.001); and GNR versus S. aureus, 1.83 (95% CI, 1.13 to 2.97; P=0.02).